Article
Oncology
Xueyi Zhu, Yuxue Cao, Mingyue Su, Mengmeng Chen, Congcong Li, La Yi, Jingjing Qin, Wuniqiemu Tulake, Fangzhou Teng, Yuanyuan Zhong, Weifeng Tang, Shiyuan Wang, Jingcheng Dong
Summary: The study shows that Cycloastragenol (CAG) attenuates airway inflammation in an ovalbumin-induced mouse asthma model by suppressing leukocytes, eosinophils, inflammatory cytokines, and inflammatory cell infiltration. Additionally, molecular docking simulations suggest that CAG inhibits autophagy pathways in lung cells, contributing to its anti-inflammatory effects in asthma.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Fanfan Liang, Kaina Zhang, Wenzhuo Ma, Heqin Zhan, Qiang Sun, LaiHua Xie, Zhenghang Zhao
Summary: Sorafenib disrupts autophagy and mitochondrial dynamics, leading to oxidative stress and cardiomyocyte apoptosis. Improving autophagy or inhibiting mitochondrial fission can attenuate Sorafenib-induced cardiotoxicity.
Article
Medicine, Research & Experimental
Dezhong Zheng, Mingyu Zhang, Tingrong Liu, Tao Zhou, Anna Shen
Summary: The study reveals that OPG induces cardiomyocyte hypertrophy and inhibits autophagy through the FAK/Beclin1 signal pathway. The phosphorylation of FAK plays a key role in this process.
Article
Biochemistry & Molecular Biology
Leander Gaarde Melin, Julie Husted Dall, Jes S. Lindholt, Lasse B. Steffensen, Hans Christian Beck, Sophie L. Elkrog, Pernille D. Clausen, Lars Melholt Rasmussen, Jane Stubbe
Summary: Supplementation of cycloastragenol can inhibit the progression of abdominal aortic aneurysm, possibly by reducing matrix metalloprotease-2 activity, preserving elastin, and reducing calcification.
Article
Biochemistry & Molecular Biology
Yingjie Xu, Zengxiang Dong, Rongzhen Zhang, Zeng Wang, Yuanqi Shi, Mingyu Liu, Jiemei Yang, Tao Yang, Runtong Zhang, Tengyu Wang, Jingyu Zhang, Yu Zhang, Fei Xiang, Yingjun Han, Jiawen Wu, Zhihan Miao, Qiuyu Chen, Qi Li, Zeyao Wang, Ye Tian, Yuanyuan Guo
Summary: Myocardial infarction (MI) is lethal due to acute ischemia and hypoxia, leading to cardiac tissue apoptosis. In this study, we investigated the role of sonodynamic therapy (SDT) in reducing MI-induced cardiomyocyte apoptosis by activating the autophagy pathway. Our results show that SDT improves cardiac function and reduces MI-induced cardiomyocyte apoptosis by enhancing autophagy. Furthermore, we found that the protective effect of SDT is mediated by the activation of MHRT-mediated autophagy. Therefore, SDT may be a potential method for the treatment of post-myocardial infarction heart failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A. Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng
Summary: The study aims to investigate the role of GRK4 in the pathogenesis and progression of myocardial infarction (MI). Results showed that GRK4 expression was increased in the heart after MI, and overexpression of GRK4 aggravated cardiac infarction and dysfunction while specific gene knockout ameliorated these effects. GRK4 inhibited autophagy and promoted cardiomyocyte apoptosis, effects mediated by HDAC4 phosphorylation and a decrease in beclin-1 expression, leading to greater impairment of cardiac function in MI patients carrying the GRK4 A486V variant.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Kuhn, Maja Menke, Frauke Senger, Claudia Mack, Franziska Dierck, Susanne Hille, Inga Schmidt, Gabriele Brunke, Pia Buenger, Nesrin Schmiedel, Rainer Will, Samuel Sossalla, Derk Frank, Thomas Eschenhagen, Lucie Carrier, Renate Luellmann-Rauch, Ashraf Yusuf Rangrez, Norbert Frey
Summary: The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Lack of FYCO1 affects autophagy induction after glucose deprivation, leading to impaired cardiac function. FYCO1 overexpression rescues cardiac dysfunction in response to biomechanical stress by inducing autophagy.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Summary: This study reveals that suppression of Akt activity in skeletal muscle of mammals associated with insulin resistance and aging could accelerate sarcopenia and reduce lifespan.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Christiane Ott, Tobias Jung, Sarah Brix, Cathleen John, Iris R. Betz, Anna Foryst-Ludwig, Stefanie Deubel, Wolfgang M. Kuebler, Tilman Grune, Ulrich Kintscher, Jana Grune
Summary: Cardiac remodeling and contractile dysfunction are major causes of hypertrophy-associated heart failure, characterized by accumulation of modified proteins due to impaired autophagy-lysosomal pathway in aged and diseased hearts. Autophagy inducer rapamycin has cardioprotective effects by improving cardiomyocyte autophagy and contractility. Endothelin 1 (ET-1) decreases autophagy and cardiomyocyte contractility, similar to siAtg5-treated cells and TAC-mice, highlighting the crucial role of autophagy in cardiomyocyte contractility and cardiac performance.
Article
Biology
Chengsi Deng, Chunlu Li, Xiang Dong, Yang Yu, Wendong Guo, Yi Guan, Xun Sun, Liu Cao
Summary: This study reports that autophagy-related gene 7 (ATG7) regulates cell cycle and survival during metabolic stress by modulating the phosphorylation and ubiquitination of PDCD4. ATG7 senses the decrease of ATP levels to suppress AKT-mediated PDCD4 phosphorylation, thereby reducing apoptosis and promoting cell survival during stress periods.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Dawei Liu, Felix Peyre, Yahir Alberto Loissell-Baltazar, Delphine Courilleau, Sandra Lacas-Gervais, Valerie Nicolas, Eric Jacquet, Svetlana Dokudovskaya, Frederic Taran, Jean-Christophe Cintrat, Catherine Brenner
Summary: This study identified six compounds through high-throughput screening that have the potential to prevent cardiac cell death caused by chemotherapy, suggesting their promising role as cardioprotective drugs.
Article
Nanoscience & Nanotechnology
Ming Fan, Fei Xie, Jianfeng Li, Junquan Li, Ting Liang
Summary: This study explores the protective mechanism of cardiomyocyte exosome nanovesicles on myocardial infarction. The findings suggest that cardiomyocyte exosomes can inhibit cardiomyocyte apoptosis and autophagy activation, and improve cardiac function in rats with myocardial infarction.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Integrative & Complementary Medicine
Qi Chen, QingYang Xu, Huilin Zhu, Junyi Wang, Ning Sun, Huimin Bian, Yu Li, Chao Lin
Summary: Sal B inhibits cardiomyocyte apoptosis and promotes angiogenesis by regulating autophagy, thereby improving myocardial ischemia.
Article
Reproductive Biology
Qinyao Wei, Huiqing Xue, Congjiao Sun, Juan Li, Haorong He, Felix Kwame Amevor, Bo Tan, Menggen Ma, Kai Tian, Zhichao Zhang, Yao Zhang, Hua He, Lu Xia, Qing Zhu, Huadong Yin, Can Cui
Summary: This study verifies that gga-miR-146b-3p attenuates proliferation and autophagy but promotes apoptosis in chicken granulosa cells (GC) by targeting AKT1 through the PI3K/AKT signaling pathway. These findings provide important insights into the molecular regulation of granulosa cell function during folliculogenesis.
Review
Cell Biology
Urna Kansakar, Fahimeh Varzideh, Pasquale Mone, Stanislovas S. Jankauskas, Gaetano Santulli
Summary: microRNAs play crucial roles in cardiovascular disease, especially in the regulation of cardiomyocyte death. This article provides an updated overview of the involvement of microRNAs in cardiomyocyte death.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
