Article
Chemistry, Multidisciplinary
Lukasz Lamch, Kazimiera A. Wilk, Imre Dekany, Agota Deak, Viktoria Hornok, Laszlo Janovak
Summary: The encapsulation of hydrophilic and amphiphilic drugs in colloidal carrier systems for sustained release is a growing concern. The use of a core-shell approach with nanocarriers can provide a solution for hydrophilic/amphiphilic drugs. Amphiphilic polymers play a key role in stabilizing the system and enhancing the chemical stability and sustained release profiles.
Article
Chemistry, Physical
Ekaterina Razuvaeva, Nikita Sedush, Evgeniya Shirokova, Stanislav Moskvichev, Dmitry Streltsov, Sergei Chvalun
Summary: This study synthesized spherical nano-sized particles of poly(D,L-lactide-co-glycolide) (PLGA) using a non-toxic catalyst and a nanoprecipitation method. The effect of formulation parameters on the properties of PLGA particles was investigated. The formation mechanism and stabilization factors of the PLGA particles were proposed and analyzed.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Daria Lytkina, Lothar Heinrich, Elena Churina, Irina Kurzina
Summary: The study focused on obtaining porous composite materials based on hydroxyapatite and a copolymer for use as bone implants. It investigated the phase and elemental composition, surface properties, and the impact of production processes on material composition. Regularities in porosity formation, surface properties, and biocompatibility were established through various experimental methods.
Article
Crystallography
Daria Lytkina, Anastasiya Gutsalova, Dmitry Fedorishin, Irina Kurzina
Summary: This study investigated the formation of new composite materials based on zinc-modified hydroxyapatite and a copolymer of lactide and glycolide, as well as their surface properties, composition, and biocompatibility. These composite materials show potential for use as materials for bone implants.
Article
Polymer Science
Arisa Kongprayoon, Gareth Ross, Nanteetip Limpeanchob, Sararat Mahasaranon, Winita Punyodom, Paul D. Topham, Sukunya Ross
Summary: Bio-derived and biocompatible nanogels based on poly(lactic acid) (PLA) and silk sericin (SS) were synthesized and embedded within nanofibers for potential use in tissue regeneration. Higher crosslink densities resulted in smaller nanogel particles with reduced drug release accumulation.
Article
Polymer Science
Airong Xu, Fen Wang, Luwei Zhang, Xingmin Xu, Zhihong Xiao, Rukuan Liu
Summary: A simple and feasible preparation approach was presented in this study to fabricate biodegradable and biocompatible composite films, addressing the issue of environmental pollution caused by polymer materials based on fossil resources being difficult to degrade. The composite films displayed good mechanical properties, re-usability, and thermal stability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Huixian Jiang, Xiang Li, Zhenjian Xing, Qun Niu, Jiangping Xu
Summary: This study prepared nanoparticles loaded with multiple drugs and evaluated their therapeutic efficacy against multidrug-resistant tuberculosis in macrophages. The nanoparticles demonstrated high cellular compatibility, maintained their concentration for a long duration, and exhibited enhanced antibacterial activity compared to free drug compounds.
CURRENT DRUG DELIVERY
(2023)
Article
Materials Science, Biomaterials
Prabhanjan S. Giram, Julie Tzu-Wen Wang, Adam A. Walters, Priyanka P. Rade, Muhammad Akhtar, Shunping Han, Farid N. Faruqu, Hend M. Abdel-Bar, Baijayantimala Garnaik, Khuloud T. Al-Jamal
Summary: A green synthetic approach using a biocompatible zinc proline complex as an initiator for PLGA synthesis was reported for the first time in this study, resulting in the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA) with controlled molecular weight and narrow polydispersity. The potential of mPEG-PLGA for delivering the poorly water-soluble chemotherapeutic drug irinotecan was demonstrated, with nanoparticles showing controlled size, surface charge, release properties, and cytotoxicity against colon and pancreatic cancer cells. The newly synthesized copolymer, via a green route, proved to be non-toxic and promising for drug delivery applications.
BIOMATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Jaspreet Kaur, Shweta Jakhmola, Ravi Raj Singh, Bhavana Joshi, Hem Chandra Jha, Abhijeet Joshi
Summary: The study demonstrates the potential of SAHA-PLGA nanoparticles in cancer treatment, showing excellent size and encapsulation efficiency, as well as significant cytotoxicity and growth inhibition effects on U87 GBM cells.
ACS APPLIED BIO MATERIALS
(2021)
Review
Spectroscopy
Sankar Renu, Kanchi Subramanian Shivashangari, Vilwanathan Ravikumar
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Cell Biology
Jagadish Hiremath, Sankar Renu, Kaissar Tabynov, Gourapura J. Renukaradhya
CELLULAR IMMUNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Sankar Renu, Ashley D. Markazi, Santosh Dhakal, Yashavanth S. Lakshmanappa, Revathi Shanmugasundaram, Ramesh K. Selvaraj, Gourapura J. Renukaradhya
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Microbiology
Sankar Renu, Ninoshkaly Feliciano-Ruiz, Shristi Ghimire, Yi Han, Jennifer Schrock, Santosh Dhakal, Veerupaxagouda Patil, Steven Krakowka, Gourapura J. Renukaradhya
VETERINARY MICROBIOLOGY
(2020)
Article
Chemistry, Applied
Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Shristi Ghimire, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya
CARBOHYDRATE POLYMERS
(2020)
Article
Multidisciplinary Sciences
Keila Y. Acevedo-Villanueva, Bailey Lester, Sankar Renu, Yi Han, Revathi Shanmugasundaram, Renukaradhya Gourapura, Ramesh Selvaraj
Article
Immunology
Yi Han, Sankar Renu, Veerupaxagouda Patil, Jennifer Schrock, Ninoshkaly Feliciano-Ruiz, Ramesh Selvaraj, Gourapura J. Renukaradhya
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Sankar Renu, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Shristi Ghimire, Yi Han, Jennifer Schrock, Santosh Dhakal, Veerupaxagouda Patil, Steven Krakowka, Harm HogenEsch, Gourapura J. Renukaradhya
Article
Immunology
Sankar Renu, Ninoshkaly Feliciano-Ruiz, Veerupaxagouda Patil, Jennifer Schrock, Yi Han, Anikethana Ramesh, Santosh Dhakal, Juliette Hanson, Steven Krakowka, Gourapura J. Renukaradhya
Summary: The study developed a novel swine influenza vaccine that enhanced antibody responses to multiple strains of influenza virus in piglets. Intranasally administered vaccine showed superior antibody induction and protective efficacy against influenza virus in piglets with maternal antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Keila Acevedo-Villanueva, Sankar Renu, Renukaradhya Gourapura, Ramesh Selvaraj
Summary: The study indicates that in-ovo administration of CNP vaccine in broilers can significantly enhance immune response against SE and reduce SE cecal load. However, there were no significant differences in body weight gain and feed conversion ratio between vaccinated birds and control group.
Editorial Material
Biotechnology & Applied Microbiology
Sankar Renu, Heather L. Wilson, Kaissar Tabynov, Jagadish Hiremath
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Mary Shank-Retzlaff, Yolanda Peris Taverner, Pallavi Joshi, Sankar Renu, Arun Chitikela, Animesh Koneru, Zhuoran Wang, Laura Bronsart, Pravansu Mohanty
Summary: Capillary-mediated vitrification (CMV) is a novel method for stabilizing biological molecules and complexes by utilizing capillary evaporation to enable rapid desiccation of aqueous solutions. CMV produces an amorphous dried product with enhanced thermal stability in less than an hour, serving as a potential alternative to traditional biopreservation methods.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Meeting Abstract
Immunology
Renukaradhya J. Gourapura, Ninoshkaly Feliciano-Ruiza, Sankar Renu, Fangjia Lu, Yi Han, Jennifer Schrock, Santosh Dhakal, Veerupaxagouda Patil, Harm HogenEsch
JOURNAL OF IMMUNOLOGY
(2020)
Review
Biotechnology & Applied Microbiology
Sankar Renu, Gourapura J. Renukaradhya
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Bradley T. Hogshead, Jessica Pempek, Santosh Dhakal, Shristi Ghimire, Sankar Renu, Kathryn L. Proudfoot, Gregory G. Habing, Gourapura J. Renukaradhya
APPLIED ANIMAL SCIENCE
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)