Article
Biochemical Research Methods
U. S. Dinish, Yik Weng Yew, Keertana Vinod Ram, Renzhe Bi, Amalina Binte Ebrahim Attia, Valerie Teo Xinhui, Poongkulali Rajarahm, Hazel Hweeboon Oon, Steven Tien Guan Thng, Malini Olivo
Summary: A handheld non-invasive confocal Raman system (CRS) was used to evaluate the differences in skin biochemicals between atopic dermatitis (AD) and psoriasis. The relative amount of water was found to decrease in the sequence of healthy skin, psoriasis, and AD. Differential trends were observed for subclasses of ceramides, with ceramide 3 being lower in lesional AD and psoriasis skin, while ceramide 2 showed a contrasting trend. The amount of cholesterol was significantly higher in lesional psoriasis.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Biochemistry & Molecular Biology
Monika Marko, Rafal Pawliczak
Summary: Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases with increasing prevalence worldwide, causing decreased quality of life and socioeconomic burden. Resveratrol and its derivatives, based on natural compounds, show potential therapeutic effects through anti-inflammatory and antioxidant pathways.
Review
Plant Sciences
Eleonora Di Salvo, Sebastiano Gangemi, Claudia Genovese, Nicola Cicero, Marco Casciaro
Summary: Polyphenols are natural compounds found in fruits, vegetables, and herbs that have antioxidant and anti-inflammatory properties. They can improve cardiovascular health and have potential neuroprotective effects. The Mediterranean diet, which is rich in polyphenols, is associated with a lower incidence of various chronic diseases, including dermatological conditions. The use of polyphenols as adjunctive therapy for atopic dermatitis, psoriasis, and chronic urticaria shows promise, although further research is needed to fully understand their mechanisms of action and optimal dosing.
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dora Hrestak, Mario Matijasic, Hana Cipcic Paljetak, Daniela Ledic Drvar, Suzana Ljubojevic Hadzavdic, Mihaela Peric
Summary: This review provides an overview of the involvement of skin microbiota in atopic dermatitis (AD) and its complex interaction with the host immune response mechanisms, as well as novel therapeutic strategies focused on restoring skin microbial homeostasis for treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Lennart M. Roesner, Ahmed K. Farag, Rebecca Pospich, Stephan Traidl, Thomas Werfel
Summary: This study compares T cells from lesional skin and blood of patients with atopic dermatitis (AD) and psoriasis, and finds that analyzing the T-cell receptor (TCR) sequences that drive skin-homing T cells helps to clarify the extent to which these infiltrating T cells are antigen-specific.
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis, Sebastiano Gangemi
Summary: Microbiome dysbiosis and cytokine alternations play crucial roles in the development of atopic dermatitis (AD) and psoriasis (PsO), two highly prevalent and burdensome pruritic skin conditions worldwide. Interleukin (IL)-33 and IL-31 are major drivers in the pathogenesis and maintenance of AD and PsO, and their potential as therapeutic targets is under extensive investigation. The relationship between dysbiosis and immunological changes has been studied extensively, with ongoing debate on the primary causative factor behind AD and PsO. This literature review aims to support the hypothesis that dysbiosis is the origin of IL-33/IL-31 dysregulation in AD and PsO, and discusses current therapeutic options targeting IL-31, IL-33, and/or the microbiome.
Article
Allergy
Taras Lyubchenko, Hannah K. Collins, Elena Goleva, Donald Y. M. Leung
Summary: A novel minimally invasive skin cytokine profiling method was developed for diagnosis and therapeutic response monitoring in skin diseases like atopic dermatitis. Markers associated with type 2 inflammatory response were readily detectable in AD lesional skin, correlating with disease severity and changes in skin transepidermal water loss.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Georgeta St Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The aging skin undergoes immunosenescence and immunological alterations, which together with environmental stressors and genetic factors can lead to immune dysregulation and epidermal barrier abnormalities, facilitating the late onset of atopic dermatitis (AD) in the elderly. While healthy aged skin shows overproduction of cytokines, older AD patients have decreased levels of Th2/Th22 related cytokines and increased expression of terminal differentiation markers, reflecting the persistence of AD in an aged skin environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Chung Hyeok Lee, Sung Jay Choe, Dong Hye Kim, Eun Jung Kim, Minseob Eom, Seung-Phil Hong, Eung Ho Choi
Summary: Results from big data analysis and animal experiments indicated that patients with atopic dermatitis (AD) had less severe skin atrophy compared to those with psoriasis (PSO) after topical glucocorticoid (TGC) treatment, possibly due to increased tissue eosinophils and periostin deposition causing skin fibrosis in AD patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Maria-Victoria Segura-Fernandez-Nogueras, Isabel Perez-Rodriguez, Miguel Soler-Gongora, Antonio Martinez-Lopez, Ana Fernandez-Gonzalez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study compared skin barrier function between healthy skin, psoriatic skin, and atopic dermatitis skin, finding that TEWL was higher at psoriatic and AD lesions, while SCH was lower. Specific TEWL and temperature values may help clinicians determine disease severity and treatment needs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Lucia Peterle, Giovanni Pioggia, Sebastiano Gangemi
Summary: Epithelium-derived cytokines may represent a therapeutic opportunity for patients with atopic dermatitis and psoriasis, especially in itch control. These three cytokines are interconnected in both acute and chronic phases of these diseases, showing potential as target therapies or biomarkers of disease activity.
Review
Immunology
Jie Yang, Minglu Xiao, Kui Ma, Hongyu Li, Mingzi Ran, Shuxu Yang, Yuguang Yang, Xiaobing Fu, Siming Yang
Summary: This review systematically discusses the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Linh Ha-Wissel, Handan Yasak, Robert Huber, Detlef Zillikens, Ralf. J. J. Ludwig, Diamant Thaci, Jennifer. E. E. Hundt
Summary: This study evaluated the use of optical coherence tomography (OCT) in evaluating and monitoring skin inflammation in patients with psoriasis and atopic dermatitis. The study found that OCT can quantitatively assess skin inflammation and be used to monitor the effectiveness of biologic therapy. Different optical characteristics were observed in psoriatic and eczema lesions during the 52-week observation period.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Alona Goldstein, Yoram Soroka, Marina Frusic-Zlotkin, Aaron Lewis, Ron Kohen
Article
Immunology
Isaac Ginsburg, Erez Koren, James Varani, Ron Kohen
INFLAMMOPHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Maya Ben-Yehuda Greenwald, Marina Frusic-Zlotkin, Yoram Soroka, Shmuel Ben-Sasson, Havazelet Bianco-Peled, Ron Kohen
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Cell Biology
Maya Ben Yehuda Greenwald, Marina Frusic-Zlotkin, Yoram Soroka, Shmuel Ben Sasson, Ronit Bitton, Havazelet Bianco-Peled, Ron Kohen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Biochemistry & Molecular Biology
R. Sirota, D. Gibson, R. Kohen
Editorial Material
Veterinary Sciences
Itzik Lenchner, Gilad Segev, Tomer Ben Ari, Ron Kohen, Roman Sirota, Yaron Bruchim
RESEARCH IN VETERINARY SCIENCE
(2018)
Article
Multidisciplinary Sciences
Tehila Beiser, Ran Numa, Ron Kohen, Rami Yaka
SCIENTIFIC REPORTS
(2017)
Article
Dermatology
Mayer Saidian, Jonathan R. T. Lakey, Adrien Ponticorvo, Rebecca Rowland, Melissa Baldado, Joshua Williams, Maaikee Pronda, Michael Alexander, Antonio Flores, Li Shiri, Stellar Zhang, Bernard Choi, Roni Kohen, Bruce J. Tromberg, Anthony J. Durkin
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Dermatology
Sapir Ron-Doitch, Yoram Soroka, Marina Frusic-Zlotkin, Dinorah Barasch, Doron Steinberg, Ron Kohen
Summary: Skin homeostasis is constantly challenged by environmental factors, with the Nrf2-keap1 pathway playing a crucial role in maintaining the skin's redox state. Research has shown that both skin and bacteria release volatile organic compounds, some of which are aldehydes that can activate the Nrf2-keap1 pathway to protect against environmental insults.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sapir Ron-Doitch, Ron Kohen
Article
Microbiology
Sapir Ron-Doitch, Marina Frusic-Zlotkin, Yoram Soroka, Danielle Duanis-Assaf, Dalit Amar, Ron Kohen, Doron Steinberg
Summary: The study found that Staphylococcus aureus and Staphylococcus epidermidis form biofilms on healthy human skin surfaces, composed of extracellular polysaccharides and extracellular DNA, providing skin protection against UVB-induced apoptosis.
Article
Biochemistry & Molecular Biology
Ilya Pinchuk, Ron Kohen, Wolfgang Stuetz, Daniela Weber, Claudio Franceschi, Miriam Capri, Mikko Hurme, Beatrix Grubeck-Loebenstein, Christiane Schon, Jurgen Bernhardt, Florence Debacq-Chainiaux, Martijn E. T. Dolle, Eugene H. J. M. Jansen, Efstathios S. Gonos, Ewa Sikora, Nicolle Breusing, Daniela Gradinaru, Maria Moreno-Villanueva, Alexander Burkle, Tilman Grune, Dov Lichtenberg
Summary: Redox steady state is crucial for cellular functions, while Oxidative Stress is associated with various pathologies. Understanding the relationship between oxidative stress biomarkers and antioxidants can help in selective treatment. The effects of different LMWA on oxidative damage biomarkers need to be carefully studied before justifying a single LMWA treatment approach.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Dror Cohen, Meital Portugal-Cohen, Miriam Oron, Marina Frusic-Zlotkin, Yoram Soroka, Ze'evi Ma'or, Dalit Amar, Ron Kohen
Summary: The skin can benefit from exposure to moderate environmental stressors, such as those found in the Dead Sea area, which activates the Nrf2-Keap1 pathway and protects against oxidative damage. The unique combinations of moderate stressors in the Dead Sea, including high-water salinity, high atmospheric pressure, and unique solar radiation, generate moderate oxidative stress in the skin, leading to the induction of intracellular electrophiles and the activation of the protecting Nrf2-Keap1 pathway. This activation results in the induction of phase II enzymes and lower apoptotic activity compared to nearby locations at higher altitudes.
Meeting Abstract
Biochemistry & Molecular Biology
Ron Kohen
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Meeting Abstract
Dermatology
M. Brandwein, A. Katz, R. Kohen
EXPERIMENTAL DERMATOLOGY
(2018)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)