Review
Pharmacology & Pharmacy
Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov, Yana G. Toropova
Summary: Currently, there is an expansion in the pharmacological possibilities of treating cancer, leading to an increase in life expectancy with chemotherapy and supportive treatment. However, complications such as anthracycline-induced cardiomyopathy are a significant concern, requiring further research to understand its development mechanisms through new models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Pharmacology & Pharmacy
Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, Deshi Dong
Summary: The study found that Naringin can prevent DOX-related cardiac injury and inhibit oxidative stress, inflammation, and apoptosis in the heart both in vivo and in vitro. These findings suggest that Naringin may serve as a novel approach to prevent cardiac toxicity induced by anthracycline drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Environmental Sciences
Sara Asaad Abdulkareem Aljumaily, Mehmet Demir, Hulya Elbe, Gurkan Yigitturk, Yasemin Bicer, Eyup Altinoz
Summary: The study aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Results showed that crocin significantly ameliorated lipid profile, cardiac markers, and oxidative stress indices caused by DOX. Additionally, crocin alleviated histopathological damage in myocardium induced by DOX.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang
Summary: Myocardial apoptosis and necroptosis are key factors in doxorubicin-induced cardiotoxicity, while phosphocreatine (PCr) has been shown to have cardioprotective effects. PCr can alleviate myocardial cell death induced by DOX by increasing antioxidant activity, and activate the TAK1 signaling pathway to promote myocardial survival.
Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yunpeng Zhang, Shuang Liu, Jing Peng, Shifeng Cheng, Qingling Zhang, Nan Zhang, Zandong Zhou, Yue Zhang, Yang Zhao, Tong Liu
Summary: This study evaluated the role of cerium oxide-based nanozymes in preventing and treating doxorubicin-induced cardiotoxicity. The nanoparticles showed excellent antioxidant response and bioregulation, effectively reversing myocardial remodeling and reducing myocardial necrosis. The study suggests that cerium oxide-based nanozymes could be a promising candidate for the prevention and treatment of doxorubicin-induced cardiotoxicity.
Article
Biochemistry & Molecular Biology
Chenfei Li, Zhen Guo, Fangyuan Liu, Peng An, Mingyu Wang, Dan Yang, Qizhu Tang
Summary: Doxorubicin (DOX) is a commonly used chemotherapeutic drug in cancer treatment, but its side effects on the heart restrict its clinical application. In this study, researchers found that apoptosis, oxidative stress, and autophagy all play important roles in DOX-induced cardiac injury. They demonstrated that overexpression of PCSK6, a protein involved in cardiovascular diseases, can protect against DOX-induced cardiac damage by promoting autophagy and inhibiting apoptosis and oxidative stress. They also identified the involvement of SIRT1 and FOXO3a in the protective effect of PCSK6.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Chen Zhang, Qinghua Dan, Song Lai, Yutong Zhang, Erer Gao, Haiyan Luo, Liping Yang, Xiaobo Gao, Cailing Lu
Summary: This study investigated the role of Rab10 in doxorubicin (DOX)-induced cardiotoxicity. The results showed that cardiac-specific overexpression of Rab10 alleviated cardiac dysfunction and mitochondrial damage caused by DOX treatment. Rab10 also inhibited apoptosis and oxidative stress in cardiomyocytes. Furthermore, Rab10 inhibited the cleavage of Mst1, a serine-threonine kinase, mediated by DOX treatment.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Xiaoliang Hu, Cheng Li, Qian Wang, Zhixing Wei, Taizhong Chen, Yuepeng Wang, Yigang Li
Summary: Doxorubicin, a drug with limited clinical application due to its cardiotoxicity, can be alleviated by Dimethyl fumarate (DMF) through reducing oxidative stress and apoptosis via Nrf2 pathway. The study found that DMF significantly improved cell viability and morphology, as well as alleviated DOX-induced cardiac injury, oxidative stress, and apoptosis. Moreover, DMF exerted its protective effects by promoting Nrf2 nuclear translocation and activating downstream antioxidant gene Hmox1. DMF may be a promising candidate to alleviate DOX-related cardiotoxicity in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuejun Wang, Li Zhang, Mengwen Feng, Zhongqing Xu, Zijie Cheng, Lingmei Qian
Summary: ELA-11 alleviated heart injury induced by DOX and inhibited apoptosis in cardiac tissues by regulating the PI3K/AKT and ERK/MAPK signaling pathways. It also protected cardiomyocytes from oxidative stress-induced apoptosis by interacting with the APJ receptor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Nonhlakanipho F. Sangweni, Rebamang A. Mosa, Phiwayinkosi Dludla, Abidemi P. Kappo, Andy R. Opoku, Christo J. F. Muller, Rabia Johnson
Summary: The study demonstrates that RA3 can alleviate hyperglycemia-induced cardiac damage through various mechanisms, including improving glucose uptake, reducing oxidative stress and antioxidant enzyme activity, decreasing intracellular lipid content, and mitigating cell apoptosis.
Article
Infectious Diseases
Ashif Iqubal, Mohammad Kashif Iqubal, Farazul Hoda, Abul Kalam Najmi, Syed Ehtaishamul Haque
Summary: The novel coronavirus has been associated with severe acute respiratory distress syndrome (ARDS) and notable cardiovascular complications. Proposed mechanisms of cardiovascular complications include virus infection, cytokine storm, altered immune response, and myocardial tissue damage. Monitoring risk-benefit ratio of treatment paradigm and cardiac injury biomarkers regularly is crucial for COVID-19 patients, along with potential clinical trials comparing anti-COVID-19 drugs with cardioprotective anti-inflammatory drugs. Vaccines are the ideal solution, but in the meantime, sanitization, social distancing, and a healthy lifestyle are key in combating the global pandemic.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Toxicology
Saima Zameer, Salman Hussain, Divya Vohora, Abul Kalam Najmi, Javed Ali, Mohd Akhtar
Summary: The study demonstrates that alendronate can improve cognitive and neurological disturbances caused by age-related disorders, including neuroinflammation, oxidative stress, and neuronal damage. Experimental findings show that alendronate can effectively reverse these changes.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohammad Shahar Yar, Mohd Akhtar
Summary: The study explored the therapeutic potential of RFM and TDF phosphodiesterase inhibitors in treating AD induced by ICV Aβ1-42 in rats. RFM and TDF were found to significantly attenuate memory deficits and neuropathological alterations induced by Aβ1-42.
PHARMACOLOGICAL REPORTS
(2021)
Article
Instruments & Instrumentation
Tinku, Mohd. Mujeeb, Abdul Ahad, Mohd. Aqil, Waseem Ahmad Siddiqui, Abul Kalam Najmi, Mymoona Akhtar, Apeksha Shrivastava, Abdul Qadir, Thasleem Moolakkadath
Summary: This study successfully optimized rubiadin-loaded niosomes using Box-Behnken design for the management of diabetic nephropathy in Wistar rats. The optimized formulation showed significant anti-diabetic activity and improvement in biochemical parameters in Wistar rats. The findings suggest that the prepared RLN formulation has potential for the management of STZ-NA-induced DN.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Sana Khan, Soumya Pati, Shailja Singh, Mohd. Akhtar, Piush Khare, Saba Khan, Sadat Shafi, Abul Kalam Najmi
Summary: This study aims to understand the role of hypercoagulation in triggering the progression of neurodegeneration in MetS. It also offers a few interventions to prevent the progression of AD in MetS targeting hypercoagulation.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Neurosciences
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhtar
Summary: This study investigated the therapeutic potential of the PDE-4 inhibitor roflumilast in Alzheimer's disease. The results showed that roflumilast improved learning and memory capacities in rats, reduced neuroinflammation and amyloid deposition, and activated the cAMP/BDNF signaling pathway.
NEUROTOXICITY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Juheb Akhter, Jasim Khan, Madhu Baghel, Mirza Masroor Ali Beg, Poonam Goswami, Mohd Amir Afjal, Shahzad Ahmad, Haroon Habib, Abul Kalam Najmi, Sheikh Raisuddin
Summary: This study investigated the therapeutic effects of rosmarinic acid (RA) against inflammation-induced acute kidney injury (AKI) and found that RA can effectively prevent cisplatin-induced AKI by inhibiting the activation of the NLRP3 signaling pathway and other related signal molecules.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Kashif Haider, Kamal Ahmad, Abul Kalam Najmi, Subham Das, Alex Joseph, M. Shahar Yar
Summary: A series of 2-aminobenzothiazole derivatives were synthesized and evaluated for their anticancer activity. Compound 8i showed the most potent inhibitory activity and high selectivity against PI3K alpha, inducing apoptosis in a dose-dependent manner.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Medicinal
Kashif Haider, Shivani Sharma, Yuba Raj Pokharel, Subham Das, Alex Joseph, Abul Kalam Najmi, Faiz Ahmad, Mohammad Shahar Yar
Summary: This report presents a new series of indole-tethered pyrazoline derivatives as potent anticancer agents. The compounds showed strong cytotoxicity against A431, HeLa, and MDAMB-231 cell lines. In addition, they exhibited inhibitory effects on colony formation, migration, and cell cycle arrest. The compounds also demonstrated potential as topoisomerase inhibitors and were found to be safe in vivo.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Immunology
Syed Sufian Ahmad, Faraha Ahmed, Ruhi Ali, Mohammed M. Ghoneim, Sultan Alshehri, Abul Kalam Najmi, Sayeed Ahmad, Mohammad Zaki Ahmad, Javed Ahmad, Mohammad Ahmed Khan
Summary: Osteoporosis, characterized by low bone mass and deteriorated bone microarchitecture, is a major cause of fractures and morbidity worldwide. Recent studies have identified the role of the immune system in the skeletal system, leading to the emergence of osteoimmunology. Immune dysregulation can cause inflammation and adversely affect bone integrity. T-lymphocyte subsets (Th17) play a significant role in the pathogenesis of osteoporosis. Therefore, studying osteoimmunology is important for understanding osteoporosis and developing immunotherapy strategies.
Review
Chemistry, Medicinal
Farazul Hoda, Afifa Khanam, Mehak Thareja, Mawrah Arshad, Mohd Ahtar, Abul Kalam Najmi
Summary: This systematic review summarizes the effects of Nigella sativa in the management of Type 2 Diabetes Mellitus (T2DM). The available evidence suggests that Nigella sativa can significantly improve glucose and insulin levels in patients with T2DM, and has a positive impact on the treatment outcomes of T2DM and its complications.
Article
Biochemistry & Molecular Biology
Sonal Gupta, Monika Saini, Nishant Joshi, Sadat Shafi, Abul Kalam Najmi, Shailja Singh
Summary: This study investigated the localization and druggability of serpentine receptors in Plasmodium, and demonstrated the strong binding interaction between PfSR12 and R138727. The findings suggest the importance of purinergic signaling and PfSR12 in the survival and development of the malaria parasite, and indicate that Prasugrel may serve as a potential antimalarial therapy targeting PfSR12.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Shaista Amin, Khursheed A. Sheikh, Ashif Iqubal, Mohammad Ahmed Khan, M. Shaquiquzzaman, Sharba Tasneem, Suruchi Khanna, A. K. Najmi, Mymoona Akhter, Anzarul Haque, Tarique Anwer, M. Mumtaz Alam
Summary: Despite advancements in Diabetes mellitus management, designing and synthesizing drug molecules that effectively improve hyperglycemia and associated complications in diabetic patients remains challenging. In this study, pyrimidine-thiazolidinedione derivatives were synthesized, characterized, and evaluated for their anti-diabetic properties. The synthesized compounds were analyzed using various techniques, including NMR, FTIR, and Mass Spectrometry. In-silico ADME studies confirmed the compounds met Lipinski's rule of five. In-vivo evaluation in diabetic rats showed that compounds 6e and 6m significantly reduced blood glucose levels without causing weight gain. Biochemical and histopathological analyses further supported the anti-diabetic effects of these compounds. Based on these findings, pyrimidine-based thiazolidinedione derivatives could be considered as novel anti-diabetic agents with minimal side effects.
BIOORGANIC CHEMISTRY
(2023)
Review
Oncology
Preeti Sharma, Mohammad Ahmed Khan, Abul Kalam Najmi, Shubhra Chaturvedi, Mohd Akhtar
Summary: Breast cancer is a major cause of malignant death in females, and triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. Myricetin (MYR), a naturally occurring compound, has been found to have anti-cancer effects in various cancers, including TNBC. It regulates multiple signaling pathways to inhibit cell proliferation and invasion and promote cell apoptosis. The PI3K/AKT/mTOR pathway is identified as a potential therapeutic target for MYR in TNBC treatment.
Review
Biochemistry & Molecular Biology
Mallika Khurana, Syed Obaidur Rahman, Shivani Agarwal, Md. Sayeed Akhtar, Mohammed S. Aldughaim, Faheem Hyder Pottoo, Abul Kalam Najmi
Summary: Research on neurodegenerative diseases has highlighted the importance of discovering biomarkers for accurate and reproducible diagnosis and prognosis. Evolving proteomic technologies, such as Mass Spectrometry, offer new avenues for rapidly identifying biomarkers, but further investigation is needed to explore the complexities of the brain and its disorders.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
