Article
Multidisciplinary Sciences
Christian G. Bolanos, Nhat M. Pham, Robert D. Mair, Timothy W. Meyer, Tammy L. Sirich
Summary: This study used metabolomic analysis to investigate the pruritus symptoms in uremic patients and found no specific solutes associated with pruritus.
Article
Dermatology
Najmeh Shamspour, Mahin Aflatoonian, Maryam Khalili, Mohsen Seifi, Maryam Mousavi, Jalal Azmandian, Saman Mohammadi, Batoul Khoundabi, Elahenaz Parsimood, Azadeh Mohebbi
Summary: This study aimed to compare the effectiveness of Pregabalin and Ketotifen in treating uremic pruritus in hemodialysis patients. The results showed that Pregabalin had a significantly lower pruritus intensity and better quality of life in the second week of treatment, with fewer side effects compared to Ketotifen.
DERMATOLOGIC THERAPY
(2022)
Article
Hematology
Delong Zhao, Yuanda Wang, Yong Wang, Aili Jiang, Ning Cao, Yani He, Junxia Wang, Zhiyong Guo, Wenhu Liu, Wei Shi, Lirong Hao, Jinyu Li, Wenge Li, Caili Wang, Jianqin Wang, Hongli Lin, Lihua Wang, Hongli Jiang, Guohua Ding, Yun Li, Wenbo Hu, Hua Yue, Jian Liu, Xiaoping Yang, Yibin Yang, Guohui Liu, Hong Li, Yuefei Xiao, Niansong Wang, Gengru Jiang, Guoying Ma, Jie Wang, Ying Li, Rongshan Li, Qian Li, Shiren Sun, Jundong Jiao, Chunsheng Xi, Guangyan Cai, Xuefeng Sun, Xiangmei Chen
Summary: This study investigates the effect of long-term hemoperfusion combined with hemodialysis on middle-molecular-weight toxins and uremic pruritus in maintenance hemodialysis patients. The results show that HP + HD can reduce B2M and PTH levels and improve pruritus independently of the use of high- or low-flux dialyzers.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Mohamed Mamdouh Elsayed, Iman Ezzat Elgohary, Heidi Hesham Said Abdelhamid, Sherif Aziz Zaki
Summary: This study is a double-blinded, placebo-controlled, multicentric randomized clinical trial that aimed to assess the effect of sertraline on uremic pruritus in hemodialysis patients. The results showed that patients treated with sertraline had a significant improvement in pruritus compared to those who received placebo, suggesting a potential role for sertraline in treating uremic pruritus in hemodialysis patients.
Article
Pharmacology & Pharmacy
Jeffrey G. Stark, Patrick K. Noonan, Robert H. Spencer, Sarbani Bhaduri, Stephen J. O'Connor, Frederique Menzaghi
Summary: This open-label study investigated the pharmacokinetics and disposition of [C-14]difelikefalin in subjects with normal renal function and subjects on hemodialysis. The results showed that subjects on hemodialysis had higher total exposure and longer plasma half-life of difelikefalin.
CLINICAL PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Mingming Pan, Guihua Wang, Li Zhou, Yan Xu, Li Yao, Chaoqing Wu, Changlin Mei, Zhanzheng Zhao, Dong Sun, Tianjun Guan, Qinkai Chen, Ming Shi, Hui Xu, Weifang Zeng, Fangqiong Li, Rui Yan, Bi-Cheng Liu
Summary: This study evaluated the safety, pharmacokinetics, and efficacy of HSK21542 in hemodialysis patients. It found that HSK21542 was well tolerated within the dose range of 0.05-0.80 μg/kg, and HSK21542-0.3 μg/kg exhibited promising efficacy in patients with moderate to severe pruritus.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Ping-Hsun Lu, Jen-Yu Wang, Hui-En Chuo, Po-Hsuan Lu
Summary: This study demonstrated that administering uremic clearance granules (UCGs) significantly reduced uremic pruritus symptoms and improved various serum biochemical markers in patients with chronic kidney disease, suggesting that UCGs could be an effective complementary therapy for managing uremic pruritus.
Article
Multidisciplinary Sciences
Aaron J. Velasquez-Mao, Mark A. Velasquez, Zhengxiong Hui, Denise Armas-Ayon, Jingshen Wang, Moriel H. Vandsburger
Summary: This study found that specific proteolytic regulators and fibrotic factors were elevated in plasma and platelets of ESRD patients during hemodialysis, leading to exacerbated platelet dysfunction and tissue dysregulation correlated with blood flow rate and dialysis vintage. The correlation between regulatory factors and fibrotic factors produced by platelets during hemodialysis directly contributes to a pro-fibrotic environment in ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Shane Sakamaki-Ching, Suzaynn Schick, Gabriela Grigorean, Jun Li, Prue Talbot
Summary: The study found that acute dermal exposure to THS can alter the human plasma proteome, initiate mechanisms of skin inflammatory disease, and elevate urinary biomarkers of oxidative harm.
Review
Medicine, General & Internal
Ya-Fei Bai, Chun-Li Wang, Ming-Zhi Xu, Ming-Jiao Pan, Qing-Yi Sun, Ru-Man Chen
Summary: Skin pruritus is a common complication in patients with uremia, impacting their quality of life. Treatments like hemodialysis can help alleviate symptoms, while traditional Chinese medicine UCG combined with HFH shows significant efficacy in treating uremic pruritus.
Article
Pharmacology & Pharmacy
Xiaoli Zhang
Summary: The study demonstrates that combined treatment of HD/HP with SC can significantly improve pruritus in uremic patients, reduce serum phosphorus and intact parathyroid hormone levels, and decrease the micro-inflammatory state.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)
Article
Medicine, General & Internal
Ichiei Narita, Yoshiharu Tsubakihara, Takuma Uchiyama, Shota Okamura, Nobuyo Oya, Naoki Takahashi, Fumitake Gejyo
Summary: This phase 2 trial suggests that 0.5 pg/kg of difelikefalin is the clinically recommended dose for treating moderate to severe pruritus in hemodialysis patients due to its efficacy, acceptable tolerability, and manageable safety profile.
Article
Dermatology
Daphne S. Bakker, Maria M. van der Wal, Lukas E. M. Heeb, Barbara Giovannone, Mindy Asamoah, Eveline M. Delemarre, Julia Drylewicz, Stefan Nierkens, Onur Boyman, Marjolein S. de Bruin-Weller, Judith L. Thijs, Femke van Wijk
Summary: The study shows that Dupilumab treatment rapidly and stably inhibits IL-4Rα, exerting an early strong immunological effect specifically on skin-homing T cells without affecting long-term skewing of T helper type cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ji Hye Yoon, Mi-Yeon Kim, Jae Youl Cho
Summary: The skin acts as a protective barrier against external factors and prevents the entry of harmful agents into the body. Skin diseases can occur when there is an overreactive response to these agents. Apigenin, a flavonoid compound, has shown potential in reducing skin inflammation by targeting inflammatory markers and molecular pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dermatology
Sapir Ron-Doitch, Yoram Soroka, Marina Frusic-Zlotkin, Dinorah Barasch, Doron Steinberg, Ron Kohen
Summary: Skin homeostasis is constantly challenged by environmental factors, with the Nrf2-keap1 pathway playing a crucial role in maintaining the skin's redox state. Research has shown that both skin and bacteria release volatile organic compounds, some of which are aldehydes that can activate the Nrf2-keap1 pathway to protect against environmental insults.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Nutrition & Dietetics
Brandon M. Kistler, Linda W. Moore, Debbie Benner, Annabel Biruete, Mona Boaz, Giuliano Brunori, Jing Chen, Christiane Drechsler, Fitsum Guebre-Egziabher, Mary Kay Hensley, Kunitoshi Iseki, Csaba P. Kovesdy, Martin K. Kuhlmann, Anita Saxena, Pieter ter Wee, Amanda Brown-Tortorici, Giacomo Garibotto, S. Russ Price, Angela Yee-Moon Wang, Kamyar Kalantar-Zadeh
Summary: The updated Clinical Practice Guidelines for nutrition in chronic kidney disease provide valuable recommendations for nutrition screening, assessment, macronutrients, and electrolytes, with a special focus on early detection and prevention of kidney disease. The guidelines suggest dietary protein intake ranges for CKD patients and emphasize the importance of individualized medical nutrition therapy for slowing down disease progression. Stakeholders are encouraged to collaborate in strengthening the evidence base through standardized outcomes and well-designed studies in CKD patients.
JOURNAL OF RENAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Sapir Ron-Doitch, Ron Kohen
Article
Endocrinology & Metabolism
Mona Boaz, Odile Azoulay, Vered Kaufman-Shriqui, Talia Weinstein
Summary: Despite having higher BMI, individuals on haemodialysis with diabetes are at a higher risk of malnutrition compared to those without diabetes. Compliance with nutrition guidelines by the International Society for Renal Nutrition and Metabolism was poor regardless of diabetes status.
Article
Biology
Mona Boaz, Vered Kaufman-Shriqui, Odile Azoulay, Talia Weinstein
Summary: This study compared the dietary status of overweight/obese and normal-weight hemodialysis patients, finding that regardless of body weight status, compliance with dietary guidelines among hemodialysis patients is poor.
Article
Nutrition & Dietetics
Vered Kaufman-Shriqui, Daniela Abigail Navarro, Olga Raz, Mona Boaz
Summary: This study aims to examine the relationship between diet quality and anxiety levels during the COVID-19 pandemic. Findings showed that most participants reported having a healthier diet before the pandemic and over half of the respondents reported at least mild anxiety.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Microbiology
Sapir Ron-Doitch, Marina Frusic-Zlotkin, Yoram Soroka, Danielle Duanis-Assaf, Dalit Amar, Ron Kohen, Doron Steinberg
Summary: The study found that Staphylococcus aureus and Staphylococcus epidermidis form biofilms on healthy human skin surfaces, composed of extracellular polysaccharides and extracellular DNA, providing skin protection against UVB-induced apoptosis.
Article
Biochemistry & Molecular Biology
Ilya Pinchuk, Ron Kohen, Wolfgang Stuetz, Daniela Weber, Claudio Franceschi, Miriam Capri, Mikko Hurme, Beatrix Grubeck-Loebenstein, Christiane Schon, Jurgen Bernhardt, Florence Debacq-Chainiaux, Martijn E. T. Dolle, Eugene H. J. M. Jansen, Efstathios S. Gonos, Ewa Sikora, Nicolle Breusing, Daniela Gradinaru, Maria Moreno-Villanueva, Alexander Burkle, Tilman Grune, Dov Lichtenberg
Summary: Redox steady state is crucial for cellular functions, while Oxidative Stress is associated with various pathologies. Understanding the relationship between oxidative stress biomarkers and antioxidants can help in selective treatment. The effects of different LMWA on oxidative damage biomarkers need to be carefully studied before justifying a single LMWA treatment approach.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Nutrition & Dietetics
Mona Boaz, Daniela Abigail Navarro, Olga Raz, Vered Kaufman-Shriqui
Summary: The COVID-19 pandemic has been linked to increased anxiety, poorer diet quality, and weight gain, with potential differences by sex. A study examining diet quality and anxiety levels during the pandemic found that while overall diet quality did not differ between sexes, there were differences in specific components of the diet score. Women tended to consume more olive oil, vegetables, and sweet baked goods, while men consumed more sweetened/carbonated drinks, red meat, alcohol, legumes, and hummus/tahini. An inverse association was found between Mediterranean diet score and anxiety levels in both women and men, with other factors like age, employment status, and language of survey also influencing anxiety levels during the lockdowns.
Article
Food Science & Technology
Tali Sinai, Rachel Axelrod, Tal Shimony, Mona Boaz, Vered Kaufman-Shriqui
Summary: This study conducted in Israeli adolescents aged 11-18 years identified five major dietary patterns, with a focus on a 'plant-based' pattern associated with healthy lifestyle and a 'junk food' pattern associated with unhealthy lifestyle. The results highlight significant correlations between lifestyle risk behaviors and suboptimal growth among adolescents.
Article
Chemistry, Medicinal
Assaf Buch, Tali Ganz, Julio Wainstein, Suzan Gilad, Rona Limor, Gabi Shefer, Mona Boaz, Naftali Stern
Summary: Low serum l-arginine and high asymmetric dimethylarginine can predict microvascular complications in type 2 diabetes mellitus. This study investigated the effects of diet and physical activity on overweight/obese and T2DM subjects. The results showed that alcohol lowers l-arginine levels, while protein intake increases l-arginine and asymmetric dimethylarginine levels. Lifestyle modification only reduces asymmetric dimethylarginine levels in subjects who achieve weight loss >5%.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Biochemistry & Molecular Biology
Dror Cohen, Meital Portugal-Cohen, Miriam Oron, Marina Frusic-Zlotkin, Yoram Soroka, Ze'evi Ma'or, Dalit Amar, Ron Kohen
Summary: The skin can benefit from exposure to moderate environmental stressors, such as those found in the Dead Sea area, which activates the Nrf2-Keap1 pathway and protects against oxidative damage. The unique combinations of moderate stressors in the Dead Sea, including high-water salinity, high atmospheric pressure, and unique solar radiation, generate moderate oxidative stress in the skin, leading to the induction of intracellular electrophiles and the activation of the protecting Nrf2-Keap1 pathway. This activation results in the induction of phase II enzymes and lower apoptotic activity compared to nearby locations at higher altitudes.
Editorial Material
Nutrition & Dietetics
Mona Boaz, Vered Kaufman-Shriqui, Linda W. Moore, Kamyar Kalantar-Zadeh
JOURNAL OF RENAL NUTRITION
(2023)
Article
Medicine, General & Internal
Boris Zingerman, Israel Khanimov, Mordechai Shimonov, Mona Boaz, Benaya Rozen-Zvi, Eyal Leibovitz
Summary: This study investigated the association between changes in serum creatinine levels and hypoglycemia during hospitalization. The results showed that patients with significant change in creatinine had a higher incidence of hypoglycemia, and the severity of creatinine change was associated with the incidence and number of hypoglycemic events. The majority of hypoglycemic events occurred within 0-6 days after the occurrence of creatinine change.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Mona Boaz, Vered Kaufman-Shriqui
Summary: Malnutrition or increased malnutrition risk significantly increases the odds of in-hospital death in COVID-19 patients. The pooled prevalence estimate for malnutrition or increased malnutrition risk in hospitalized adults during the COVID-19 pandemic is 52.61%.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
