Article
Biochemistry & Molecular Biology
Weiyu Chen, Sergey Tumanov, Stephanie M. Y. Kong, David Cheng, Erik Michaeelsson, Andre Bongers, Carl Power, Anita Ayer, Roland Stocker
Summary: This study found that the pharmacological inhibition of myeloperoxidase (MPO) activity with AZM198 can convert pre-existing unstable atherosclerotic lesions into stable plaques in a preclinical model. This highlights the potential therapeutic potency of MPO inhibition for high-risk patients and the development of novel protective strategies against cardiovascular diseases.
Article
Chemistry, Medicinal
Carol H. Hu, Meriah W. Neissel Valente, O. Scott Halpern, Sutjano Jusuf, Javed A. Khan, Gregory A. Locke, Gerald J. Duke, Xiaoqin Liu, Franck J. Duclos, Ruth R. Wexler, Ellen K. Kick, Joanne M. Smallheer
Summary: This study reports the design and evaluation of MPO inhibitors for the treatment of cardiovascular disease, showcasing potent macrocyclic MPO inhibitors with TPO selectivity that were synthesized through alkylating chemistry optimization.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Soil Science
Taiki Mori, Ryota Aoyagi, Kanehiro Kitayama, Jiangming Mo
Summary: The study found that the BG:NAG ratio does not necessarily indicate the carbon or nitrogen limitation status of soil microbes. Contrary to the assumption, nitrogen-enriched conditions did not always lead to an increase in the BG:NAG ratio compared to ambient conditions. Instead, the ratio may be influenced by the decomposition stage and target substrates of the NAG enzyme.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Article
Immunology
Jacob F. Rehring, Triet M. Bui, Carlos Samuel Galan-Enriquez, Jessica M. Urbanczyk, Xingsheng Ren, Hannah L. Wiesolek, David P. Sullivan, Ronen Sumagin
Summary: MPO plays a crucial role in modulating PMN trafficking in inflammation, with MPO knockout mice showing significantly enhanced inflammatory PMN tissue accumulation due to increased migratory ability.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Debora dos Anjos Weber Luz, Ana Paula de Santi Rampazzo, Stephanie Carvalho Borges, Camila Quaglio Neves, Priscila Dayane de Freitas Santos, Nilza Cristina Buttow, Cassiano Pires, Rilton Alves de Freitas, Ciomar Aparecida Bersani Amado, Odinei Hess Goncalves, Maria Raquel Marcal Natali
Summary: Inflammatory bowel diseases (IBDs) are chronic gastrointestinal inflammatory diseases characterized by intestinal ulcerations. Curcuminoid nanoparticles extracted from Curcuma longa L. showed potential for treating experimental colitis in rats.
Article
Biochemistry & Molecular Biology
Nejra Cosic-Mujkanovic, Paulina Valadez-Cosmes, Kathrin Maitz, Anna Lueger, Zala N. Mihalic, Marah C. Runtsch, Melanie Kienzl, Michael J. Davies, Christine Y. Chuang, Akos Heinemann, Rudolf Schicho, Gunther Marsche, Julia Kargl
Summary: This study shows that myeloperoxidase (MPO), a neutrophil-derived enzyme, promotes the proliferation and inhibits the apoptosis of lung cancer cells. It functions by increasing the phosphorylation of AKT and ERK, and can be found inside the cells and in the nucleus. Blocking MPO uptake or inhibiting its enzymatic activity reduces its effects on cancer cell function. Animal experiments demonstrate that tumor-bearing mice treated with the MPO inhibitor 4-ABAH have reduced tumor burden.
Review
Biochemistry & Molecular Biology
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS) catalyzed by the enzyme myeloperoxidase MPO. The reactions of RCS with various organic molecules and the chemical mechanisms of chlorinated derivatives formation are described. The review also examines the presence of RCS in various pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jean B. Regard, Tyler J. Harrison, Jake Axford, Laura Axford, Lac Lee, Xianglin Ren, Lin Deng, Aimee Reynolds, Justin Mao, Qian Liu, Anup Patnaik, Evan Cohick, Micah Hollis-Symynkywicz, Sally Loi, Simone Riek, Una McKeever, David Dunstan, MooJe Sung, Nathaniel F. Ware, Alan P. Brown, Lawrence G. Hamann, Jovita Marcinkeviciene, Andrew W. Patterson, Martin L. Marro
Summary: MPO is an important enzyme involved in the innate immune response. A novel MPO inhibitor, IN-4, has been discovered with high potency, selectivity, and oral bioavailability. This inhibitor shows promise as a therapeutic agent for various inflammatory conditions, including cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Jian Huang, Dipender Gill, Verena Zuber, Paul M. Matthews, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan
Summary: This study used MR and colocalization analysis to investigate the causal relationships between CVD-related proteins and cognitive function. The findings suggest that certain genetically predicted protein concentrations are associated with cognitive function, indicating potential therapeutic targets for reducing the genetic risks conferred by cardiovascular disease.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Matthias W. G. Zeller, Cuihua Wang, Edmund J. Keliher, Gregory R. Wojtkiewicz, Aaron Aguirre, Kevin Maresca, Chunyan Su, Leonard Buckbinder, Jing Wang, Matthias Nahrendorf, John W. Chen
Summary: Myeloperoxidase (MPO) is an enzyme involved in post-myocardial infarction injury and is a potential therapeutic target. However, the lack of an imaging reporter to select appropriate patients and assess therapeutic efficacy has hindered clinical development. This study found that an MPO-specific PET imaging agent can track the treatment effect of an MPO inhibitor in experimental myocardial infarction, providing a potential non-invasive method to report MPO activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Luis B. Carvalho, Jose Luis Capelo Martinez, Carlos Lodeiro, Rafael Bento, Rajiv Dhir, Jeremiah J. Morrissey, Luis Campos Pinheiro, Mariana Medeiros, Hugo M. Santos
Summary: Urinary proteomics can predict bladder cancer recurrence and identify dysregulation of inflammation and immune systems as key drivers of disease worsening. Proteomics can be used to monitor the effectiveness of therapy in the inflammatory and immune systems.
JOURNAL OF PROTEOMICS
(2023)
Article
Immunology
Wei Lin, Chanjuan Shen, Yong Zhong, Joshua D. Ooi, Peter Eggenhuizen, Ya-Ou Zhou, Hui Luo, Jing Huang, Jin-Biao Chen, Ting Wu, Ting Meng, Zhou Xiao, Xiang Ao, Weisheng Peng, Rong Tang, Hongling Yin, Xiangcheng Xiao, Qiaoling Zhou, Ping Xiao
Summary: Patients with MPO-ANCA GN who had immune complex deposits in the kidney showed lower platelet count, lower sC3 and sIgG levels, and higher serum creatinine levels. Additionally, patients with low sC3 levels at the initial diagnosis and during treatment displayed a trend toward poorer kidney survival, indicating the potential benefit of complement targeted therapies in AAV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Guillaume Gauchotte, Agathe Bochnakian, Philippe Campoli, Emilie Lardenois, Muriel Brix, Etienne Simon, Sophie Colomb, Laurent Martrille, Pierre-Antoine Peyron
Summary: The study evaluates the sensitivity and specificity of CD15 and MPO, with glycophorin C co-staining, compared to standard histology in skin wound vitality determination. The results show that CD15 and MPO have potential for early detection of vital reaction, with good sensitivity and specificity. Confirmation studies in larger cohorts are needed to further validate their accuracy in forensic pathology.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mariana Bastos dos Santos, Beatriz Carvalho Marques, Gabriela Miranda Ayusso, Mayara Aparecida Rocha Garcia, Luana Chiquetto Paracatu, Ivani Pauli, Vanderlan Silva Bolzani, Adriano Defini Andricopulo, Valdecir Farias Ximenes, Maria Luiza Zeraik, Luis Octavio Regasini
Summary: A series of chalcones and their B-aryl analogues were synthesized and evaluated for their inhibitory effects on MPO chlorinating activity. B-thiophenyl chalcone showed inhibition of MPO activity with low toxicity, making it a potential candidate for new non-steroidal anti-inflammatory compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maass, Juergen Konradi, Dennis Mehrkens, Simon Geissen, Felix S. Nettersheim, Simon Braumann, Erik Michaelsson, Richard J. Nies, Samuel Lee, Marie-Christin Redzinski, Vera B. M. Peters, Harshal N. Nemade, Philipp von Stein, Holger Winkels, Volker Rudolph, Stephan Baldus, Matti Adam, Martin Mollenhauer
Summary: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, and ischemic cardiomyopathy is becoming a leading reason for hospitalization in the western world. Neutrophils (PMN) play a key role in the inflammatory response of the ischemic myocardium, and the enzyme myeloperoxidase (MPO) expressed in PMN is an important mediator of their inflammatory capacities. Reducing PMN count and inhibiting MPO showed positive effects on scar formation and cardiac function in murine models of MI, suggesting that MPO could be a promising pharmacological target for preventing long-term morbidity after MI.
Editorial Material
Obstetrics & Gynecology
Alvaro Luiz Lage Alves, Janaina Campos Senra, Caroline Reis Goncalves, Bruna Roque Ribeiro, Carolina Nogueira de Sao Jose, Eduardo Batista Candido, Lucas Barbosa Silva, Agnaldo Lopes Silva-Filho
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2020)
Editorial Material
Obstetrics & Gynecology
Alvaro Luiz Lage Alves, Janaina Campos Senra, Carolina Nogueira de Sao Jose, Bruna Roque Ribeiro, Rafaela de Souza Furtado, Lucas Barbosa Silva, Agnaldo Lopes Silva-Filho
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2020)
Article
Obstetrics & Gynecology
R. R. Campos, T. Baeta, A. Silva-Filho, S. M. Rezende, A. L. L. Rocha
Editorial Material
Obstetrics & Gynecology
Luiz G. O. Brito, Gustavo S. Romao, Cesar E. Fernandes, Agnaldo L. Silva-Filho
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2020)
Article
Obstetrics & Gynecology
Gabriel Oliveira Bernardes Gil, Cassiano Asano, Warne Pedro de Andrade, Maria Luisa Braga Vieira Gil, Eduardo Batista Candido, Marcos Regalin, Izabella Nobre Queiroz, Farley Soares Cantidio, Darly Gomes Soares Delfino, Agnaldo Lopes Silva-Filho
Summary: In this study, a mathematical model was developed to predict the age at which premature ovarian insufficiency might occur after teletherapy radiation. By studying the relationship between oocyte survival rate and radiation dose, a linear function was obtained to estimate the decrease in time to premature ovarian insufficiency.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Editorial Material
Obstetrics & Gynecology
Aline Evangelista Santiago, Agnaldo Lopes da Silva Filho, Eduardo Batista Candido, Paulo Ayrosa Ribeiro, Julio Cesar Rosa e Silva, Walquiria Quida Salles Pereira Primo, Jesus Paula Carvalho, Sergio Podgaec, Carlos Augusto Pires Costa Lino, Ricardo de Almeida Quintairos, Luiz Gustavo Oliveira Brito
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Biotechnology & Applied Microbiology
Michael Zarnowski Passos, Agnaldo Lopes da Silva-Filho, Wladmir Cardoso Brandao, Mariana Furtado Meinberg, Rogeria Andrade Werneck
Summary: Human papillomavirus (HPV) is the second largest human carcinogen, responsible for a significant percentage of cancers worldwide. Despite the availability of an HPV vaccine, low uptake is attributed to poor quality information on the Internet. Most of the information reaching the public is not accurate, leading to potentially harmful vaccination decisions. Further analysis, particularly on the impact of social networks, is crucial in understanding the dissemination of information.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Obstetrics & Gynecology
Luisa Silva de Carvalho Ribeiro, Barbara Flecha D'Abreu, Aline Evangelista Santiago, Eduardo Batista Candido, Gustavo Salata Romao, Marcos Felipe Silva de Sa, Agnaldo Lopes da Silva Filho
Summary: This narrative review examines the knowledge on how to communicate bad news in obstetrics and gynecology (ob-gyn). It found that simulation, feedback/debriefing, lectures, and protocols can improve doctors' performance in delivering bad news. The context and manner of communication are more impactful for patients than the content itself. Ob-gyn doctors could benefit from specific protocols and education, given the unique nature of their specialty.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Microbiology
Alexandre G. S. Silva-Filho, Andgelo Mombert, Cristiano C. Nascimento, Bianca B. Nobrega, Douglas M. M. Soares, Ana G. S. Martins, Adao H. R. Domingos, Isaias Santos, Olavo H. P. Della-Torre, Brian A. Perry, Dennis E. Desjardin, Cassius V. Stevani, Nelson Menolli Jr
Summary: During nocturnal field expeditions in the Brazilian Atlantic Rainforest, a new genus of bioluminescent fungus with reduced form, named Eoscyphella, was discovered. The phylogenetic analyses confirmed its position in the Cyphellopsidaceae family and its relation to the genera Merismodes and Cyphellopsis.
Editorial Material
Obstetrics & Gynecology
Agnaldo Lopes da Silva Filho, Eduardo Batista Candido, Mariana Seabra Leite Praca, Pedro Henrique Tannure Saraiva, Rivia Mara Lamaita, Michel Canis
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)
Article
Oncology
Luiza Perez, Kimberley Tran, Vanessa Alvarenga-Bezerra, Diya Chadha, Libby Dotson, Fernanda Assir, Eduardo Cordioli, Mariano Tamura Vieira Gomes, Sergio Podgaec, Agnaldo Lopes da Silva-Filho, Nimmi Ramanujam, Renato Moretti-Marques
Summary: This study evaluated the levels of knowledge, attitudes, and practices related to cervical cancer screening and diagnosis, as well as the acceptance of self-screening techniques, among women in Brazil. The findings showed that participants had good levels of knowledge, attitudes, and practices, and were interested in self-screening methods. Adequate knowledge, attitudes, and practices are crucial for the successful implementation of a self-screening program.
Review
Obstetrics & Gynecology
Rivia Lamaita, Carolina Melo, Claudia Laranjeira, Paula Barquero, Joyce Gomes, Agnaldo Silva-Filho
Summary: Multiple sclerosis (MS) is a neurological disease that typically affects young women of reproductive age, leading to concerns about pregnancy. The impact of MS on fertility is not significant, and the disease does not necessarily hinder assisted reproductive technology. Healthcare providers should be prepared to discuss and provide counseling on fertility, pregnancy, and related matters for better outcomes.
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2021)
Article
Multidisciplinary Sciences
Antonio Viana da Silva Filho, Jose Carlos De Araujo, Armin Raabe
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2020)
Article
Oncology
Eduardo Paulino, Andreia Cristina de Melo, Agnaldo Lopes Silva-Filho, Luiza de Freitas Maciel, Luiz Claudio Santos Thuler, Paul Goss, Angelica Nogueira-Rodrigues
JCO GLOBAL ONCOLOGY
(2020)
Article
Obstetrics & Gynecology
Arilto Eleuterio da Silva Junior, Jesus Paula Carvalho, Sophie Francoise Mauricette Derchain, Angelica Nogueira Rodrigues, Renato Moretti, Eduardo Batista Candido, Ricardo dos Reis, Aline Evangelista Santiagol, Agnaldo Lopes da Silva Filho
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2019)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
