Journal
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
Volume 6, Issue 4, Pages 356-363Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bspc.2011.05.007
Keywords
Retinal prosthesis; Retinal implant; Biomedical electrodes; Neuromuscular stimulation; Iridium oxide; Integrated circuit design; Telemetry; Medical devices
Categories
Funding
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [1117093, 1117601] Funding Source: National Science Foundation
- NEI NIH HHS [R01 EY016674, R01 EY016674-04A1] Funding Source: Medline
- NIBIB NIH HHS [U01 EB018873, R01 EB022013] Funding Source: Medline
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A small, hermetic, wirelessly-controlled retinal prosthesis has been developed for pre-clinical studies in Yucatan minipigs. The device was attached conformally to the outside of the eye in the socket and received both power and data wirelessly from external sources. Based on the received image data, the prosthesis drove a subretinal thin-film polyimide array of sputtered iridium oxide stimulating electrodes. The implanted device included a hermetic titanium case containing a 15-channel stimulator and receiver chip and discrete circuit components. Feed throughs in the hermetic case connected the chip to secondary power- and data-receiving coils, which coupled to corresponding external power and data coils driven by power amplifiers. Power was delivered by a 125 kHz carrier, and data were delivered by amplitude shift keying of a 15.5 MHz carrier at 100 kbps. Stimulation pulse strength, duration and frequency were programmed wirelessly from an external computer system. The final assembly was tested in vitro in physiological saline and in vivo in two minipigs for up to five and a half months by measuring stimulus artifacts generated by the implant's current drivers. Published by Elsevier Ltd.
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