Article
Biochemistry & Molecular Biology
Su Ji Min, Heesu Lee, Myoung-Sook Shin, Jae Wook Lee
Summary: The study aimed to synthesize and analyze the anti-inflammatory effects of 23 coumarin derivatives on LPS-induced inflammation in RAW264.7 macrophages. Cytotoxicity tests showed that none of the compounds were toxic, and coumarin derivative 2 exhibited the highest anti-inflammatory activity by reducing nitric oxide production and suppressing proinflammatory cytokine expression. The compound also inhibited several key signaling pathways involved in inflammation. Overall, coumarin derivative 2 shows potential as an anti-inflammatory drug for the treatment of both acute and chronic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Zhihong Zhang, Dongsheng Wang, Ping Sheng, Ping Yu, Zheling Zeng
Summary: This study aimed to investigate the anti-inflammatory activity of ethanol extracts (EE) of C. camphora seed and the changes after digestion and hydrolysis. The results showed that EE, digested ethanol extracts (dEE), and hydrolysed ethanol extracts (hEE) exhibited cell protection function and significantly reduced pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased, most of it was retained after digestion and hydrolysis. The findings suggest that the anti-inflammatory activity of EE is relatively stable and may facilitate the processing and consumption of related products.
Article
Chemistry, Medicinal
Li-Shan Yan, Shuang Cui, Brian Chi-Yan Cheng, Xing-Bin Yin, Yi-Wei Wang, Xin-Yu Qiu, Ci-Ren Nima, Yi Zhang, Shuo-Feng Zhang
Summary: The anti-inflammatory effect of Sichen formula was investigated in this study. It was found that Sichen formula inhibited the secretion of inflammatory mediators, reduced the recruitment of macrophages, and suppressed the expression of related proteins in lung tissue. In cell experiments, Sichen formula also suppressed the production of inflammatory mediators and inhibited the activation of related signaling pathways. These findings provide pharmacological justifications for the use of Sichen formula in the treatment of respiratory diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Qi Sun, Bing Wang, Mengqiu Li
Summary: This study found that HMGB1 expression is increased and miR-23a-3p expression is significantly reduced in sepsis. Overexpression of miR-23a-3p inhibits LPS-induced inflammation in murine macrophages by directly downregulating HMGB1.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Areerat Kunanopparat, Asada Leelahavanichkul, Peerapat Visitchanakun, Patipark Kueanjinda, Pornpimol Phuengmaung, Kritsanawan Sae-khow, Atsadang Boonmee, Salisa Benjaskulluecha, Tanapat Palaga, Nattiya Hirankarn
Summary: The response of macrophages to LPS may determine the clinical manifestations of sepsis, while Ezh2 may interfere with this response. Results showed that Ezh2-deficient macrophages exhibited less severe LPS-induced inflammation and more severe LPS tolerance, partly due to the upregulation of Socs3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Ahmed Esmael, Thomas M. Petro
Summary: IL-33 and IRF3 play important roles in the control of infection with macrophage-tropic viruses. IRF3 is required for the expression of IL-33 and the repression of M2 macrophage phenotypic markers, and IL-33 decreases the ability of macrophages to control infection with macrophage-tropic viruses.
Article
Cell Biology
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin
Summary: This study investigated the pathophysiological role of BRISC in acute liver failure. The expression of BRISC components was found to increase in kupffer cells (KCs) upon LPS treatment, and the deficiency of BRISC significantly attenuated liver damage and inflammation response. The study demonstrated that BRISC is involved in NF-kappa B-mediated proinflammatory cytokines production in LPS-treated KCs. This research opens the possibility for the development of new strategies to inhibit KCs-driven inflammation in liver diseases.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Hamsalakshmi, Suresh Joghee, Sreeram P. Kalarikkal, Gopinath M. Sundaram, T. Durai Ananda Kumar, Saravana Babu Chidambaram
Summary: The study demonstrated the anti-inflammatory effects of extracts from the aerial parts of Trichodesma indicum, with fraction FE showing the strongest ability to reduce inflammatory cytokines without cytotoxicity. The major compound in FE, 1,2-benzenedicarboxylic acid diisooctyl ester, exhibited good inhibition against key inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Rubia Isler Mancuso, Juliana Hofstatter Azambuja, Sara Teresinha Olalla Saad
Summary: This study demonstrates that ART pretreatment effectively prevents inflammation induced by LPS, protecting the body from inflammatory damage by regulating various immune cell types, reducing inflammatory cytokines and chemokines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jiradej Makjaroen, Pornpimol Phuengmaung, Wilasinee Saisorn, Suwasin Udomkarnjananun, Trairak Pisitkun, Asada Leelahavanichkul
Summary: Lipopolysaccharide (LPS) tolerance, which reduces the immune response to repeated LPS stimulation, may contribute to sepsis-induced immune exhaustion. Macrophages with LPS tolerance showed decreased energy, reduced protein abundance, and down-regulated anti-viral genes. In asymptomatic mice, LPS tolerance was associated with higher viral abundance in the cecum and decreased expression of anti-viral genes, suggesting it could lead to viral reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tomiyasu Murata, Kazunori Hashimoto, Susumu Kohno, Chiaki Takahashi, Masayoshi Yamaguchi, Chihiro Ito, Itoigawa Masataka, Roji Kojima, Kiyomi Hikita, Norio Kaneda
Summary: Derrisfolin A induces the expression of endogenous regucalcin protein, reducing the expression of inflammatory cytokines and apoptosis in pancreatic cells and macrophages. In co-culture conditions, derrisfolin A can also alleviate oxidative/nitrosative stress caused by macrophages on pancreatic cells.
Article
Chemistry, Multidisciplinary
Ahmad Almatroudi, Mohammed A. Alsahli, Mansoor Ali Syed, Amjad Ali Khan, Arshad Husain Rahmani
Summary: This study investigates the therapeutic role of prostaglandin D-2 (PGD(2)) in lipopolysaccharide (LPS)-induced lung injury. The results show that PGD(2) has anti-inflammatory properties, maintains lung tissue structure, and reduces cell death.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Yuran Su, Sifan Ai, Youqing Shen, Wen Cheng, Chenyu Xu, Lei Sui, Yanhong Zhao
Summary: Phenotypic transformation of macrophages plays a crucial role in the immune response related to periodontitis. Mesenchymal stem cells (MSCs) can modulate the immune system through their secretome. The secretome derived from LPS-pretreated or 3D-cultured MSCs has been shown to reduce inflammation, including periodontitis, by inducing M2 macrophage polarization. This study investigated the effects of secretome derived from LPS-pretreated and 3D culture of periodontal ligament stem cells (PDLSCs) on macrophages. The results showed that the secretome had the potential to regulate macrophages, promote tissue regeneration, and could be used as a treatment for inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shanshan Wei, Ting Wang, Qi Cao, Xue Chen, Zhiyong Chu, Zhenzhen Zhang
Summary: Torin2 has anti-inflammatory activity and can reverse inflammatory activation while reducing cellular damage.
Article
Biochemistry & Molecular Biology
Priska Jost, Franziska Klein, Benjamin Brand, Vanessa Wahl, Amanda Wyatt, Daniela Yildiz, Ulrich Boehm, Barbara A. A. Niemeyer, Martin Vaeth, Dalia Alansary
Summary: Mitochondria play a crucial role in modulating T cell function through their control of energy production and Ca2+ homeostasis. The mitochondrial Ca2+ uniporter (MCU) regulates Ca2+ signals and affects T cell activation. However, the specific effects of MCU on regulatory CD4 T cells (Treg) and their suppressive potential are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
