Article
Multidisciplinary Sciences
K. G. Aghila Rani, Nelson C. Soares, Betul Rahman, Hamza M. Al-Hroub, Mohammad H. Semreen, Sausan Al Kawas
Summary: The study investigates the biochemical and pathophysiological changes caused by medwakh smoking and examines the salivary metabolomics profile of medwakh smokers. Analysis of saliva samples reveals 37 uniquely and differentially abundant metabolites and 20 differentially altered metabolic pathways in medwakh smokers. The study highlights the association of altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels with the distinctive saliva metabolomics profile in medwakh smokers. Further research is needed to explore the diagnostic utility of these altered metabolites in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yeon-Hee Lee, Chon Suk, Seung-Il Shin, Ji-Youn Hong
Summary: This study aimed to investigate the neuroendocrine responses based on cortisol, dehydroepiandrosterone (DHEA), cortisol/DHEA ratio, and chromogranin A levels, which reflect the activity of the hypothalamic-pituitary-adrenal axis, according to the presence or absence of psychological stress in patients with gingivitis and periodontitis compared to that in healthy controls. The results showed that salivary cortisol and chromogranin A levels increased with the severity of periodontal disease; their levels were the highest in the periodontitis group and were significantly higher in the following descending order: periodontitis, gingivitis, and healthy control groups. Periodontitis and psychological stress were significant and strong predictors of above-average cortisol levels and cortisol/DHEA ratios.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Alessandra Lais Pinho Valente Pires, Lisia Daltro Borges Alves, Adriana Mendonca da Silva, Franco Arsati, Ynara Bosco de Oliveira Lima-Arsati, Jean Nunes dos Santos, Rodrigo Tripody Calumby, Valeria Souza Freitas
Summary: This study analyzed the use of salivary biomarkers to identify psychological disorders in individuals with OLP and found that cortisol was the most commonly quantified biomarker, although other biomarkers such as DHEA, IgA, adiponectin, and alpha-amylase were also evaluated.
Review
Medicine, General & Internal
Sylwia Chojnowska, Iwona Ptaszynska-Sarosiek, Alina Kepka, Malgorzata Knas, Napoleon Waszkiewicz
Summary: Stress, anxiety and depression are often characterized by activation of the stress axis, leading to similar symptoms and closely related occurrences. Current diagnosis methods lack laboratory tests for confirmation, hence studying salivary components may aid in quick diagnosis and treatment monitoring. Promising salivary biomarkers such as cortisol, sIgA, lysozyme, melatonin, sAA, CgA, and FGF-2, show fluctuations in saliva concentrations, indicating strong associations with psychological issues like stress, depression, and anxiety.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Psychology, Multidisciplinary
Bruno Spiljak, Maja Vilibic, Ana Glavina, Marija Crnkovic, Ana Seserko, Liborija Lugovic-Mihic
Summary: Numerous psychoneuroimmune factors can be measured in saliva to understand the bodily reactions to psychological stress. Academic stress affects the psychological and physiological well-being of students, with younger students experiencing higher stress levels primarily related to academic tasks and concerns. Measuring stress levels during academic stress can improve our understanding of the nature and impact of stressful events, as well as prevent adverse reactions to long-term stress.
BEHAVIORAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anna Zalewska, Anna Klimiuk, Sara Zieba, Olga Wnorowska, Malgorzata Rusak, Napoleon Waszkiewicz, Izabela Szarmach, Krzysztof Dzierzanowski, Mateusz Maciejczyk
Summary: Alzheimer's disease is associated with oxidative imbalance in the body, affecting both saliva secretion and antioxidant system functions.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Takanori Kooriyama, Niwako Ogata
Summary: Research on salivary biomarkers of stress responses in dogs is important for advancing studies and improving treatment methods.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Haidong Guo, Runfang Yang, Jin He, Ke Chen, Wen Yang, Junjun Liu, Kai Xiao, Hongxia Li
Summary: Edaravone combined with dexamethasone showed significant protective effects on smoke-induced inhalational lung injury in rats by regulating oxidative stress, inflammatory response, and apoptosis. The combination therapy could be a potential therapeutic option for the treatment of smoke inhalation-induced pulmonary dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Health Care Sciences & Services
Paolo Gisondi, Davide Geat, Francesco Bellinato, Laura Spiazzi, Elisa Danese, Martina Montagnana, Giuseppe Lippi, Giampiero Girolomoni
Summary: This study found that patients with psoriasis exhibit higher levels of psychological stress, anxiety, and depression symptoms, as well as impaired cortisol response to stress. Psoriasis may be directly associated with psychological stress.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Koyo Koizumi, Naoyasu Hirao, Haruna Yamanami, Hideki Ohira
Summary: This study investigated the negative effect of psychological stress on facial impressions. By comparing the facial images before and after a stress task through an online survey, it was found that the post-stress facial impressions were more tired, older, and irritated, while less clean-cut and healthy.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Urology & Nephrology
Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Motoaki Saito
Summary: Exposure to psychological/mental stress can affect urinary function and lower urinary tract dysfunctions, with changes occurring at multiple levels including micturition and lower urinary tract tissues. The brain plays a crucial role in regulating responses to stress, but how stress-induced changes affect urinary function at different levels is still unclear, presenting potential insights into a stress-mediated modulation of micturition.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Endocrinology & Metabolism
Sandra L. L. Grimm, Samuel Reddick, Xiaoyu Dong, Connor Leek, Amy Xiao Wang, Manuel Cantu Gutierrez, Sean M. M. Hartig, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Summary: This study demonstrates the essential role of miR-30a in regulating lung development and angiogenesis. Wild-type female mice show greater protection against hyperoxic lung injury than males, and this sex-dependent difference is eliminated when miR-30a is deleted. Transcriptomic analysis reveals that miR-30a deletion affects pathways related to cell cycle and neuroactive ligand-receptor interaction in female lungs. The findings suggest that miR-30a is a key factor in mediating the resilience of the female preterm lung to neonatal hyperoxic lung injury.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Medicine, General & Internal
Pamela Villavicencio, Cristina Bravo, Antoni Ibarz, Silvia Sole
Summary: This study found that males and females exhibit different physiological and psychological responses when facing stressors. Males showed significantly higher somatic anxiety post-startle, while females exhibited significantly higher somatic anxiety post-startle and lower self-confidence levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Guenes Bolatli, Fatih Tas, Naci Omer Alayunt
Summary: This study aimed to investigate the potential damage mechanisms of sodium hypochlorite (NaOCl), a widely used substance, and the protective effects of Thymus vulgaris on NaOCl exposure. Rats were exposed to different concentrations of NaOCl with or without T. vulgaris inhalation. Biochemical, histopathological, and immunohistochemical analyses were conducted on serum and lung tissue samples. The results showed that 15% NaOCl caused significant lung injury and increased TNF-alpha expression, while T. vulgaris inhalation attenuated these effects. Therefore, the use of NaOCl should be limited due to its harmful effects on the lungs, and T. vulgaris inhalation could potentially provide protection against NaOCl-induced damage.
Article
Biochemistry & Molecular Biology
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, Cheol-Su Kim, Kyu-Jae Lee
Summary: This study investigated the effects of 4 weeks of hydrogen gas inhalation on community-dwelling adults of various ages. The results showed that hydrogen gas inhalation did not adversely affect white blood cell counts, and oxidative stress markers and dementia-related biomarkers improved. Therefore, hydrogen gas inhalation may be a good treatment option for cognitive dysfunction and improvement of Alzheimer's disease.