Review
Pharmacology & Pharmacy
Danielle E. Large, Rudolf G. Abdelmessih, Elizabeth A. Fink, Debra T. Auguste
Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Takafumi Fukui, Hironao Tateno, Takashi Nakamura, Yuma Yamada, Yusuke Sato, Norimasa Iwasaki, Hideyoshi Harashima, Ken Kadoya
Summary: This study investigated the potential of liposomes as an efficient drug-delivery system for treating disorders of the central nervous system. By optimizing the liposomes and conducting experiments in a rat model, the study confirmed successful retrograde transport to the spinal cord and dorsal root ganglia. Modifying the liposomes with different substances improved their transport efficiency, providing valuable insights for the future development of novel DDS targeting the CNS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ponien Kou, Elizabeth S. Levy, An D. Nguyen, Donglu Zhang, Shu Chen, Yusi Cui, Xing Zhang, Fabio Broccatelli, Jennifer Pizzano, Jennifer Cantley, Elizabeth Bortolon, Emma Rousseau, Michael Berlin, Peter Dragovich, Vijay Sethuraman
Summary: PROTACs, including monovalent and bivalent protein degraders, are a promising technology in drug development. The market entry of bivalent PROTACs has been limited due to their complex physicochemical properties. Encapsulation in liposome systems can improve the pharmacokinetics of PROTACs, as shown in studies of two bivalent PROTAC molecules.
Review
Pharmacology & Pharmacy
Farshad Mirzavi, Mehdi Barati, Anvar Soleimani, Roghayyeh Vakili-Ghartavol, Mahmoud Reza Jaafari, Mohammad Soukhtanloo
Summary: Liposomal delivery system has shown promising results in treating melanoma by safely and effectively delivering therapeutic agents to the tumor site. By using liposomal delivery system, the success rate of current melanoma therapies can be improved and resistance can be overcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Magdalena Paluch, Dongren Wang, Michael R. Buchmeiser, Marcin K. Chmielewski
Summary: New thermo- and pH-responsive polymers based on pyridin-2-yl monomers were synthesized using reversible addition-fragmentation chain-transfer polymerization. A UV-vis study of intramolecular thermal cyclization in the synthesized polymers confirmed the potential application of rapid and complete elimination of small molecules at high temperatures, making it promising for drug delivery materials design.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Monika Kluzek, Yaara Oppenheimer-Shaanan, Tali Dadosh, Mattia I. Morandi, Ori Avinoam, Calanit Raanan, Moshe Goldsmith, Ronit Goldberg, Jacob Klein
Summary: Drug delivery via nanovehicles has been successfully applied in clinical settings, but bacterial infections in the form of biofilms present a challenge to traditional antimicrobial therapies. Liposomes can serve as versatile drug vectors for biofilm treatment, but the balance between colloidal stability and biofilm penetration needs to be addressed. This study proposes a liposomic functionalization strategy using membrane-embedded pMPC moieties, which overcomes the limitations of conventional strategies and improves cellular uptake and cargo conveyance.
Review
Chemistry, Multidisciplinary
Nafiseh Ebrahimi, Chenghao Bi, David J. Cappelleri, Gastone Ciuti, Andrew T. Conn, Damien Faivre, Neda Habibi, Alexander Hosovsky, Veronica Iacovacci, Islam S. M. Khalil, Veronika Magdanz, Sarthak Misra, Chytra Pawashe, Rasoul Rashidifar, Paul Eduardo David Soto-Rodriguez, Zoltan Fekete, Amir Jafari
Summary: Magnetism has shown great potential in actuating a variety of bio/soft robots, from microscale robots to normal size soft robots, offering advantages like novel actuation strategies and diverse applications in the biomedical field. There is still significant room for development in this area, with potential for further advancements and applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mark A. B. Kreutzberger, Ravi R. Sonani, Junfeng Liu, Sharanya Chatterjee, Fengbin Wang, Amanda L. Sebastian, Priyanka Biswas, Cheryl Ewing, Weili Zheng, Frederic Poly, Gad Frankel, B. F. Luisi, Chris R. Calladine, Mart Krupovic, Birgit E. Scharf, Edward H. Egelman
Summary: This study investigates the supercoiling structures of bacterial and archaeal flagellar filaments, revealing the atomic structures that enable stable supercoiling under torsional stress. The results suggest the significance of convergent evolution in microbial locomotion.
Review
Pharmacology & Pharmacy
Diana Guimaraes, Artur Cavaco-Paulo, Eugenia Nogueira
Summary: Liposomes are effective drug delivery systems that improve therapeutic efficacy, being nontoxic and biodegradable. Key aspects such as design, production techniques, drug loading, and characterization for in vitro and in vivo performance are essential for successful liposomal formulations. Other topics explored include functionalization, targeting strategies, stability, limitations, and current market applications of liposomes in various therapeutic fields.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Adam J. Plaunt, Tam L. Nguyen, Michel R. Corboz, Vladimir S. Malinin, David C. Cipolla
Summary: While inhalation route has been used for pharmacologic effect, it posed challenges for treating lung disease until sophisticated device and formulation technologies emerged. Now, there are several inhalation device technologies that efficiently deliver therapeutics to the lung and avoid excessive deposition elsewhere. Formulation technologies and drug chemistry modifications have also emerged to overcome degradation and clearance mechanisms, improve tolerability, or facilitate intracellular uptake.
Article
Chemistry, Multidisciplinary
Marie-Charlotte Diringer, Pierre Coliat, Clelia Mathieu, Nina Laurent, Carole Mura, Mainak Banerjee, Chen Zhu, Anna Grabowska, Alison Ritchie, Philip Clarke, Alexandre Bernard, Claire Vit, Helene Burckel, Georges Noel, Peter Harvey, Xavier Pivot, Alexandre Detappe
Summary: This study reports the development of a clinically transferable liposomal formulation, NP TSC, which improves tumor reoxygenation through enhanced oxygen diffusion in the tumor environment. Pharmacokinetic analysis performed on 37 patients guided the selection of optimal fixed dosage for validation in a triple-negative breast cancer model. The formulation exhibited non-toxicity and improved tumor vasculature normalization, transiently increased tumor oxygenation, and significantly enhanced the efficacy of radiation therapy.
Article
Chemistry, Multidisciplinary
Xiangdong Xue, Marina Ricci, Haijing Qu, Aaron Lindstrom, Dalin Zhang, Hao Wu, Tzu-Yin Lin, Yuanpei Li
Summary: The development of iron-crosslinked rosmarinic liposomes (Rososomes) presents a novel strategy with robust stability, high drug loading, and synergistic anti-cancer efficacy. The crosslinked Rososomes demonstrate better anticancer efficacy compared to free rosmarinic acid, doxorubicin, non-crosslinked Rososome, and DOXIL on a syngeneic mouse model of breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Biophysics
Bruna G. Carvalho, Bianca B. M. Garcia, Antonio A. Malfatti-Gasperini, Sang W. Han, Lucimara G. de la Torre
Summary: The association between chondroitin sulfate (CS) and cationic liposomes (CLs)/lipoplex (CL-pDNA) was analyzed in this study. The results showed that the electrostatic interaction between CS and CL/CL-pDNA could reorganize the lipid bilayers and form nanoscale vesicles. These findings have implications for the development of novel carriers for drug and gene delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Jong-Soo Choi, Jae-Won Park, Young-Bae Seu, Kyung-Oh Doh
Summary: FLLD, a folate-incorporated liposomal formulation of cholesteryl Dox, demonstrated enhanced cytotoxicity in FR-positive KB cells, promising as an anticancer drug with improved targeting effect compared to LLD.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)