Journal
BIOMEDICAL MATERIALS
Volume 9, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-6041/9/4/045009
Keywords
nanodiamond; Schwann cells; neurons; functionalization; amine; peripheral nerve
Funding
- EPSRC
- Biotechnology and Biological Sciences Research Council [BB/D524983/1, BB/E012981/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K002503/1] Funding Source: researchfish
- BBSRC [BB/D524983/1, BB/E012981/1] Funding Source: UKRI
- EPSRC [EP/K002503/1] Funding Source: UKRI
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In this study, we report the production of amine functionalized nanodiamond. The amine functionalized nanodiamond forms a conformal monolayer on a negatively charged surface produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybrid cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating the potential of the coating for applications in the treatment of peripheral nerve injury.
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