Article
Biochemistry & Molecular Biology
Ankita Dhiman, Amit Kumar Sharma, Dimpy Bhardwaj, Garima Agrawal
Summary: In order to meet the increasing food demand of the growing world population and reduce the environmental impact of agrochemicals, the development of smart nanoformulation is crucial. This study focuses on the development of dual stimuli responsive alginate based microgels for controlled release of agrochemicals and soil remediation. The microgels, prepared using functionalized alginate and a crosslinker, showed sustained release of the herbicide diuron in specific environmental conditions and demonstrated potential for sustainable agriculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Hainan Jin, Lei Wang, Shuyuan Yang, Jiayu Wen, Yan Zhang, Lianzhou Jiang, Xiaonan Sui
Summary: This study investigated the effects of soy protein isolate (SPI) on the properties of calcium alginate (CA) microgels, including morphology, encapsulation efficiency, storage stability, and digestion behavior. The results showed that the addition of SPI improved the protein loading efficiency and storage stability of the microgels. The presence of SPI also affected the swelling and digestion behavior of the microgels. Overall, this study demonstrated that SPI can be used to develop an effective controlled release delivery system using CA microgels.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Dong Yang, Keyi Gao, Yang Bai, Lei Lei, Tongtong Jia, Kaidi Yang, Chaohua Xue
Summary: This study utilized a microfluidic approach to synthesize magnetic alginate microparticles and chitosan-coated magnetic alginate microparticles, achieving controlled drug release. By investigating the model drug amoxicillin, it was found that particle size affects drug release rate, while chitosan coating extended drug release time by two times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Wenxin Jiang, Wei Xiang, Longquan Xu, Dan Yuan, Zhiming Gao, Bing Hu, Yanlei Li, Yuehan Wu
Summary: This study prepared complexes of alginate microgels (AMs) and hexadecyltrimethylammonium bromide (CTAB), which effectively stabilized oil-water emulsions. It was found that different concentrations of CTAB significantly improved the emulsifying capacity of AMs and enhanced the stability of the emulsions against centrifugation, pH changes, and NaCl concentration. The interfacial adsorption and morphology observation indicated that CTAB complexing contributed to the improved interfacial activities of the CAMs and the formation of an interfacial layer on the oil droplets' surface.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Luping Gu, David Julian McClements, Jiaying Li, Yujie Su, Yanjun Yang, Junhua Li
Summary: In this study, alginate/kappa-carrageenan composite beads were developed for encapsulation and release of egg yolk immunoglobulin Y (IgY) under simulated gastrointestinal conditions. The composite beads showed higher efficiency in protecting IgY activity and slower release kinetics compared to pure alginate beads, making them promising carriers for hydrophilic immunoglobins.
FOOD HYDROCOLLOIDS
(2021)
Article
Materials Science, Multidisciplinary
Xiaoxue Yuan, Ran Liu, Wenchang Zhang, Xiaoqiang Song, Lei Xu, Yan Zhao, Lei Shang, Jingsong Zhang
Summary: The study successfully prepared CMCS and SA blend membranes using solution casting technique, which can modulate the swelling rates and release rates of the membranes by simply changing the weight ratio of CMCS/SA. These blend membranes show promise as biomaterials for modulating permeation behavior and developing drug delivery systems.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Zhiming Luo, Haoyue Zhang, Runze Chen, Hanting Li, Fang Cheng, Lijun Zhang, Jia Liu, Tiantian Kong, Yang Zhang, Huanan Wang
Summary: Conventional manufacturing techniques for microfluidic chips have limitations in terms of multiple-layered structures, fabrication process, and productivity. Digital light processing technology has emerged as a cost-efficient approach, but the resolution for microchannels is limited. In this study, an innovative DLP printing strategy was developed for high resolution and scalable microchannel fabrication.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Haoran Cheng, Haishan Wu, Ting Guo, Hyun Jin Park, Jinglei Li
Summary: A zinc insulin hexamer-loaded alginate hydrogel was prepared and characterized for oral insulin administration. The hydrogel showed controlled release of insulin in simulated gastric and intestinal fluids, with no cytotoxicity observed. In diabetic mice, the hydrogel demonstrated significant and prolonged hypoglycemic effect.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Food Science & Technology
Luis Marangoni Junior, Plinio Ribeiro Rodrigues, Renan Garcia da Silva, Ronierik Pioli Vieira, Rosa Maria Vercelino Alves
Summary: This study prepared SA/HC films with different HC loadings, showing that incorporating HC increased the maximum degradation temperature and thickness of the films, while reducing the water vapor transmission rate. Although tensile strength was not significantly affected, elongation at break experienced a significant reduction.
FOOD AND BIOPROCESS TECHNOLOGY
(2021)
Article
Agricultural Engineering
Bochao Wei, Jiaquan Jiang, Chengxiang Gao, Lidan Zhang, Yaowei Zhan, Shuting Jiang, Yuanqiong Li, Shaolong Sun, Jianghui Xie, Xiaolin Fan
Summary: The nutrient release mechanism of bio-oil polymer coated controlled-release fertilizer (BCRF) was studied, revealing that the channels in the coating layer play a crucial role in controlling the release rate. Adjusting the ratio of bio-oil polymer and coating technology can improve the controlled-release performance of BCRF.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Z. Yu, Y. Yang, C. Wang, G. Shi, J. Xie, B. Gao, Y. C. Li, Y. Wan, D. Cheng, T. Shen, S. Hou, S. Zhang, X. Ma, Y. Yao, Y. Tang, J. Chen
Summary: A novel biobased controlled-release fertilizer with self-healing function, enabled by soy-protein microcapsules, successfully reduced nutrient release rate and extended nutrient release longevity. This represents a new direction for the development of high efficiency and environmentally friendly fertilizers to improve agriculture and food sustainability.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hamid Rashidzadeh, Farzad Seidi, Mohammadreza Ghaffarlou, Marziyeh Salehiabar, Jalil Charmi, Kadir Yaray, Hamed Nosrati, Yavuz Nuri Ertas
Summary: As noble metals, high atomic number elements can localize X-ray radiation within tumor cells by exploiting different mechanisms. In this study, alginate-coated platinum nanoparticles were synthesized and used as a radiosensitizer to enhance X-ray therapeutic efficacy in breast cancer. The nanoparticles not only improved biocompatibility and stability, but also induced higher levels of intracellular ROS and enhanced cancer cell death under X-ray irradiation. Both in vitro and in vivo results demonstrated the radiosensitizing properties of the nanosystem. The importance of radiosensitizers for improving radiotherapy outcomes was highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Anuja S. Kulkarni, Savita R. Tapase, Kisan M. Kodam, Vaishali S. Shinde
Summary: Stimuli responsive curcumin loaded microgels based on Pluronic F-127 were developed, showing affinity for hydrophobic drug release, pH and temperature-dependent properties, and dose-dependent inhibition of MDA-MB-231 cell growth with effective IC50 value of 3.8 +/- 0.2 mu g mL(-1) after 24 hours. These microgels offer additional advantages over conventional drug therapies for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Olga I. Vernaya, Andrey N. Ryabev, Tatyana I. Shabatina, Daria L. Karlova, Andrey V. Shabatin, Lyudmila N. Bulatnikova, Alexander M. Semenov, Mikhail Ya. Melnikov, Vladimir I. Lozinsky
Summary: Targeted drug release is a significant research focus in the development of drug delivery systems, and cryostructuring offers a suitable approach for efficient macroporous carriers. This study examined cryogenically structured carriers based on alginate/chondroitin sulfate mixtures and evaluated their physicochemical properties and the absorption/release of bactericides. The results showed that the concentration and ratio of alginate/chondroitin sulfate significantly influenced the swelling properties and porosity of the carriers, and the presence of chondroitin sulfate slowed down the release of certain antibiotics.
Article
Food Science & Technology
Ozra Salehi, Masoud Sami, Atefe Rezaei
Summary: In this study, D limonene was encapsulated in beta-cyclodextrin nanosponges to enhance its solubility and stability, showing improved antioxidant and antimicrobial activity. The nanosponges demonstrated controlled release of encapsulated D limonene in various food simulants and simulated gastrointestinal conditions, indicating their potential as a preservative with enhanced antibacterial properties. Further in vivo studies are necessary to confirm their application in the field of nutrition and genomics.