Article
Chemistry, Analytical
Omnia A. El-Naem, Christine M. El-Maraghy
Summary: This work developed an LC-MS/MS method for the simultaneous analysis of ranitidine and metronidazole in plasma, with a simple protein precipitation procedure for extraction and effective chromatographic separation on a C-18 column. The method showed good sensitivity and accuracy, and could be applied for bioavailability studies.
ANALYTICAL METHODS
(2021)
Article
Biochemical Research Methods
Dominique A. Garrison, Yan Jin, Muhammad Erfan Uddin, Alex Sparreboom, Sharyn D. Baker
Summary: A simple, fast, and precise LC-MS/MS method was developed and validated for the quantitation of the tyrosine kinase inhibitor gilteritinib in micro-volumes of mouse plasma. The method showed high accuracy, good linear responses, and suitability for pharmacokinetic studies.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Veterinary Sciences
Shiting Xie, Yixing Lu, Jun Wang, Changcheng Lin, Peiyu Ye, Xiaolin Liu, Wenguang Xiong, Zhenling Zeng, Dongping Zeng
Summary: A selective and sensitive LC-MS/MS method was developed and validated for the simultaneous quantification of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ in cat plasma. The method showed good precision, accuracy, recovery, and linearity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Analytical
Wen-si Huang, Jing-hua Yu, Xing-xing Diao
Summary: A simple and sensitive LC-MS/MS method was established for quantitation of rhGH in rat plasma. The method involved enzymatic digestion and the use of suitable surrogate peptides for quantitative analysis. The method exhibited good linearity, accuracy, and precision, and was successfully applied to pharmacokinetic studies in rats. It offers advantages such as simple sample preparation, short processing time, wide linear range, small plasma volume, and low limit of quantification.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Mohammad Mohiminul Islam, Ethan F. Kub, Vilashini Rajaratnam, Shama P. Mirza
Summary: Carmofur is an effective acid ceramidase inhibitor with superior efficacy against aggressive glioblastoma cell lines. It is also a potential lead inhibitor of the main protease (MPRO) of SARS-CoV-2 and has shown efficacy against various cancers and non-cancerous diseases. A sensitive LC-MS/MS method for quantitative bioanalysis of carmofur using mouse plasma is reported in this study.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Chemistry, Analytical
L. T. van der Heijden, A. Gebretensae, B. Thijssen, L. van Andel, A. L. Nijstad, Y. Wang, H. Rosing, A. D. R. Huitema, J. H. Beijnen
Summary: A highly sensitive method using LC-MS/MS was developed for quantification of vinblastine, vincristine, vinorelbine, and its active metabolite in human plasma. The method was successfully applied in pharmacokinetic studies and in vivo mouse models research.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Xun Fang, Qi Lu, Jichun Han
Summary: AZD7648 is a potent DNA-PK inhibitor being developed for ovarian cancer treatment. This study developed a simple and sensitive LC-MS/MS method for determining the concentration of AZD7648 in rat plasma. The method was validated and proven to be selective, sensitive, and reliable, and successfully applied to pharmacokinetic study.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemical Research Methods
Dan Chen, Kaixin Du, Xiaochen Niu, Hongwei Zhang, Xue Zhang, Yu Tang, Jianchun Zhao
Summary: A sensitive LC-MS/MS method for the determination of amlexanox in rat plasma was successfully established and validated, and applied to pharmacokinetic study. The method involved the use of Capcell Pak C18 column and triple quadrupole mass in MRM for detection, with calibration curves ranging from 50 to 2000 ng/mL.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Chemistry, Medicinal
Guanxuanzi Zhang, Na Zhang, Liuhan Dong, Nan Bai, Yun Cai
Summary: A LC-MS/MS method for quantifying contezolid in plasma and cerebrospinal fluid (CSF) has been developed and verified in this study. Using linezolid as the internal standard, protein precipitation was performed. The LC-MS/MS analysis was performed using an Agilent EclipsePlus C18 column and acetonitrile and water mobile phases. The method showed good linearity, precision, and recovery rates in both plasma and CSF samples.
Article
Chemistry, Analytical
Dong Xiang, Tinghui Zhao, Jue Wang, Yang Cao, Qiuxia Yu, Lu Liu, Hengyi Yu, Xiping Li, Ninghong Li, Yang Yi, Xuepeng Gong
Summary: A sensitive and robust LC-MS/MS method was developed and validated for the quantification of olverembatinib in human plasma and cerebrospinal fluid (CSF). The method involved liquid-liquid extraction and precipitation enrichment for plasma and CSF pretreatment, respectively. The detection was performed by electrospray ionization in a positive ion mode using multiple reaction monitoring. The method proved to be accurate and precise, with a successful application in measuring olverembatinib concentrations in plasma and CSF from chronic myeloid leukemia patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Jian He, Wenxia Liu, Yu Zhang, Zunjian Zhang, Yuan Tian
Summary: A rapid and sensitive chiral liquid chromatography-tandem mass spectrometry method was established for the enantioseparation and determination of clopidogrel bisulfate enantiomers in beagle plasma. The results revealed that R-CB exhibited higher concentrations in beagle plasma compared to S-CB.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Yixin Hu, Jianyuan Wu, Xin Jiang, Guiying Chen, Yang Zhang, Luqin Si, Hongliang Jiang, Jiangeng Huang, Jianying Huang
Summary: A rapid, simple and sensitive LC-MS/MS method was developed and validated to quantify abiraterone and its metabolites in human plasma. The method showed good accuracy, precision and stability, making it suitable for pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Medicinal
Mi Hye Kwon, Dae Young Lee, Hee Eun Kang
Summary: A simple and rapid LC-MS/MS method was developed to determine DA-7010 levels in plasma samples from mice, rats, and dogs, with successful validation and application in preclinical pharmacokinetic studies. The systemic exposure of DA-7010 was found to be approximately four times higher in dogs compared to mice or rats.
Article
Biochemical Research Methods
Stefan A. J. Buck, Peter de Bruijn, Inge M. Ghobadi-Moghaddam-Helmantel, Mei H. Lam, Ronald de Wit, Stijn L. W. Koolen, Ron H. J. Mathijssen
Summary: Currently, there are several available oral androgen receptor signalling inhibitors for the treatment of advanced prostate cancer. Quantification of plasma concentrations of these drugs is highly relevant for various purposes, such as therapeutic drug monitoring in oncology. In this study, a LC-MS/MS method was developed and validated for the simultaneous quantification of abiraterone, enzalutamide, and darolutamide. The clinical applicability of quantifying enzalutamide and darolutamide in patients with metastatic castration-resistant prostate cancer was also demonstrated.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Emma Eckernas, Adam Bendrioua, Chiara Cancellerini, Christopher Timmermann, Robin Carhart-Harris, Kurt-Jurgen Hoffmann, Michael Ashton
Summary: A highly sensitive LC-MS/MS method has been developed and validated for the quantification of DMT and its metabolites in human plasma. The method showed good accuracy, precision, sensitivity, and selectivity. It can be applied to future studies aiming to characterize DMT disposition and its relationship to immediate psychedelic or long-term antidepressive effects.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Letter
Obstetrics & Gynecology
Pathum Sookaromdee, Viroj Wiwanitkit
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Thermodynamics
Lorenzo Gini, Simone Maccarini, Alberto Traverso, Stefano Barberis, Rafael Guedez, Emanuel Pesatori, Valentina Bisio
Summary: High efficiency, flexibility, and competitive capital costs contribute to the potential of supercritical CO2 (sCO2) systems as a promising technology for renewable power generation in a low carbon energy scenario. The article discusses the innovative supercritical systems proposed by DOE-NETL and EU Horizon 2020 programs, particularly for high-temperature applications. It also presents the off-design and dynamic analysis of a sCO2 demonstration plant, highlighting the relationships between regulating parameters and discussing the potential for providing primary reserve for the electrical grid.
APPLIED THERMAL ENGINEERING
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Pathum Sookaromdee, Viroj Wiwanitkit
INTERNATIONAL DENTAL JOURNAL
(2023)
Editorial Material
Emergency Medicine
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Letter
Otorhinolaryngology
Amnuay Kleebayoon, Viroj Wiwanitkit
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Letter
Pediatrics
Pathum Sookaromdee, Viroj Wiwanitkit
INDIAN JOURNAL OF PEDIATRICS
(2023)
Letter
Cardiac & Cardiovascular Systems
Amnuay Kleebayoon, Viroj Wiwanitkit
Letter
Clinical Neurology
Amnuay Kleebayoon, Viroj Wiwanitkit
WORLD NEUROSURGERY
(2023)
Letter
Cardiac & Cardiovascular Systems
Amnuay Kleebayoon, Viroj Wiwanitkit
Letter
Oncology
Amnuay Kleebayoon, Rujittika Mungmunpuntipanitp, Viroj Wiwanitkit
JOURNAL OF NEURO-ONCOLOGY
(2023)
Letter
Biotechnology & Applied Microbiology
Pathum Sookaromdee, Viroj Wiwanitkit
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Amnuay Kleebayoon, Viroj Wiwanitkit
Letter
Medical Laboratory Technology
Beuy Joob, Viroj Wiwanitkit
CLINICAL LABORATORY
(2023)
Letter
Medical Laboratory Technology
Pathum Sookaromdee, Viroj Wiwanitkit
CLINICAL LABORATORY
(2023)
Letter
Medicine, General & Internal
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
NIGERIAN POSTGRADUATE MEDICAL JOURNAL
(2023)