Article
Chemistry, Multidisciplinary
Zhihai Fan, Hongxiang Liu, Zhaozhao Ding, Liying Xiao, Qiang Lu, David L. Kaplan
Summary: This study successfully mimicked the complex anisotropic structures of different tissues in vitro using a composite materials strategy. Cryogels containing two types of silk nanofibers were prepared, and these bioactive cryogels showed the ability to promote bone regeneration and modulate inflammation, angiogenesis and osteogenesis responses in vivo, suggesting a promising strategy for tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yong-Ho Seo, Su-Hyun Hwang, Yu-Na Kim, Hyung-Joon Kim, Eun-Bin Bae, Jung-Bo Huh
Summary: The study aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. The results showed satisfactory bone regeneration efficiency in the cancellous and two-layer groups, while the cortical group exhibited poor bone regeneration. Further studies are needed to explore methods for regulating the ratio of cortical and cancellous bones in two-layer bones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiaofan Chen, Haicheng Wang, Yuning Wang, Ying Shi, Zuolin Wang
Summary: This study investigated and compared the effects of combining deproteinized bovine bone mineral (DBBM) with autologous cortical (CorBC) or cancellous bone chips (CanBC) as bone grafts on guided bone regeneration (GBR) both in vivo and in vitro. The results showed that the combination of DBBM and CanBC had a more favorable osteogenic effect compared to DBBM and CorBC, as demonstrated by various evaluation methods.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Computer Science, Interdisciplinary Applications
Ina Schmidt, Areti Papastavrou, Paul Steinmann
Summary: Continuum bone remodelling is an important tool for predicting the effects of mechanical stimuli on bone density evolution. This study presents a novel approach that models both cancellous and cortical bone types, and demonstrates the significant impact of including cortical bone on the density evolution of cancellous bone. The interaction between different bone types should not be neglected in bone remodelling studies.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Zhichao Ma, Bin Huang, Fangzhou Lu, Hongwei Zhao, Luquan Ren
Summary: The energy absorption and toughening effect of cartilage are important for protecting bone from damage, and the presence of the cartilage layer can significantly enhance the strength and ductility of the bone structure.
Article
Endocrinology & Metabolism
Shun-Neng Hsu, Louise A. Stephen, Scott Dillon, Elspeth Milne, Behzad Javaheri, Andrew A. Pitsillides, Amanda Novak, Jose Luis Millan, Vicky E. MacRae, Katherine A. Staines, Colin Farquharson
Summary: This study found that in mice with advanced CKD, bone density increased in cortical bone but decreased in trabecular bone. TNAP expression was decreased while PHOSPHO1 expression was increased in CKD bones. In P1KO CKD mice, cortical BMD was restored and other structural parameters improved. In vitro experiments showed that hyperphosphatemia and/or hyperparathyroidism downregulated TNAP and PHOSPHO1 expressions.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Bin Wu, Le Yuan, Mao Liu, Miaoning Tang, Di Jiang, Yang Yi, Songyun Ma, Bin Yan, Yi Lu
Summary: Orthodontic treatment can affect the remodeling of cancellous bone in alveolar bone and its bone mineral density. This study quantified the effect of bone mineral density on the viscoelastic behavior of alveolar bone and assessed orthodontic forces at different bone mineral densities.
Article
Nutrition & Dietetics
Ana Torres-Costoso, Vicente Martinez-Vizcaino, Fatima Baptista, Sara Reina-Gutierrez, Sergio Nunez de Arenas-Arroyo, Luis Enrique Hernandez-Castillejo, Miriam Garrido-Miguel
Summary: This study used cluster analysis to examine body composition phenotypes in young adults and assessed their associations with bone health outcomes. The results showed that individuals with higher lean mass had better bone health compared to other body composition categories. Additionally, individuals with similar average lean mass index but higher fat mass had better bone outcomes.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Summary: Middle-aged men living with human immunodeficiency virus (MLWH) have a significantly higher risk of hip fracture, almost a decade earlier than those without infection. Limited data on cortical and trabecular bone deficit in MLWH were observed. This study found that MLWH had lower hip bone density and deficits in certain bone parameters compared to age and body mass index-matched controls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Immunology
Youfeng Guo, Haihong Zhao, Feng Wang, Haowei Xu, Xiaowei Liu, Tao Hu, Desheng Wu
Summary: This study investigated the correlation between body composition, fractures, and telomere length (TL). The results indicated that TL was positively and negatively associated with bone mineral density (BMD) and bone mineral content (BMC) in different body parts. TL was also found to be related to the occurrence of wrist and spine fractures, and this correlation showed some sex specificity. Further research is needed to validate these associations in the skull, upper limbs, and wrists.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Mateus Augusto Bim, Andre de Araujo Pinto, Hector Cris Colares de Angelo, Isadora Gonzaga, Adriana Coutinho de Azevedo Guimaraes, Erico Pereira Gomes Felden, Wellington Roberto Gomes de Carvalho, Karen Hind, Andreia Pelegrini
Summary: This study aimed to assess the relationship between bone mass and lean mass (LM) and fat mass (FM) in normal-weight and overweight adolescents. The results showed that only LM was associated with bone mass in both normal-weight and overweight adolescents. LM was found to be the main predictor of bone mass in these groups.
Review
Critical Care Medicine
Haicheng Wang, Yifan Zhang, Chuan Ren, Kai Ding, Qi Zhang, Yanbin Zhu, Wei Chen
Summary: Understanding the characteristics and mechanics of trabecular bone is crucial for studying fractures and surgical planning. Recent advancements in imaging, biomechanics, and finite element analysis have contributed to a better understanding of trabecular bone. This article reviews the research progress and provides a comprehensive overview of the latest findings on proximal femoral trabecular bone and their clinical significance.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Materials Science, Multidisciplinary
Sina Asadollahi, Mehdi Dehestani
Summary: In this study, the micro- and sub-microstructures of human cortical bone were analyzed, and modified equations were derived to estimate the nine orthotropic elastic constants based on sub-microstructural architectures and bone mineral density. The analytical models showed good agreement with nanoindentation tests and experimental results of direct tensile and punching shear tests, suggesting potential for predicting material properties of cortical bone.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atila Gokcek, Esra Ogutcu Karabay, Merve Aktimur Yegin, Emin Cakmakci, Serap Gencer
Summary: This study aimed to describe a more accessible and safe diagnostic tool for osteoporosis or osteopenia diagnosis. The cortical thickness (CoT) measurement of various bones via ultrasonography was evaluated for its accuracy in relation to bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DXA). The results showed that CoT measurements of certain bones were significantly higher in osteoporotic or osteopenic patients compared to controls.
ACADEMIC RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Di Yang, Rongrong Xu, Yinfang Tu, Yunfeng Xiao, Hongwei Zhang, Weijie Liu, Pin Zhang, Haoyong Yu, Yuqian Bao, Ying Yang, Junfeng Han
Summary: Sleeve gastrectomy leads to a decrease in femoral neck and total hip bone mineral density (BMD) in both women and men. Changes in body composition are associated with BMD loss at different time points and bone sites.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Allergy
Di Huang, Maie S. Taha, Angela L. Nocera, Alan D. Workman, Mansoor M. Amiji, Benjamin S. Bleier
Summary: Nasal epithelium-derived extracellular vesicles (EVs) play a crucial role in antiviral immunity by delivering functional miR-17 and directly neutralizing viral infections. However, cold exposure can impair EV secretion, microRNA packaging, and antiviral binding, leading to weakened antiviral effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Jingjing Du, Yang Zhang, Jiaqi Wang, Mengjie Xu, Miao Qin, Xiumei Zhang, Di Huang
Summary: In this study, whitlockite/polyurethane (WH/PU) composite scaffolds were successfully prepared and characterized. The results showed that WH/PU composite scaffolds had high porosity, compressive strength, and elasticity. They also exhibited good compatibility with cells and promoted cell proliferation and alkaline phosphatase activity. Therefore, the WH/PU scaffolds hold promise for bone tissue engineering applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Astronomy & Astrophysics
A. Albert, R. Alfaro, J. C. Arteaga-Velazquez, H. A. Ayala Solares, E. Belmont-Moreno, T. Capistran, A. Carraminana, S. Casanova, J. Cotzomi, S. Coutino De Leon, E. De la Fuente, C. de Leon, R. Diaz Hernandez, M. A. DuVernois, J. C. Diaz-Velez, C. Espinoza, K. L. Fan, N. Fraija, K. Fang, J. A. Garcia-Gonzalez, F. Garfias, A. Jardin-Blicq, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, A. Lara, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martinez-Castro, J. A. Matthews, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. Newbold, M. U. Nisa, Y. Perez Araujo, Y. Son, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, A. Sandoval, M. Schneider, J. Serna-Franco, A. J. Smith, R. W. Springer, K. Tollefson, I. Torres, R. Torres-Escobedo, X. Wang, K. Whitaker, E. Willox, H. Zhou
Summary: With 2321 days of observation, the HAWC Gamma-Ray Observatory detected a TeV halo associated with PSR J0359+5414, indicating that TeV halos could commonly exist around pulsars and are not dependent on the configuration of the pulsar magnetosphere.
ASTROPHYSICAL JOURNAL LETTERS
(2023)
Article
Biology
Yuyuan Zhang, Kaiqun Wang, Yaoyao Du, Huiyuan Yang, Guanjie Jia, Di Huang, Weiyi Chen, Yanhu Shan
Summary: Tumor immunotherapy aims to enhance CD8+ T cell killing of tumor cells, but the impact of tumor heterogeneity on tumor-immune interactions is not well understood. A cellular-level computational model was developed to investigate this. The model showed that the distribution of proliferating/quiescent tumor cells in a solid tumor mass changed with tumor evolution and influenced the suppressive functions of a tumor mass on T cells. Despite not fully inhibiting T cells, quiescent tumor cells had improved long-term survival due to their interior location. Overall, this model provides a useful framework for studying collective-targeted strategies in immunotherapy.
BULLETIN OF MATHEMATICAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Yu Gu, Fenyan Miao, Kejun Liu, Yimeng Su, Yan Wei, Yinchun Hu, Xiaojie Lian, Weimo Han, Weiyi Chen, Di Huang
Summary: In this study, a conductive hydrogel was prepared using gelatin methacryloyl (GelMA) and graphene oxide (GO) by adjusting their concentrations during the cross-linking process. The addition of 0.1% GO improved the mechanical properties of the hydrogel to 16.37 +/- 1.89 KPa, while the conductivity increased to 1.36 +/- 0.09 mu S/cm. Mineralization of the hydrogel significantly enhanced its mechanical properties to 26.38 +/- 2.29 KPa. Cell experiments demonstrated that electrical stimulation of the mineralized hydrogel improved the alkaline phosphatase activity of the cells. GelMA/GO conductive hydrogel shows promise for bone repair and tissue engineering.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Materials Science, Multidisciplinary
Huixiu Ding, Min Kang, Shan Liang, Yinchun Hu, Yan Wei, Di Huang
Summary: Mineralization is a key factor in evaluating the performance of bone repair materials. This study utilized biomimetic methods to create mineralized PCL nanofibrous membranes with shish-kebab (SK) structure, which enhanced cell proliferation and osteoinductive ability. The SK structure increased the specific surface area of the membrane, providing more nucleation sites for the mineralization and crystallization of calcium phosphate (CaP), leading to improved bone repair performance.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Engineering, Civil
Zhitao Hu, Di Huang, Shuaian Wang
Summary: Bus exterior advertising is a powerful tool for establishing brand awareness as it can reach a wide audience frequently. Targeted advertising is crucial for the effectiveness of a certain advertisement category, which depends on the exposure to the interested target audience. Deploying buses with specific advertisement categories to the bus lines that match their target areas enhances overall advertising effectiveness.
JOURNAL OF TRANSPORTATION ENGINEERING PART A-SYSTEMS
(2023)
Article
Biotechnology & Applied Microbiology
Jiapu Wang, Xuefeng Wang, Ziwei Liang, Weiwei Lan, Yan Wei, Yinchun Hu, Longfei Wang, Qi Lei, Di Huang
Summary: By combining bionic inorganic particles and hydrogels to mimic the organic-inorganic characteristics of natural bone extracellular matrix, multifunctional hydrogels with bone tissue repair effects and excellent antibacterial activity have been developed, providing a promising minimally invasive treatment biomaterial in bone repair fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Correction
Engineering, Biomedical
Hui Yang, Yinchun Hu, Min Kang, Huixiu Ding, Yue Gong, Xiangfei Yin, Ruize Sun, Yuhong Qin, Yan Wei, Di Huang
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Environmental
Hongyu Jiang, Fengxia Bao, Jinzhao Wang, Jianhua Chen, Yifan Zhu, Di Huang, Chuncheng Chen, Jincai Zhao
Summary: Photosensitized renoxification of HNO3 produces HONO in a high yield, which is an important source for atmospheric HONO. This study provides evidence of the direct formation of NO2* as a key intermediate during the photosensitizing renoxification of HNO3 using humic acid (HA) as a model environmental photosensitizer. The high HONO yield originates from the heterogeneous reaction of NO2* with co-adsorbed water molecules on HA. This work deepens our understanding of atmospheric HONO formation and the transformation of RNS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Runhua Yao, Hui Wang, Ruifeng Shan, Lin Liu, Yuyu Zhao, Yonghua Sun, Xiaohong Yao, Di Huang, Ruiqiang Hang
Summary: Porous Zn-based scaffolds with 1 wt.%Mg and 3 vol.% beta-TCP were fabricated, exhibiting reliable mechanical properties, desirable degradability, and osteogenic activity, which have great potential as next-generation bone repair materials.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Kuo Wang, Chaorong Guo, Zhennan Li, Rui Zhang, Zhimin Feng, Gengkun Fang, Di Huang, Jiaojiao Liang, Ling Zhao, Zicha Li
Summary: The application of machine learning algorithms reveals that the energy levels of donor, acceptor, and transport materials play a crucial role in improving the open-circuit voltage (V-oc) of binary bulk heterojunction organic solar cells (OSCs). Among the algorithms tested, the eXtreme Gradient Boosting (XGBoost) model provides the best prediction accuracy. The highest occupied molecular orbital (HOMO) of the donor is identified as the most important factor in improving V-oc. Experimental verification demonstrates the reliability of the machine learning prediction for high V-oc in binary OSCs.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Astronomy & Astrophysics
A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velazquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, C. Brisbois, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, S. Coutino de Leon, E. de la Fuente, C. de Leon, R. Diaz Hernandez, J. C. Diaz-Velez, B. L. Dingus, M. A. DuVernois, M. Durocher, K. Engel, C. Espinoza, K. L. Fan, M. Fernandez Alonso, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Huentemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, S. Kaufmann, D. Kieda, W. H. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, R. Lopez-Coto, K. Malone, V. Marandon, O. Martinez, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, A. Peisker, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, F. Salesa Greus, A. Sandoval, M. Schneider, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, L. Villasenor, X. Wang, F. Werner, E. Willox, H. Zhou
Summary: The latest HAWC catalog detected two sources in the Galactic plane region at 56 TeV, 3HWC J1930+188 and 3HWC J1928+178. The former is associated with the known TeV source SNR G054.1+00.3, while the latter is associated with the pulsar PSR J1928+1746, confirmed by recent analysis of H.E.S.S. data. Additionally, a new source HAWC J1932+192 potentially associated with the pulsar PSR J1932+1916 was discovered.
ASTROPHYSICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Gang Lin, Xiaoliang Zhou, Limin Liu, Huangmin Li, Di Huang, Jing Liu, Jie Li, Zhaohuan Wei
Summary: In this study, a novel modification method based on the separator was proposed to inhibit the dendrite generation in rechargeable aqueous zinc-based batteries (AZBs). By uniformly spraying sonicated Ketjen black (KB) and zinc oxide nanoparticles (ZnO) on the separators, the electric field at the anode interface was homogenized by the highly conductive KB. The ZnO in the uniform KB conductive network provided sites for zinc deposition, reduced the by-products of the zinc anode electrode, and improved the electrochemical performance of AZBs.
Article
Materials Science, Biomaterials
Yu Cao, Longfei Wang, Xiumei Zhang, Yi Lu, Yan Wei, Ziwei Liang, Yinchun Hu, Di Huang
Summary: In this study, hydrogel dressings with adjustable contractility and adhesion were fabricated, which can rapidly close wounds, adjust shrinkage rate, and achieve high adhesion strength and regional adhesion. Sutures-free wound closure can be achieved by adjusting the material temperature, and the dressings can promote scar-free wound healing.
REGENERATIVE BIOMATERIALS
(2023)
