Article
Cell Biology
Jun Ochiai, Larakaye Villanueva, Hope Niihara, Yutaka Niihara, Joan Oliva
Summary: This study developed a method to engineer multilayer adipose stem cell cell sheets (ASCCSs) using chemically defined/serum-free culture media, which can differentiate into osteoblasts and chondrocytes. The number of cells per cell sheet was estimated using cell sheet transmittance, providing important non-invasive information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell & Tissue Engineering
Elena Stocco, Silvia Barbon, Marco Mammana, Giovanni Zambello, Martina Contran, Pier Paolo Parnigotto, Veronica Macchi, Maria Teresa Conconi, Federico Rea, Raffaele De Caro, Andrea Porzionato
Summary: Severe tracheal injuries pose a challenge in surgical practice, but decellularized scaffolds provide a potential solution. This systematic review examines studies on decellularized/bioengineered tracheal implantation, including orthotopic implant results and clinical cases.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Engineering, Biomedical
Yujian Liu, Kaifu Zheng, Zijie Meng, Lei Wang, Xi Liu, Baolin Guo, Jiankang He, Xiyang Tang, Mingyao Liu, Nan Ma, Xiaofei Li, Jinbo Zhao
Summary: In this study, a cell-free tissue-engineered tracheal substitute was developed using a 3D-printed polycaprolactone scaffold coated with a gelatin-methacryloyl hydrogel. Transforming growth factor-β1 (TGF-β) and stromal cell-derived factor-1α (SDF-1) were embedded in the scaffold to facilitate cell recruitment and differentiation. The tracheal substitute showed positive results in promoting the recruitment of cells and enhancing differentiation towards a chondrocyte phenotype.
Article
Otorhinolaryngology
So Jeong Kim, Soo Yeon Jung, Min Ji Lee, Jung Ho Bae, Han Su Kim
Summary: The decellularized porcine tracheal mucosa can prevent nasal mucosal injuries from progressing to septal perforations, promote the repair of mucosal defects, and protect nasal cartilage, as shown in the experimental results.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Multidisciplinary Sciences
Jun Tu, Yuyang Zeng, Ran An, Jiaming Sun, Huicai Wen
Summary: Researchers have engineered stromal vascular fraction (SVF) extracted from fat into nanovesicles (SVF-EVs) to promote angiogenesis in acellular matrix. SVF-EVs not only enhance migration of vascular endothelial cells in vitro but also facilitate lipogenic differentiation of mesenchymal stem cells. In vivo experiments demonstrate that SVF-EVs enhance retention of decellularized adipose tissue and promote formation of vascular networks with large lumen diameter, accompanied by adipocyte regeneration. These findings suggest that SVF-EVs can be a viable method for accelerating revascularization in acellular matrix and have potential for rapid clinical transformation.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Biomaterials
Boyou Zhang, Fei Sun, Yi Lu, Zhihao Wang, Zhiming Shen, Lei Yuan, Qiang Wu, Cong Wu, Hongcan Shi
Summary: A novel rapid decellularized tracheal preparation method using SLES was developed to construct tissue engineering trachea (TET) with revascularization functions. Results showed that appropriate SLES treatment reduced immunogenicity, retained tracheal matrix structure, and preserved bioactive components.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Philipp Nessbach, Sascha Schwarz, Tanja D. Becke, Hauke Clausen-Schaumann, Hans-Guenther Machens, Stefanie Sudhop
Summary: Three-dimensional scaffolds made through bioprinting can promote wound healing, especially for complex chronic wounds. The co-cultivation of collagen type I with human umbilical vein endothelial cells (HUVECs) and adipose stromal cells (ASCs) has been found to accelerate angiogenesis and wound healing.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Wenli He, Chunying Shi, Jia Yin, Feifei Huang, Wenjing Yan, Jin Deng, Bing Zhang, Bin Wang, Haiping Wang
Summary: Spinal cord injury leads to irreversible damage of sensory and motor function, but current treatments fail to provide an optimal environment for cell repair. This study introduces a novel biomaterial that successfully creates a suitable environment for promoting cell proliferation and differentiation, resulting in significant improvement in motor function recovery for spinal cord injury.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Surgery
Pir Muneeb Rehman, Fariha Sahrish, Sahar Iqbal, Tuba Tariq, Muhammad Shoaib, Sehrish Rubab, Muhamad Imran, Mehwish Niazi, Saima Irum, Muhammad Aqeel
Summary: This article reports a case of gastrointestinal intestinal stromal tumor in a 65-year-old patient, which was diagnosed through clinical examination and histopathological examination. The tumor was located in the anterior lesser omentum and was a massive cystic swelling.
JOURNAL OF SURGICAL CASE REPORTS
(2023)
Article
Engineering, Biomedical
Jeong Hun Park, Ju Young Park, Inn-Chul Nam, Se-Hwan Hwang, Choung-Soo Kim, Jin Woo Jung, Jinah Jang, Hyungseok Lee, Yeongjin Choi, Sun Hwa Park, Sung Won Kim, Dong-Woo Cho
ACTA BIOMATERIALIA
(2015)
Article
Engineering, Biomedical
Ju Young Park, Yeong-Jin Choi, Jin-Hyung Shim, Jeong Hun Park, Dong-Woo Cho
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Review
Materials Science, Biomaterials
Ju Young Park, Ge Gao, Jinah Jang, Dong-Woo Cho
JOURNAL OF MATERIALS CHEMISTRY B
(2016)
Review
Engineering, Biomedical
Jinah Jang, Ju Young Park, Ge Gao, Dong-Woo Cho
Article
Engineering, Biomedical
Young-Joon Seol, Ju Young Park, Wonju Jeong, Tae-Ho Kim, Shin-Yoon Kim, Dong-Woo Cho
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2015)
Article
Engineering, Electrical & Electronic
Ju Young Park, Jinah Jang, Hyun-Wook Kang
MICROELECTRONIC ENGINEERING
(2018)
Article
Engineering, Biomedical
Ge Gao, Ju Young Park, Byoung Soo Kim, Jinah Jang, Dong-Woo Cho
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Jeong Hwa Kim, Ju Young Park, Songwan Jin, Sik Yoon, Jong-Young Kwak, Young Hun Jeong
Article
Engineering, Biomedical
Wonil Han, Narendra K. Singh, Joeng Ju Kim, Hyeonji Kim, Byoung Soo Kim, Ju Young Park, Jinah Jang, Dong-Woo Cho
Article
Biochemistry & Molecular Biology
Jongmin Kim, Ju Young Park, Jeong Sik Kong, Hyungseok Lee, Jae Yon Won, Dong Woo Cho
Summary: The retinal pigment epithelium (RPE) plays a crucial role in retinal degenerative diseases, but there is currently no cure. Research has shown that bioink derived from porcine Bruch's membrane can enhance RPE functionality, and a Bruch's membrane-mimetic substrate (BMS) developed using 3D printing technology can facilitate appropriate RPE functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ju Young Park, Sneha Mani, Geremy Clair, Heather M. Olson, Vanessa L. Paurus, Charles K. Ansong, Cassidy Blundell, Rachel Young, Jessica Kanter, Scott Gordon, Alex Y. Yi, Monica Mainigi, Dan Dongeun Huh
Summary: This study introduces a novel microengineered system that can model trophoblast invasion, an important process in early human pregnancy. The researchers demonstrate the role of decidualized stromal cells in trophoblast migration and uncover previously unknown effects of pre-implantation maternal immune cells on trophoblast invasion.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Ju Young Park, Hyunryul Ryu, Byungjun Lee, Dong-Heon Ha, Minjun Ahn, Suryong Kim, Jae Yun Kim, Noo Li Jeon, Dong-Woo Cho
Article
Engineering, Biomedical
Jinah Jang, Hun-Jun Park, Seok-Won Kim, Heejin Kim, Ju Young Park, Soo Jin Na, Hyeon Ji Kim, Moon Nyeo Park, Seung Hyun Choi, Sun Hwa Park, Sung Won Kim, Sang-Mo Kwon, Pum-Joon Kim, Dong-Woo Cho
Article
Engineering, Biomedical
Jin-Hyung Shim, Ki-Mo Jang, Sei Kwang Hahn, Ju Young Park, Hyuntae Jung, Kyunghoon Oh, Kyeng Min Park, Junseok Yeom, Sun Hwa Park, Sung Won Kim, Joon Ho Wang, Kimoon Kim, Dong-Woo Cho
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.