Journal
BIOMATERIALS
Volume 35, Issue 30, Pages 8576-8584Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.06.050
Keywords
Foreign body giant cell; Foreign body response; Macrophage; Silk; Degradation
Funding
- Next-Generation BioGreen21 Program (Center for Nutraceutical & Pharmaceutical Materials) [PJ009051]
- Rural Development Administration, Republic of Korea
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Grafted macromolecules often induce granuloma formation with foreign body giant cell (FBGC) infiltration, and this is the main reason for graft failure. Diacylglycerol kinase (DAGK) is an important intracellular mediator of FBGC formation in macrophages. In this study, 4-hexylresorcinol (4HR) inhibited DAGK delta in a macrophage cell line (RAW264.7 cells). As a result of DAGK-delta inhibition by 4HR, FBGC formation was significantly inhibited in RAW264.7 cells. Silk fibroin is a well-known natural macromolecule, and when it is grafted into bone defects, it results in granuloma formation with massive FBGC formation. 4HR-incorporating silk graft materials displayed significant reduction of granuloma formation and increases in the extent of new bone formation in a rabbit calvarial defect model. In conclusion, 4HR could inhibit foreign body reaction via a DAGK-mediated pathway. (C) 2014 Elsevier Ltd. All rights reserved.
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