Review
Chemistry, Multidisciplinary
Xingyi Wan, Zhirong Liu, Linlin Li
Summary: Stem cells have potential in tissue repair, and the design and fabrication of biomaterials for regenerative medicine should closely mimic the physiochemical properties of the natural ECM to enhance stem cell function. Optimization of biophysical factors can achieve desirable stem cell functions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Health Care Sciences & Services
David M. Z. B. Hennes, Anna Rosamilia, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee
Summary: Endometrial mesenchymal stem/progenitor cells (eMSC) show potential for applications in treating chronic and degenerative human diseases, with less invasive extraction methods and improved potency and proliferative capacity. They are particularly useful for pelvic organ prolapse treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Polymer Science
Meaghan E. Harley-Troxell, Richard Steiner, Rigoberto C. Advincula, David E. Anderson, Madhu Dhar
Summary: Neural injuries can greatly impact people's quality of life, so regenerative medicine and tissue engineering have become promising fields for research on nerve repair. This review evaluates the use of natural and synthetic polymers and different fabrication methods that can influence cell behavior. The review also assesses the body's reactions to implanted materials.
Review
Engineering, Biomedical
Ziyi Feng, Meiqi Jin, Junzhi Liang, Junning Kang, Huazhe Yang, Shu Guo, Xiaoting Sun
Summary: Bone damage may require bone grafting and bone tissue engineering can be an alternative strategy. Mesenchymal stem cells (MSCs) are important for tissue engineering due to their ability to differentiate into various cell types. The regulation of MSCs differentiation and the role of mitochondria in this process are crucial for efficient bone regeneration.
ACTA BIOMATERIALIA
(2023)
Review
Materials Science, Multidisciplinary
Dan He, Haiyan Li
Summary: Cell-cell interactions are crucial in tissue and organ development, and the effects of biomaterials on these interactions have been gaining attention in tissue engineering research. This review provides comprehensive information on cell co-culture technologies and the effects of biomaterials on cell-cell interactions, aiming to promote further research in the field.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Robert P. Accolla, Jia-Pu Liang, Taylor R. Lansberry, Irayme Labrada Miravet, Marlon Loaisiga, Baltasar Lopez Sardi, Cherie L. Stabler
Summary: An oxygen-generating composite material called OxySite is developed by encapsulating calcium peroxide (CaO2) within polydimethylsiloxane and formulating it into microbeads for tissue integration. Material parameters are modulated to study oxygen generation kinetics and cellular applications. In vitro and in vivo experiments demonstrate the improved metabolic activity and function of cells when coencapsulated with optimized OxySite microbeads.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Shuqin Zhang, Denghui Xie, Qun Zhang
Summary: This review summarizes the current status and prospects of bone regeneration therapy, introducing the roles of scaffolds and stem cells in tissue engineering, common treatment strategies for bone metabolism-related diseases, and the direction for further development.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Dakshi Kochhar, Megan K. DeBari, Rosalyn D. Abbott
Summary: This review highlights the biophysical properties of silk as a polymeric biomaterial that can dynamically regulate cellular fates, affecting cell behaviors such as adhesion, proliferation, migration, and differentiation. The unique mechanical properties, bioactive component sequestration, degradability, well-defined architectures, and biocompatibility of silk play a crucial role in unlocking the body's inherent regenerative potential.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Rebecca Powell, Despoina Eleftheriadou, Simon Kellaway, James B. Phillips
Summary: This review discusses the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behavior, as well as highlights representative cases of controllable cell microenvironments developed through the combination of cell biology and tissue engineering principles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Sandra Stamnitz, Aleksandra Klimczak
Summary: Mesenchymal stem cell-based therapies show promise in bone tissue regeneration, but cell tracking and maintenance in the injury site pose challenges. Seeding cells onto a biocompatible scaffold may offer a potential solution. The development of bone tissue engineering involves optimizing various variables like stem cell source, osteogenic molecular factors, scaffold design, and suitable animal models.
Review
Chemistry, Multidisciplinary
Fernando J. Aguilar-Ayala, Fernando J. Aguilar-Perez, Geovanny Nic-Can, Rafael Rojas-Herrera, Gabriela Chuc-Gamboa, David Aguilar-Perez, Beatriz A. Rodas-Junco
Summary: Biomaterials and stem cells are crucial in regenerative medicine, particularly in the development of autologous therapies. While progress has been made, challenges remain in understanding the characteristics of biomaterials and the molecular mechanisms regulating stem cell behavior.
APPLIED SCIENCES-BASEL
(2022)
Article
Materials Science, Biomaterials
Xiangyun Yao, Zhiwen Yan, Xu Wang, Huiquan Jiang, Yun Qian, Cunyi Fan
Summary: Graphene and its derivatives have extraordinary electrochemical and mechanical properties, leading to extensive research in tissue engineering and regenerative medicine. Reduced graphene oxide (rGO) shares structural and functional similarities with graphene, influencing neurogenic differentiation of stem cells.
REGENERATIVE BIOMATERIALS
(2021)
Article
Engineering, Biomedical
Revital Goldshmid, Haneen Simaan-Yameen, Liaura Ifergan, Claudia Loebel, Jason A. Burdick, Dror Seliktar
Summary: This study evaluates how mechanical properties of a scaffold can alter the phenotype and genotype of human mesenchymal stromal cells (hMSCs), aiming to enhance their differentiation potential along the myogenic, neurogenic, or chondrogenic lineages. The shear storage modulus of a hydrogel scaffold was controlled by adjusting the amount of cross-linker, and it was found that materials with lower storage moduli promoted neurogenic differentiation, while those with intermediate moduli favored myogenic differentiation, and higher moduli favored chondrogenic differentiation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Biomedical
Cathal D. O'Connell, Serena Duchi, Carmine Onofrillo, Lilith M. Caballero-Aguilar, Anna Trengove, Stephanie E. Doyle, Wiktor J. Zywicki, Elena Pirogova, Claudia Di Bella
Summary: Human articular cartilage has limited self-repair ability, leading to the development of osteoarthritis. Tissue engineering solutions are being researched to regenerate cartilage. The approaches can be categorized as ex situ and in situ strategies, each with its own challenges, opportunities, and prospects for cartilage repair.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
