Review
Chemistry, Multidisciplinary
Mengyu Chang, Zhiyao Hou, Man Wang, Chunxia Li, Jun Lin
Summary: Hyperthermia therapy has emerged as a strategy against malignant tumors, particularly when combined with nanomaterial-based photothermal therapy or magnetic hyperthermia. While these treatments alone may not completely cure cancer, when combined with cancer immunotherapy, they have shown potential for enhanced therapeutic outcomes against both primary tumors and metastatic lesions, as well as preventing cancer recurrence and prolonging survival period.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Yuanying Zhang, Nan Yang, Ziyi Dong, Jiahui Wu, Rui Liao, Yanling Zhang, Gege Zhang, Mengfei Ren, Feng Wang, Xiaochen Dong, Pingping Liang
Summary: Avoiding the low specificity of phototheranostic reagents at the tumor site is a major challenge. Angiogenesis in the tumor is not only the premise of tumor occurrence but also the basis of tumor growth, invasion, and metastasis, making it an ideal strategy for tumor therapy. Biomimetic cancer cell membrane-coated nanodrugs (mBPP NPs) have been prepared with homotypic cancer cell membranes, protocatechuic acid, and a near-infrared phototherapeutic agent diketopyrrolopyrrole derivative for photodynamic/photothermal synergistic therapy. The mBPP NPs show high biocompatibility, excellent phototoxicity, and antiangiogenic ability, and can specifically bind to tumor cells and vasculature after intravenous injection, providing a novel avenue for cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Shaochen Wang, Qiaoqiao Zhou, Shuling Yu, Shuang Zhao, Jiahua Shi, Jintao Yuan
Summary: This study reports a nanotherapeutic system with excellent photothermal performance, stable drug loading, tumor targeting, and strong membrane penetration. The system showed outstanding photothermal performance and therapeutic efficacy in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Polymer Science
Pedro D. Fernandes, Fernao D. Magalhaes, Ruben F. Pereira, Artur M. Pinto
Summary: Conventional cancer therapies have long-term side effects, while phototherapy and immunotherapy offer alternative treatments with different merits. Metal-organic frameworks (MOFs) have shown significant potential in the fields of cancer phototherapy and immunotherapy due to their unique properties. By addressing the drawbacks of current therapies, MOF nanoplatforms enable effective and low-side-effect combinatorial synergistical treatment for cancer.
Article
Nanoscience & Nanotechnology
Shanshan Liu, Ruixiang Song, Xiaosong Li, Feifan Zhou
Summary: Nanomaterials play a crucial role in the treatment of malignant tumors, offering unique properties that make them ideal for synergistic treatment strategies. By utilizing nanoplatform-mediated phototherapies in combination with other therapies, such as photochemotherapy, photoradiotherapy, and photoimmunotherapy, challenges in the current treatment of malignant tumors can be better addressed.
Review
Engineering, Environmental
Xinyu Zhang, Haiyan Ge, Yanling Ma, Linlin Song, Yansong Ma, Guanglong Tian, Lei Wang, Qingwei Meng, Xiao Sun
Summary: Immunotherapy is widely used in clinical practice, but its therapeutic effects on many cancers are poor due to dose-limiting immune responses. The combination of ferroptosis and immunotherapy in cancer nanomedicine provides a new opportunity for selectively triggering tumor immunity and eradicating tumors. Various engineered nanomaterials, including metal oxides, metal-organic frameworks, and liposomes, can improve ferroptosis in tumor cells and mediate antitumor immunity by activating the tumor immune microenvironment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Vellingiri Yasothamani, Laxmanan Karthikeyan, Selvaraj Shyamsivappan, Yuvaraj Haldorai, Dayakar Seetha, Raju Vivek
Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.
Article
Engineering, Biomedical
Zachary R. Stephen, Miqin Zhang
Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Qiaohui Chen, Niansheng Li, Xiaoyuan Wang, Yuqi Yang, Yuting Xiang, Xingyu Long, Jinping Zhang, Jia Huang, Li Chen, Qiong Huang
Summary: Mitochondria-targeting chemodynamic therapy nanodrugs (M-CDT nanodrugs) have shown great potential in cancer treatment by efficiently generating reactive oxygen species at the mitochondrial site. Various M-CDT nanodrug designs have been developed to overcome the limitations of traditional chemodynamic therapy and have demonstrated excellent spatial specificity and anti-cancer efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lianxiang Luo, Han Wang, Wen Tian, Xiaoling Li, Zheng Zhu, Riming Huang, Hui Luo
Summary: Ferroptosis, as an iron-dependent programmed cell death induced by lipid peroxidation, plays a significant role in cancer therapy. Utilizing nanomaterials targeting ferroptosis shows promise in developing new cancer treatments, but the various design ideas require systematic summaries and new insights for effective clinical application. Further optimization of nanomaterials design is essential to make them suitable for clinical treatment.
Review
Pharmacology & Pharmacy
Xingyu Long, Xiaojie Zhang, Qiaohui Chen, Min Liu, Yuting Xiang, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Xiaoyuan Wang, Chong Liu, Yayun Nan, Qiong Huang
Summary: This article comprehensively summarizes recent advances in nucleus-targeting phototherapy, classifying it into three categories and providing insights and prospects for future developments. This mini-review provides unique insights and valuable clues in the design of phototherapy nanodrugs and other nucleus-targeting drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li
Summary: PROTAC technology allows for direct degradation of target proteins and has broad applications.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Pharmacology & Pharmacy
Jia-Jie Xu, Wan-Chen Zhang, Ya-Wen Guo, Xiao-Yi Chen, You-Ni Zhang
Summary: This article discusses the therapeutic potential of metal nanoparticles as anticancer drugs, including their application in tumor targeting and the risk factors involved in clinical use.
Review
Biotechnology & Applied Microbiology
Peng Liu, Lu Hao, Min Liu, Shuo Hu
Summary: Due to the overexpression of glutathione (GSH) in cancer cells, various metal nanomedicines with GSH responsiveness and exhaustion capacity have been developed for specific tumor ablation. These metal nanomedicines have shown promising applications in synergistic cancer therapy, including chemotherapy, photodynamic therapy (PDT), sonodynamic therapy (SDT), chemodynamic therapy (CDT), ferroptotic therapy, and radiotherapy. The field of metal nanomedicine holds great potential for future development, but also faces challenges that need to be addressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hanhan Xie, Ming Yang, Xiaoli He, Zhen Zhan, Huaide Jiang, Yanmei Ma, Chengzhi Hu
Summary: In this study, a two-dimensional all-in-one theranostic nanoplatform based on MnPS3 was designed and applied for imaging-guided synergistic photothermal-chemodynamic therapy. The nanoplatform exhibited efficient photothermal conversion efficiency and pH/NIR-responsive Fenton catalytic activity, enabling effective photothermal therapy and chemodynamic therapy. It can also serve as a theranostic agent for multimodal imaging, facilitating real-time monitoring and guidance of the therapeutic process. After therapy, the nanoplatform can be efficiently excreted from the body, alleviating concerns of long-term retention and potential toxicity.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.