Article
Nanoscience & Nanotechnology
Natsuki Hayakawa, Yukiya Kitayama, Kazunori Igarashi, Yu Matsumoto, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: Regulation of nanomaterial-cell interaction is crucial for biomedical applications. This study demonstrates the use of oriented adsorption of immunoglobulin G to regulate the immune response and achieve stealth capability.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Wenqi Song, Liwei Qian, Yuxuan Yang, Yuzhen Zhao, Zongcheng Miao, Qiuyu Zhang
Summary: The study introduced a new method using macromolecularly functional monomer and crosslinker to stabilize and imprint a template protein, leading to the successful fabrication of BSA-imprinted microspheres with excellent adsorption capacity and selectivity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Jeroen J. Koomen, Tim R. Knobbe, Tanja Zijp, Daan Kremer, C. Tji Gan, Erik A. M. Verschuuren, Stephan J. L. J. Bakker, Daan J. Touw, Pieter Colin, TransplantLines Investigators
Summary: This study aimed to establish plasma concentration ranges reflecting the currently used target ranges of whole blood tacrolimus concentrations. By developing a pharmacokinetic model and performing simulations, it was found that the whole blood target ranges for kidney and lung transplant recipients corresponded to plasma concentration ranges of 0.06-0.26 ng/mL and 0.10-0.93 ng/mL, respectively.
CLINICAL PHARMACOKINETICS
(2023)
Article
Multidisciplinary Sciences
Neng Zhang, Shiqian Feng, Ye Tian, Ling Zhuang, Gan Cha, Saiya Duan, Hongmei Li, Xiangqun Nong, Zehua Zhang, Xiongbing Tu, Guangjun Wang
Summary: In this study, 10 FKBP genes were identified and characterized in the locust. These genes showed periodic expression during different developmental stages and were mainly expressed in the fat body, hemolymph, testis, and ovary.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zuokun Yang, Yongle Zhang, Guoping Wang, Shaohua Wen, Yanxiang Wang, Liu Li, Feng Xiao, Ni Hong
Summary: In this study, the interaction between the p23 protein of citrus tristeza virus (CTV) and the FKBP17-2 protein encoded by plants was identified and confirmed through experimental assays. It was found that the interaction plays a significant role in the viral replication process and movement. Additionally, FKBP17-2 was also observed to interact with the coat protein (CP) of CTV, suggesting a complex interaction network involved in CTV infection and movement.
Article
Polymer Science
Matteo Chiarello, Laura Anfossi, Simone Cavalera, Fabio Di Nardo, Fiora Artusio, Roberto Pisano, Claudio Baggiani
Summary: This study investigates the effects of different polymerization times on the binding properties of ciprofloxacin-imprinted nanoMIPs. It shows that short, medium, and long polymerization times result in nanoMIPs with distinct binding properties, indicating the importance of polymerization time in determining the characteristics of nanoMIPs.
Article
Chemistry, Analytical
Min Cui, Yinghua Gong, Meigui Du, Ke Wang, Tianduo Li, Xiaolong Zhu, Shuai Wang, Xiliang Luo
Summary: A specific and long-term antifouling biosensor interface was constructed based on a protein imprinted hydrogel for sensitive analysis of human immunoglobulin G (IgG) in complex biological media. The biosensor showed high sensitivity and selectivity in quantifying target IgG in complex biological samples, with a response range of 0.5 - 200.0 ng/mL and a limit of detection of 0.03 ng/mL (S/N = 3).
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Thomas Nehls, Tim Heymann, Christian Meyners, Felix Hausch, Frederik Lermyte
Summary: In order to understand protein structure sufficiently, a combination of techniques is needed. The study uses chemistry to label proteins sensitively to oxidation, allowing observation of conformational changes. This method provides a valuable tool for mass spectrometry researchers studying higher-order protein structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Agronomy
Takanori Kuronuma, Hitoshi Watanabe
Summary: The occurrence of calcium (Ca2+) deficiency disorders is a severe issue in horticulture crop production. Research has shown the impact of gene expression on the occurrence of these disorders, particularly genes related to Ca2+ movement. Studying gene expression and its relation to Ca2+ deficiency disorders can help reveal causative genes in different horticulture crops.
Article
Multidisciplinary Sciences
Mangaljeet Singh, Kirandeep Kaur, Avinash Sharma, Rajvir Kaur, Dimple Joshi, Megha Chatterjee, Iman Dandapath, Amarjeet Kaur, Harpreet Singh, Prabhjeet Singh
Summary: Peptidyl-prolyl cis-trans isomerases (PPIases) are enzymes capable of cis-trans isomerization of the prolyl peptide bond, playing essential roles in various cellular processes. This study conducted a genome-wide analysis of PPIases in different Penicillium spp. and found variations in gene numbers and activities under salt stress. The halotolerant strain P. oxalicum showed significant enhancement in mycelial PPIase activity under salt stress, suggesting the importance of these enzymes in salt stress adaptation.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Valentina Testa, Laura Anfossi, Simone Cavalera, Matteo Chiarello, Fabio Di Nardo, Thea Serra, Claudio Baggiani
Summary: Increasing amounts of surfactant decrease the binding affinity for ionic ligands strongly, and more weakly for non-ionic ligands. This effect is general, occurring for both 2,4,5-T and 2,4-D, as well as for imprinted and non-imprinted polymers, mainly depending on the presence or absence of an ionic charge.
Article
Polymer Science
Nebewia Griffete, Laurent Michot, Carlo Gonzato
Summary: This paper reports the synthesis of small, stable and water-compatible superparamagnetic molecularly imprinted nanocomposites using water-soluble photoinitiators based on dithiocarbamate. These nanocomposites were able to specifically and selectively bind green fluorescent protein as a model protein. This is the first time that water-soluble photoinitiators have been used to prepare this kind of imprinted materials.
Article
Oncology
Zeqiang Sun, Xin Qin, Juanjuan Fang, Yueqing Tang, Yidong Fan
Summary: FKBP10 and FKBP11 play important roles in ccRCC phenotypes and are potential prognostic markers as well as new therapeutic targets for patients with ccRCC. Increased expression levels of FKBP10 and FKBP11 were associated with worse overall survival (OS). GSEA revealed that FKBP10 is mainly involved in cell metabolism and autophagy, whereas FKBP11 is mainly associated with immune-related biological processes and autophagy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Analytical
Weidong Zhang, Ying Zhang, Ruya Wang, Pan Zhang, Yanyan Zhang, Edward Randell, Mengyuan Zhang, Qiong Jia
Summary: Molecularly imprinted polymers (MIPs) have emerged as artificial antibodies with significant applications in the field of bioanalysis. Conventional bulk MIPs suffer from limitations such as low adsorption capacity, poor site accessibility, restricted mass transfer, and irregular morphology. Surface molecularly imprinted polymers (SMIPs) have garnered attention due to their large surface area, fast mass transfer, and high adsorption capacity and efficiency. This review provides a comprehensive summary of the preparation of SMIPs, including components and polymerization strategies, and discusses their applications in amino acids, peptides, and proteins. Furthermore, future trends and challenges in the design and development of SMIPs are described.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Environmental
Min Cui, Zhongmei Che, Yinghua Gong, Tianduo Li, Wei Hu, Shuai Wang
Summary: A highly sensitive protein MIPs biosensor was developed for the selective recognition of human C-reactive protein. The biosensor combined conductive and biocompatible graphdiyne nanosheets, antifouling MIPs, and utilized dopamine as a functional monomer. The biosensor showed excellent selectivity, reversibility, reusability, as well as good antifouling ability, sensitivity, and stability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
