Article
Pharmacology & Pharmacy
Ana Vitoria Pupo Silvestrini, Bryan Wender Debiasi, Fabiola Garcia Praca, Maria Vitoria Lopes Badra Bentley
Summary: The field of nanomedicine has witnessed significant advancements in the design and study of non-lamellar liquid-crystalline nanoparticles, which possess unique structural and functional characteristics that can be widely applied in drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tejashree Waghule, K. Laxmi Swetha, Aniruddha Roy, Ranendra Narayan Saha, Gautam Singhvi
Summary: PEGylated liposomes and lyotropic liquid crystals were developed to prolong the plasma circulation time of Temozolomide, leading to improved pharmacokinetics and biodistribution, and potential for efficient treatment of glioblastoma.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Clinical Neurology
Yolanda Silva Blas, Michael N. Diringer, Benjamin Lo, Jaime Masjuan, Natalia Perez de la Ossa, Matthew Cardinal, Florence Yong, Tong Zhu, Gang Li, Steven Arkin
Summary: This study identified the maximum tolerated dose of PF-05230907 in subjects with acute intracerebral hemorrhage and evaluated its overall safety and tolerability. Thrombotic events were only observed at the highest dose level tested, with the maximum tolerated dose estimated to be 24 µg/kg.
Article
Health Care Sciences & Services
Masahiro Kojima
Summary: This study proposes an adaptive design for early identification of maximum tolerated dose (MTD) in order to accelerate dose-finding trials. The identification of MTD is determined adaptively using Bayesian analysis, leading to a shortened study period.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ayesha Waheed, Saima Zameer, Niha Sultana, Asad Ali, Mohd Aqil, Yasmin Sultana, Zeenat Iqbal
Summary: This study successfully formulated Lyotropic liquid crystalline nanoparticles loaded with Apigenin and optimized them for excellent particle size, PdI, and entrapment efficiency. The nanoparticles exhibited sustained release and improved permeation, showing promising potential for the treatment and management of skin cancer.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Javier Montalt-Tordera, Michael Quail, Jennifer A. Steeden, Vivek Muthurangu
Summary: Deep learning can improve contrast in low-dose cardiovascular MRA. Evaluation of image quality and diagnostic confidence showed comparability between enhanced LD-MRA and HD-MRA. Vessel diameter measurements also demonstrated comparability.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Acoustics
Yuheng Wang, Wenshu Mai, Tao Yin, Shunqi Zhang, Zhipeng Liu
Summary: Magneto-acoustic-electrical tomography (MAET) is a promising technology that combines ultrasound and electrical impedance imaging methods for the early diagnosis of tumors and biocurrent monitoring. This study proposes a MAET method that combines liquid metal image enhancement and maximum length sequence (MLS)-coded excitation to improve the signal-to-noise ratio (SNR) of MAET. The results show that liquid metal can enhance the imaging quality of tissue MAET, and the MLS-coded excitation significantly improves the SNR and reduces the total experimental time.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Haubold, Rene Hosch, Lale Umutlu, Axel Wetter, Patrizia Haubold, Alexander Radbruch, Michael Forsting, Felix Nensa, Sven Koitka
Summary: The required amount of ICM for CT can be reduced by 50% while maintaining image quality and diagnostic accuracy using GANs. The networks achieving 50% reduction in ICM dose reached 100% consistency in the crucial question of pathological consistency. More studies are needed to confirm these initial results.
EUROPEAN RADIOLOGY
(2021)
Article
Engineering, Environmental
Viktoria Neubertova, Olga Guselnikova, Yusuke Yamauchi, Anastasia Olshtrem, Silvie Rimpelova, Erik Cizmar, Martin Orendac, Jan Duchon, Lenka Volfova, Jan Lancok, Vit Herynek, Premysl Fitl, Pavel Ulbrich, Ludek Jelinek, Patrik Schneider, Juraj Kosek, Pavel Postnikov, Zdenka Kolska, Vaclav Svorcik, Sergii Chertopalov, Oleksiy Lyutakov
Summary: This study explores the covalent functionalization of MXenes for bioimaging applications. By using a chelating agent and Gd3+ ions, the commonly diamagnetic MXenes were transformed into paramagnetic materials, enabling their use in magnetic resonance imaging. Covalent functionalization not only enhanced the stability and cytocompatibility of MXenes but also prevented the leakage of Gd3+ ions. This work expands the bioapplication of MXenes by introducing an MRI contrast and developing covalent functionalization strategies.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Haubold, Gregor Jost, Jens Matthias Theysohn, Johannes Maximilian Ludwig, Yan Li, Jens Kleesiek, Benedikt Michael Schaarschmidt, Michael Forsting, Felix Nensa, Hubertus Pietsch, Rene Hosch
Summary: The aim of this study is to use virtual contrast enhancement to reduce the amount of hepatobiliary gadolinium-based contrast agent in magnetic resonance imaging with generative adversarial networks (GANs) in a large animal model. The results show that virtual contrast enhancement can recreate the image impression of normal-dose imaging from low-dose data with an 80% reduction in gadolinium-based contrast agent dose.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xueyan Zhou, Xiaobing Fan, Devkumar Mustafi, Federico Pineda, Erica Markiewicz, Marta Zamora, Deepa Sheth, Olufunmilayo Olopade, Aytekin Oto, Gregory S. Karczmar
Summary: The study showed that a low dose of Gd-based contrast agent can be as effective as a high dose for quantitative analysis of DCE-MRI data, with tumor parameters obtained from the low dose data significantly larger. Combining parameters from two different doses may provide useful diagnostic information for cancer characterization.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Pharmacology & Pharmacy
Kyrylo Klimenko
Summary: Modern High-Throughput Screening (HTS) techniques can rapidly determine the bioactivity of thousands of chemicals, but the interpretation of active or inactive compounds may overlook potential non-monotonic dose-response relationships (NMDR). This study investigated the presence of NMDR in Androgen receptor (AR) agonism and found evidence of NMDR for several compounds. The challenges of using HTS data to determine NMDR and the benefits of this analysis are discussed.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Medicine, Legal
Damien van Berlo, Marjolijn Woutersen, Andre Muller, Marja Pronk, Jelle Vriend, Betty Hakkert
Summary: The concept of the Maximum Tolerated Dose (MTD) was originally introduced for carcinogenicity testing, but has been mistakenly applied to other toxicity endpoints in test guidelines and guidances. This results in tests being performed at doses too low to elicit toxicity, negatively impacting the reliability of studies and causing a waste of experimental animals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Sumin Baek, Okkyun Lee
Summary: A novel data-driven approach for nanoparticle agent identification using a photon-counting detector is proposed, showing potential for specific identification of targets in CT imaging to improve clinical diagnosis. The method utilizes the energy sensitivity of the detector to exploit the K-edge of nanoparticle agents, with demonstrated robustness in identifying targets with different agent concentrations without background noise.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mahogany Oldham, Anna Conrey, Corinne Pittman, Cameron Fisher, Simone Hargrett, Kamille West, Mary Jackson, Staci Martin, Matthew M. Hsieh, Neal Jeffries, Mihailo Kaplarevic, Dachelle Johnson, Purevdorj Olkhanud, Courtney D. Fitzhugh
Summary: A computer program has been developed to reliably titrate hydroxyurea to maximum tolerated dose, which has shown to increase fetal hemoglobin levels in patients with sickle cell disease. Further studies are needed to evaluate the program's effectiveness.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Sarah E. Bamford, Dilek Yalcin, Wil Gardner, David A. Winkler, Thomas M. Kohl, Benjamin W. Muir, Shaun Howard, Eric A. Bruton, Paul J. Pigram
Summary: The self-organizing map with relational perspective mapping (SOM-RPM) is an unsupervised machine learning method used for visualizing and interpreting high-dimensional hyperspectral data. In this study, SOM-RPM was applied to stitched ToF-SIMS datasets to provide a direct comparison in both 2D and 3D. The quantitative assessment of annealing-induced chemical breakdown trends was conducted on spin-coated polyaniline (PANI) films, revealing differences in peak intensity ratios.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yuen Yi Lam, Angel Tan, Cameron J. Nowell, Kristian Kempe, Ben J. Boyd
Summary: Metabolic oligosaccharide engineering (MOE) allows the introduction of functionality to cell membranes through synthetic monosaccharides. MOE enables the expression of unnatural sugars (e.g., peracetylated mannose-azide) on cell surfaces, and the azide group can participate in a copper-free click reaction with an alkyne probe (e.g., dibenzocyclooctyne, DBCO), providing insights into monosaccharide metabolism in cells.
Article
Biochemistry & Molecular Biology
Patrick Tai, Andrew J. Clulow, Ben J. Boyd, Matt Golding, Harjinder Singh, David W. Everett
Summary: Sphingomyelin and cholesterol in the milk fat globule membrane form functional liquid-ordered domains. These domains resist digestion by bile and play a crucial role in gastrointestinal digestion. By using small-angle X-ray scattering, the structural changes in various model bilayer systems were investigated upon interaction with bovine bile. The results showed that the complexation of sphingomyelin with cholesterol can inhibit the disruption of vesicles by bile at lower cholesterol concentrations. The swelling of biliary mixed micelles was influenced by the cholesterol concentration, with less swelling observed at higher cholesterol concentrations. The importance of these findings is discussed.
CHEMISTRY AND PHYSICS OF LIPIDS
(2023)
Article
Pharmacology & Pharmacy
Renae K. Barr, Bryce W. Barber, Jessica R. Tait, Cornelia B. Landersdorfer, Sam Salman, Gabrielle C. Musk, Madhu Page-Sharp, Kevin T. Batty, Joseph Kado, Laurens Manning, Jonathan R. Carapetis, Ben J. Boyd
Summary: Regular intramuscular injections of benzathine penicillin G (BPG) have been the main method for secondary prophylaxis of rheumatic heart disease (RHD) since the 1950s. However, patient adherence is poor due to pain, the need for regular injections, and challenges in resource-limited settings. A slow release implant with extended treatment duration could be a potential alternative.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
See Yoong Wong, Andrew L. Hook, Wil Gardner, Chien-Yi Chang, Ying Mei, Martyn C. Davies, Paul Williams, Morgan R. Alexander, Davide Ballabio, Benjamin W. Muir, David A. Winkler, Paul J. Pigram
Summary: Biofilm formation is a major problem in hospitals, and researching biofilm-resistant materials is critical. Polymer microarrays can efficiently discover new biofilm-resistant polymers. This study investigates bacterial attachment and surface chemistry on a polymer microarray to better understand Pseudomonas aeruginosa biofilm formation. Analyzing the data using linear multivariate analysis and a nonlinear self-organizing map reveals fragment ions associated with bacterial biofilm formation. Considering these insights, a second analysis is conducted that explicitly considers interactions between key fragments. This improved model provides chemical insights for designing materials that prevent pathogen attachment.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Clinical Neurology
Sining Ye, Paschalis Theotokis, Jae Young Lee, Min Joung Kim, Danica Nheu, Olivia Ellen, Thomas Bedford, Padmanabhan Ramanujam, David K. Wright, Stuart J. McDonald, Amani Alrehaili, Maha Bakhuraysah, Jung Hee Kang, Christopher Siatskas, Cedric S. Tremblay, David J. Curtis, Nikolaos Grigoriadis, Mastura Monif, Stephen M. Strittmatter, Steven Petratos
Summary: Genetically modified transplantable bone marrow stem cells can deliver Nogo receptor-Fc therapeutic protein and promote neurorepair during experimental autoimmune encephalomyelitis.
BRAIN COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Syaza Y. Binte Abu Y. Bakar, Malinda Salim, Andrew J. Clulow, Susanne Seibt, Cornelia B. Landersdorfer, Donna T. Geddes, Kevin R. Nicholas, Ben J. Boyd
Summary: Colostrum provides essential bioactive components for the infant gut microbiota colonization and preventing infectious diseases. However, substitutes are urgently needed for premature infants when colostrum is unavailable. This study aimed to design an appropriate lipid component for a colostrum substitute and evaluate its ability to reduce inflammation in intestinal cells. Analysis showed that the digestion of colostrum and the substitute mixtures had similar lipid profiles but exhibited subtle differences in self-assembly behavior. Bifidobacteria cultured on the substitute mixtures modulated the biological markers of necrotizing enterocolitis, suggesting the potential of these substitutes in reducing the characteristics associated with this disease.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Chiara Pasquarella, Serena Bertoni, Nadia Passerini, Ben J. Boyd, Karlis Berzins
Summary: This study evaluated the performance of different spectral ranges in the kinetic in situ analysis of lipid polymorphic transformations and found that the low-frequency Raman (LFR) domain showed superior characteristics and structural sensitivity.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Food Science & Technology
A. R. Mukurumbira, R. A. Shellie, R. Keast, E. A. Palombo, B. W. Muir, S. R. Jadhav
Summary: Foodborne pathogens and spoilage microorganisms pose a threat to public health and the food industry. Synthetic antimicrobials face challenges due to antimicrobial resistance, thus essential oils offer a potential natural alternative. This study found that essential oils from lemon myrtle, thyme, and Tasmanian mountain pepper showed antimicrobial activity against common food spoilage and pathogenic bacteria and fungi, with lemon myrtle and thyme exhibiting stronger activity. The vapor phase of the oils also showed antimicrobial activity and potential as antifungals for specific microorganisms.
Article
Chemistry, Physical
Vincent He, Victor J. Cadarso, Susanne Seibt, Ben J. Boyd, Adrian Neild
Summary: In this study, a microfluidic approach was used to prepare different aqueous and lipid droplets and induce phase transformations in the liquid medium. The results showed that when the lipid droplets and aqueous droplets coalesced, distinct structures with different compositions formed on the two sides of the merged droplet. Through diffusion limited interface, water molecules gradually hydrated the lipid portion, leading to a series of phase transformations. This study provides a new approach for studying the kinetics of phase transformations and identifying non-equilibrium phases in droplet-based lyotropic liquid systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Coatings & Films
Wil Gardner, David A. Winkler, David L. J. Alexander, Davide Ballabio, Benjamin W. Muir, Paul J. Pigram
Summary: In this study, two different ToF-SIMS imaging datasets were used to evaluate the impact of data preprocessing methods and SOM hyperparameters on the performance of SOM. It was found that preprocessing is generally more important than hyperparameter selection, and there are complex interactions between different parameters. The results of this study are important for understanding the effects of data processing on hyperspectral imaging data.
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
(2023)
Article
Polymer Science
Dilek Yalcin, Sarah Bamford, Maria Espiritu, Nick Rigopoulos, Ivan Martinez-Botella, David Alexander, Yesim Gozukara, Mark Greaves, Eric A. Bruton, Patrick J. Kinlen, Shaun Howard, Paul J. Pigram, Benjamin W. Muir, Thomas M. Kohl
Summary: A novel polymer blend formulation was developed by adding polyurethane (PU) and sulfonyldiphenol (SDP) to a dinonylnaphthalene sulfonic acid (DNNSA)-doped polyaniline (PANI) matrix. The results showed that the inclusion of PU and SDP remarkably improved the thermal stability of the films, maintaining desirable conductivity levels over a week. This study provides insights into the functionality, optimization, and deployment of these new film types.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Chemistry, Multidisciplinary
Xiangfeng Lai, Seong Hoong Chow, Anton P. Le Brun, Benjamin W. Muir, Phillip J. Bergen, Jacinta White, Heidi H. Yu, Jiping Wang, Jill Danne, Jhih-hang Jiang, Francesca L. Short, Mei-Ling Han, Richard A. Strugnell, Jiangning Song, Neil R. Cameron, Anton Y. Peleg, Jian Li, Hsin-Hui Shen
Summary: This study successfully developed a lipid nanoparticle based on monolaurin that can effectively eliminate the polysaccharides of Gram-negative bacteria. When used in conjunction with polymyxin B, these nanoparticles have a synergistic antimicrobial effect through multiple mechanisms.
Article
Hematology
Jason S. Palazzolo, Anukreity Ale, Heidi Ho, Shweta Jagdale, Brad R. S. Broughton, Robert L. Medcalf, David K. Wright, Karen Alt, Christoph E. Hagemeyer, Be'eri Niego
Summary: A novel thrombolytic agent called SCE5-scuPA, which combines single-chain urokinase plasminogen activator (scuPA) with a single-chain antibody (SCE5) that targets the activated glycoprotein IIb/IIIa platelet receptor, showed improved clot degradation and potential for treating acute ischemic stroke in experimental studies.
Article
Chemistry, Analytical
Sevvandi Kandanaarachchi, Wil Gardner, David L. J. Alexander, Benjamin W. Muir, Philippe A. Chouinard, Sheila G. Crewther, David J. Scurr, Mark Halliday, Paul J. Pigram
Summary: This study investigated six different computational methods for tiling artifact removal in ToF-SIMS imaging. The results show that there is no universally acceptable method and the effectiveness of the artifact removal method depends on the specific characteristics of the data set analyzed.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
