Article
Engineering, Biomedical
Kyoung Sub Kim, Sanghee Lee, Kun Na, You Han Bae
Summary: This study describes a strategy using antigen and adjuvant encapsulated dendritic cell-targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development. Oral delivery of the nanoparticles enhances dendritic cell maturation and induces cancer-specific T helper type 1 and type 2 responses in the blood. Repeated oral administration of the nanoparticles increases the population of immune cells and completely prevents melanoma development.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Polymer Science
Vladimir E. Silant'ev, Mikhail E. Shmelev, Andrei S. Belousov, Aleksandra A. Patlay, Roman A. Shatilov, Vladislav M. Farniev, Vadim V. Kumeiko
Summary: Brain tumors are difficult to treat due to their various forms and limited effective chemotherapeutic agents. This is further complicated by the poor transport of drugs across the blood-brain barrier. Carbohydrate-based nanoparticles offer a promising solution for targeted drug delivery, providing biocompatibility, biodegradability, and reduced side effects.
Article
Pharmacology & Pharmacy
Xiaoqing Du, Yuqi Hou, Jia Huang, Yan Pang, Chenlu Ruan, Wei Wu, Chenjie Xu, Hongwei Zhang, Lifang Yin, Wei He
Summary: This article discusses the co-delivery of chemotherapeutics and immunostimulants, proposing an asynchronous release strategy to achieve a synergistic effect between chemotherapy and immunotherapy. The study found that the intracellular asynchronous release of cytotoxic agents could enhance the immunogenicity of cancer cells and improve the antitumor immune response.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Polymer Science
Janarthanan Pushpamalar, Puviarasi Meganathan, Hui Li Tan, Nuraina Anisa Dahlan, Li-Ting Ooi, Bibi Noorheen Haleema Mooneerah Neerooa, Raahilah Zahir Essa, Kamyar Shameli, Sin-Yeang Teow
Summary: Delivering drugs to target sites with minimal off-target cytotoxicity is crucial for successful disease therapy. Polysaccharides have high biocompatibility and are extensively studied as biomaterials for drug delivery systems. By crosslinking polysaccharides with various molecules to form hydrogel DDS, the physical and chemical properties of carrier drugs can be improved, leading to enhanced functionalities in nanotechnology.
Article
Polymer Science
Rashmi Sharma, Rimpy Pahwa, Munish Ahuja
Summary: Iodine-loaded poly(silicic acid) gellan nanocomposite film was successfully fabricated and demonstrated enhanced thermal stability, mechanical properties, moisture resistance, antibacterial activity, and mucoadhesive strength, making it a potential candidate for antibacterial applications in pharmaceuticals.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Xiaoru Sun, Huitong Ruan, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, Lize Xiong, Wenguo Cui, Cheng Li
Summary: A nanobiosignal delivery system modified by LRP1 high-affinity peptide ligand was constructed to regulate neuroinflammation by targeting microglia. The nanobiosignaler significantly reduced the secretion of pro-inflammatory cytokines, induced specific M2 microglia differentiation, and improved cognitive function impairment.
Article
Chemistry, Physical
Xiaoru Sun, Huitong Ruan, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, Lize Xiong, Wenguo Cui, Cheng Li
Summary: In this study, a nanobiosignal delivery system modified by a high-affinity peptide ligand RAP12 was constructed to specifically regulate neuroinflammation via targeting microglia. The nanobiosignal delivery system significantly reduced the secretion of pro-inflammatory cytokines, induced specific M2 microglia differentiation, and remarkably alleviated cognitive function impairment in a mouse model. This study suggests that the nanobiosignal delivery system has wide application prospects in the future.
Article
Chemistry, Multidisciplinary
Lu Han, Xu-Wei Liu, Tao Zang, Hao Ren, Dun-Sheng Liang, Shuan-Chen Bai, Cang Li, Xiao-Ping Liao, Ya-Hong Liu, Chaoqun Zhang, Jian Sun
Summary: The targeted antibiotic delivery system developed in this study, using PEG-PALA nanoparticles, effectively delivered antibiotics to treat enteropathogens while reducing the dosage needed. The system demonstrated minimal impact on the gut microbiota and showed good biocompatibility.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Dengyun Nie, Ting Guo, Miao Yue, Wenya Li, Xinyu Zong, Yinxing Zhu, Junxing Huang, Mei Lin
Summary: CRISPR/Cas9 technology is a powerful gene editing tool with great potential in oncology. However, its efficiency and safety issues restrict its widespread application. Developing a suitable delivery method, such as nanoparticles, is urgently needed.
Article
Fisheries
Fei Han, Yuan Zhang, Na Song, Tianxiang Gao
Summary: This study focused on the burbot fish and characterized 19 Toll-like receptor (TLR) genes in it, examining their expression patterns after pathogen exposure. The researchers found that TLR genes, essential in the fish's innate immune system, were tandemly repeated, indicating an evolution in the fish's immune system. Different TLR subfamilies showed tissue-specific expressions, and the response of TLR genes to pathogen exposure was also investigated. The results revealed time and tissue-specific expression patterns and highlighted the crucial role of TLR genes in the burbot's immune response.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Han-yuan Zheng, Yu-dun Liu, Yu-lei Zhang, Qing-hua Shi, Xue-li Hou, Lin An
Summary: In this study, a supramolecular drug delivery system based on PDCA micelles has been developed to transport CPT to the therapeutic target. The CPT@PDCA micelles show high encapsulation efficiency and pH-responsive release behavior. CPT-loaded PDCA exhibits decreased toxicity to normal cells and comparable inhibitory effect on tumor proliferation compared with CPT alone.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Immunology
Rodolfo F. Marques, Filipe Menegatti de Melo, Janaina Tenorio Novais, Irene S. Soares, Daniel Youssef Bargieri, Alba Marina Gimenez
Summary: This study describes the immune response induced by Poly(I:C) and Montanide ISA 720 in mice immunized with a recombinant protein vaccine against Plasmodium vivax. The results showed that mice vaccinated with the recombinant protein and Montanide ISA 720 exhibited a stronger humoral immune response with antibodies of higher affinity to the antigen. Additionally, Poly(I:C) caused more perturbations in the T cell transcriptome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alexander Lamoot, Sonia Jangra, Gabriel Laghlali, Prajakta Warang, Gagandeep Singh, Lauren A. Chang, Seok-Chan Park, Kim De Swarte, Zifu Zhong, Benoit Louage, Emily De Lombaerde, Tingting Ye, Yong Chen, Sara Cuadrado-Castano, Stefan Lienenklaus, Niek N. Sanders, Bart N. Lambrecht, Adolfo Garcia-Sastre, Michael Schotsaert, Bruno G. De Geest
Summary: Lipid nanoparticle (LNP)-encapsulated poly(I:C), a synthetic dsRNA, enhances immune activation, boosts anti-SARS-CoV-2 response, and has great potential as a vaccine adjuvant.
Article
Chemistry, Applied
Prince Allawadhi, Vishakha Singh, Kannan Govindaraj, Isha Khurana, Lopmudra P. Sarode, Umashanker Navik, Anil Kumar Banothu, Ralf Weiskirchen, Kala Kumar Bharani, Amit Khurana
Summary: Polysaccharides are important biological polymers with diverse applications. Polysaccharide nanoparticles exhibit excellent drug delivery properties and therapeutic effects, making them promising for applications in diabetes, organ fibrosis, and arthritis.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Liwei Mao, Wei Wu, Miao Wang, Jianmin Guo, Hui Li, Shihua Zhang, Jiake Xu, Jun Zou
Summary: Managing OA is a clinical challenge due to the avascular, dense, and occluded tissue structure. New drugs and nanomaterial delivery systems offer promising advancements in treatment efficacy, with nanoparticles showing credible improvement in drug penetration and retention.
Article
Allergy
Ersin Gul, Esra Hazar Sayar, Bilgi Gungor, Fehime Kara Eroglu, Naz Surucu, Sevgi Keles, Sukru Nail Guner, Siddika Findik, Esin Alpdundar, Ihsan Cihan Ayanoglu, Basak Kayaoglu, Busra Nur Geckin, Hatice Asena Sanli, Tamer Kahraman, Cengiz Yakicier, Meltem Muftuoglu, Berna Oguz, Deniz Nazire Cagdas Ayvaz, Ihsan Gursel, Seza Ozen, Ismail Reisli, Mayda Gursel
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Oncology
Deniz Cansen Kahraman, Tamer Kahraman, Rengul Cetin-Atalay
MOLECULAR CANCER THERAPEUTICS
(2019)
Letter
Allergy
Mayda Gursel, Ihsan Gursel
Review
Immunology
Virgil Schijns, Alberto Fernandez-Tejada, Zarko Barjaktarovic, Ilias Bouzalas, Jens Brimnes, Sergey Chernysh, Sveinbjorn Gizurarson, Ihsan Gursel, Ziga Jakopin, Maria Lawrenz, Cristina Nativi, Stephane Paul, Gabriel Kristian Pedersen, Camillo Rosano, Ane Ruiz-de-Angulo, Bram Slutter, Aneesh Thakur, Dennis Christensen, Ed C. Lavelle
IMMUNOLOGICAL REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Banu Bayyurt Kocabas, Kubra Almacioglu, Esin Alpdundar Bulut, Gozde Gucluler, Gizem Tincer, Defne Bayik, Mayda Gursel, Ihsan Gursel
JOURNAL OF CONTROLLED RELEASE
(2020)
Editorial Material
Immunology
Alexandros Sarantopoulos, Doug Brown, Ursula Wiedermann, Carmen Alvarez Dominguez, Christian Bogdan, Ihsan Gursel, Srda Jankovic, Claude LeClerc, Massimo Locati, Anne Spurkland, Frederico Regateiro, Pierre Van Damme, Aurelija Zvirbliene, Felix M. Wensveen
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Allergy
Emine Vezir, Ersoy Civelek, Emine Dibek Misirlioglu, Muge Toyran, Murat Capanoglu, Esra Karakus, Tamer Kahraman, Meltem Ozguner, Fatma Demirel, Ihsan Gursel, Can Naci Kocabas
Summary: The study found an interaction between obesity and asthma in children, manifested in airway and systemic inflammation. Obesity and asthma can affect levels of inflammatory markers in the body, but no significant interaction was found in terms of airway inflammation.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Virgil Schijns, Dragomira Majhen, Peter van der Ley, Aneesh Thakur, Artur Summerfield, Rita Berisio, Cristina Nativi, Alberto Fernandez-Tejada, Carmen Alvarez-Dominguez, Sveinbjorn Gizurarson, Alla Zamyatina, Antonio Molinaro, Camillo Rosano, Ziga Jakopin, Ihsan Gursel, Siobhan McClean
Summary: Vaccines are crucial in preventing infections and improving mortality rates worldwide, and rational design of vaccines can enhance their efficacy. Understanding immune correlates of protection is key in selecting the best vaccine antigens and adjuvants for optimal immune responses. Harnessing this knowledge is imperative in preventing future life-threatening diseases.
Article
Immunology
Caner Ozdemir, Nefise Akcelik, Fatma Neslihan Ozdemir, Irem Evcili, Tamer Kahraman, Ihsan Gursel, Mustafa Akcelik
Summary: The study investigated the effects of the bcsE gene and BcsE protein on bacterial physiology and pathogenicity in SalmonellaTyphimurium and Salmonella Group C1. The results showed that mutations in the bcsE gene led to inhibition of biofilm and pellicle formation, as well as alterations in the biofilm morphology. Additionally, the mutant strains exhibited increased swimming and swarming motility compared to the wild-type strains. The study also demonstrated that the BcsE protein triggered high levels of humoral and cellular responses, leading to a significant decrease in systemic persistence in the liver and spleen samples of the mutant strains. Moreover, invasion abilities on epithelial cells were abolished in the bcsE gene mutant strains.
PATHOGENS AND DISEASE
(2021)
Article
Immunology
Muzaffer Yildirim, Tugce Canavar Yildirim, Nilsu Turay, Tugce Bildik, Bilgehan Ibibik, Irem Evcili, Pelin Gulizar Ersan, Unal M. Tokat, Ozgur Sahin, Ihsan Gursel
Summary: TEXs have the potential to be an effective immune adjuvant delivery system that initiates a strong humoral and cell-mediated tumor-specific immune response, but engineering TEXs to harbor immunostimulatory molecules remains a challenge.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Volkan Yazar, Gizem Kilic, Ozlem Bulut, Tugce Canavar Yildirim, Fuat C. Yagci, Gamze Aykut, Dennis M. Klinman, Mayda Gursel, Ihsan Gursel
INTERNATIONAL IMMUNOLOGY
(2020)
Review
Immunology
Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Volkan Yazar, Ismail Cem Yilmaz, Ihsan Gursel, Mayda Gursel
TURKISH JOURNAL OF IMMUNOLOGY
(2020)
Review
Biology
Ozlem Bulut, Ihsan Gursel
TURKISH JOURNAL OF BIOLOGY
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
