Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
T. B-D Mcewan, R. A. Sophocleous, P. Cuthbertson, K. J. Mansfield, M. L. Sanderson-Smith, R. Sluyter
Summary: The study revealed that scratched cells release adenosine 5'-triphosphate (ATP) which activates P2Y(2) receptors to facilitate wound closure in HaCaT keratinocytes. Inhibition of ATP release and P2Y(2) receptor activation impaired wound healing, highlighting the importance of autocrine purinergic signaling in this process.
Review
Biochemistry & Molecular Biology
George Bibby, Blerta Krasniqi, Izaak Reddy, Durairaj Sekar, Kehinde Ross
Summary: Inhibition strategies targeting miRNAs can promote wound healing, and comparing chemical modifications of different miRNAs is essential to determine the most translationally viable options.
Review
Engineering, Biomedical
Shuduan Mao, Junjie Man, Jialei Wang, Li Fu, Chengliang Yin, Hassan Karimi-Maleh
Summary: As the largest organ in the body, the skin plays vital roles in barrier function, immune response, water loss prevention, and waste excretion. Traditional treatment methods for skin lesions are still inadequate in terms of repair time, costs, and results. The rapid development of bioprinting technology has provided new ideas to overcome these challenges.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Polymer Science
Yt Jun Cheah, Muhamad Ramdzan Buyong, Mohd Heikal Mohd Yunus
Summary: Electrical stimulation is a promising field in wound healing, offering various mechanisms and approaches to enhance wound repair. Understanding the effects of electrical stimulation on cellular and molecular levels can improve the speed and quality of wound healing. Exploring the application and integration of electroconductive biomaterials has opened up new possibilities for modern wound dressings.
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hairul-Islam Mohamed Ibrahim, Muthukumar Thangavelu, Ashraf Khalifa
Summary: In this study, collagen hydrolysates modified with honey-propolis wax (HPW) were tested on wound healing in a mouse model. Results showed that the CHDs-HPW mixture significantly enhanced wound healing and reduced inflammation, indicating its potential as a therapeutic approach for damaged human skin.
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Article
Engineering, Multidisciplinary
Yan Li, Juan Wang, Yan Wang, Wenguo Cui
Summary: Hydrogel fibers, derived from the combination of hydrogel and electrospinning, have shown great potential in tissue regeneration and wound healing due to their structural properties and biological functions. Researchers have been particularly interested in the high specific surface area and mechanical advantages provided by these materials, making them promising for various biomedical applications.
COMPOSITES PART B-ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Shengli Lu, Liping Lu, Yang Liu, Zenan Li, Yuan Fang, Zhizhao Chen, Jianda Zhou
Summary: Extracellular vesicles (EVs) can act as messengers to facilitate communication between cells, and have shown potential for disease treatment. Studies have demonstrated that native EVs can promote tissue repair, and engineering strategies can enhance their therapeutic effects. Further exploration is needed for the clinical application of engineered EVs in wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Kunxi Zhang, Shifeng Yan, Guifei Li, Lei Cui, Jingbo Yin
Article
Oncology
Huijie Gu, Zhongyue Huang, Xiaofan Yin, Jieping Zhang, Lunli Gong, Jiong Chen, Ke Rong, Jun Xu, Lixia Lu, Lei Cui
EXPERIMENTAL CELL RESEARCH
(2015)
Article
Cell & Tissue Engineering
Kaisaier Aji, Munila Maimaijiang, Abudusaimi Aimaiti, Mulati Rexiati, Baihetiya Azhati, Hamulati Tusong, Lei Cui
STEM CELLS INTERNATIONAL
(2016)
Article
Orthopedics
Shuaijun Li, Yun Zhang, Yidan Sun, Weigang Cao, Lei Cui
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Transplantation
Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Yingfang Zhou, Lei Cui, Wenpei Bai
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Article
Cell & Tissue Engineering
Chichi Li, Wei Bi, Yiming Gong, Xiaojun Ding, Xuehua Guo, Jian Sun, Lei Cui, Youcheng Yu
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2016)
Article
Materials Science, Biomaterials
Weijun Zhang, Kunxi Zhang, Guifei Li, Shifeng Yan, Lei Cui, Jingbo Yin
BIOMATERIALS SCIENCE
(2018)
Article
Cell & Tissue Engineering
Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Lei Cui, Wenpei Bai
STEM CELL RESEARCH & THERAPY
(2019)
Article
Cell & Tissue Engineering
Ting Shang, Shuaijun Li, Yun Zhang, Laiya Lu, Lei Cui, Fang Fang Guo
STEM CELL RESEARCH & THERAPY
(2019)
Article
Oncology
Huakai Wang, Shiyong Yu, Huan Peng, Yijun Shu, Wenjie Zhang, Qi Zhu, Yingxia Wu, Yijun Xu, Jiqi Yan, Honggang Xiang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Engineering, Environmental
Mingliang Zhou, Xiaolin Wu, Jiaxin Luo, Guangzheng Yang, Yuezhi Lu, Sihan Lin, Fei Jiang, Wenjie Zhang, Xinquan Jiang
Summary: The incorporation of copper peptide into silk-based scaffolds promotes M2 macrophage polarization, assisting bone tissue repair, and offers a new approach for bioactive ion-based biomaterial design.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Cell & Tissue Engineering
Yejia Yu, Mengyu Li, Yuqiong Zhou, Yueqi Shi, Wenjie Zhang, Geehun Son, Jing Ge, Jun Zhao, Zhiyuan Zhang, Dongxia Ye, Chi Yang, Shaoyi Wang
STEM CELL RESEARCH & THERAPY
(2020)
Article
Oncology
Chenxiao Zhou, Wanchun Su, Haotian Han, Na Li, Gang Ma, Lei Cui
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2020)
Article
Engineering, Biomedical
Wenjie Zhang, Chun Feng, Guangzheng Yang, Guanglong Li, Xun Ding, Shaoyi Wang, Yuandong Dou, Zhiyuan Zhang, Jiang Chang, Chengtie Wu, Xinquan Jiang
Article
Engineering, Biomedical
Kunxi Zhang, Li Song, Jia Wang, Shifeng Yan, Guifei Li, Lei Cui, Jingbo Yin
ACTA BIOMATERIALIA
(2017)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
