Review
Pharmacology & Pharmacy
Panangattukara Prabhakaran Praveen Kumar, Dong-Kwon Lim
Summary: Gold nanoparticles have been extensively studied for their promising applications in various biomedical fields. By combining with polymers, the functionality and biocompatibility of gold nanoparticles can be further enhanced. Additionally, design of responsive nanocomposites has potential for novel therapeutic applications.
Review
Multidisciplinary Sciences
Abhijeet Hiwrale, Swati Bharati, Prashant Pingale, Amarjitsing Rajput
Summary: Nanofibers with large surface area and various surface functions have the potential to revolutionize therapeutic areas such as cardiovascular disorders, infectious diseases, and wound healing. This article systematically studies the history, advantages, disadvantages, types, and polymers used in nanofiber technology, focusing on the electrospinning method and its types. The applications and recent advancements of nanofabrication technology are also discussed.
Review
Pharmacology & Pharmacy
Hossein Hosseinkhani, Abraham J. Domb, Ghorbanali Sharifzadeh, Victoria Nahum
Summary: The development of biological methods has generated interest in the possibility to regenerate human tissues. Stem cell research, gene therapy, and tissue engineering have advanced tissue and organ regeneration technology. Technical issues still remain in gene therapy, especially in the clinical use of viral vectors. Non-viral gene transfection agents are emerging as potentially safe and effective alternatives for treating genetic and acquired diseases.
Review
Biochemistry & Molecular Biology
Olga Krasilnikova, Anna Yakimova, Sergey Ivanov, Dmitri Atiakshin, Andrey A. Kostin, Dmitry Sosin, Peter Shegay, Andrey D. Kaprin, Ilya Klabukov
Summary: Gene-activated materials (GAMs) offer a promising approach for the treatment of defects in the oral and maxillofacial regions by combining tissue engineering and gene therapy. GAMs involve implanting biocompatible materials enriched with gene-carrying vectors into the defect site to transfect recipient cells and secrete therapeutic proteins. Various designs of GAMs can be used depending on the material, encoded protein, vector, and connection method. Plasmid-based GAMs have shown particular interest in the treatment of periodontitis, jaw bone defects, teeth avulsion, and other pathologies in the oral and maxillofacial regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mahnaz Amini, Jagadeesh K. Venkatesan, Wei Liu, Amelie Leroux, Tuan Ngoc Nguyen, Henning Madry, Veronique Migonney, Magali Cucchiarini
Summary: ACL injuries are common in humans, and current surgical repair methods have limited effectiveness. Gene therapy, using gene vectors to enhance ACL repair, shows promise in experimental models. However, there are still challenges to overcome before gene therapy can be effectively translated into clinical applications, such as physiological barriers and host immune responses. Biomaterial-guided gene therapy, inspired by drug delivery systems, may provide a solution for future treatment of ACL injuries in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Ranjith Kumar Kankala, Ya-Hui Han, Hong-Ying Xia, Shi-Bin Wang, Ai-Zheng Chen
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in biomedical applications, but traditional MSNs have limitations such as reduced drug encapsulation efficacy and poor degradability. Hierarchically-engineered MSNs have been developed by tuning the pore sizes, modifying the surfaces, and engineering the siliceous networks. These engineered MSNs have complex structures and can be applied in drug delivery, bioimaging, tissue engineering, and other fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Vahid Mansouri, Nima Beheshtizadeh, Maliheh Gharibshahian, Leila Sabouri, Mohammad Varzandeh, Nima Rezaei
Summary: Regenerative medicine plays a crucial role in cancer treatment by providing novel therapies that alleviate patient suffering and accelerate healing. This field's development will continue to advance our understanding of cancer and promote future research in the field.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Review
Polymer Science
Sybele Saska, Livia Pilatti, Alberto Blay, Jamil Awad Shibli
Summary: 3D printing is valuable in tissue engineering, but the structures produced are static. 4D printing is a new technology that uses smart materials to enable dynamic changes in printed structures, allowing engineered tissues to undergo planned morphological changes.
Article
Engineering, Biomedical
Ting-Ting Li, Shiqi Wang, Jiaxin Li, Ying Zhang, Xing Liu, Liyan Liu, Hao-kai Peng, Hai-tao Ren, Lei Ling, Jia-Horng Lin, Ching-Wen Lou
Summary: This study modulates the surface morphology of bone scaffolds using PDA, PPy, and HA coatings to enhance electrochemical stability and activity, leading to increased biological activity of the scaffolds. The findings extend the value of applying textile structures in the medical field.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Materials Science, Multidisciplinary
Siyi Wang, Feilong Wang, Xiao Zhao, Fan Yang, Yuqian Xu, Fanyu Yan, Dandan Xia, Yunsong Liu
Summary: Bone tissue engineering (BTE) utilizes polymers as effective materials for treating bone defects. The photothermal effects of near-infrared (NIR) light can promote osteogenesis and have additional benefits. Combining polymer scaffolds with NIR light-assisted photothermal therapy (PTT) results in positive bone regeneration outcomes.
MATERIALS & DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Sachchidanand Soaham Gupta, Vivek Mishra, Maumita Das Mukherjee, Parveen Saini, Kumar Rakesh Ranjan
Summary: Amino acids have emerged as promising biomaterials for synthesizing functional polymers, offering a wide range of applications in drug delivery, tissue engineering, and biosensing. These polymers, such as polyamides, polyesters, and polyurethanes, allow for control of functionality, conjugation, crosslinking, and mechanical/thermal properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
S. Arumugam, Y. Ju
Summary: The development of suitable bioactive scaffolds for bone tissue engineering is crucial to mimic the extracellular bone matrix, while the use of CNTs-reinforced composites in the biomedical field is increasing due to their outstanding properties.
MATERIALS TODAY CHEMISTRY
(2021)
Review
Polymer Science
Vinna K. K. Sugiaman, Jeffrey, Silvia Naliani, Natallia Pranata, Rudy Djuanda, Rosalina Intan Saputri
Summary: The challenge in dentistry is to revitalize dental pulp using tissue engineering technology, which requires a biomaterial scaffold. The scaffold acts as a 3D framework that supports cell growth and provides a suitable environment for cell activation and communication. Selecting a safe, biocompatible scaffold with adequate characteristics is crucial in regenerative endodontics. Natural or synthetic polymer scaffolds have gained attention due to their excellent mechanical properties and good biological characteristics for cell regeneration. This review discusses the latest developments in utilizing these scaffold polymers for dental pulp tissue regeneration.
Review
Pharmacology & Pharmacy
Yolanda Diebold, Laura Garcia-Posadas
Summary: The conjunctiva, as a complex ocular tissue, plays a crucial role in protecting the ocular surface, but faces challenges in treatment. Cell therapy and tissue engineering techniques show promise in providing better treatment options for conjunctival diseases.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
