Article
Dentistry, Oral Surgery & Medicine
Hiroaki Kitajima, Keiji Komatsu, Takanori Matsuura, Ryotaro Ozawa, Juri Saruta, Samira Rahim Taleghani, James Cheng, Takahiro Ogawa
Summary: A novel implant model with cactus-inspired spikes and bone-inspired trabeculae was developed to optimize roughness on zirconia. The size of the spikes significantly affected osteoblast function. Different nano-trabecula sizes were examined to explore their impact on osteoblast function in combination with the spikes.
JOURNAL OF PROSTHODONTIC RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Anyue Wang, Wenhong Yuan, Yu Song, Yanjun Zang, Yanling Yu
Summary: The study investigated the effect of kaempferol-loaded micro-nanocomposite coating on the osseointegration of implants in osteoporotic rats. Results showed that the coating improved the osseointegration ability of the implants and could potentially be used for clinical treatment of osteoporosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
A. Jayasree, N. T. Raveendran, T. Guo, S. Ivanovski, K. Gulati
Summary: This study proposed the fabrication of dual micro-nano anisotropic titania nanopores on micro-machined titanium to enhance osteoblast performance, which was evaluated through culture of primary human osteoblasts and an oral salivary biofilm model. The results showed that the dual micro-nanotopography significantly promoted osteoblast proliferation and differentiation without influencing oral biofilm formation.
MATERIALS TODAY ADVANCES
(2022)
Article
Biophysics
Marcel F. Kunrath, Gabriel Rubensam, Felipe V. F. Rodrigues, Daniel R. Marinowic, Patricia Sesterheim, Silvia D. de Oliveira, Eduardo R. Teixeira, Roberto Hubler
Summary: Multifunctional surfaces have great potential in accelerating and promoting the healing process around dental implants, but their cellular biocompatibility, molecular activity, and release of functionalized molecules need further investigation for clinical use.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Pankaj Chauhan, Veena Koul, Naresh Bhatnagar
Summary: The surface of dental implants is crucial for osseointegration, with SLA representing the most widely accepted surface. Ti6Al4V ELI alloy demonstrates a different surface topography compared to CP-Ti, and optimization of acid etching parameters can achieve micro- and nano-level topography, enhancing surface properties.
Article
Chemistry, Physical
V Sudhisha, N. Rajendran
Summary: The current research focuses on a hybrid material of zinc phosphate doped Poly(3,4-ethylenedioxythiophene PEDOT) electropolymerized on titania nanotube arrays (TNTA) for orthopaedic applications. Preliminary characterization studies were conducted to evaluate the material's morphology, composition, phase transformation, functional groups, and wettability. The material also exhibited excellent corrosion resistance, biocompatibility, and antibacterial properties.
SURFACES AND INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Yifan Zhang, Karan Gulati, Ze Li, Ping Di, Yan Liu
Summary: Titanium and its alloys are ideal materials for dental implants, but long-term success may be hindered by implant-related infections and inadequate osseointegration. Recent development in nanotechnology has focused on nanoscale modifications and application of nanomaterials for improving dental implant performance.
Article
Biophysics
Zhiqiang Xu, Junhui Huang, Yuqi He, Jingjing Su, Lin Xu, Xiuxia Zeng
Summary: Ordered microscale titanium surface with uniform titania nanotubes can promote cell attachment and osteogenic differentiation, and cell proliferation recovers over time.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Food Science & Technology
Bababode Adesegun Kehinde, Poorva Sharma, Sawinder Kaur
Summary: There is a growing demand for nutritional and functional foods, prompting food processors to adopt processing techniques that conserve bioactive components in foods and minimize environmental impact. Ultrasonication has been proven as an effective solution to these concerns. Research has shown that ultrasonication has significant effects on quality parameters of food products, making it a valuable technique for the food industry.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biophysics
An-tian Xu, Yi-wen Xie, Jian-gang Xu, Jia Li, Hui Wang, Fu-ming He
Summary: The study suggests that Sr-SLA has immunomodulatory ability in adjusting the functional status of macrophages, by inhibiting M1 polarization while promoting M2 polarization.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Hui Wang, Yang Ma, Jia Li, Chuan Zhou, Antian Xu, Yangbo Xu, Fuming He
Summary: Research demonstrated that implant surfaces treated with strontium can promote osteogenesis through autophagy activation and inhibit osteoclast differentiation. In vivo experiments further confirmed the improvement of osseointegration and regulation of autophagy levels by the surface treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Long Bai, Peiru Chen, Ya Zhao, Ruiyue Hang, Xiaohong Yao, Bin Tang, Changsheng Liu, Yin Xiao, Ruiqiang Hang
Summary: The study developed a biomimetic implant coating that regulated the participatory processes during osseointegration, showing promising results in in vitro experiments.
Article
Chemistry, Multidisciplinary
Simin Sharifi, Solmaz Maleki Dizaj, Elham Ahmadian, Alireza Karimpour, Abdollah Maleki, Mohammad Yousef Memar, Mohammad Ali Ghavimi, Elaheh Dalir Abdolahinia, Khang Wen Goh
Summary: A biodegradable micro/nano-structured porous hemostatic gelatin-based sponge with excellent hemostatic properties was prepared. In vitro tests demonstrated its ability to absorb blood and showed compatibility with human cells. Clinical assessment confirmed its outstanding blood absorption capacity in dental surgeries.
Article
Food Science & Technology
Fabiana Helen Santos, Sandeep K. Panda, Danielle Cristine Mota Ferreira, Gargi Dey, Gustavo Molina, Franciele Maria Pelissari
Summary: Recently, there has been growing interest in nutraceutical compounds for the development of anti-infective and anti-inflammatory nutritional formulations. Various bio-based delivery vehicles, such as micro and nano particles, nano-emulsions, and liposome-based models, have shown potential in enhancing the bioaccessibility and bioavailability of these compounds. This review aims to provide recent information on effective nutraceuticals and suitable delivery vehicles for combating infections and inflammatory conditions.
Article
Materials Science, Multidisciplinary
Yao Ding, Zhang Yuan, Jin-Wei Hu, Kun Xu, Hong Wang, Peng Liu, Kai-Yong Cai
Summary: The fabrication of micro-nano-structured Ti substrates using double acid corrosion and hydrothermal treatment, followed by immobilization of mesoporous polydopamine nanoparticles as photothermal agent, resulted in physical stress on bacteria and enhanced mesenchymal stem cell osteogenic differentiation. In vivo animal experiments confirmed that the modified Ti implants could improve osseointegration.
Article
Engineering, Biomedical
Teisuke Akimoto, Takeshi Ueno, Yusuke Tsutsumi, Hisashi Doi, Takao Hanawa, Noriyuki Wakabayashi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Satoshi Tateshima, Naoki Kaneko, Masahiro Yamada, Gary Duckwiler, Fernando Vinuela, Takahiro Ogawa
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Engineering, Biomedical
Chie Yoshihara, Takeshi Ueno, Peng Chen, Yusuke Tsutsumi, Takao Hanawa, Noriyuki Wakabayashi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Masahiro Yamada, Jun Watanabe, Takeshi Ueno, Takahiro Ogawa, Hiroshi Egusa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Engineering, Biomedical
Keigo Isoshima, Takeshi Ueno, Yuki Arai, Hiroki Saito, Peng Chen, Yusuke Tsutsumi, Takao Hanawa, Noriyuki Wakabayashi
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2019)
Article
Multidisciplinary Sciences
Zuo Wang, Eiko Yoshida Kohno, Kenji Fueki, Takeshi Ueno, Yuka Inamochi, Kazuki Takada, Noriyuki Wakabayashi
Summary: The flipped classroom was found to be more effective than traditional lectures in clinical dental education for knowledge acquisition, with the number of learning occasions being the decisive factor. The flipped classroom was crucial for team-based learning outcomes.
Article
Engineering, Biomedical
Nadia Kartikasari, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Xindie He, Yuya Kamano, Hiroshi Egusa
Summary: This study shows that titanium nanosurfaces with anisotropically patterned nanospikes can regulate macrophage polarization to inhibit osteoclast differentiation of osteoclast precursors, indicating that nanotopographic cues play a key role in this process rather than other physicochemical properties.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Takayuki Ikeda, Takeshi Ueno, Juri Saruta, Makoto Hirota, Wonhee Park, Takahiro Ogawa
Summary: UV surface treatment of titanium disks enhances adhesion strength and retention time of oral connective tissues, promotes adherence of mucosal fibroblasts, and contributes to the prevention of peri-implantitis by creating a seal of gingival soft tissue around the implant neck.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Atsushi Takaichi, Kenji Fueki, Natsuko Murakami, Takeshi Ueno, Yuka Inamochi, Junichiro Wada, Yuki Arai, Noriyuki Wakabayashi
Summary: This study reviewed the current status of the digital workflow of removable partial dentures (RPDs) and summarized information about the fabrication methods and material properties. The results showed that using CAD/CAM frameworks and PMMA discs for digital RPDs offer numerous advantages over conventional RPDs.
JOURNAL OF PROSTHODONTIC RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Kenji Fueki, Yuka Inamochi, Junichiro Wada, Yuki Arai, Atsushi Takaichi, Natsuko Murakami, Takeshi Ueno, Noriyuki Wakabayashi
Summary: This study comprehensively reviewed the current status of digital workflows in fabricating removable partial dentures (RPDs) using evidence from clinical trials and case reports. The results showed that full-digital RPDs can be fabricated without a gypsum definitive cast, but the indication for full-digital RPDs is limited to specific cases. Challenges in digital impression-taking and MMR recording need to be addressed in order to expand the application of digital RPDs.
JOURNAL OF PROSTHODONTIC RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Nadia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa
Summary: Researchers have successfully created a smart titanium nanosurface that mimics the surface properties of tooth root cementum, leading to the regeneration of periodontal tissues. This nanosurface induces the formation of dentoalveolar fibrous joints, resulting in the regeneration of functional periodontium.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Xindie He, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Minoru Ishibashi, Hideki Kitaura, Itaru Mizoguchi, Hiroshi Egusa
Summary: This study investigated the effects of titanium nanosurfaces on the development of osteocyte lacunar-canalicular networks and osseointegration of dental implants. The results showed that titanium nanosurfaces promoted the development of osteocyte lacunar-canalicular networks and strengthened osseointegration.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Qian Zhao, Takeshi Ueno, Peng Chen, Kosuke Nozaki, Tianbo Tan, Takao Hanawa, Noriyuki Wakabayashi
Summary: Researchers have been exploring the use of micro-/submicro-/nanostructured (MSN) surfaces to modify dental implants for the past few decades. In this study, a Ti-Zr alloy was modified for the first time using H2SO4/H2O2 treatment. The effects of various treatment conditions on the surface structure of the Ti-Zr alloy were investigated. The results showed that the MSN Ti-45Zr alloy surface had similar surface characteristics and cell attachment level compared to Ti after H2SO4/H2O2 treatment.
SURFACES AND INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Huaze Wu, Takeshi Ueno, Kosuke Nozaki, Huichuan Xu, Yuki Nakano, Peng Chen, Noriyuki Wakabayashi
Summary: This study utilized anodization as a novel approach to immobilize lithium ions on a titanium surface and evaluated the changes in surface characteristics. The results showed that the surface charge characteristics were enhanced on the 3V-anodized surface, leading to increased adsorption of extracellular matrix proteins and improved attachment of osteoblast cells. This study suggests that anodization could be an effective method to promote osseointegration by modifying the surface charge characteristics and allowing for enhanced biological adhesion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.