Article
Medicine, Research & Experimental
Sandra Georgy Chafik, Haidy E. Michel, Ebtehal El-Demerdash
Summary: This study aimed to investigate the potential protective effects of a selective CB2 receptor agonist, 1-phenylisatin, on acute nephrotoxicity induced by cisplatin. The results showed that 1-phenylisatin significantly mitigated the damage to the kidneys caused by cisplatin through its anti-apoptotic, anti-inflammatory, and antioxidant effects. These effects were mainly mediated through the CB2 receptor.
Article
Pharmacology & Pharmacy
Fu Guangtao, Wen Zhenkang, Deng Zhantao, Li Mengyuan, Li Qingtian, Ma Yuanchen, Chen Yuanfeng, Zheng Qiujian
Summary: The study suggests that icariin attenuates wear particle-induced inflammation and osteolysis by down-regulating the ERα-mediated NF-kappa B signaling pathway in macrophages.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Zhaoyang Yin, Ge Gong, Xinhui Liu, Jian Yin
Summary: Joint replacement surgery is the most effective treatment for end-stage arthritis, but aseptic loosening caused by periprosthetic osteolysis is a common complication. Inflammation induced by wear particles and its effect on macrophages/osteoclasts play a key role in this process. Researchers have developed intervention approaches to regulate macrophage/osteoclast activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Xiangchao Meng, Wei Zhang, Zhuocheng Lyu, Teng Long, You Wang
Summary: This study demonstrates that zinc oxide nanoparticles (ZnO NPs) can attenuate inflammation induced by polymer wear particles by regulating the MEK-ERK-COX-2 axis, thus preventing inflammatory osteolysis in bone tissue.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Pharmacology & Pharmacy
Saki Sultana, Ian Burkovskiy, Juan Zhou, Melanie M. Kelly, Christian Lehmann
Summary: Early activation of CB2R with HU308 reduced brain injury size and restored leukocyte response to endotoxin in the peripheral microcirculation. Late inhibition of CB2R with AM630 also improved the peripheral leukocyte response to endotoxin without exacerbating the extent of brain injury.
CANNABIS AND CANNABINOID RESEARCH
(2021)
Review
Critical Care Medicine
Mariane C. G. Leite-Avalca, Aleksander Zampronio, Christian Lehmann
Summary: Sepsis is a life-threatening condition caused by dysregulated host response to infection, with no definitive treatment available. Research on the endocannabinoid system, specifically the role of CB1 and CB2 receptors in sepsis pathophysiology, may provide insights for new therapeutic strategies. Understanding the modulation of host immune response by CB1 and CB2 in sepsis could contribute to improving outcomes for patients.
Article
Nanoscience & Nanotechnology
Hui Li, Xiao-Lei Fan, Yi-Nan Wang, Wei Lu, Haoyi Wang, Runzhi Liao, Min Zeng, Jun-Xiao Yang, Yihe Hu, Jie Xie
Summary: This study demonstrates that USC-EVs can prevent UHMWPE particle-induced osteolysis by reducing inflammation, suppressing bone resorption, and promoting bone formation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Immunology
Ruixuan Yu, Yongjian Yuan, Zhicheng Liu, Long Liu, Zhaoning Xu, Yunpeng Zhao, Chunwang Jia, Pengfei Zhang, Hang Li, Yuhao Liu, Yi Wang, Weiwei Li, Lin Nie, Xuecheng Sun, Yuhua Li, Ben Liu, Haichun Liu
Summary: The study found that selenium methionine (Se-Met) has inhibitory effects on titanium particle-induced osteolysis, possibly by regulating ROS-dependent NLRP3 inflammasome activation and the beta-catenin signaling pathway to alleviate inflammation. These findings suggest that Se-Met may serve as a potential therapeutic agent for treating titanium particle-induced osteolysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Orthopedics
Andre Lunz, Moritz Von Falkenhayn, Sebastian Jaeger, Tobias Reiner, Christian Merle, Marcus R. Streit, Tobias Renkawitz, Moritz M. Innmann
Summary: This study aimed to determine the minimum 20-year survival rates of a cementless press-fit cup in young patients. The results showed that the 22-year survival rate for aseptic cup or inlay revision was 94%, and the survival rate for aseptic cup loosening was 99%.
Article
Orthopedics
Halldor Bergvinsson, Vasilis Zampelis, Martin Sundberg, Jon Tjornstrand, Gunnar Flivik
Summary: This study compared the wear characteristics and clinical outcomes of vitamin E infused highly cross-linked polyethylene cups with regular ultra-high molecular weight polyethylene cups. The results showed reduced wear and good clinical outcomes in the vitamin E infused cups up to 5 years.
Article
Chemistry, Physical
Qianli Huang, Jia Wan, Zhengxiao Ouyang, Tao Li, Dapeng Zhao, Hong Wu, Tang Liu, Wei Zhang, Luxin Liang
Summary: In this study, spherical Ti and Ta particles with similar sizes were used to mimic wear debris. It was found that Ta particles had a naturally formed oxide layer on their surfaces, with more hydroxyls and lower zeta potential. In vitro experiments showed that Ta particles had milder effects on osteoblast, macrophage, and osteoclast response compared to Ti particles. Additionally, the in vivo osteolytic effect of Ta particles was weaker than that of Ti particles after injection into the cranial sites of mice for 2 weeks.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Orthopedics
Steffen Brodt, Kathleen Bischoff, Marcel Schulze, Dimitri Nowack, Andreas Roth, Georg Matziolis
Summary: The use of additional acetabular screws increases osteolysis in the periacetabular bone stock, but does not affect wear or clinical scores of the cup construct.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Medicine, General & Internal
Hui Li, Yihe Hu, Min Zeng, Junxiao Yang, Xiaolei Fan, Yinan Wang, Jie Xie
Summary: The study showed that PLGA NPs carrying USC-derived exosomes can prevent polyethylene-induced osteolysis and reduce bone absorption, suggesting a potential therapeutic strategy for periprosthetic osteolysis.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Pan Gao, Mengying Cao, Xueli Jiang, Xiaolin Wang, Guoping Zhang, Xinru Tang, Chunjie Yang, Issei Komuro, Junbo Ge, Liliang Li, Yunzeng Zou
Summary: This study aims to identify the specific cell death type responsible for diabetic heart dysfunction and propose a promising therapeutic strategy by intervening in the cell death pathway. The researchers found that necroptosis was activated in the later stages of diabetes and played a functional role in cardiac dysfunction. Cannabinoid receptor 2 (CB2R) was identified as a key regulator of necroptosis. CB2R transcriptionally repressed necroptosis through interaction with BACH2, and MLKL formed a negative feedback to phosphorylate CB2R. This study provides a novel molecular mechanism loop for the regulation of necroptosis centered by CB2R, which represents a promising alternative strategy for controlling diabetic heart dysfunction.
Editorial Material
Automation & Control Systems
Guangjie Han, Adnan M. Abu-Mahfouz, Joel J. P. C. Rodrigues, Xianbin Wang
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2022)
Article
Engineering, Electrical & Electronic
Fang Fang, Bibo Wu, Shu Fu, Zhiguo Ding, Xianbin Wang
Summary: This paper investigates the energy efficient potential of simultaneous transmission and reflection-reconfigurable intelligent surface (STAR-RIS) in a MIMO enabled NOMA system. An algorithm is proposed to optimize the transmit beamforming and phases of the low-cost passive elements on the STAR-RIS for maximizing system energy efficiency. Simulation results demonstrate the superior energy efficiency performance of the proposed algorithm using NOMA technology over OMA scheme and random phase shift scheme.
IEEE TRANSACTIONS ON COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Ruitao Chen, Xianbin Wang
Summary: Mobile collaborative computing (MCC) is a new platform that effectively improves the quality of mobile service by utilizing idle computational resources in distributed mobile devices through peer-to-peer task offloading. This paper proposes a concept of value of service (VoS) to represent the total value of tasks and devices based on their performance. A situation-aware offloading scheme is proposed to maximize VoS by leveraging changing resource availability conditions. The paper also presents solutions to maximize VoS for binary and partial offloading scenarios.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Orthopedics
Kai Zheng, Houyi Sun, Weicheng Zhang, Feng Zhu, Jun Zhou, Rongqun Li, Dechun Geng, Yaozeng Xu
Summary: This study evaluated the mid-term outcomes of navigation-assisted total knee arthroplasty (TKA) using the adjusted mechanical alignment (aMA) technique. The study found that aMA technique obtained satisfactory mid-term clinical outcomes and may be associated with better early clinical outcomes than conventional mechanical alignment (MA) technique.
ORTHOPAEDIC SURGERY
(2023)
Article
Engineering, Biomedical
Siming Zhang, Gaoran Ge, Yi Qin, Wenhao Li, Jiale Dong, Jiawei Mei, Ruixiang Ma, Xianzuo Zhang, Jiaxiang Bai, Chen Zhu, Weiwei Zhang, Dechun Geng
Summary: Poor wound healing after diabetes mellitus is characterized by persistent bleeding, inflammation dysregulation, blocked cell proliferation, infection susceptibility, and impaired tissue remodeling. Conventional wound dressings have limited functionality and fail to meet the requirements of diabetic wound healing. Stimuli-responsive hydrogels, which can change their properties in response to various stimuli, have shown promise in improving therapeutic efficacy and reducing toxicity for diabetic wound healing.
MATERIALS TODAY BIO
(2023)
Article
Computer Science, Information Systems
Yanxin Li, Wei Wang, Mingqian Liu, Nan Zhao, Xu Jiang, Yunfei Chen, Xianbin Wang
Summary: In this article, a UAV-assisted NOMA transmission scheme is proposed to achieve secure downlink transmission via artificial jamming. The tradeoff between jamming power and sum rate is investigated by optimizing power allocation, user scheduling, and UAV trajectory, aiming to balance security and transmission performance.
IEEE SYSTEMS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Thakshanth Uthayakumar, Abubaker Abdelhafiz, Xianbin Wang, Ming Jian
Summary: The nonlinear distortions with memory effects caused by strong crosstalk between multiple power amplifier (PA) branches in multiple-input multiple-output (MIMO) systems pose challenges for behavioral modeling and linearization techniques. In this study, a decomposed cross-correlation based single-input-single-output (CC-SISO) architecture is proposed to estimate and cancel the simultaneous nonlinear and reverse crosstalk in PAs. This architecture significantly reduces the complexity of MIMO digital predistortion (DPD) models and eliminates the need for signal feedback paths, thus simplifying hardware implementation.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2023)
Review
Computer Science, Information Systems
Qihui Wu, Wei Wang, Zuguang Li, Bo Zhou, Yang Huang, Xianbin Wang
Summary: The sixth-generation (6G) wireless network aims to provide ubiquitous connectivity and diverse scenarios for various emerging applications. Full spectrum plays a crucial role in achieving the ambitious goal of a Tbps-scale data rate in 6G. This paper reviews the scenario and potential spectrum plan for 6G and introduces SpectrumChain, a blockchain-based dynamic spectrum-sharing (DSS) framework. The unique characteristics of blockchain for DSS and key technologies are presented. Finally, the conclusion and future development trends are discussed.
SCIENCE CHINA-INFORMATION SCIENCES
(2023)
Review
Engineering, Biomedical
Kai Zheng, Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, Huaiyu Wang, Dechun Geng
Summary: This review summarizes the current advanced nanomaterials for the diagnosis and therapy of bone-related diseases. First, the potential utility of nanomaterials for biological imaging and biomarker detection is discussed. Second, the special functions of nanomaterials as therapeutic delivery platforms for bone homeostasis regulation and cellular modulation are highlighted. Finally, perspectives in this field are offered, including current key bottlenecks and future directions, which may help in exploiting nanomaterials with novel properties and unique functions. This review provides scientific guidance to enhance the development of advanced nanomaterials for the diagnosis and therapy of bone-related diseases.
BIOACTIVE MATERIALS
(2023)
Article
Telecommunications
Zuguang Li, Wei Wang, Qihui Wu, Xianbin Wang
Summary: In order to achieve secure and efficient dynamic spectrum sharing with guaranteed revenue and quality of service in future wireless communications, a consortium blockchain based DSS framework is proposed. Regulators supervise the entire DSS process to ensure revenue for each participant. Each MNO on the chain can act as a spectrum provider or requestor based on their demand, and the spectrum resource allocation is recorded on the chain with a smart contract. Optimal spectrum pricing and buying strategies are solved using a multi-leader multi-follower Stackelberg game model, and the equilibrium is determined with a proposed algorithm. A prototype is built using Hyperledger Fabric consortium blockchain, and the average latency is evaluated. Simulations and prototype evaluations confirm the feasibility of blockchain based DSS and reveal that average latency increases with the number of participants, providing valuable insights for real-world applications.
IEEE TRANSACTIONS ON COGNITIVE COMMUNICATIONS AND NETWORKING
(2023)
Review
Endocrinology & Metabolism
Yuhu Zhao, Xiaole Peng, Qing Wang, Zhiyu Zhang, Liangliang Wang, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng
Summary: The homeostasis of bone microenvironment is essential for bone health, involving both osteoblasts' bone formation and osteoclasts' bone resorption. In recent years, leptin, a hormone derived from adipocytes, has been found to affect bone homeostasis through the hypothalamic relay and the sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery provides a new perspective on the synergistic effects of the endocrine and nervous systems on skeletal homeostasis.
Article
Cell Biology
Yu Xia, Gaoran Ge, Haixiang Xiao, Mingzhou Wu, Tianhao Wang, Chengyong Gu, Huilin Yang, Dechun Geng
Summary: This research provides evidence for the key role of REPIN1 in iron metabolism-related osteoporosis. The study demonstrates that sh-Repin1 therapy can rescue bone loss in an iron-overload-induced osteoporosis mouse model, and reveals the mechanism of REPIN1 promoting apoptosis by regulating iron metabolism.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Hao Xu, Wentao Wang, Xin Liu, Wei Huang, Chen Zhu, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng
Summary: Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. Bone-targeted therapy has been considered a promising therapeutic approach for handling the challenges in drug therapy for skeletal diseases. Recent advances in therapeutic strategies based on bone targeting, including targeting strategies based on bone structure and remodeling biology, as well as bone-targeted therapeutic agents and drug delivery strategies, are discussed in this review.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Cell & Tissue Engineering
Xiaole Peng, Qing Wang, Wenming Li, Gaoran Ge, Jiachen Peng, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng
Summary: MicroRNAs (miRNAs) are a class of endogenous single-stranded short noncoding RNAs that play vital roles in epigenetic regulation of pathological and physiological processes in animals. They fine-tune the expression of multiple genes posttranscriptionally, directing fundamental cellular pathways. miRNAs have been implicated in the onset and development of rheumatoid arthritis (RA), a chronic inflammatory disease characterized by complex pathogenesis and high morbidity, disability, and mortality rates. Understanding the deregulated miRNAs and impaired cellular functions in RA is crucial for improving clinical management and identifying potential therapeutic targets. This review comprehensively discusses the involvement of miRNAs in excessive inflammation, synovial hyperplasia, progressive joint damage, and the clinical potential of extracellular miRNAs as diagnostic and predictive biomarkers in RA.
Proceedings Paper
Computer Science, Information Systems
Zewei Jing, Qinghai Yang, Yan Wu, Meng Qin, Kyung Sup Kwak, Xianbin Wang
Summary: In this paper, an adaptive cooperative task offloading algorithm is proposed to maximize the time-averaged energy efficiency for small cell MEC networks enabled by millimeter-wave backhauls. The algorithm makes a good tradeoff between cooperation utility and total energy consumption, and ensures network stability and task admission rate fulfillment.
2022 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE (WCNC)
(2022)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
