Biomarkers for invasive aspergillosis: the challenges continue

Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies

(2013) Thomas R. Rogers et al.   BRITISH JOURNAL OF HAEMATOLOGY

Fungal diagnosis: how do we do it and can we do better?

(2013) John R. Perfect   CURRENT MEDICAL RESEARCH AND OPINION

Significant Decline in Galactomannan Signal during Storage of Clinical Serum Samples

(2013) Gemma Johnson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of Real-Time PCR, Galactomannan Enzyme-Linked Immunosorbent Assay (ELISA), and a Novel Lateral-Flow Device for Diagnosis of Invasive Aspergillosis

(2013) P. L. White et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Mass spectrometry and tandem mass spectrometry characterization of protein patterns, protein markers and whole proteomes for pathogenic bacteria

(2013) Jennifer Intelicato-Young et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Utility of galactomannan antigen detection in bronchoalveolar lavage fluid in immunocompromised patients

(2013) Kyle R. Brownback et al.   MYCOSES

Concentration of exhaled breath condensate biomarkers after fractionated collection based on exhaled CO2signal

(2013) Matteo Goldoni et al.   Journal of Breath Research

Antibody specific to thioredoxin reductase as a new biomarker for serodiagnosis of invasive aspergillosis in non-neutropenic patients

(2012) Li-ning Shi et al.   CLINICA CHIMICA ACTA

Developments in novel breath tests for bacterial and fungal pulmonary infection

(2012) Stephen T. Chambers et al.   CURRENT OPINION IN PULMONARY MEDICINE

Galactomannan testing might be useful for early diagnosis of fusariosis

(2012) Małgorzata Mikulska et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis

(2012) Maria P. Domingo et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples

(2012) Mark Reinwald et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

(2012) Milos Petrik et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Comparison of Serum and Bronchoalveolar Lavage Galactomannan in Diagnosing Invasive Aspergillosis in Solid-Organ Transplant Recipients

(2012) Payam Tabarsi et al.   Experimental and Clinical Transplantation

Piperacillin/tazobactam (TazocinTM) seems to be no longer responsible for false-positive results of the galactomannan assay

(2012) M. Mikulska et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Biosynthesis of the Fungal Cell Wall Polysaccharide Galactomannan Requires Intraluminal GDP-mannose

(2012) Jakob Engel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interlaboratory and Interstudy Reproducibility of a Novel Lateral-Flow Device and Influence of Antifungal Therapy on Detection of Invasive Pulmonary Aspergillosis

(2012) N. P. Wiederhold et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Routine Identification of Medical Fungi by the New Vitek MS Matrix-Assisted Laser Desorption Ionization–Time of Flight System with a New Time-Effective Strategy

(2012) Xavier Iriart et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Novel Extraction Method Combining Plasma with a Whole-Blood Fraction Shows Excellent Sensitivity and Reproducibility for Patients at High Risk for Invasive Aspergillosis

(2012) J. Springer et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Detection of Galactomannan in Bronchoalveolar Lavage Fluid Samples of Patients at Risk for Invasive Pulmonary Aspergillosis: Analytical and Clinical Validity

(2012) J. D'Haese et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Diagnostic Accuracy of PCR Alone Compared to Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis: a Systematic Review

(2012) T. Avni et al.   JOURNAL OF CLINICAL MICROBIOLOGY

MALDI-TOF MS proteomic phenotyping of filamentous and other fungi from clinical origin

(2012) Federica Del Chierico et al.   Journal of Proteomics

Sensitivity and Specificity of a Blood and Urine Galactomannan Antigen Assay for Diagnosis of Systemic Aspergillosis in Dogs

(2012) R.S. Garcia et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis

(2012) Koichi Izumikawa et al.   MEDICAL MYCOLOGY

Molecular and Microscopic Analysis of Bacteria and Viruses in Exhaled Breath Collected Using a Simple Impaction and Condensing Method

(2012) Zhenqiang Xu et al.   PLoS One

A MIQE-Compliant Real-Time PCR Assay for Aspergillus Detection

(2012) Gemma L. Johnson et al.   PLoS One

Detection of Urinary Excreted Fungal Galactomannan-like Antigens for Diagnosis of Invasive Aspergillosis

(2012) Simon F. Dufresne et al.   PLoS One

Systematic Review and Meta-Analysis of Detecting Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosing Invasive Aspergillosis

(2012) Mingxiang Zou et al.   PLoS One

MALDI-TOF-MS-based species identification and typing approaches in medical mycology

(2012) Oliver Bader   PROTEOMICS

Diagnostic potential of nested PCR, galactomannan EIA, and Beta-D-glucan for invasive aspergillosis in pediatric patients

(2012) Parisa Badiee et al.   Journal of Infection in Developing Countries

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

(2012) Hubertus Haas   Frontiers in Microbiology

Standardisation and reporting for nucleic acid quantification

(2011) Jim Huggett et al.   ACCREDITATION AND QUALITY ASSURANCE

Invasive Mycoses: Diagnostic Challenges

(2011) Luis Ostrosky-Zeichner   AMERICAN JOURNAL OF MEDICINE

Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry

(2011) Carol Davis et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Rapid identification of Aspergillus fumigatus within the section Fumigati

(2011) Rita Serrano et al.   BMC MICROBIOLOGY

Detection of Aspergillus in lung and other tissue samples using the MycAssay Aspergillus real-time PCR kit

(2011) C. Lass-Flörl et al.   CANADIAN JOURNAL OF MICROBIOLOGY

 -D-Glucan Assay for the Diagnosis of Invasive Fungal Infections: A Meta-analysis

(2011) D. E. Karageorgopoulos et al.   CLINICAL INFECTIOUS DISEASES

MALDI-TOF MS Andromas strategy for the routine identification of bacteria, mycobacteria, yeasts, Aspergillus spp. and positive blood cultures

(2011) E. Bille et al.   CLINICAL MICROBIOLOGY AND INFECTION

Species identification of Aspergillus, Fusarium and Mucorales with direct surface analysis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

(2011) E. De Carolis et al.   CLINICAL MICROBIOLOGY AND INFECTION

Detection of Candida albicans by Mass Spectrometric Fingerprinting

(2011) Sarah Zehm et al.   CURRENT MICROBIOLOGY

Molecular mechanism of Aspergillus fumigatus adherence to host constituents

(2011) Donald C Sheppard   CURRENT OPINION IN MICROBIOLOGY

Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases—the role of factors affecting assay performance

(2011) Zdenek Racil et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Molecular Detection and Species-Specific Identification of Medically Important Aspergillus Species by Real-Time PCR in Experimental Invasive Pulmonary Aspergillosis

(2011) T. J. Walsh et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Detection and Measurement of Fungal Burden in a Guinea Pig Model of Invasive Pulmonary Aspergillosis by Novel Quantitative Nested Real-Time PCR Compared with Galactomannan and (1,3)- -D-Glucan Detection

(2011) M. Lengerova et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Diagnosis of Invasive Aspergillosis by a Commercial Real-Time PCR Assay for Aspergillus DNA in Bronchoalveolar Lavage Fluid Samples from High-Risk Patients Compared to a Galactomannan Enzyme Immunoassay

(2011) R. Torelli et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Ribosomal and Mitochondrial DNA Target for Real-Time PCR Diagnosis of Invasive Aspergillosis

(2011) L. Millon et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Evaluation of Aspergillus PCR Protocols for Testing Serum Specimens

(2011) P. Lewis White et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Diagnostic Accuracy of Serum 1,3-β-d-Glucan for Pneumocystis jiroveci Pneumonia, Invasive Candidiasis, and Invasive Aspergillosis: Systematic Review and Meta-Analysis

(2011) Akira Onishi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Detection of Aspergillus species in BACTEC blood cultures

(2011) C. Rosa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice

(2011) C. O. Morton et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Identification of virulence factors and diagnostic markers using immunosecretome of Aspergillus fumigatus

(2011) Awanit Kumar et al.   Journal of Proteomics

Unsuitability of exhaled breath condensate for the detection of Herpesviruses DNA in the respiratory tract

(2011) Cristina Costa et al.   JOURNAL OF VIROLOGICAL METHODS

False positive galactomannan Platelia due to piperacillin-tazobactam

(2011) M.P. Gerlinger et al.   MEDECINE ET MALADIES INFECTIEUSES

A Consistent Phylogenetic Backbone for the Fungi

(2011) I. Ebersberger et al.   MOLECULAR BIOLOGY AND EVOLUTION

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for the Identification of Clinically Relevant Bacteria

(2011) Cinzia Benagli et al.   PLoS One

Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD

(2011) TETYANA ZAKHARKINA et al.   RESPIROLOGY

False-positiveAspergillusgalactomannan assay in solid organ transplant recipients with histoplasmosis

(2011) P. Vergidis et al.   Transplant Infectious Disease

Response to: Lack of intra-laboratory reproducibility in using PlateliaAspergillusenzyme immunoassay test for detection ofAspergillusgalactomannan antigen

(2011) A. Bizzini et al.   Transplant Infectious Disease

Exhaled breath condensate sampling is not a new method for detection of respiratory viruses

(2011) Lieselot Houspie et al.   Virology Journal

Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients

(2010) Li-Yang Hsu et al.   BMC INFECTIOUS DISEASES

Matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry for fast and accurate identification of clinically relevant Aspergillus species

(2010) A. Alanio et al.   CLINICAL MICROBIOLOGY AND INFECTION

Microorganisms direct identification from blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2010) L. Ferreira et al.   CLINICAL MICROBIOLOGY AND INFECTION

A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: comparison with the diagnostic performance of galactomannan and of (1→ 3) – β – d-glucan chromogenic assay in serum samples

(2010) J. Acosta et al.   CLINICAL MICROBIOLOGY AND INFECTION

Clinical utility and prognostic value of bronchoalveolar lavage galactomannan in patients with hematologic malignancies

(2010) Me-Linh Luong et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Detection and investigation of invasive mould disease

(2010) M. Cuenca-Estrella et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Critical Stages of Extracting DNA from Aspergillus fumigatus in Whole-Blood Specimens

(2010) P. L. White et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Aspergillus PCR: One Step Closer to Standardization

(2010) P. L. White et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Identification of Pathogenic Rare Yeast Species in Clinical Samples: Comparison between Phenotypical and Molecular Methods

(2010) E. Cendejas-Bueno et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis

(2010) Seong Yeon Park et al.   JOURNAL OF INFECTION

Difficulties in using 1,3- -D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies - high frequency of false-positive results and their analysis

(2010) Z. Racil et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Suitability of Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry in a Laboratory Developed Test Using Cystic Fibrosis Carrier Screening as a Model

(2010) Daniel H. Farkas et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Differential transcriptional profiles induced by amphotericin B formulations on human monocytes during response to hyphae ofAspergillus fumigatus

(2010) Maria Simitsopoulou et al.   MEDICAL MYCOLOGY

Novel diagnostics: progress toward a breath test for invasiveAspergillus fumigatus

(2010) Stephen T. Chambers et al.   MEDICAL MYCOLOGY

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Rapid Species Diagnosis for Invasive Candidiasis Using Mass Spectrometry

(2010) Carine Marinach-Patrice et al.   PLoS One

False-positive serum and bronchoalveolar lavage Aspergillus galactomannan assays caused by different antibiotics

(2010) Viboon Boonsarngsuk et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients by Detection of Galactomannan in the Bronchoalveolar Lavage Fluid

(2010) Alessandro C. Pasqualotto et al.   TRANSPLANTATION

Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin

(2010) Markus Schrettl et al.   PLoS Pathogens

A fungal phylogeny based on 82 complete genomes using the composition vector method

(2009) Hao Wang et al.   BMC EVOLUTIONARY BIOLOGY

Contribution of Galactomannan Antigen Detection in BAL to the Diagnosis of Invasive Pulmonary Aspergillosis in Patients With Hematologic Malignancies

(2009) Anne Bergeron et al.   CHEST

Comparison of Lateral Flow Technology and Galactomannan and (1->3)- -D-Glucan Assays for Detection of Invasive Pulmonary Aspergillosis

(2009) N. P. Wiederhold et al.   Clinical and Vaccine Immunology

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Bronchoalveolar Lavage Fluid Galactomannan for the Diagnosis of Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases

(2009) Johan Maertens et al.   CLINICAL INFECTIOUS DISEASES

Characterization and identification of proteases secreted by Aspergillus fumigatus using free flow electrophoresis and MS

(2009) Madlen Neustadt et al.   ELECTROPHORESIS

PCR-based diagnosis of human fungal infections

(2009) Prasanna D Khot et al.   Expert Review of Anti-Infective Therapy

Filamentous fungal characterizations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2009) C. Santos et al.   JOURNAL OF APPLIED MICROBIOLOGY

Rapid Real-Time Nucleic Acid Sequence-Based Amplification-Molecular Beacon Platform To Detect Fungal and Bacterial Bloodstream Infections

(2009) Y. Zhao et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Fast and Reliable Identification of Clinical Yeast Isolates

(2009) G. Marklein et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Dynamics of extracellular release of Aspergillus fumigatus DNA and galactomannan during growth in blood and serum

(2009) C. O. Morton et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Detection of Aspergillus DNA by a nested PCR assay is able to improve the diagnosis of invasive aspergillosis in paediatric patients

(2009) M. Hummel et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Prospective Monitoring for Invasive Aspergillosis Using Galactomannan and Polymerase Chain Reaction in High Risk Pediatric Patients

(2009) Saro H. Armenian et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Exhaled breath condensate appears to be an unsuitable specimen type for the detection of influenza viruses with nucleic acid-based methods

(2009) Kirsten St. George et al.   JOURNAL OF VIROLOGICAL METHODS

Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis

(2009) Carlo Mengoli et al.   LANCET INFECTIOUS DISEASES

Detection of 2-Pentylfuran in the breath of patients withAspergillus fumigatus

(2009) Stephen T. Chambers et al.   MEDICAL MYCOLOGY

Why the need for qPCR publication guidelines?—The case for MIQE

(2009) Stephen A. Bustin   METHODS

The innate immune response to Aspergillus fumigatus

(2009) Viviane Balloy et al.   MICROBES AND INFECTION

The Role of Bronchoalveolar Lavage Galactomannan in the Diagnosis of Pediatric Invasive Aspergillosis

(2009) Rishi Desai et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Identification of a Putative Crf Splice Variant and Generation of Recombinant Antibodies for the Specific Detection of Aspergillus fumigatus

(2009) Mark Schütte et al.   PLoS One

Discrimination of Aspergillus isolates at the species and strain level by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry fingerprinting

(2008) Justin M. Hettick et al.   ANALYTICAL BIOCHEMISTRY

Assessment of Aspergillus fumigatus Burden in Pulmonary Tissue of Guinea Pigs by Quantitative PCR, Galactomannan Enzyme Immunoassay, and Quantitative Culture

(2008) A. C. Vallor et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillus Section Fumigati: Antifungal Susceptibility Patterns and Sequence-Based Identification

(2008) L. Alcazar-Fuoli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of an Immunochromatographic Lateral-Flow Device for Rapid Serodiagnosis of Invasive Aspergillosis

(2008) C. R. Thornton   Clinical and Vaccine Immunology

Performance Characteristics of the Platelia Aspergillus Enzyme Immunoassay for Detection of Aspergillus Galactomannan Antigen in Bronchoalveolar Lavage Fluid

(2008) S. Husain et al.   Clinical and Vaccine Immunology

1,3- -D-Glucan Antigenemia for Early Diagnosis of Invasive Fungal Infections in Neutropenic Patients with Acute Leukemia

(2008) L. Senn et al.   CLINICAL INFECTIOUS DISEASES

Outcome and Medical Costs of Patients with Invasive Aspergillosis and Acute Myelogenous Leukemia–Myelodysplastic Syndrome Treated with Intensive Chemotherapy: An Observational Study

(2008) Lennert Slobbe et al.   CLINICAL INFECTIOUS DISEASES

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

(2008) Ben De Pauw et al.   CLINICAL INFECTIOUS DISEASES

Correlation between galactomannan antigen levels in serum and neutrophil counts in haematological patients with invasive aspergillosis

(2008) C. Cordonnier et al.   CLINICAL MICROBIOLOGY AND INFECTION

Diagnosis of invasive aspergillosis by galactomannan antigenemia detection using an enzyme immunoassay

(2008) L. J. Wheat et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

False positivity of the Aspergillus galactomannan Platelia ELISA because of piperacillin/tazobactam treatment: does it represent a clinical problem?

(2008) K. Orlopp et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Value of Serial Quantification of Fungal DNA by a Real-Time PCR-Based Technique for Early Diagnosis of Invasive Aspergillosis in Patients with Febrile Neutropenia

(2008) M. Cuenca-Estrella et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Utility of Galactomannan Enzyme Immunoassay and (1,3)  -D-Glucan in Diagnosis of Invasive Fungal Infections: Low Sensitivity for Aspergillus fumigatus Infection in Hematologic Malignancy Patients

(2008) R. Y. Hachem et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Role of (1→3)-β-D-glucan in the diagnosis of invasive aspergillosis

(2008) Francisco M. Marty et al.   MEDICAL MYCOLOGY