Interferons as biomarkers and effectors: lessons learned from animal models

The Dynamics of Mouse Cytomegalovirus-Specific CD4 T Cell Responses during Acute and Latent Infection

(2014) S. M. Walton et al.   JOURNAL OF IMMUNOLOGY

Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells

(2014) P. Bochtler et al.   JOURNAL OF IMMUNOLOGY

TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain

(2014) L. N. Sorensen et al.   JOURNAL OF IMMUNOLOGY

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-  on STAT3 and Smads

(2014) K. Tanaka et al.   JOURNAL OF IMMUNOLOGY

Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN- 1) in Response to Influenza A Infection

(2014) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Systems Biology in Immunology: A Computational Modeling Perspective

(2011) Ronald N. Germain et al.   Annual Review of Immunology

Autoimmune disease: A role for new anti-viral therapies?

(2011) David H. Dreyfus   AUTOIMMUNITY REVIEWS

Treatment of multiple sclerosis with Anti-CD20 antibodies

(2011) Barbara Barun et al.   CLINICAL IMMUNOLOGY

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

Epstein-Barr virus and multiple sclerosis: interaction with HLA

(2011) E Sundqvist et al.   GENES AND IMMUNITY

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Immune tolerance in multiple sclerosis

(2011) Joan M. Goverman   IMMUNOLOGICAL REVIEWS

Distinct antiviral activities of IFN-α subtypes

(2011) Kathrin Gibbert et al.   Immunotherapy

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Stimulated Genes and Their Protein Products: What and How?

(2011) Ernest C. Borden et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Systems Biology of Interferon Responses

(2011) Paul Hertzog et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Highly Pathogenic Avian Influenza Viruses Do Not Inhibit Interferon Synthesis in Infected Chickens but Can Override the Interferon-Induced Antiviral State

(2011) N. Penski et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Sculpting the immune response to infection

(2011) Paul J Hertzog et al.   NATURE IMMUNOLOGY

Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

(2011) Wibke Bayer et al.   Retrovirology

Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

(2011) Kyoko Shinya et al.   Virology Journal

Systematic review of genome-wide expression studies in multiple sclerosis

(2011) A. K. Kemppinen et al.   BMJ Open

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

(2011) Kimberly E. Taylor et al.   PLoS Genetics

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response

(2011) Noëlla Arnaud et al.   PLoS Pathogens

Interferon   is associated with type 1 interferon-inducible gene expression in dermatomyositis

(2010) A. P. Liao et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon-β modulates type 1 immunity during influenza virus infection

(2010) Jae-Kwang Yoo et al.   ANTIVIRAL RESEARCH

Lysine methylation of promoter-bound transcription factors and relevance to cancer

(2010) George R Stark et al.   CELL RESEARCH

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

(2010) Jennifer L. Berard et al.   GLIA

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice

(2010) Golo Ahlenstiel et al.   JOURNAL OF GASTROENTEROLOGY

Scientific Registry of the International Society for Heart and Lung Transplantation: Introduction to the 2010 annual reports

(2010) Marshall I. Hertz et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Interferon-Lambda: A New Addition to an Old Family

(2010) Raymond P. Donnelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Preclinical and Clinical Development of Pegylated Interferon-Lambda 1 in Chronic Hepatitis C

(2010) Eleanor L. Ramos   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Epstein-Barr Virus Latent Infection and BAFF Expression in B Cells in the Multiple Sclerosis Brain: Implications for Viral Persistence and Intrathecal B-Cell Activation

(2010) Barbara Serafini et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

High Level of Genetic Compatibility between Swine-Origin H1N1 and Highly Pathogenic Avian H5N1 Influenza Viruses

(2010) Cássio Pontes Octaviani et al.   JOURNAL OF VIROLOGY

Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways

(2010) J. Melchjorsen et al.   JOURNAL OF VIROLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

Interferon-β is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis

(2010) CL Galligan et al.   Multiple Sclerosis Journal

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

(2010) Danlin Jia et al.   PLoS One

Myocarditis

(2010) Lori A. Blauwet et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Antiviral Strategies: The Present and Beyond

(2010) J. Burke et al.   Current Molecular Pharmacology

Preferential Upregulation of Interferon-α Subtype 2 Expression in HIV-1 Patients

(2009) C. Lehmann et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis

(2009) Jethro Trees Ritter et al.   CARDIOVASCULAR PATHOLOGY

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Turning Point in Myocarditis

(2009) Madeleine W. Cunningham   CIRCULATION RESEARCH

Regulatory effects of IFN-β on production of osteopontin and IL-17 by CD4+ T Cells in MS

(2009) Meiyue Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-retroviral effects of type I IFN subtypes in vivo

(2009) Nicole Gerlach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Myocarditis: Infection Versus Autoimmunity

(2009) Noel R. Rose   JOURNAL OF CLINICAL IMMUNOLOGY

CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

(2009) C. M. Snyder et al.   JOURNAL OF IMMUNOLOGY

Physical Requirements and Functional Consequences of Complex Formation between the Cytomegalovirus IE1 Protein and Human STAT2

(2009) S. Krauss et al.   JOURNAL OF VIROLOGY

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

(2009) I. Moraga et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation

(2009) Karen E. Johnson et al.   VIROLOGY

Enhanced anti-HCV activity of interferon alpha 17 subtype

(2009) Aurelie Dubois et al.   Virology Journal

Feeling manipulated: cytomegalovirus immune manipulation

(2009) Mindy Miller-Kittrell et al.   Virology Journal

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production

(2008) S. B. Rasmussen et al.   JOURNAL OF GENERAL VIROLOGY

Enhanced Pathogenesis of an Attenuated Herpes Simplex Virus for Mice Lacking Stat1

(2008) T. J. Pasieka et al.   JOURNAL OF VIROLOGY

Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza

(2008) J. Steel et al.   JOURNAL OF VIROLOGY

INTERFEROME: the database of interferon regulated genes

(2008) Shamith A. Samarajiwa et al.   NUCLEIC ACIDS RESEARCH

Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15

(2008) Susana Guerra et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens