Article
Multidisciplinary Sciences
Ana Campar, Ines Alves, Beatriz Santos-Pereira, Rafaela Nogueira, Miguel Mendonca Pinto, Carlos Vasconcelos, Salome S. Pinho
Summary: This study reveals a deficiency in the glycosylation pathway in muscle tissues of patients with idiopathic inflammatory myopathies, resulting in loss of branched N-glycans. The lack of glycosylation is associated with increased IL-6 production, while glycan supplementation decreases IL-6 levels. This highlights the biological and clinical importance of glycosylation in the immunopathogenesis of inflammatory myopathies.
Article
Biochemistry & Molecular Biology
So Hee Park, Kyung Ah Lee, Jae-Hyeog Choi, SaeGwang Park, Dae-Wook Kim, So Young Jung
Summary: Obese psoriatic patients experience higher disease severity and exhibit poorer treatment responses and clinical outcomes. This study aimed to clarify the role of obesity in the pathogenesis of psoriasis, focusing on immunological changes. Results showed that obesity could exacerbate psoriasis through mechanisms that involve elevated proinflammatory cytokine secretion and an expanded Th17 cell population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Li Jiao, Shougang Guo
Summary: This review summarizes the research progress and prospects of anti-interleukin-6 (IL-6) therapy in the treatment of central nervous system inflammatory demyelinating diseases (IDDs).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maha Maqsood, Saima Sharif, Shagufta Naz, Tasnim Farasat, Farkhanda Manzoor, Maqsood Cheema, Muhammad Saqib
Summary: This case-control study aimed to determine the role of IL-6 and IL-18 in the development of diabetic nephropathy in the Pakistani population. The findings showed that increased expression of IL-6 and decreased expression of IL-18 were associated with the development of DN.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Katie Fahy, Alexandros Alexiou, Konstantinos Daras, Kate Mason, Davara Bennett, David Taylor-Robinson, Ben Barr
Summary: Over the past decade, budget cuts to local authority in England have affected cultural, environmental, and planning services, leading to potential impacts on population mental health. This study found that cuts in CEP spending were associated with worsening mental health outcomes, particularly in relation to planning and development services. These impacts were more significant in affluent areas.
Article
Gastroenterology & Hepatology
Adam G. Clooney, Julia Eckenberger, Emilio Laserna-Mendieta, Kathryn A. Sexton, Matthew T. Bernstein, Kathy Vagianos, Michael Sargent, Feargal J. Ryan, Carthage Moran, Donal Sheehan, Roy D. Sleator, Laura E. Targownik, Charles N. Bernstein, Fergus Shanahan, Marcus J. Claesson
Summary: The study found reduced microbiota diversity and increased variability in patients with CD and UC compared to controls. Longitudinal analysis showed decreased temporal microbiota stability in IBD, especially in patients with changes in disease activity. Machine learning was able to separate disease from controls and active from inactive disease.
Article
Clinical Neurology
Yanjun Song, Qiuting Dong, Zhen'ge Chang, Chenxi Song, Kongyong Cui, Shaoyu Wu, Guofeng Gao, Rui Fu, Ying Gao, Kefei Dou
Summary: This study evaluated the impact of sleep quality on the long-term risk of stroke among middle-aged and elderly adults in England. It found that poor sleep quality was associated with a significantly higher risk of stroke. Improving sleep quality can reduce the risk of stroke.
Article
Biochemistry & Molecular Biology
Luciana de Brito Falcao, Anacelia Gomes de Matos, Deysi Viviana Tenazoa Wong, Roberto Cesar Pereira Lima-Junior, Priscila da Silva Mendonca, Ana Patricia Nogueira Aguiar, Roberta Taiane Germano de Oliveira, Emanna Odilia de Castro Lima, Ronald Feitosa Pinheiro, Silvia Maria Meira Magalhaes
Summary: The study found that patients with MDS had lower levels of IL-33, especially in those with more advanced stages and worse prognosis. There was no significant correlation between IL-33 and IL-6 levels. These results highlight the close association between immunological disorders and the pathogenesis of MDS.
Article
Biology
Quesia Euclides Teixeira, Dennis de Carvalho Ferreira, Alexandre Marques Paes da Silva, Lucio Souza Goncalves, Fabio Ramoa Pires, Florence Carrouel, Denis Bourgeois, Irna Sufiawati, Luciana Armada
Summary: The expression of pro-inflammatory cytokines IL-1 beta, IL-6 and TNF-alpha is higher in chronic apical periodontitis lesions (CAPLs) in elderly individuals compared to adults. Ageing may act as a modifier on periradicular disease, although further research is needed to understand the reasons and consequences of inflammation in the elderly.
Article
Immunology
Adi Haramati, Ariel Rechtman, Omri Zveik, Nitzan Haham, Livnat Brill, Adi Vaknin-Dembinsky
Summary: The study aimed to evaluate the longitudinal changes of interleukin (IL)-6 levels in the sera of NMOSD patients and their correlation with disease activity and brain volume. The results showed significantly increased IL-6 levels during relapse in NMOSD patients, which were also correlated with relapse severity and brain atrophy.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aliyah Alcala, Brooke Osborne, Blake Allen, Aleshia Seaton-Terry, Toran Kirkland, Margaret Whalen
Summary: The study reveals that tributyltin (TBT) can increase the production of pro-inflammatory cytokines IL-1 beta and IL-6 by peripheral blood mononuclear cells (PMBCs). TBT may interact with specific Toll-like receptors (TLRs) to stimulate the production of these cytokines. These findings contribute to the understanding of the mechanism through which TBT induces chronic inflammation.
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Riley J. Morrow, Amr H. Allam, Belinda Yeo, Siddhartha Deb, Carmel Murone, Elgene Lim, Cameron N. Johnstone, Matthias Ernst
Summary: This study uncovers a novel mechanism where IL-6 and its associated STAT3 signaling pathway stimulate proliferation between sub-clones in inflammatory breast cancer. The sensitivity of IL-6 responsive sub-clones to Tocilizumab suggests a potential therapeutic strategy for a subset of patients with this aggressive form of breast cancer.
Article
Medicine, General & Internal
Mojtaba Norouzi, Majid Pirestani, Ehsan Arefian, Abdolhossein Dalimi, Javid Sadraei, Hamed Mirjalali
Summary: This study is the first to report the release of exosome-like vesicles by the human parasite Blastocystis, demonstrating the role of this parasite, particularly ST1, in proinflammatory and anti-inflammatory cytokines and modulating the host response.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Keeley M. Fairbrass, P. John Hamlin, David J. Gracie, Alexander C. Ford
Summary: This study found that over two-thirds of patients with IBD experienced IBS-type symptoms during a >6 year follow-up, which were associated with increased healthcare utilisation, worse anxiety, depression, somatoform symptom and quality of life scores.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Statistics & Probability
Joshua L. Warren, Marie Lynn Miranda, Joshua L. Tootoo, Claire E. Osgood, Michelle L. Bell
Summary: The study introduces spatial and spatiotemporal distributed lag data fusion methods for predicting ambient air pollution concentrations, incorporating predictive information from surrounding grid cells. Results show that the new methods often provide improved model fit and predictive accuracy when lagged information is beneficial. The code to apply these methods is available in the R package DLfuse.
ANNALS OF APPLIED STATISTICS
(2021)
Article
Environmental Sciences
Ji-Young Son, Rebecca L. Muenich, Danica Schaffer-Smith, Marie Lynn Miranda, Michelle L. Bell
Summary: Disproportionate location of CAFOs in North Carolina highlights environmental disparities related to race and socioeconomic status, with potential for more pronounced environmental justice disparities when using a buffer method for exposure assessment.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Ji-Young Son, M. Benjamin Sabath, Kevin J. Lane, Marie Lynn Miranda, Francesca Dominici, Qian Di, Joel Schwartz, Michelle L. Bell
Summary: This study found that individuals living in low socioeconomic status and high greenness areas had lower associations between PM2.5 exposure and mortality. Multiple aspects of disparity factors and their interactions may affect health disparities from air pollution exposures.
Article
Environmental Sciences
Mercedes A. Bravo, Marie Lynn Miranda
Summary: This study found an association between prenatal exposure to fine particulate matter (PM2.5) and small-for-gestational-age (SGA) birth and lower birthweight percentile. Comparing successive pregnancies in the same women, the study better controlled for confounding factors and strengthened the evidence for causal relationship between PM2.5 exposure and pregnancy outcomes.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Bonnie R. Joubert, Marianthi-Anna Kioumourtzoglou, Toccara Chamberlain, Hua Yun Chen, Chris Gennings, Mary E. Turyk, Marie Lynn Miranda, Thomas F. Webster, Katherine B. Ensor, David B. Dunson, Brent A. Coull
Summary: Humans are exposed to a variety of chemical and non-chemical mixtures throughout their lives, and it is important to investigate the health impacts of these mixtures. However, there are challenges in analyzing mixture data in epidemiological studies, such as high correlation among health and exposure measures, missing observations, violation of modeling assumptions, and computational challenges. The PRIME program aims to address these challenges by developing and expanding statistical methods for mixtures. This review summarizes new methods from PRIME projects and provides insights for method selection and application.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Carolina Avendano, Aaron Lilienfeld, Liz Rulli, Melissa Stephens, Wendy Alvarez Barrios, Joseph Sarro, Michael E. Pfrender, Marie Lynn Miranda
Summary: This study conducted at a midsized Midwestern university in the US revealed a significant decrease in positive COVID-19 cases among the study population with a robust vaccination program, even in the presence of highly transmissible variants and congregate living.
Article
Health Care Sciences & Services
Steven J. Krieg, Carolina Avendano, Evan Grantham-Brown, Aaron Lilienfeld Asbun, Jennifer J. Schnur, Marie Lynn Miranda, Nitesh Chawla
Summary: This study analyzes a data-driven COVID-19 testing program implemented at a mid-sized university. It demonstrates the effectiveness of using machine learning models to predict high-risk students and highlights the improvement in positivity rate and testing speed. The authors also discuss the potential for other organizations to adopt similar strategies to reduce community transmission.
NPJ DIGITAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Mercedes A. Bravo, Joshua L. Warren, Man Chong Leong, Nicole C. Deziel, Rachel T. Kimbro, Michelle L. Bell, Marie Lynn Miranda
Summary: This study assessed the spatial variability and temporal trends in PM2.5 and O3 concentrations in North Carolina and their associations with community characteristics. The results showed that while pollutant concentrations have decreased, disparities in exposure have increased for racially and educationally isolated communities.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Samantha M. Hall, Sharon Zhang, Kate Hoffman, Marie Lynn Miranda, Heather M. Stapleton
Summary: There are associations between placental PFAS concentrations and birth outcomes, suggesting potential effects of PFAS on fetal health.
Article
Environmental Sciences
Ji-Young Son, Hayon Michelle Choi, Marie Lynn Miranda, Michelle L. Bell
Summary: Exposure to heat during pregnancy increases the risk of preterm birth, especially in urbanized areas, low SES, or in the Coastal Plain. There is also a significant preterm birth-heat risk in areas with low greenness in urbanized areas. Heat waves did not show significantly positive associations with preterm birth.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mercedes A. Bravo, Dominique Zephyr, Daniel Kowal, Katherine Ensor, Marie Lynn Miranda
Summary: Racial/ethnic disparities in academic performance may result from structural racism and adverse exposures. This study investigated childhood lead exposure, racial residential segregation, and early educational outcomes, and found that high lead exposure and racial isolation were associated with worse reading scores for non-Hispanic Black (NHB) children.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
Steven J. Krieg, Jennifer J. Schnur, Marie Lynn Miranda, Michael E. Pfrender, Nitesh Chawla
Summary: Asymptomatic and presymptomatic hosts of SARS-CoV-2 pose a risk for the spread of COVID-19, with asymptomatic transmission rates higher than previously estimated. The transmission rate for presymptomatic cases is similar to that of symptomatic cases, and different symptoms are associated with different transmission rates.
PUBLIC HEALTH REPORTS
(2022)
Article
Environmental Sciences
Shan Zhou, Robert J. Griffin, Alexander Bui, Aaron Lilienfeld Asbun, Mercedes A. Bravo, Claire Osgood, Marie Lynn Miranda
Summary: This study found socioeconomic and demographic disparities in air pollution levels in North Carolina. Areas with less reliable predictions were often non-urban areas characterized by educational and economic deprivation, while areas with reliable predictions were often urban areas with higher population density and better economic conditions. Furthermore, the predictive uncertainty of PM2.5 has increased in recent years, while the predictive reliability of O3 has improved.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Rashida Callender, Joally M. Canales, Carolina Avendano, Elena Craft, Katherine B. Ensor, Marie Lynn Miranda
Summary: This study examines the economic and mental health impacts of COVID-19 in relation to previous exposure to flooding events. The results show that individuals who experienced flood-related home damage or income loss during Hurricane Harvey are more likely to experience anxiety and income loss during the pandemic.
ENVIRONMENTAL RESEARCH
(2022)
Letter
Medicine, General & Internal
Sue Anne Bell, Marie Lynn Miranda, Julie P. W. Bynum, Matthew A. Davis
