Journal
BIOMARKERS
Volume 17, Issue 5, Pages 407-415Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2012.677860
Keywords
Latent TGF-beta binding protein 2 (LTBP-2); heart failure; heart failure with reduced ejection fraction; signaling pathway; biomarker
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Funding
- National 973 Program of China [2010CB529505]
- National Natural Science Foundation of China [81170206]
- Research Fund for the Doctoral Program of Higher Education of China [20091106110018]
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Background: We have observed increased expression of latent TGF-beta binding protein (LTBP)-2 mRNA in human failing hearts. This study was aimed to further confirm LTBP-2 act as a novel marker in human acute heart failure. Methods and results: We demonstrated that median level of LTBP-2 in myocardial samples from heart failure patients was significantly elevated, and TGF-beta 1 significantly promoted LTBP-2 expression in neonatal rat cardiomyocytes. To investigate the potential of LTBP-2 as a biomarker to diagnose heart failure with reduced ejection fraction (HFREF), another cohort of 133 consecutive patients with dyspnea were enrolled. In receiver operating characteristic (ROC) curve analyses to detect HFREF, LTBP-2 achieved an area under curve (AUC) of 0.67 (95% confidence intervals (CI) 0.58-0.75), comparable to the diagnostic ability of NT-proBNP 0.68 (95% CI 0.59-0.77). Conclusion: The serum LTBP-2 levels might act as a promising biomarker in HFREF.
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