Journal
BIOMARKERS
Volume 17, Issue 5, Pages 422-429Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2012.680608
Keywords
cancerous inhibitor of protein phosphatase 2A (CIP2A); hepatocellular carcinoma; mRNA expression; Prognosis
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Funding
- National Natural Science Foundation of China [30872489, 30972916]
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Objective: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC). Methods: CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction. Results: Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival. Conclusions: Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.
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