Article
Biochemistry & Molecular Biology
Oscar Diaz-Santana, Nuria Cardenes-Sanchez, Francisco Conde-Hardisson, Argimiro Rivero-Rosales, Miguel Suarez de Tangil Navarro, Daura Vega-Moreno
Summary: Determining the approximate dates of written documents based on ink composition is a challenging process with legal requirements. Studies have successfully dated manuscripts by analyzing the evolution of dye and solvent concentrations in the ink. This study evaluates novel ink compounds and degradation products to potentially open new avenues for universal dating tools.
Article
Chemistry, Analytical
Nikolai Yu Tiuftiakov, Andrey Kalinichev, Evgeniia Khairullina, Elizaveta K. Gigiadze, Maria A. Peshkova, Ilya I. Tumkin
Summary: This study introduces a simple and cost-effective technique for classifying writing inks based on digital color analysis (DCA) and investigates the dynamics of artificial aging of writing inks under UV irradiation. The proposed approach shows superior precision in ink classification compared to conventional Raman scattering method, demonstrating potential applications in document investigation for suspected forgery and the study of processes reflected in color changes over time.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Shengbin He
Summary: We have developed a no-cost, lightweight, human-powered dispenser using an empty ballpoint pen. This dispenser allows freehand drawing of test and control lines and can imprint antibodies on nitrocellulose membranes without affecting their microstructure and chromatographic function. A lateral flow assay using the pen dispenser detected HCG at a sensitivity comparable to standard tests using traditional benchtop dispensers.
Article
Biochemistry & Molecular Biology
Johan Kjeldbjerg Lassen, Robert Bradshaw, Palle Villesen, Simona Francese
Summary: Questioned document examination aims to determine if a document has been forged, and spectroscopy-based methods are the preferred technique for this evaluation. In recent years, Matrix-Assisted Laser Desorption Ionisation-Mass Spectrometry Imaging (MALDI-MSI) has emerged as a powerful tool for analyzing finger marks, blood, and hair. This study investigated the use of MALDI-MSI combined with chemometric approaches to differentiate between different gel pen inks over a period of 44 days, achieving accurate classification and demonstrating the potential for further studies.
Article
Chemistry, Multidisciplinary
Ahmed A. Gawad, Tarek M. Salama, Islam Ibrahim, Mohamed Meshref, Gehad G. Mohamed, Abdallah F. Zedan
Summary: This study introduces a hybrid spectroscopic and chromatography approach to investigate the infrared luminescence (IRL) behavior of blue ballpoint (BP) pen inks. Through various analytical techniques, it is revealed that the presence of crystal violet and other triaryl methane dyes is responsible for IRL in some ink samples. Additionally, the inclusion of phthalocyanine dye results in luminescence quenching in non-luminescent ink samples due to spectral overlap.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Deski Beri, Septian Budiman, Nofi Yendri Sudiar, Alfajri Yusra, Erianjoni Erianjoni, Ganefri Ganefri, Ali Amran
Summary: This report presents a method for encapsulating inorganic pigments in w/o microemulsion gels and studying their solubility. The results show that the inorganic pigments have good solubility in the system and the self-made ink resembles factory-made inks in physical appearance. However, further research is needed to investigate its long-term stability and corrosion resistance.
Article
Engineering, Electrical & Electronic
Ming Xin, Ning Lu, Dejian Yin, Ruowen Tao, Jiean Li, Le Liu, Hongxing Liu, Yi Shi, Lijia Pan
Summary: The paper proposes a capacitive pulse diagnosis system with a novel ballpoint pen-like probe structure and electromechanical control modules, which effectively collects pulse condition characteristics. This design provides a new approach to digitalize the cognitive category of traditional Chinese medicine, offering opportunities to better understand and analyze physiological signals for health monitoring and disease treatment applications.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Mechanical
Alan Hase
Summary: This study utilized AE sensing to detect AE waves during friction, effectively evaluating wear and lubrication between friction surfaces, and identifying the impact of different ink types on the writing performance of ballpoint pens.
Article
Chemistry, Analytical
Andrey Kalinichev, Anastasia Kravchenko, Ivan P. Gryazev, Arseniy A. Kechin, Oleg R. Karpukhin, Evgeniia M. Khairullina, Liudmila A. Kartsova, Anna G. Golovkina, Vladimir A. Kozynchenko, Maria A. Peshkova, Ilya I. Tumkin
Summary: A novel approach to classify blue ballpoint pen inks based on selective extraction, digital color analysis, and hierarchical cluster analysis was proposed. This method could be highly time- and cost-efficient in authenticating handwritten documents. The colorimetric distance between the original and extracted ink traces in the RGB color space was found to be the optimal descriptor for clustering. The developed method outperformed high-performance liquid chromatography in providing a more informative analysis for phthalocyanine dyes-based inks.
Review
Chemistry, Analytical
Arya Suresh Babu, Anjali Tomar, Shweta Sharma
Summary: This study explores the existing trends in examining the sequence of ink strokes using vibrational spectroscopic techniques (infrared and Raman spectroscopy) and proposes future research directions in this field. The findings suggest that factors like paper type and time gap between strokes do not affect the determination of stroke sequence. The use of multiple analytical techniques in combination with vibrational spectroscopic techniques can provide reliable results.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ines Fritz
Summary: Handwriting with a modern fountain pen offers a unique experience, involving tactile perception, visual impression, and ink wetness. Quantitative analysis of ink consumption data and physical and chemical properties reveals that ink wetness is primarily dependent on surface tension, followed by viscosity and conductivity, with unexpected correlations.
MATERIALS & DESIGN
(2022)
Article
Multidisciplinary Sciences
Sajal Chakraborty, Ho-Yeol Park, Sung Il Ahn
Summary: In this study, cost effective direct laser patterning of copper on thin polyimide substrates was achieved by controlling the focal length of the laser. The appropriate focal length was found to reduce defects on the patterned copper and surface damage of the polyimide. Different copper growth patterns were observed depending on the focal length used. The resistivity of the patterns decreased after cleaning, indicating a decrease in adhesion. A 70 μm scan gap resulted in the lowest sheet resistance and the least change in resistance after cleaning. This method showed potential for application in bioelectronics.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Mehwish Sharif, Sohail Chand, Syed Azhar Ali Shah Tirmazi, Umar Farooq, Muhammad Makshoof Athar, Madeeha Batool
Summary: A population study was conducted on four colors of Pakistani ballpoint pen inks commonly used in the market. UV/Vis spectroscopy and FTIR spectroscopy were used to investigate and discriminate the ballpoint pen inks. The results were compared in terms of discriminating power (DP), and statistical techniques were applied for data analysis. The study found that green ballpoint pen inks had the highest DP when using UV/Vis and FTIR techniques. Black and red inks showed the highest DPs using UV/Vis spectroscopy, while blue ink achieved the highest DP using FTIR spectroscopy. Using chemometric techniques improved the DP and obtained higher DPs compared to visual examination.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2022)
Article
Polymer Science
Yushi Tamaki, Kimihiko Sugiura
Summary: This study investigated the influence of Catalyst-Layer structure on Polymer Electrolyte Fuel Cell performance, especially focusing on CL thickness and electrode area. The results showed that the overpotentials of activation and diffusion increased with thicker CL, and the gas diffusivity of multilayer catalyst electrode was worse than that of a single layer MEA. Increasing electrode area also worsened the diffusion overpotential, leading to flooding/plugging phenomena.
Article
Chemistry, Analytical
Xu Hu, Xiaoxia Zhang, Zhongwen Diao
Summary: A rapid quantification method was developed to simultaneously determine nine volatile solvents commonly found in ink entries. The method utilized gas chromatography and flame ionization detector, reducing the analysis time to 9-12 minutes. The method provides sensitive, precise, and accurate quantification of nine volatile solvents in ink entries, improving analytical efficiency and requiring lower instrument requirements.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Applied
Sofia F. Prazeres, Felix Zapata, Nadia Canilho, Andreea Pasc, Carmen Garcia-Ruiz, Gemma Montalvo
MICROPOROUS AND MESOPOROUS MATERIALS
(2019)
Article
Environmental Sciences
Carlos Edo, Miguel Tamayo-Belda, Sergio Martinez-Campos, Keila Martin-Betancor, Miguel Gonzalez-Pleiter, Gerardo Pulido-Reyes, Carmen Garcia-Ruiz, Felix Zapata, Francisco Leganes, Francisca Fernandez-Pinas, Roberto Rosal
MARINE POLLUTION BULLETIN
(2019)
Article
Genetics & Heredity
Ines Gregorio, Carmen Garcia-Ruiz, Pilar Martinez
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2019)
Article
Anatomy & Morphology
V. A. Toledo-Gonzalez, F. E. Ortega-Ojeda, G. M. Fonseca, C. Garcia-Ruiz, P. Perez-Lloret
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2019)
Article
Automation & Control Systems
Karla Leiva Miranda, Fernando E. Ortega-Ojeda, Carmen Garcia-Ruiz, Pedro Saez Martinez
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2019)
Article
Chemistry, Analytical
Pablo Prego-Meleiro, Oscar Quintela-Jorge, Gemma Montalvo, Carmen Garcia-Ruiz
MICROCHEMICAL JOURNAL
(2019)
Review
Chemistry, Analytical
Felix Zapata, Carmen Garcia-Ruiz
Summary: This work comprehensively reviews fundamental concepts about explosives and their classifications, proposing a new classification based on their chemical composition for researchers to analyze and identify explosives effectively.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Review
Instruments & Instrumentation
Felix Zapata, Adrian Lopez-Fernandez, Fernando Ortega-Ojeda, Gemma Montalvo, Carmen Garcia-Ruiz
Summary: This work aims to design a practical beginner's guide to Raman microscopy for undergraduate students, teachers, or practitioners who need to use it for the first time. It explains the main concepts about Raman microscopy, methodology development, and results interpretation using acetaminophen drugs as an example, demonstrating the instrumental potential effectively. Detection and unequivocal identification of different components in mixtures were successfully demonstrated, even for low concentration components, promoting an easy implementation of the Raman microscopy technique in laboratory settings.
APPLIED SPECTROSCOPY REVIEWS
(2021)
Article
Medicine, Legal
Pablo Prego-Meleiro, Gemma Montalvo, Oscar Quintela-Jorge, Carmen Garcia-Ruiz
FORENSIC SCIENCE INTERNATIONAL
(2020)
Article
Chemistry, Analytical
Jose Manuel Matey, Carmen Garcia-Ruiz, Gemma Montalvo, Juan Carlos Gomez-Soro, Daniel Gutierrez-Delicado, Jovita Rodriguez-Gallardo, Maria A. Martinez
JOURNAL OF ANALYTICAL TOXICOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Victor Toledo Gonzalez, Fernando Ortega Ojeda, Gabriel M. Fonseca, Carmen Garcia-Ruiz, Pablo Navarro Caceres, Pilar Perez-Lloret, Maria del Pilar Marin Garcia
Article
Medicine, Legal
Pablo Prego-Meleiro, Gemma Montalvo, Oscar Quintela-Jorge, Carmen Garcia-Ruiz
FORENSIC SCIENCE INTERNATIONAL
(2020)
Review
Biochemistry & Molecular Biology
Felix Zapata, Victoria Pastor-Ruiz, Fernando Ortega-Ojeda, Gemma Montalvo, Ana Victoria Ruiz-Zolle, Carmen Garcia-Ruiz
Summary: Human UPE is influenced by internal stressors such as diseases and brain activity, making it a potential tool for diagnosing various illnesses and mood disorders. However, further research is needed to address unresolved controversial points.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Review
Chemistry, Analytical
Felix Zapata, Jose Manuel Matey, Gemma Montalvo, Carmen Garcia-Ruiz
Summary: This work reviews fundamental concepts about drugs, focusing on new psychoactive substances (NPS) and their classifications. A revised classification based on chemical composition is proposed to merge recent chemical groupings of NPS from various institutions, aiming to be useful for forensic practitioners/researchers.
MICROCHEMICAL JOURNAL
(2021)
Article
Medicine, Legal
Irene Burgos-Diez, Felix Zapata, Manuel Jose Chamorro-Sancho, Manuel Jesus Ruano-Rando, Jose Luis Ferrando-Gil, Carmen Garcia-Ruiz, Gemma Montalvo, Fernando Ortega-Ojeda
Summary: This study achieved 3D digital reconstruction of cavities created by different projectiles in ballistic soap blocks using CT analysis and 3D Slicer imaging software, improving measurement sensitivity and accuracy, and the ability to preserve evidence.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2021)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
