Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

Drugs of Abuse That Mediate Advanced Glycation End Product Formation: A Chemical Link to Disease Pathology

(2009) Jennifer B. Treweek et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mitochondrial Metabolism and Cancer

(2009) Frank Weinberg et al.   Annals of the New York Academy of Sciences

Extracellular/Microenvironmental Redox State

(2009) Luksana Chaiswing et al.   ANTIOXIDANTS & REDOX SIGNALING

Peptidylarginine deiminase 4 and citrullination in health and disease

(2009) Consuelo Anzilotti et al.   AUTOIMMUNITY REVIEWS

Application of biochemical markers in development of drugs for treatment of osteoarthritis

(2009) Per Qvist et al.   BIOMARKERS

The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke

(2009) Stephen P. Faux et al.   BIOMARKERS

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

(2009) M.A. Karsdal et al.   BIOMARKERS

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

(2009) A. J. Schetter et al.   CARCINOGENESIS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The receptor RAGE: Bridging inflammation and cancer

(2009) Astrid Riehl et al.   Cell Communication and Signaling

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction

(2009) Stefan Kralev et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

A Fresh Prospect of Extracellular Matrix Hydrolytic Enzymes and Their Substrates

(2009) M. Roycik et al.   CURRENT PHARMACEUTICAL DESIGN

Low Serum Level of the Endogenous Secretory Receptor for Advanced Glycation End Products (esRAGE) Is a Risk Factor for Prevalent Vertebral Fractures Independent of Bone Mineral Density in Patients With Type 2 Diabetes

(2009) M. Yamamoto et al.   DIABETES CARE

RAS in cellular transformation and senescence

(2009) Gina M. DeNicola et al.   EUROPEAN JOURNAL OF CANCER

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes

(2009) Ann V. Schwartz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Characterization of Anti-Advanced Glycation End Product Antibodies to Nonenzymatically Lysine-Derived and Arginine-Derived Glycated Products

(2009) Yeong-Gon Choi et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Is bone quality associated with collagen age?

(2009) D. J. Leeming et al.   OSTEOPOROSIS INTERNATIONAL

Characteristics, Formation, and Pathophysiology of Glucosepane: A Major Protein Cross-Link

(2009) Johan Svantesson Sjöberg et al.   REJUVENATION RESEARCH

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?

(2008) Helen R. Griffiths   AUTOIMMUNITY REVIEWS

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Biochemical Markers for Monitoring Response to Therapy: Evidence for Higher Bone Specificity by a Novel Marker Compared with Routine Markers

(2008) D. J. Leeming et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development

(2008) Lidiya S. Orlichenko et al.   CLINICAL & EXPERIMENTAL METASTASIS

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Mining the plasma proteome for cancer biomarkers

(2008) Samir M. Hanash et al.   NATURE

Should subchondral bone turnover be targeted when treating osteoarthritis?

(2008) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality

(2008) M. A. Karsdal et al.   OSTEOPOROSIS INTERNATIONAL

Can cancer be reversed by engineering the tumor microenvironment?

(2008) Donald E. Ingber   SEMINARS IN CANCER BIOLOGY

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY