Journal
BIOMARKERS
Volume 14, Issue 3, Pages 161-170Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500902777616
Keywords
White blood cell; neutrophil; monocyte; cervical cancer; tumour marker
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Funding
- National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea [7-2006- 0153]
- CMB-YUHAN research grant of Yonsei University College of Medicine for 2006 [6-2006-0030]
- Korea Research Foundation
- Korean Government (MOEHRD, Basic Research Promotion Fund) [KRF-2006-311-e00339]
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Simple, non-aversive methods to identify cervical neoplasia are needed. The purpose of this study was to investigate the clinical value of differential white blood cell (WBC) counts as a biomarker for cervical neoplasia. We performed a retrospective review of laboratory results in 407 cervical cancers, 495 cervical intraepithelial neoplasias (CIN) and 916 healthy controls. Because pretreatment neutrophil and monocyte counts showed the potential as a biomarker, we combined these parameters and designated this combined marker MNM (multiplication of neutrophil and monocyte counts). MNM showed a sensitivity of 53.1% and a specificity of 78.1%, which are much higher than those of SCC-Ag. On Cox multivariate analysis, MNM positivity (hazard ratio = 2.82, p = 0.042), stage and tumour size were independent predictors of poor prognosis. Our findings suggest that pretreatment MNM could be a candidate as a simple and cost-effective biomarker in cervical cancer.
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