Journal
BIOMACROMOLECULES
Volume 14, Issue 11, Pages 3870-3879Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm400991k
Keywords
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Funding
- Direction Generale de l'Armenent (DGA) of France
- Region Ile-de-France
- Fondation de l'UCP
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A fibrin hydrogel at physiological concentration (5 mg/mL) was associated with polyvinyl alcohol (PVA) inside an interpenetrating polymer networks (IPN) architecture. Previously, PVA has been modified with methacrylate functions in order to cross-link it by free-radical polymerization. The fibrin network was synthesized by the enzymatic hydrolysis of fibrinogen by thrombin. The resulting self-supported materials simultaneously exhibit the properties of the fibrin hydrogel and those of the synthetic polymer network. Their storage modulus is 50-fold higher than that of the fibrin hydrogel and they are completely rehydratable. These materials are noncytotoxic toward human fibroblast and the fibrin present on the surface of PVAm-based IPNs favors cell development.
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