Article
Biochemistry & Molecular Biology
Alexander Vladimirovich Ivanov, Mikhail Aleksandrovich Popov, Arkady Andreevich Metelkin, Valery Vasil'evich Aleksandrin, Evgeniy Gennad'evich Agafonov, Maria Petrovna Kruglova, Ekaterina Vladimirovna Silina, Victor Aleksandrovich Stupin, Ruslan Andreevich Maslennikov, Aslan Amirkhanovich Kubatiev
Summary: Coronary artery disease (CAD) and coronary artery bypass graft (CABG) are associated with a decrease in blood glutathione (bGSH) level. This study aimed to examine the associations of bGSH with glucose and plasma aminothiols in CAD patients before CABG and in the early postoperative period. The results showed that bGSH and its redox status were lower in CAD patients at admission, and CABG had no significant effect on these parameters except for an increase in the bGSH/hemoglobin ratio. Additionally, an association was found between an increase in oxidized GSH in the blood after surgery and fasting glucose levels.
Article
Cardiac & Cardiovascular Systems
Thomas Aschacher, Ulrike Baranyi, Olivia Aschacher, Eva Eichmair, Barbara Messner, Daniel Zimpfer, Roxana Moayedifar, Guenther Laufer, Maximilian Y. Emmert, Sigrid E. Sandner
Summary: The study evaluated the protective effect of an endothelial damage inhibitor on radial artery grafts, showing that EDI treatment significantly reduces endothelial and sub-endothelial damage, lowers reactive oxygen species levels, increases oxidation-reduction potential, and enhances the expression of factors indicative of vascular protection. This suggests that EDI may have the potential to reduce graft disease and failure in patients undergoing CABG.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Savvas Lampridis, Sarah J. George
Summary: This review examined the status of nonautologous grafts in coronary artery bypass grafting and found that autologous endothelial cell-seeded synthetic grafts have shown promising results but require further investigation.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tianyu Xia, Bo Li, Wei Zhang, Zhe Wang, Xiaofeng Ye, Mi Zhou, Haiqing Li, Jiapei Qiu, Yunpeng Zhu, Qiang Zhao
Summary: Our study aimed to identify the independent risk factors for major adverse cardiovascular events (MACE-4) after coronary artery bypass grafting using radial artery grafts (RA-CABG). We found that prior myocardial infarction and radial artery graft to the left anterior descending artery (non-left internal mammary artery to LAD) were independent predictors of MACE-4 after RA-CABG.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Huiru Chen, Zilan Wang, Ke Si, Xiaoxiao Wu, Hanyu Ni, Yanbing Tang, Wei Liu, Zhong Wang
Summary: This study evaluated the efficacy of external stenting for SVGs in CABG and found that it significantly reduced intimal hyperplasia area and thickness, improved lumen uniformity, and did not increase SVG failure rate.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gabor Veres, Andreas Simm, Gabor Szabo
Summary: This study found that endothelial function of saphenous vein grafts decreases with age in patients treated with coronary artery bypass grafting. Age should be taken into consideration when maintaining grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Mingmei Li, Zhenxing Yu, Qiong Chen, Qian Zhao, Xiang Chen, Changjiang Lei, Xiaohui Wang, Rui Yang
Summary: The meta-analysis compares sternal wound infections in patients who underwent coronary bypass surgery using bilateral internal mammary artery grafts versus single internal mammary artery grafts. The analysis includes studies from multiple languages and found that bilateral internal mammary artery grafting is associated with significantly higher rates of sternal wound infection, particularly in diabetic individuals, the elderly, and those who underwent pedicled or skeletonized preparation.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
He Jiao, Jinghui Li, Yunpeng Bai, Zhigang Guo
Summary: This study compared the outcomes of sequential and individual saphenous vein grafts in coronary artery bypass grafting. The results showed that sequential grafts had higher rates of graft failure and long-term mortality, but also an increased risk of perioperative repeat revascularization. Based on the study, the selection of surgical techniques should be based on patients and surgeons.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ilkun Park, Kuk Bin Choi, Joong Hyun Ahn, Wook Sung Kim, Young Tak Lee, Dong Seop Jeong
Summary: For patients undergoing CABG, DM may have no impact on cardiac death, MI, or revascularization rates, but can reduce the risk of graft failure for BITA grafts. For DM patients, strict control of preoperative hyperglycemia can reduce the occurrence of postoperative wound infection and facilitate the use of BITA in CABG.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ho Young Hwang, Jin Chul Paeng, Jeehoon Kang, Myoung-jin Jang, Ki-Bong Kim
Summary: The study found that graft occlusion during the 5 years after coronary artery bypass grafting was associated with the functional significance of coronary artery stenosis, particularly when the stenosis degree was not severe.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Hiroshi Sato, Joji Fukada, Yu Iwashiro, Yukihiko Tamiya
Summary: This study compared the 20-year outcomes of coronary artery grafting (CABG) using radial artery (RA) grafts (free and I-composite) and internal thoracic artery (ITA) grafts. The results showed that the 20-year patency of the I-composite ITA-RA graft was better than that of the free RA graft, suggesting that the I-composite graft may be an effective conduit for CABG.
Article
Mathematics, Applied
Pierfrancesco Siena, Michele Girfoglio, Francesco Ballarin, Gianluigi Rozza
Summary: In this work, a machine learning-based Reduced Order Model (ROM) is proposed for the investigation of hemodynamics in a patient-specific configuration of Coronary Artery Bypass Graft (CABG). The ROM method extracts a reduced basis space using a Proper Orthogonal Decomposition (POD) algorithm and employs Artificial Neural Networks (ANNs) for computation. The Full Order Model (FOM) is represented by the Navier-Stokes equations discretized using a Finite Volume (FV) technique. The novelties of this study include the use of FV method in a patient-specific configuration, a data-driven ROM technique, and a mesh deformation strategy based on Free Form Deformation (FFD) technique. The performance of the ROM approach is analyzed in terms of error and speed-up achieved.
JOURNAL OF SCIENTIFIC COMPUTING
(2023)
Article
Cardiac & Cardiovascular Systems
Donald S. Likosky, Raymond J. Strobel, Xiaoting Wu, Robert S. Kramer, Baron L. Hamman, James K. Brevig, Michael P. Thompson, Amir A. Ghaferi, Min Zhang, Eric J. Lehr
Summary: This study evaluated whether interhospital variation in mortality rates for coronary artery bypass grafting was driven by complications and failure to rescue. The study found a positive correlation between hospital failure to rescue rates and complications, suggesting that early recognition and management of complications are important factors in improving the success of coronary artery bypass grafting.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Psychology, Multidisciplinary
Martina Smorti, Francesca Ginobbi, Tommaso Simoncini, Federica Pancetti, Alessia Carducci, Giulia Mauri, Angelo Gemignani
Summary: Literature has shown that hospitalized women with high-risk pregnancy tend to develop anxious and depressive symptoms. This study integrated quantitative and qualitative methods to analyze the levels of depression, anxiety, and pregnancy-related anxiety in hospitalized high-risk pregnant women compared to non-hospitalized women with low-risk pregnancies. The study also examined the emotions experienced by the hospitalized high-risk group. The results showed that the hospitalized high-risk group reported higher levels of general anxiety and depression compared to the low-risk pregnancy group. The narratives revealed that the symptoms of anxiety and depression in hospitalized women were related to the loneliness of being away from family.
CURRENT PSYCHOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Saitta, Francesco Sturla, Alessandro Caimi, Alessandra Riva, Maria Chiara Palumbo, Giovanni Nano, Emiliano Votta, Alessandro Della Corte, Mattia Glauber, Dante Chiappino, Massimiliano M. Marrocco-Trischitta, Alberto Redaelli
Summary: The study demonstrated the utilization of a convolutional neural network for automated segmentation and quantification of relevant thoracic aortic features in TEVAR planning. The trained CNN showed high performance on a test set and was capable of generalizing to pathological cases, providing accurate segmentations. By comparing parameters between different arch configurations, it revealed significant differences in angulation and tortuosity at PLZ 3 for CILCA arches compared to standard arches.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Psychology, Biological
Suzanne Hoogeveen, Julia M. Haaf, Joseph A. Bulbulia, Robert M. Ross, Ryan McKay, Sacha Altay, Theiss Bendixen, Renatas Berniunas, Arik Cheshin, Claudio Gentili, Raluca Georgescu, Will M. Gervais, Kristin Hagel, Christopher Kavanagh, Neil Levy, Alejandra Neely, Lin Qiu, Andre Rabelo, Jonathan E. Ramsay, Bastiaan T. Rutjens, Hugh Turpin, Filip Uzarevic, Robin Wuyts, Dimitris Xygalatas, Michiel van Elk
Summary: Regardless of religious beliefs, scientists are considered more authoritative than spiritual gurus, indicating that science is universally seen as a reliable heuristic for information.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Multidisciplinary Sciences
Diego Candia-Rivera, Vincenzo Catrambone, Julian F. Thayer, Claudio Gentili, Gaetano Valenza
Summary: The century-long debate on bodily states and emotions continues, with this study investigating the brain-heart interplay during emotional experiences. Using a computational model, the researchers found that sympathetic-vagal activity plays a leading and causal role in initiating the emotional response, and the subsequent dynamic interplay between the central and autonomic nervous systems sustains the processing of emotional arousal.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Montisci, Mattia Glauber, Antonio Miceli
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Psychology, Clinical
Graziella Orru, Barbara De Marchi, Giuseppe Sartori, Angelo Gemignani, Cristina Scarpazza, Merylin Monaro, Cristina Mazza, Paolo Roma
Summary: This proof-of-concept paper supports the use of machine learning as a viable alternative to traditional psychometric techniques in developing shorter versions of parent psychological tests. The results show that state-of-the-art machine learning item selection techniques can reduce the length of a test by 72% while capturing 92% of the original test's variance.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Computer Science, Cybernetics
Pasquale Bufano, Niccolo Albertini, Simone Chiarelli, Vincenzo Barone, Marta Valleggi, Gianluca Parrini, Alessandro Tognetti, Valentina Cesari, Angelo Gemignani, Danilo Menicucci
Summary: Previous studies have shown that total sleep deprivation has a significant impact on sustained attention, but these studies have used tests that lack ecological validity. In this study, we evaluated the effects of total sleep deprivation on daily-life activities by using a virtual reality task, and found that sustained attention declines after 36 hours of total sleep deprivation, accompanied by greater cognitive effort.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Pediatrics
Rebecca Ciacchini, Graziella Orru, Elisa Cucurnia, Silvia Sabbatini, Francesca Scafuto, Alessandro Lazzarelli, Mario Miccoli, Angelo Gemignani, Ciro Conversano
Summary: This study aimed to explore the psychological correlates of social media and internet problematic use during the first year of the covid-19 pandemic. Findings showed that 11% of the participants were significantly addicted to social media, largely females. Self-esteem and anxiety were significantly correlated with social media addiction. Gender (female) and trait anxiety were identified as predictors of social media addiction.
Article
Surgery
Bleri Celmeta, Antonio Miceli, Matteo Ferrarini, Mattia Glauber
Summary: This article presents a case of mitral valve re-repair due to early repair failure, utilizing a repeated right anterior minithoracotomy. The surgical procedure was successful and the patient had good clinical outcomes at follow-up.
INNOVATIONS-TECHNOLOGY AND TECHNIQUES IN CARDIOTHORACIC AND VASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maria Grazia Andreassi
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Borghini, Antonella Mercuri, Jonica Campolo, Marina Parolini, Rudina Ndreu, Stefano Turchi, Maria Grazia Andreassi
Summary: A strong relationship between Chr9p21 rs1333049 variant and LTL was identified, and they interactively affect the risk of poor prognosis in CAD patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jonica Campolo, Andrea Borghini, Marina Parolini, Antonella Mercuri, Stefano Turchi, Maria Grazia Andreassi
Summary: Clinical and epidemiological evidence suggests a link between coronary artery disease (CAD) and cancer. This study aimed to identify risk factors and biomarkers that could predict cancer incidence and death in CAD patients. The study found that age, smoking, obesity, and systemic inflammatory indexes were associated with cancer incidence, while age was a predictor of cancer death. Lung and gastrointestinal cancer patients had higher levels of a specific biomarker. The study suggests that reducing risk factors and suppressing chronic inflammation may help prevent cancer in CAD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Guido Vagheggini, Francesca Marzetti, Mario Miniati, Lorenzo Bernardeschi, Mario Miccoli, Giulia Boni Brivio, Simone Meini, Eugenia Panait, Elena Cini, Angelo Gemignani
Summary: This study assessed the impairment at three months in patients who recovered from COVID-19. The findings revealed that a considerable proportion of patients experienced psychological distress, impaired respiratory gas exchange capacity, and worsened quality of life even after recovery.
Article
Psychology, Multidisciplinary
Andrea Poli, Angelo Giovanni Icro Maremmani, Angelo Gemignani, Mario Miccoli
Summary: Mindfulness, achieved through meditation, has been shown to improve attentional functions and emotional well-being. This study aimed to assess the effectiveness of a mindfulness program in reducing anxiety and depression in primary school students. The program successfully lowered anxiety levels and led to changes in temperament characteristics.
BEHAVIORAL SCIENCES
(2022)
