Article
Polymer Science
Emna Chaabouni, Vitalii Tkachenko, Loic Vidal, Noureddine Allouche, Abraham Chemtob
Summary: A novel class of fully photodegradable all-acrylic poly(hydroxyethyl acrylate)-b-poly(o-nitrobenzyl acrylate) (PHEA-PNBA) nanoparticles has been investigated, showing the ability for fast and complete degradation. These nanoparticles are synthesized through dispersion polymerization-induced self-assembly and utilize a self-immolation mechanism for degradation. The focus of the research is on understanding the reaction parameters that control degradation rates.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Jun He, Dongni Lin, Ying Chen, Li Zhang, Jianbo Tan
Summary: A new method has been developed in this study to prepare PNIPAM-based block copolymer nanoparticles with different morphologies through aqueous photoinitiated polymerization-induced self-assembly, and it was found that the reaction temperature plays a crucial role in both morphology and polymerization kinetics of the nanoparticles.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhengping Tan, Wei Lan, Xi Mao, Lianbin Zhang, Xiaobing Luo, Jiangping Xu, Jintao Zhu
Summary: A simple and effective method for preparing Multicompartment micelles (MCMs) by adjusting the hydrodynamics in microfluidic channels was reported. Well-defined MCMs were formed through hydrodynamics-dependent secondary assembly. Quantum dots (QDs) could be selectively loaded into different domains, allowing for tuning of the emission spectrum of MCMs/QDs hybrid particles.
Article
Polymer Science
R. Simonutti, D. Bertani, R. Marotta, S. Ferrario, D. Manzone, M. Mauri, M. Gregori, A. Orlando, M. Masserini
Summary: This study investigates the effect of using different common solvents on the self-assembly behavior of block copolymer nanoparticles, finding that the hydrogen bonding ability of the solvent strongly influences the size and shape of the particles, as well as their cytotoxicity.
Article
Engineering, Chemical
Guanrui Li, Daniel C. C. Barzycki, Ralm G. G. Ricarte
Summary: Polymerization induced self-assembly (PISA) is a method for producing block copolymer nanoparticles in situ. The encapsulation of the drug phenylacetic acid (PA) in poly(glycerol monomethacrylate)-block-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) nanoparticles during PISA was investigated. The morphology of the nanoparticles was characterized and the encapsulation efficiency (p) was quantified. Increasing the PA loading resulted in a shift in the nanoparticle morphology and at a 32 mg/ml PA loading, p maximized at -80%. The impact of increasing the PHPMA degree of polymerization on p was minimal, suggesting the importance of the hydrophilic block for drug encapsulation during PISA.
Article
Polymer Science
Deborah Y. Liu, Daniel Krogstad
Summary: The study explores the use of ionic liquid as both a curing agent and a structure-directing agent in epoxy/BCP blends, achieving a wide range of self-assembled structures in the uncured blends, including hexagonally packed cylinders and lamellar structures. Many compositions undergo phase transitions during the curing process, with some transitions proving to be quite complex.
Article
Polymer Science
Yanyan Zhu, Changhang Huang, Liangshun Zhang, David Andelman, Xingkun Man
Summary: The kinetic paths of structural evolution and formation of block copolymer (BCP) particles were investigated using dynamic self-consistent field theory (DSCFT). The study revealed that the self-assembly process of BCP in a poor solvent leads to the formation of striped ellipsoids, onion-like particles, and double-spiral lamellar particles. The shape transition between onion-like particles and striped ellipsoidal ones can be reversible by controlling the temperature and solvent selectivity. Additionally, changing the intermediate bi-continuous structure into a layered one is crucial for the formation of striped ellipsoidal particles.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Yuhan Wei, Fujun Liu, Min Li, Zhibo Li, Jing Sun
Summary: The solubility effect on the self-assembly of PEG-b-PNPE block copolymer with a crystalline core-forming polypeptoid in aqueous solution was systematically investigated. It was found that the balance between the crystallization and solubility of the polymer dominates the nanostructures. Depending on the restriction of PNPE block crystallization, either 1D nanofibers or 2D nanosheets induced by CDSA were observed.
Article
Chemistry, Multidisciplinary
Xiangmin Ding, Dandan Liu, Xi Jiang, Xuesi Chen, Ronald N. Zuckermann, Jing Sun
Summary: The interplay between crystalline packing and hierarchical assembly is essential for the fabrication of complex superstructures from polymers. This study demonstrates the formation of distinct hierarchical superstructures by tuning the balance between surface energy and crystallization energy of a diblock copolymer containing an N-octylglycine peptoid block. The partially ordered micellar aggregates serve as key intermediates and template the formation of superstructures. The fiber-like branch of the superstructures exhibits living linear growth and shows promise for biomedical applications.
Review
Chemistry, Physical
Yilin Liu, Fangfang Ke, Yuanchao Li, Yi Shi, Zhen Zhang, Yongming Chen
Summary: Significant progress has been made in block copolymer self-assembly in the past few decades. With the development of nanoscience and nanotechnology, more complex structures are needed for block copolymer self-assembly based nanoplatforms to meet specific multimodal or multiplexed applications.
Article
Polymer Science
Isabella R. Dorsman, Matthew J. Derry, Victoria J. Cunningham, Steven L. Brown, Clive N. Williams, Steven P. Armes
Summary: The study discovered an unexpected reduction in dispersion viscosity when heating block copolymer vesicles above a critical temperature, with a thermal transition from vesicles to worms and then to spheres observed. Moreover, the addition of a suitable comonomer was found to lower the critical onset temperature required for the vesicle-to-worm transition, as confirmed by rheology and small-angle X-ray scattering experiments. The thermal transitions observed were irreversible on normal experimental timescales.
Article
Nanoscience & Nanotechnology
Jiajing Li, Paulina A. Rincon-Delgadillo, Hyo Seon Suh, Geert Mannaert, Paul F. Nealey
Summary: Directed self-assembly of block copolymers has attracted interest from the semiconductor industry due to its potential for achieving semiconductor-relevant structures with a relatively simple and low-cost process. However, the kinetic trapping of self-assembling structures into defective states poses challenges for high-volume manufacturing. A study on the kinetics of defect annihilation in chemoepitaxy DSA revealed a statistical model that suggests all dislocations can be removed by sufficiently long annealing time. Further analysis showed that the distribution of defects is largely influenced by the role of guiding stripes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Geon Gug Yang, Jaehyun Ko, Hee Jae Choi, Jang Hwan Kim, Min Hyuk Kim, Chungseong Park, Hyeon Min Jin, Il-Doo Kim, Sang Ouk Kim, Dong-Ha Kim, Kyu Hyo Han
Summary: This study introduces a transparent, flexible, and sensitive gas sensor building platform using multilevel self-assembly of block copolymers and polystyrene colloids. By overlaying two different patterned template structures, a hierarchically porous Pd metal mesh structure is obtained, demonstrating superior sensing performance and high mechanical flexibility.
Article
Chemistry, Multidisciplinary
Jared I. Bowman, Cabell B. Eades, Maria A. Vratsanos, Nathan C. Gianneschi, Brent S. Sumerlin
Summary: Polymerization-induced self-assembly (PISA) is a powerful technique for producing block copolymer nanostructures, and ultrafast photoiniferter PISA can be used to quickly create various nanostructures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Ki Hyun Kim, Yoon Huh, Inkyu Song, Du Yeol Ryu, Jeong Gon Son, Joona Bang
Summary: This article presents a perspective on recent developments in block copolymers (BCPs) and bottlebrush block copolymers (BBCPs), focusing on their potential in creating nanostructures. The first part discusses the progress made in high-chi linear BCPs derived from conventional poly(styrene-b-methyl methacrylate) (PS-b-PMMA) pairs. The second part reviews the literature on BBCPs that have the ability to form supra-100 nm nanostructures. The future prospects of BCP lithography are also discussed.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Chemistry, Applied
Yoko Sakai-Otsuka, Yu Ogawa, Toshifumi Satoh, Wen-Chang Chen, Redouane Borsali
Summary: A carbohydrate-based fullerene derivative was synthesized and applied to a lamellar-forming high-chi block copolymer system to realize an ordered donor/acceptor network. Through thermal annealing, a well-defined D/A lamellar structure with sub-10 nm domain features was achieved. The molecules of the derivative were localized in phase-separated nanodomains without disrupting the lamellar morphology, showing potential for new strategies in blend synthesis.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Hua Wei, Zhenwu Wang, Hua Zhang, Youju Huang, Zongbao Wang, Yang Zhou, Ben Bin Xu, Sami Halila, Jing Chen
Summary: Ionic gel-based electronic devices exhibit ultrahigh stretchability, transparency, and conformal adhesion. By introducing new materials, the technology achieves good performance in various application scenarios. In the future, this approach is expected to develop new tactical sensing applications in smart robotics, human-machine interfaces, and wearable monitoring systems.
CHEMISTRY OF MATERIALS
(2021)
Article
Polymer Science
Anette Lofstrand, Alexei Vorobiev, Muhammad Mumtaz, Redouane Borsali, Ivan Maximov
Summary: Vapor phase infiltration into a self-assembled block copolymer can enhance the etch selectivity for pattern transfer. By optimizing the process parameters, it was found that a high concentration of alumina infiltration can be achieved by reducing the exposure time and using appropriate precursor pulse durations. These results are significant for further understanding of the mechanisms involved in sequential infiltration synthesis and for optimizing carbohydrate-based etch masks for sub-10 nm pattern transfer.
Article
Engineering, Environmental
Jean-Sebastien Benas, Fang-Cheng Liang, Wei-Chen Chen, Chung-Wei Hung, Jung-Yao Chen, Ye Zhou, Su-Ting Han, Redouane Borsali, Chi-Ching Kuo
Summary: This review discusses the encapsulation of perovskite materials with block copolymers (BCPs) and highlights the use of Lewis acid base interaction to improve the stability of perovskite materials.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Marilia Cestari, Barbara Sthefani Caldas, Dyenefer Pereira Fonseca, Rodolfo Bento Balbinot, Danielle Lazarin-Bidoia, Issei Otsuka, Celso Vataru Nakamura, Redouane Borsali, Edvani Curti Muniz
Summary: Nanofibers containing silk fibroin, chondroitin sulfate, and silver sulfadiazine were prepared using electrospinning technique. The addition of poly (ethylene oxide) improved the electrospinnability. The nanofibers had a diameter between 262 and 328 nm before PEO removal and between 242 and 345 nm after PEO removal. CS and SSD remained in the nanofibers, and CS significantly influenced the remaining SSD content. The nanofibers were non-toxic to Vero cells and had antibacterial activity depending on the concentration of CS.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Hamed Ahmadi-Nohadani, Steve Nono-Tagne, Christopher J. Barrett, Issei Otsuka
Summary: A smart photo-actuator based on natural polysaccharides has been developed using electrospinning techniques. By controlling the solvent composition and polymer concentration, continuous nanofibers and nonwoven fabrics with responsive properties to UV and visible light are obtained.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Bassam Felipe Mogharbel, Marco Andre Cardoso, Ana Carolina Irioda, Priscila Elias Ferreira Stricker, Robson Camilotti Slompo, Julia Maurer Appel, Nathalia Barth de Oliveira, Maiara Carolina Perussolo, Claudia Sayuri Sacaki, Nadia Nascimento da Rosa, Dilcele Silva Moreira Dziedzic, Christophe Travelet, Sami Halila, Redouane Borsali, Katherine Athayde Teixeira de Carvalho
Summary: This study describes the development of nanoparticles capable of delivering L-DOPA and curcumin across the blood-brain barrier. The nanoparticles exhibited good biocompatibility and blood compatibility, making them potential formulations for brain delivery of these drugs.
Article
Chemistry, Multidisciplinary
Taiki Nishimura, Satoshi Katsuhara, Chaehun Lee, Brian J. Ree, Redouane Borsali, Takuya Yamamoto, Kenji Tajima, Toshifumi Satoh, Takuya Isono
Summary: This study introduces a novel block copolymer system by utilizing carbohydrates and inorganic hybrids, synthesized through click reactions. The block copolymers demonstrated various microphase-separated structures in both bulk and thin film states, with potential for nanopatterning applications after reactive ion etching.
Article
Chemistry, Multidisciplinary
Antoine Rousseau, Julie Michaud, Stephanie Pradeau, Sylvie Armand, Sylvain Cottaz, Emeline Richard, Sebastien Fort
Summary: Soluble fragments of peptidoglycan called muropeptides are released from the cell wall of bacteria, triggering immune responses in mammals and plants. They play a crucial role in inducing antibiotic resistance in bacteria. Efficient production methods for muropeptides are desired to understand their mechanism and develop new antibacterial and immunostimulant agents.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Sukanya Luang, Xavier Fernandez-Luengo, Alba Nin-Hill, Victor A. Streltsov, Julian G. Schwerdt, Santiago Alonso-Gil, James R. Ketudat Cairns, Stephanie Pradeau, Sebastien Fort, Jean-Didier Marechal, Laura Masgrau, Carme Rovira, Maria Hrmova
Summary: In this study, the researchers investigate the binding and conformational behavior of beta-D-glucosides in the barley beta-D-glucan glucohydrolase. They find that the Trp286/Trp434 clamp plays a crucial role in substrate hydrolysis. Mutations in the clamp affect processive catalysis, and phylogenomic analysis reveals the evolutionary advantage of the tryptophan clamp.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Tomas A. Rush, Joanna Tannous, Matthew J. Lane, Muralikrishnan Gopalakrishnan Meena, Alyssa A. Carrell, Jacob J. Golan, Milton T. Drott, Sylvain Cottaz, Sebastien Fort, Jean-Michel Ane, Nancy P. Keller, Dale A. Pelletier, Daniel A. Jacobson, David Kainer, Paul E. Abraham, Richard J. Giannone, Jesse L. Labbe
Summary: This study demonstrates that lipo-chitooligosaccharides (LCOs) have a significant impact on the fungal metabolic profile of the human pathogen Aspergillus fumigatus, affecting the competitive dynamics between fungi and bacteria. These findings highlight the importance of LCOs in non-plant-symbiotic interactions.
Article
Chemistry, Multidisciplinary
Paul Rivollier, Eric Samain, Sylvie Armand, Isabelle Jeacomine, Emeline Richard, Sebastien Fort
Summary: In this study, efficient gram-scale synthesis of α2,3- and α2,6-sialyllactose oligosaccharides and mimetics was achieved through metabolically engineered bacterial cells grown at high cell density. New Escherichia coli strains were designed to co-express sialic acid synthase and N-acylneuraminate cytidylyltransferase, along with α2,3-sialyltransferase or α2,6-sialyltransferase. The resulting sialylated oligosaccharides showed binding affinity for Sambucus nigra lectin and proved to be stable competitive inhibitors of Vibrio cholerae neuraminidase, indicating their potential for anti-adhesion therapy against influenza viral infections.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kevin Renault, Yoan Capello, Shun Yao, Sami Halila, Anthony Romieu
Summary: Latent cyclic carbon-centered nucleophiles, known as latent C-nucleophiles, have proven to be valuable in the field of reaction-based fluorescent probes. They are used to introduce a Michael acceptor moiety for analyte detection or to promote fluorogenic cascade reactions. C-nucleophiles with additional reactive handles offer opportunities for tuning properties and using ad hoc chemical moiety for drug-releasing capabilities. By exploring functionalized derivatives of barbituric acid, piperidine-2,4-dione, and Meldrum's acid, a versatile candidate suitable for structural optimization was identified. This study opens up possibilities for multifunctional fluorescence imaging probes and optically modulated theranostics.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Mycology
Manuel I. Villalobos Solis, Nancy L. Engle, Margaret K. Spangler, Sylvain Cottaz, Sebastien Fort, Junko Maeda, Jean-Michel Ane, Timothy J. Tschaplinski, Jesse L. Labbe, Robert L. Hettich, Paul E. Abraham, Tomas A. Rush
Summary: The role of lipo-chitooligosaccharides (LCOs) as signaling molecules in fungal-plant symbiotic relationships is being redefined. New evidence suggests that LCOs are more common in fungi than previously thought and they affect different aspects of fungal growth and development. However, there is still no scientific evidence of the effects of LCOs on Laccaria bicolor.
FRONTIERS IN FUNGAL BIOLOGY
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Anette Lofstrand, Reza Jafari Jam, Muhammad Mumtaz, Karolina Mothander, Tommy Nylander, Alexei Vorobiev, Ahibur Rahaman, Wen-Chang Chen, Redouane Borsali, Ivan Maximov
Summary: This study demonstrates the successful pattern transfer of 6 nm half-pitch horizontal cylinders into silicon using sequential infiltration synthesis, with an increasing alumina content after each infiltration cycle and reaching 2.4 vol% after four cycles. A dry etching process for sub-10 nm patterns was developed, achieving an etch selectivity of more than 2:1 of silicon over alumina-like etch mask material. These results are expected to be useful for nanofabrication and applications in the sub-10 nm regime.
ADVANCES IN PATTERNING MATERIALS AND PROCESSES XXXVIII
(2021)