Journal
BIOMACROMOLECULES
Volume 14, Issue 1, Pages 1-9Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm300814h
Keywords
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Funding
- University of Buenos Aires [UBACyT X-003]
- Agencia Nacional de Promocion Cientifica y Tecnologica [ANPCyT PICT 06-33973]
- National Science Research Council of Argentina [CONICET PIP 112-200801-02533269, PIP 0220, UBACyT W636]
- CONICET
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Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.
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