Article
Oncology
Fanny Pinot, David Bourhis, Vincent Bourbonne, Romain Floch, Maelle Mauguen, Frederique Blanc-Beguin, Ulrike Schick, Mohamed Hamya, Ronan Abgral, Gregoire Le Gal, Pierre-Yves Salaun, Francois Lucia, Pierre-Yves Le Roux
Summary: This study aimed to develop and evaluate an automated threshold method based on total lung function for the delineation of lung functional volumes using Gallium-68 MAA lung PET/CT imaging. The results showed that the WLF threshold method provided more reliable and consistent functional volumes, especially in patients with normal PFTs, as compared to the pmax method. This new approach, relatively unaffected by the presence of hot spots, is clinically meaningful for clinicians.
Article
Medicine, General & Internal
Jimmy Z. Yu, Tobias Granberg, Roya Shams, Sven Petersson, Magnus Skold, Sven Nyren, Johan Lundberg
Summary: This study used DCE-MRI to detect pulmonary perfusion disturbances in individuals with persistent dyspnea after COVID-19. The results showed that the post-COVID group had longer pulmonary perfusion time compared to the control group. There was a correlation between dyspnea and perfusion parameters in male patients, but not in female patients. These findings suggest sex differences in the mechanisms underlying post-COVID dyspnea.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Anne-Eva van der Wijk, Theodosia Georgakopoulou, Rob Steendam, Johan Zuidema, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel
Summary: Drug development for neurological diseases faces challenges due to the blood-brain barrier. This study examined the potential of biodegradable microspheres to cross the blood-brain barrier and deliver drugs to the brain tissue. The results showed that microspheres of various compositions were able to extravasate into the brain parenchyma without causing significant tissue damage.
Review
Radiology, Nuclear Medicine & Medical Imaging
Simon M. F. Triphan, Grzegorz Bauman, Philip O. Konietzke, Marilisa Konietzke, Mark Wielpuetz
Summary: Lung perfusion, an essential process for oxygenation, is regulated by hypoxic pulmonary vasoconstriction (HPV) in response to obstructive airway diseases. Various MRI techniques have been developed to visualize lung perfusion, and dynamic-contrast enhanced MRI is widely used in clinical assessment. Non-contrast techniques are still being researched and validated. Preliminary data on these techniques in evaluating therapy effects are emerging. Level of Evidence 5, Technical Efficacy Stage 5.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Materials Science, Biomaterials
Yixin Zhang, Hanwen Liang, Qian Luo, Jianlin Chen, Nan Zhao, Wenxia Gao, Yuji Pu, Bin He, Jing Xie
Summary: Biodegradable polymer particles with varying properties were prepared and injected for aesthetic medicine applications, showing a correlation between degradation rate and collagen regeneration. Faster degrading microspheres induced inflammatory responses, while moderate molecular weight microspheres demonstrated long-term collagen regeneration effects. Size, morphology, and degradation behavior of the microspheres were found to impact foreign body reactions and collagen regeneration.
REGENERATIVE BIOMATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Antti Nykanen, Andrea Mariscal, Aadil Ali, Olivia Hough, Vinicius S. Michaelsen, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee
Summary: Near-infrared fluorescence (NIRF) imaging enables noninvasive real-time evaluation of lung perfusion and edema during ex vivo lung perfusion (EVLP). Prospective clinical studies are needed to determine the role of NIRF imaging in donor lung assessment and selection, and prediction of posttransplant outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucy Edwards, John C. Waterton, Josephine Naish, Christopher Short, Thomas Semple, Geoff J. M. Parker, Marta Tibiletti
Summary: The purpose of this study was to pool and summarize published data of pulmonary blood flow, pulmonary blood volume, and mean transit time of the human lung obtained through perfusion MRI or CT. The study concluded that reference values for healthy lung tissue were obtained, but data on diseased lung were insufficient for analysis.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Efe Ilicak, Greta Thater, Safa Ozdemir, Jascha Zapp, Lothar R. Schad, Stefan O. Schoenberg, Frank G. Zoellner, Meike Weis
Summary: This study investigated the feasibility of non-contrast-enhanced functional lung imaging in 2-year-old children after congenital diaphragmatic hernia repair. The results showed that this method successfully generated ventilation and perfusion maps, and the results were consistent with dynamic contrast-enhanced MRI. This method provides a new option for lung imaging in CDH patients without the need for ionizing radiation or contrast agents.
EUROPEAN RADIOLOGY
(2023)
Article
Engineering, Biomedical
Deteng Zhang, Honghao Zheng, Keyu Geng, Jianhua Shen, Xue Feng, Peifang Xu, Yiyuan Duan, Yifan Li, Ronghuan Wu, Zhongru Gou, Changyou Gao
Summary: Biodegradable polymer microparticles with hierarchical textures were fabricated in this study, with the surface microstructures stabilized against annealing and enhanced cell-material interaction through dopamine deposition. These microspheres significantly promoted bone regeneration in vivo, as confirmed by various analyses.
Article
Pharmacology & Pharmacy
E. Kaplan, S. Kaplan
Summary: The study found that CTPI parameters including hepatic blood flow (BF), time to start (TTS) and hepatic perfusion index (HPI) can predict progressive disease (PD) in HCC lesions in the third month after TARE treatment. However, the CTPI parameters in the first month after TARE did not play a significant role in predicting treatment response and determining the effects on the microvascular level.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Optics
Qingqing Shang, Fen Tang, Lingya Yu, Hamid Oubaha, Darwin Caina, Songlin Yang, Sorin Melinte, Chao Zuo, Zengbo Wang, Ran Ye
Summary: The challenge of low imaging contrast of microspheres in air can be effectively overcome by using partially Ag-plated microspheres, which significantly enhances the imaging contrast of the system. This was experimentally verified by imaging the Blu-ray disc surface and colloidal particle arrays.
Article
Chemistry, Applied
Fan Leng, Sai Lei, Bin Luo, Siyao Lv, Long Huang, Xulin Jiang
Summary: This study introduces a novel size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres, and demonstrates its effectiveness in hemostasis and endovascular embolization through in vitro and in vivo experiments.
CARBOHYDRATE POLYMERS
(2022)
Article
Cell Biology
Stephan Arni, Tatsuo Maeyashiki, Necati Citak, Isabelle Opitz, Ilhan Inci
Summary: The study found that subnormothermic EVLP at 28 degrees Celsius improved lung function and inflammatory parameters, which were also observed post left lung transplantation.
Article
Green & Sustainable Science & Technology
Darija Lemic, Matej Oreskovic, Katarina M. Mikac, Marijan Marijan, Slaven Juric, Kristina Vlahovicek-Kahlina, MarkoD Vincekovic
Summary: This study explores biopolymeric microspheres containing apitoxin as a novel environmentally friendly formulation for plant protection. The encapsulated apitoxin has a steady initial and long residual effect on insects, making it an effective alternative eco-friendly control method in agricultural production. The microspheres loaded with apitoxin demonstrated significantly better gastric action compared to contact action, showing promising potential for future application and development.
Article
Medicine, General & Internal
Jianghui Duan, Sheng Xie, Hongliang Sun, Jing An, Huan Li, Ling Li, Robert Grimm, Andreas Voskrebenzev, Jens Vogel-Claussen
Summary: PREFUL MRI can be used as an alternative test for the detection of CPE, without the need for breath-holding, contrast agents, or ionizing radiation. The study found that PW-PREFUL MRI has good diagnostic performance for chronic pulmonary embolism. Compared with V/Q SPECT/CT imaging, PW-PREFUL MRI can show segmental and subsegmental hypoperfusion with moderate agreement. The quantitative results indicate that the QN value is lower and QDP value is higher in the CPE group compared to the non-CPE group.
FRONTIERS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Lan Wu, Lin-Ping Wu, Jingya Wu, Jin Sun, Zhonggui He, Cristina Rodriguez-Rodriguez, Katayoun Saatchi, Lea Ann Dailey, Urs O. Hafeli, Dongmei Cun, Mingshi Yang
Summary: This study found that LPNs showed a prolonged and enhanced gene silencing effect compared to LPXs after pulmonary administration, possibly due to the sustained release characteristics of PLGA and the more stable retention of LPNs in lung tissue. Additionally, the presence of PLGA effectively alleviated the acute inflammatory effect of cationic lipids on the lungs. The findings suggest that PLGA-based LPNs may be an effective formulation strategy for sustained gene silencing effects in the lung via pulmonary administration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Yael N. Slavin, Kristina Ivanova, Javier Hoyo, Ilana Perelshtein, Gethin Owen, Anne Haegert, Yen-Yi Lin, Stephane LeBihan, Aharon Gedanken, Urs O. Hafeli, Tzanko Tzanov, Horacio Bach
Summary: The study developed stable and biocompatible silver-lignin nanoparticles with antibacterial activity through a green synthesis approach, showing potential as a treatment for multidrug-resistant bacterial infections and as an anti-inflammatory agent.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Tullio V. F. Esposito, Helene Stutz, Cristina Rodriguez-Rodriguez, Marta Bergamo, Lovelyn Charles, Reka Geczy, Colin Blackadar, Jorg P. Kutter, Katayoun Saatchi, Urs O. Hafeli
Summary: Albumin microparticles, particularly macroaggregated albumin (MAA), are commonly used in pharmaceutical applications for drug delivery and imaging. A microfluidic platform was developed to create more tunable and precise MAA particles, demonstrating potential for pharmaceutical utility in targeted drug delivery and distribution assessment in vivo. The microfluidic chip offers an elegant and controllable method for preparing albumin microparticles for biomedical applications.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Zeynab Nosrati, Pedro L. Esquinas, Cristina Rodriguez-Rodriguez, Thuy Tran, Anil Maharaj, Katayoon Saatchi, Urs O. Hafeli
Summary: Radiolabeling with dual isotopes of I-123 and I-125 allows for simultaneous evaluation of drug pharmacokinetics and biodistribution, with a new technique developed to overcome gamma spectrum overlap. The method was successfully applied in a study of fenofibrate delivery in rats, showing promising potential for quantitative analysis of drug performance in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Cyril Tous, Ning Li, Ivan P. Dimov, Samuel Kadoury, An Tang, Urs O. Hafeli, Zeynab Nosrati, Katayoun Saatchi, Gerald Moran, Marcus J. Couch, Sylvain Martel, Simon Lessard, Gilles Soulez
Summary: This study experimentally verified a theoretical forces balance model to improve the success rate of MRN. By manipulating MRI gradients, the direction and velocity of injected particles were successfully controlled in the experiment, providing important insights for the application of MRN.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose Carlos De la Vega, Pedro Luis Esquinas, Jovan Kaur Gill, Selin Jessa, Bradford Gill, Yogesh Thakur, Katayoun Saatchi, Urs O. Hafeli
Summary: The study compared the image quality and absorbed dose of iodine and rhenium-based X-ray contrast agents, and demonstrated the potential of rhenium-doped scaffolds to enhance catheter imaging. Monte Carlo simulations suggested a reduction in absorbed dose of high kVp X-rays with high-quality image acquisition, aiding in rapid and precise catheter placement.
CONTRAST MEDIA & MOLECULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Gokce Engudar, Cristina Rodriguez-Rodriguez, Narenda Kumar Mishra, Marta Bergamo, Guillaume J. Amouroux, Knud J. Jensen, Katayoun O. Saatchi, Urs O. Hafeli
Summary: This study found that the pharmacokinetics of insulin can be directly controlled with metal ions after covalent attachment of specific abiotic ligands. This provides new insights for exploring novel drug delivery strategies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Colin Blackadar, Ka-Yee Grace Choi, Mary F. Embree, Heather M. Hennkens, Cristina Rodriguez-Rodriguez, Robert E. W. Hancock, Katayoun Saatchi, Urs O. Hafeli
Summary: Single-photon emission computed tomography (SPECT) is a useful tool for noninvasively visualizing the biodistribution of silver-containing compounds in rodents. The study found that antimicrobial silver nanoparticles, formed by neutron irradiation of palladium foil, can be stably incorporated into the lungs of mice without significant uptake in other organs. In a mouse model of pulmonary Pseudomonas aeruginosa infection, the nanoparticles effectively reduced bacterial burden without inducing excessive inflammation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Ning Li, Cyril Tous, Ivan P. Dimov, Dominic Cadoret, Phillip Fei, Yasamin Majedi, Simon Lessard, Zeynab Nosrati, Katayoun Saatchi, Urs O. Hafeli, An Tang, Samuel Kadoury, Sylvain Martel, Gilles Soulez
Summary: This study aimed to develop a method for accurate quantification and localization of superparamagnetic nanoparticles and validate the method in a phantom and swine model. The results showed that magnetic drug-eluting beads (MDEBs) can be steered into desired body regions using 3D VIBE sequences, and the volume relationship allows for accurate assessment of MDEB distribution.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Tullio V. F. Esposito, Cristina Rodriguez-Rodriguez, Colin Blackadar, Evan F. Haney, Daniel Pletzer, Robert E. W. Hancock, Katayoun Saatchi, Urs O. Hafeli
Summary: This study investigated the pharmacokinetics of a well-characterized IDR molecule, IDR-1018. The distribution and clearance of the peptide were found to vary depending on the route of administration and dose. The study also revealed that local administration could avoid peptide toxicity associated with systemic administration.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Tanya Saxena, Claire Sie, Kristine Lin, Daisy Ye, Katayoun Saatchi, Urs O. Hafeli
Summary: Peptides are small biomolecules that can stimulate or inhibit important functions in the human body. However, the clinical use of peptides through oral delivery is limited due to their sensitive structure and physiological barriers in the gastrointestinal tract. These barriers can be overcome by chemical and mechanical approaches, and nuclear imaging provides a better platform for observing the gastrointestinal transit and quantitative distribution of radiolabeled peptides. This review provides a brief background on the oral delivery of peptides and discusses how nuclear imaging can aid in the study of their gastrointestinal transit.
Article
Pharmacology & Pharmacy
Katayoun Saatchi, Francois Benard, Navjit Hundal, Joshua Grimes, Sergey Shcherbinin, Maral Pourghiasian, Donald E. Brooks, Anna Celler, Urs O. Hafeli
Summary: This study aimed to prepare and evaluate a gallium-functionalized long-circulating polymer for cardiac blood pool imaging. The results showed that this polymer had good biodistribution, low toxicity, and lower radiation dose, making it suitable for cardiac blood pool imaging.
Article
Chemistry, Multidisciplinary
Lennart Bohrmann, Tobias Burghardt, Cristina Rodriguez-Rodriguez, Matthias M. Herth, Katayoun Saatchi, Urs O. Hafeli
Summary: This study presents a modular conjugation strategy based on click chemistry for the modification of high molecular weight hyperbranched polyglycerol (HPG) with sgc8 aptamer, fluorescent dyes, and In-111. The results indicate strong affinity of sgc8 against solid tumor-derived cell lines, but nonspecific uptake of scrambled ssDNA-functionalized HPG in cells highlights inherent challenges of aptamer-targeted probes. The study validates HPG-sgc8 as a nontoxic nanoprobe with high affinity against breast and lung cancer cells, and shows increased stability compared to free sgc8.
Review
Medicine, Research & Experimental
Lennart Bohrmann, Tobias Burghardt, Charles Haynes, Katayoun Saatchi, Urs O. Hafeli
Summary: Aptamers are single stranded oligonucleotides that can recognize a variety of molecular targets with high specificity and affinity. They have been increasingly used to create targeted probes for in vivo molecular imaging and therapy, covering major imaging modalities such as nuclear imaging, magnetic resonance imaging, x-ray computed tomography, echography, fluorescence imaging, as well as newer modalities like surface enhanced Raman spectroscopy.