Role of nuclear Lamin A/C in cardiomyocyte functions

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations

(2013) Takuro Arimura et al.   CARDIOVASCULAR RESEARCH

Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation

(2013) W. Wu et al.   HUMAN MOLECULAR GENETICS

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Mutations in LMNA Modulate the Lamin A - Nesprin-2 Interaction and Cause LINC Complex Alterations

(2013) Liu Yang et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Mapping of lamin A- and progerin-interacting genome regions

(2012) Nard Kubben et al.   CHROMOSOMA

Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers

(2012) Ingrid A.W. van Rijsingen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Risk Factors for Malignant Ventricular Arrhythmias in Lamin A/C Mutation Carriers

(2012) Ingrid A.W. van Rijsingen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

(2012) J. C. Choi et al.   Science Translational Medicine

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

A truncated lamin A in the Lmna−/−mouse line

(2012) Daniel Jahn et al.   Nucleus

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene

(2011) A. Muchir et al.   CARDIOVASCULAR RESEARCH

LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle

(2011) George Dialynas et al.   HUMAN MOLECULAR GENETICS

Post-natal myogenic and adipogenic developmental

(2011) Nard Kubben et al.   Nucleus

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LMNA E82K Mutation Activates FAS and Mitochondrial Pathways of Apoptosis in Heart Tissue Specific Transgenic Mice

(2010) Dan Lu et al.   PLoS One

Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency

(2010) C. Coffinier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins

(2008) A. Muchir et al.   HUMAN MOLECULAR GENETICS

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

(2008) José María González et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease

(2007) Cordula M. Wolf et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY