Journal
BIOLOGY OF THE CELL
Volume 106, Issue 1, Pages 1-12Publisher
WILEY
DOI: 10.1111/boc.201300054
Keywords
Kinesin; Mitosis; Microtubule; Phosphorylation; tpx2
Categories
Funding
- Myhrvold Family Fellowship from the Fannie and John Hertz Foundation
- Malkin Scholars Program from the Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Medical Scientist Training Program training grant [GM08152]
- Cellular and Molecular Basis of Disease training grant [GM08061]
- National Institutes of Health [GM072656, GM107209]
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Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and high fidelity. A core element of this machinery is the kinesin-5 motor protein, which plays essential roles in spindle formation and maintenance. In this review, we discuss how the structural and mechanical properties of kinesin-5 motors uniquely suit them to their mitotic role. We describe some of the small molecule inhibitors and regulatory proteins that act on kinesin-5, and discuss how these regulators may influence the process of cell division. Finally, we touch on some more recently described functions of kinesin-5 motors in non-dividing cells. Throughout, we highlight a number of open questions that impede our understanding of both this motor's function and the potential utility of kinesin-5 inhibitors.
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