Article
Obstetrics & Gynecology
Ann-Kristin Dicke, Jakob Albrethsen, Bradley L. Hoare, Margot J. Wyrwoll, Alexander S. Busch, Daniela Fietz, Adrian Pilatz, Clara Buehlmann, Anders Juul, Sabine Kliesch, Joerg Gromoll, Ross A. D. Bathgate, Frank Tuettelmann, Birgit Stallmeyer
Summary: This study reveals that bi-allelic loss-of-function variants in the INSL3 and RXFP2 genes are associated with bilateral cryptorchidism and male infertility, while heterozygous variant carriers are unaffected phenotypically. These findings have diagnostic value for patients with familial/bilateral cryptorchidism and shed light on the importance of INSL3 and RXFP2 in testicular descent and fertility.
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Shouxing Duan, Xuewu Jiang, Jianhong Li, Maxian Fu, Zhuo Li, Yiyi Cheng, Yangmu Zhuang, Ming Yang, Wenfeng Xiao, Hongyan Ping, Yao Xie, Xiaojun Xie, Xuan Zhang
Summary: Testicular hypoplasia can lead to sexual and reproductive problems, as well as an increased risk of cancer. Previous research has neglected the study of abnormal development of the gubernaculum, which plays a key role in testicular hypoplasia. This study investigated the mechanism by which INSL3 regulates the proliferation, migration, and apoptosis of gubernacular cells, and found that INSL3 activates the PLC/PKC signaling pathway to promote cell growth and migration.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Endocrinology & Metabolism
Heidi P. Elamo, Helena E. Virtanen, Jorma Toppari
Summary: Cryptorchidism, or undescended testis, is a common genital malformation in newborn male babies. Its etiology is complex and involves genetic, hormonal, environmental, and other factors. Understanding the genetics of cryptorchidism and testicular regression is important for prevention and treatment of this condition.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Richard Ivell, Linn Salto Mamsen, Claus Yding Andersen, Ravinder Anand-Ivell
Summary: INSL3 is a peptide hormone produced and secreted by fetal Leydig cells in the testes. It acts through the RXFP2 receptor to promote testis descent in male fetuses and serves as an important biomarker for Leydig cell differentiation. Maternal exposure to endocrine disrupting chemicals may reduce INSL3 levels and lead to cryptorchidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Ali Mohammed Pitia, Itaru Minagawa, Yasuyuki Abe, Keiichiro Kizaki, Koh-ichi Hamano, Hiroshi Sasada, Kazuyoshi Hashizume, Tetsuya Kohsaka
Summary: This study investigates the function of INSL3 in pregnant goats, showing that the corpus luteum acts as both a source and target of INSL3 while extra-ovarian reproductive organs also serve as targets. Expression levels of INSL3 and RXFP2 peak in middle pregnancy in the corpus luteum, while RXFP2 expression levels in extra-ovarian reproductive organs vary among different organs and remain relatively stable during pregnancy. These findings provide evidence of an active intra- and extra-ovarian INSL3 hormone-receptor system operating during pregnancy in goats.
CELL AND TISSUE RESEARCH
(2021)
Article
Environmental Sciences
Wadson Rodrigues Rezende, Lia Raquel de Souza Santos, Lilian Franco-Belussi, Classius De Oliveira
Summary: This study examined the effects of agricultural activities on the testicular morphology of three neotropical anuran species, revealing different sensitivities to agricultural pressures among the species.
ENVIRONMENTAL POLLUTION
(2021)
Review
Endocrinology & Metabolism
Aditi Sharma, Suks Minhas, Waljit S. Dhillo, Channa N. Jayasena
Summary: Male infertility due to testicular failure is a common issue, with multiple factors contributing to this condition. While new therapeutic approaches have been developed, there is currently a lack of high-quality clinical trial data available.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Veterinary Sciences
Yongfu La, Xiaoming Ma, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan
Summary: In this study, the expression patterns of miRNAs in yak testes at different development stages were analyzed using deep sequencing data. A total of 737 known and 359 novel miRNAs were identified. GO annotation and KEGG pathway analysis revealed the involvement of various target genes in different biological processes. The qRT-PCR results confirmed the consistency with the sequencing data.
BMC VETERINARY RESEARCH
(2023)
Article
Biology
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander Agoulnik
Summary: Specific small molecule RXFP2 agonists induce proper development of reproduction and bone through experimental validation, providing potential for oral administration.
COMMUNICATIONS BIOLOGY
(2022)
Article
Environmental Sciences
Gustavo Nazareno Monteiro, Douglas Santos Monteiro, Rodrigo Juliano Oliveira, Andrea Luiza Cunha-Laura, Ernani Aloysio Amaral, Sarah Alves Auharek
Summary: This study aimed to evaluate the testicular toxicity of Terephthalic acid (TPA) on male mice exposed in utero and during lactation. The results showed that TPA only changed reproductive parameters in the fetal period and high concentrations of TPA significantly altered the volumetric ratio of testicular elements.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Angela K. Lucas-Herald, Rod T. Mitchell
Summary: Sertoli cells play an important role in gonadal development, germ cell survival, and spermatogenesis. The levels of AMH and inhibin B in individuals with DSD are regulated and can impact their gonadal function throughout life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Gustavo Nazareno Monteiro, Douglas Santos Monteiro, Rodrigo Juliano Oliveira, Andrea Luiza Cunha-Laura, Ernani Aloysio Amaral, Sarah Alves Auharek
Summary: The present study aimed to evaluate the testicular toxicity of TPA on male mice exposed in utero and during lactation. The results showed that TPA had an effect on reproductive parameters in the fetal period but not in adulthood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Fisheries
Shriya Purohit, Partigya Sharma, Gaurav Bhatt, Sachin Kothiyal, Mahender Singh, Prakash Nautiyal, Indrashis Bhattacharya
Summary: This study examines the seasonal variations of testicular development in Schizothorax plagiostomus, a popular game-food fish found in the cold waters of mountainous regions in India. The study reveals changes in testicular-somatic index throughout the year and the presence of different types of sperm cells at different reproductive phases. The study also evaluates the semen volume, sperm density, and motility in male brooders, providing valuable information for conservation and artificial breeding programs of this species.
AQUACULTURE REPORTS
(2022)
Article
Multidisciplinary Sciences
Seiya Oura, Akinori Ninomiya, Fuminori Sugihara, Martin M. Matzuk, Masahito Ikawa
Summary: Characterization of protein-protein interactions is crucial for understanding protein functions. Proximity-dependent biotin identification has been explored as an alternative method for mapping transient protein-protein interactions. In this study, we applied proximity labeling proteomics in testis and identified components of a complex involved in cell-cycle gene expression.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Gertjan Vereecke, Justine Defreyne, Dorien Van Saen, Sarah Collet, Jo Van Dorpe, Guy T'Sjoen, Ellen Goossens
Summary: This study aimed to investigate the effects of hormonal therapy on spermatogenesis in transgender women (TW), and found that adequate hormonal therapy can lead to complete suppression of spermatogenesis in most cases, but in some cases, spermatogenesis may still occur. It is crucial to discuss sperm preservation before starting hormone therapy.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Luca De Toni, Alexander I. Agoulnik, Marco Sandri, Carlo Foresta, Alberto Ferlin
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Cell Biology
Hooi Hooi Ng, Maria Esteban-Lopez, Alexander I. Agoulnik
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Meeting Abstract
Endocrinology & Metabolism
Robert Bennett, Frederick Hamel, Ronda L. Simpson, Alexander I. Agoulnik
Article
Biochemistry & Molecular Biology
Elena M. Kaftanovskaya, Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Courtney Myhr, Brian A. Ho, Briana A. Cervantes, Thomas D. Shupe, Mahesh Devarasetty, Xin Hu, Xin Xu, Samarjit Patnaik, Kenneth J. Wilson, Elena Barnaeva, Marc Ferrer, Noel T. Southall, Juan J. Marugan, Colin E. Bishop, Irina U. Agoulnik, Alexander I. Agoulnik
Meeting Abstract
Biochemistry & Molecular Biology
Alexander Agoulnik, Hooi Ng, Mariluz Soula, Bryan Rivas, Juan Marugan
Article
Multidisciplinary Sciences
Yasemin Ceyhan, Manqi Zhang, Jingtao Guo, Carlos G. Sandoval, Jean Vacher, Elena M. Kaftanovskaya, Alexander I. Agoulnik, Irina U. Agoulnik
Article
Genetics & Heredity
Anbarasi Kothandapani, Samantha R. Lewis, Jessica L. Noel, Abbey Zacharski, Kyle Krellwitz, Anna Baines, Stephanie Winske, Chad M. Vezina, Elena M. Kaftanovskaya, Alexander Agoulnik, Emily M. Merton, Martin J. Cohn, Joan S. Jorgensen
Review
Endocrinology & Metabolism
Maria Esteban-Lopez, Alexander Agoulnik
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Biology
Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya, Judy L. Vasquez, Jean Vacher, Filip K. Knop, Lubov Nathanson, Alexander I. Agoulnik, Michael M. Ittmann, Irina U. Agoulnik
Summary: Research has shown that INPP4B signaling can protect mice from diet-induced metabolic dysfunction and help prevent multiple cancers associated with this condition.
COMMUNICATIONS BIOLOGY
(2021)
Article
Physiology
Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J. Wilson, Juan J. Marugan, Alexander Agoulnik
Summary: ML290 has been demonstrated to have renal protective effects in the UUO mouse model by reducing apoptosis and remodeling the extracellular matrix in the kidney.
FRONTIERS IN PHYSIOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Maria Esteban-Lopez, Kenneth Wilson, Courtney Myhr, Elena Kaftanovskaya, Mark Henderson, Noel Southall, Xin Hu, Elena Barnaeva, Mare Ferrer, David Kim
Review
Reproductive Biology
Yasemin Ceyhan, Manqi Zhang, Carlos G. Sandoval, Alexander Agoulnik, Irina U. Agoulnik
Summary: Phosphatidylinositol polyphosphate phosphatases (PI phophatases) are important for testicular function and spermatogenesis. They regulate various processes such as cellular signaling and cytoskeletal organization. Deficiency of PI phosphatases can lead to infertility in both mice and humans.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biology
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander Agoulnik
Summary: Specific small molecule RXFP2 agonists induce proper development of reproduction and bone through experimental validation, providing potential for oral administration.
COMMUNICATIONS BIOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Hooi Hooi Ng, Daniela Medina, Kenneth Wilson, Juan Marugan, Alexander Agoulnik, Joshua Hutcheson
Meeting Abstract
Cardiac & Cardiovascular Systems
Hooi Hooi Ng, Daniela Medina, Alexander I. Agoulnik, Joshua Hutcheson