Journal
BIOLOGY OF REPRODUCTION
Volume 86, Issue 4, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.111.096826
Keywords
acid-base transporter; epithelia; male reproductive tract; pH regulation; reproduction; sperm capacitation
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Funding
- National Natural Science Foundation of China [31000517, 30900513]
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HCO3- plays critically important roles during virtually the entire process of reproduction in mammals, including spermatogenesis, sperm capacitation, fertilization, and development of early stage embryos. Therefore, the acid-base balance in the male and female reproductive tracts must be finely modulated. The fluid milieu in the epididymis is acidic, containing very low concentration of HCO3-. In this acidic low HCO3- environment, mature sperm are rendered quiescent in the epididymis. In contrast, the luminal fluid in the female uterus and oviduct is alkaline, with very high concentration of HCO3- that is essential for sperm to fulfill fertilization. HCO3- transporter of solute carrier 4 (SLC4) and SLC26 families represent the major carriers for HCO3- transport across the plasma membrane. These transporters play critical roles in intracellular pH regulation and transepithelial HCO3- transport. The physiological roles of these transporters in mammalian reproduction are of fundamental interest to investigators. Here we review recent progress in understanding the expression of HCO3- transporters in reproductive tract tissues as well as the physiological roles of these transporters in mammalian reproduction.
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