Kisspeptins in Reproductive Biology: Consensus Knowledge and Recent Developments1

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

(2011) Janette H. Quennell et al.   ENDOCRINOLOGY

Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain

(2011) Shel-Hwa Yeo et al.   ENDOCRINOLOGY

Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

(2011) Jeremy T. Smith et al.   ENDOCRINOLOGY

Kisspeptin Regulates Gonadotroph and Somatotroph Function in Nonhuman Primate Pituitary via Common and Distinct Signaling Mechanisms

(2011) Raúl M. Luque et al.   ENDOCRINOLOGY

Regulation ofKiss1Expression by Sex Steroids in the Amygdala of the Rat and Mouse

(2011) Joshua Kim et al.   ENDOCRINOLOGY

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat

(2010) Víctor M. Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neurokinin B and the hypothalamic regulation of reproduction

(2010) Naomi E. Rance et al.   BRAIN RESEARCH

Kisspeptins: Bridging energy homeostasis and reproduction

(2010) Juan M. Castellano et al.   BRAIN RESEARCH

The Neurobiology of Preovulatory and Estradiol-Induced Gonadotropin-Releasing Hormone Surges

(2010) Catherine A. Christian et al.   ENDOCRINE REVIEWS

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

(2010) Ginah L. Kim et al.   ENDOCRINOLOGY

BAX-Dependent and BAX-Independent Regulation ofKiss1Neuron Development in Mice

(2010) Sheila J. Semaan et al.   ENDOCRINOLOGY

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

(2010) Kathryn Backholer et al.   ENDOCRINOLOGY

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

(2010) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep

(2010) Heather J. Billings et al.   ENDOCRINOLOGY

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

(2010) Michael N. Lehman et al.   ENDOCRINOLOGY

The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons

(2010) E. Hrabovszky et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Decrease in HypothalamicKiss1andKiss1rExpression: A Potential Mechanism for Fasting-induced Suppression of the HPG Axis in the Adult Male Rhesus Monkey (Macaca mulatta)

(2010) F. Wahab et al.   HORMONE AND METABOLIC RESEARCH

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

(2010) Jose Donato et al.   JOURNAL OF CLINICAL INVESTIGATION

An Immunohistochemical Study on the Expressional Dynamics of Kisspeptin Neurons Relevant to GnRH Neurons Using a Newly Developed Anti-kisspeptin Antibody

(2010) Norio Iijima et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat

(2010) Cadence True et al.   JOURNAL OF NEUROENDOCRINOLOGY

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

(2010) L.-Y. Fu et al.   JOURNAL OF NEUROSCIENCE

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

(2010) Y. Wakabayashi et al.   JOURNAL OF NEUROSCIENCE

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

Timing and completion of puberty in female mice depend on estrogen receptor  -signaling in kisspeptin neurons

(2010) C. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy balance and puberty onset: emerging role of central mTOR signaling

(2010) Juan Roa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats1

(2009) Tamami Homma et al.   BIOLOGY OF REPRODUCTION

Kisspeptin Signaling in the Brain

(2009) Amy E. Oakley et al.   ENDOCRINE REVIEWS

Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe

(2009) Kathryn Backholer et al.   ENDOCRINOLOGY

Kisspeptin Neurons in the Ovine Arcuate Nucleus and Preoptic Area Are Involved in the Preovulatory Luteinizing Hormone Surge

(2009) J. T. Smith et al.   ENDOCRINOLOGY

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Postnatal Development of an Estradiol-Kisspeptin Positive Feedback Mechanism Implicated in Puberty Onset

(2009) Jenny Clarkson et al.   ENDOCRINOLOGY

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist

(2009) R. Pineda et al.   ENDOCRINOLOGY

Distribution and Postnatal Development ofGpr54Gene Expression in Mouse Brain and Gonadotropin-Releasing Hormone Neurons

(2009) Allan E. Herbison et al.   ENDOCRINOLOGY

Kisspeptin Increases γ-Aminobutyric Acidergic and Glutamatergic Transmission Directly to Gonadotropin-Releasing Hormone Neurons in an Estradiol-Dependent Manner

(2009) Justyna Pielecka-Fortuna et al.   ENDOCRINOLOGY

The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep

(2009) Guanliang Cheng et al.   ENDOCRINOLOGY

Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones

(2009) Julie Bakker et al.   HORMONES AND BEHAVIOR

Possible Role of Oestrogen in Pubertal Increase of Kiss1/Kisspeptin Expression in Discrete Hypothalamic Areas of Female Rats

(2009) K. Takase et al.   JOURNAL OF NEUROENDOCRINOLOGY

Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain

(2009) J. Clarkson et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents

(2009) M. P. Corander et al.   JOURNAL OF NEUROENDOCRINOLOGY

Regulation of Kiss1 and Dynorphin Gene Expression in the Murine Brain by Classical and Nonclassical Estrogen Receptor Pathways

(2009) M. L. Gottsch et al.   JOURNAL OF NEUROSCIENCE

The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion

(2009) J. Donato et al.   JOURNAL OF NEUROSCIENCE

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

(2009) V. M. Navarro et al.   JOURNAL OF NEUROSCIENCE

Metabolic control of puberty onset: New players, new mechanisms

(2009) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of GPR54 Signaling by GRK2 and β-Arrestin

(2009) Macarena Pampillo et al.   MOLECULAR ENDOCRINOLOGY

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states

(2008) J. Roa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Follicle-Stimulating Hormone Responses to Kisspeptin in the Female Rat at the Preovulatory Period: Modulation by Estrogen and Progesterone Receptors

(2008) J. Roa et al.   ENDOCRINOLOGY

Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals

(2008) Xavier d'Anglemont de Tassigny et al.   ENDOCRINOLOGY

Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels

(2008) Xinhuai Liu et al.   ENDOCRINOLOGY

Opposite Roles of Estrogen Receptor (ER)-α and ERβ in the Modulation of Luteinizing Hormone Responses to Kisspeptin in the Female Rat: Implications for the Generation of the Preovulatory Surge

(2008) J. Roa et al.   ENDOCRINOLOGY

Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep

(2008) Jeremy T. Smith et al.   ENDOCRINOLOGY

Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy

(2008) Suresh Ramaswamy et al.   ENDOCRINOLOGY

Alterations in Hypothalamic KiSS-1 System in Experimental Diabetes: Early Changes and Functional Consequences

(2008) J. M. Castellano et al.   ENDOCRINOLOGY

Kisspeptin-10 Facilitates a Plasma Membrane-Driven Calcium Oscillator in Gonadotropin-Releasing Hormone-1 Neurons

(2008) Stephanie Constantin et al.   ENDOCRINOLOGY

Persistent Impairment of Hypothalamic KiSS-1 System after Exposures to Estrogenic Compounds at Critical Periods of Brain Sex Differentiation

(2008) V. M. Navarro et al.   ENDOCRINOLOGY

KiSS-1 and GPR54 Genes are Co-Expressed in Rat Gonadotrophs and Differentially Regulated In Vivo by Oestradiol and Gonadotrophin-Releasing Hormone

(2008) N. Richard et al.   JOURNAL OF NEUROENDOCRINOLOGY

Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels

(2008) C. Zhang et al.   JOURNAL OF NEUROSCIENCE

Kisspeptin-GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge

(2008) J. Clarkson et al.   JOURNAL OF NEUROSCIENCE

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

(2008) A Kemal Topaloglu et al.   NATURE GENETICS

Timeline: the role of kisspeptins in reproductive biology

(2008) Manuel Tena-Sempere   NATURE MEDICINE

The Creb1 coactivator Crtc1 is required for energy balance and fertility

(2008) Judith Y Altarejos et al.   NATURE MEDICINE

Kisspeptins and the control of gonadotropin secretion in male and female rodents

(2008) J. Roa et al.   PEPTIDES

From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

(2008) Michelle L. Gottsch et al.   PEPTIDES

The neuroanatomy of the kisspeptin system in the mammalian brain

(2008) Jens D. Mikkelsen et al.   PEPTIDES

Intracellular signaling pathways activated by kisspeptins through GPR54: Do multiple signals underlie function diversity?

(2008) Justo P. Castaño et al.   PEPTIDES

Ghrelin as a pleotrophic modulator of gonadal function and reproduction

(2008) Manuel Tena-Sempere   Nature clinical practice. Endocrinology & metabolism

Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: The case for the rostral periventricular area of the third ventricle (RP3V)

(2007) Allan E. Herbison   BRAIN RESEARCH REVIEWS

Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptinin Vivo

(2007) J. T. Smith et al.   ENDOCRINOLOGY

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

(2007) Juan Roa et al.   FRONTIERS IN NEUROENDOCRINOLOGY