Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Mahsa Noroozzadeh, Marziyeh Salehi Jahromi, Hanieh Gholami, Mina Amiri, Fahimeh Ramezani Tehrani
Summary: In the prenatally-androgenized rat model of PCOS, the expression of the FSHR and actR genes in ovarian granulosa cells was significantly decreased, leading to abnormal ovarian folliculogenesis and ovulation dysfunction.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Endocrinology & Metabolism
Xiaojun Kuang, Yongzhe Tang, Hong Xu, Min Ji, Dongmei Lai
Summary: This review assesses the effectiveness of various therapies in recovering ovarian function in patients with primary ovarian insufficiency (POI) and explores a comprehensive evaluation method. The results indicate a lack of scientific evidence supporting any therapy in effectively restoring ovarian function in patients with POI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Endocrinology & Metabolism
Gillian P. Johnson, Caitlan G. A. Onabanjo, Kate Hardy, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: The glycosylation variants of follicle-stimulating hormone (FSH) have differential effects on ovarian follicle growth and survival, with partially glycosylated FSH promoting follicle function and fully glycosylated FSH causing follicle damage and apoptosis.
Article
Environmental Sciences
Haojia Ma, Keishi Ishida, Chenke Xu, Kyosuke Takahashi, Yu Li, Chenhao Zhang, Qiyue Kang, Yingting Jia, Wenxin Hu, Daisuke Matsumaru, Tsuyoshi Nakanishi, Jianying Hu
Summary: The study found that TPhP delayed puberty timing in mice and affected ovarian function, possibly by inhibiting estrogen receptor signaling. After 40 days of exposure to TPhP, a significant decrease in the number of follicles was observed in mice, indicating a decline in ovarian reserve.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Jingyi Wen, Kecheng Huang, Xiaofang Du, Hanwang Zhang, Ting Ding, Cuilian Zhang, Wenmin Ma, Ying Zhong, Wenyu Qu, Yi Liu, Zhiying Li, Song Deng, Aiyue Luo, Yan Jin, Jinjin Zhang, Shixuan Wang
Summary: The study found that inhibin B levels rapidly decrease with age in healthy reproductive age women. Inhibin B is positively correlated with AMH, AFC, and other ovarian reserve markers, and has a slightly higher predictive value for AFC compared to FSH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O'Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Summary: Translation: Despite advances in ovarian cancer therapy, recurrent OC remains a poor-prognosis disease. Targeting the follicle-stimulating hormone receptor (FSHR) with monoclonal antibodies has shown potential for treating OC and other FSHR-positive cancers, and may overcome the challenge of off-target interactions.
Article
Obstetrics & Gynecology
Lidia Minguez-Alarc, Paige L. Williams, Irene Souter, Jennifer B. Ford, Russ Hauser, Jorge E. Chavarro
Summary: This study examined the association between self-reported psychological stress and markers of ovarian reserve. The results showed that higher levels of stress were associated with lower follicle count and serum AMH levels. These associations varied by several socioeconomic factors.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Urology & Nephrology
Thomas A. Masterson, Darren Turner, Duyen Vo, Ruben Blachman-Braun, Jordan C. Best, Gerwin Westfield, Nathan Bryson, Ranjith Ramasamy
Summary: The study found that short-acting testosterone preparations have less suppression on FSH and LH compared to longer-acting formulations, indicating potential differences in the impact on semen parameters and fertility. Further clinical trial data is needed to confirm these findings.
SEXUAL MEDICINE REVIEWS
(2021)
Article
Endocrinology & Metabolism
Uchechukwu T. Agwuegbo, Emily Colley, Anthony P. Albert, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: Recent studies have shown that the hypo-glycosylated FSH glycoform FSH21/18 is more bioactive than the fully-glycosylated FSH24. FSH21/18 predominates in women of reproductive prime while FSH24 is more common in peri-post-menopausal women. Differential FSH glycosylation modulates FSHR oligomerization, with high concentrations of FSH21/18 and FSH24 leading to dissociation of FSHR oligomers into monomers, and low concentrations promoting FSHR association into oligomers.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura
Summary: Coastal organisms, such as grass puffers, synchronize their reproduction with the lunar cycle. The secretion of prostaglandin E2 (PGE2) into the seawater during spawning triggers the trembling behavior of grass puffers, which is synchronized with the lunar-regulated beach-spawning behavior. The semilunar transcription factor CCAAT/ enhancer-binding protein d (cebpd) plays a role in the transcription regulation of gonadotropin-releasing hormone 1 (gnrh1) in grass puffers.
Article
Multidisciplinary Sciences
Li-Te Lin, Chia-Jung Li, Kuan-Hao Tsui
Summary: Serum testosterone levels are positively correlated with serum anti-Mullerian hormone levels in infertile women, suggesting that androgen insufficiency may be a potential risk factor for diminished ovarian reserve, while androgen excess may lead to excess ovarian reserve.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yahao Wang, Yangang Wang
Summary: This study found accelerated ovarian aging in women with type 2 diabetes mellitus (T2DM) and its correlation with disturbed lipid profile. It highlights the importance of carefully managing accelerated ovarian aging and its adverse impacts in T2DM, especially with the increasing number of young female patients diagnosed with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingli Tao, Liangliang Zhang, Xuan Zhang, Yuanyuan Chen, Qianqian Chen, Ming Shen, Honglin Liu, Shoulong Deng
Summary: The study showed that melatonin promoted the development of secondary follicles and peripheral angiogenesis, while follicle-stimulating hormone significantly increased the number of antral follicles and peripheral angiogenesis. Melatonin and FSH may regulate the expression of VEGF and antioxidant enzymes to affect follicular development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Maria de Leon, Horacio Cardenas, Edyta Vieth, Robert Emerson, Matthew Segar, Yunlong Liu, Kenneth Nephew, Daniela Matei
GYNECOLOGIC ONCOLOGY
(2016)
Article
Oncology
Horacio Cardenas, Janice Zhao, Edyta Vieth, Kenneth P. Nephew, Daniela Matei
Article
Oncology
Jiyoon Lee, Bakhtiyor Yakubov, Cristina Ivan, David R. Jones, Andrea Caperell-Grant, Melissa Fishel, Horacio Cardenas, Daniela Matei
Article
Oncology
Salvatore Condello, Livia Sima, Cristina Ivan, Horacio Cardenas, Gary Schiltz, Rama K. Mishra, Daniela Matei
Article
Oncology
Yinu Wang, Horacio Cardenas, Fang Fang, Salvatore Condello, Pietro Taverna, Matthew Segar, Yunlong Liu, Kenneth P. Nephew, Daniela Matei
Review
Oncology
Guangyuan Zhao, Horacio Cardenas, Daniela Matei
Article
Oncology
Hao Huang, Yinu Wang, Manoj Kandpal, Guangyuan Zhao, Horacio Cardenas, Yanrong Ji, Anusha Chaparala, Edward J. Tanner, Jianjun Chen, Ramana V. Davuluri, Daniela Matei
Article
Biochemistry & Molecular Biology
Horacio Cardenas, Fang Fang, Guanglong Jiang, Susan M. Perkins, Chi Zhang, Robert E. Emerson, George Hutchins, Harold N. Keer, Yunlong Liu, Daniela Matei, Kenneth Nephew
Summary: This study investigated the impact of DNA methylation on the initiation and progression of high-grade serous ovarian cancer (HGSOC), as well as its association with platinum resistance. The findings suggest potential roles for hypomethylating agents in treating HGSOC, providing important insights into the epigenetic landscape of HGSOC tumorigenesis and potential therapeutic strategies.
Article
Multidisciplinary Sciences
Yuying Tan, Junjie Li, Guangyuan Zhao, Kai-Chih Huang, Horacio Cardenas, Yinu Wang, Daniela Matei, Ji-Xin Cheng
Summary: Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation is associated with platinum-based chemotherapy resistance in cancer cells. Cisplatin-resistant cells exhibit increased fatty acid uptake, decreased glucose uptake, and lipogenesis, indicating a shift in metabolism from glucose to fatty acid dependence. Blocking beta-oxidation combined with platinum-based chemotherapy suppresses ovarian cancer cell proliferation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Guangyuan Zhao, Yuying Tan, Horacio Cardenas, David Vayngart, Yinu Wang, Hao Huang, Russell Keathley, Jian-Jun Wei, Christina R. Ferreira, Sandra Orsulic, Ji-Xin Cheng, Daniela Matei
Summary: Fatty acids are an important energy source and component of cell membranes. This study investigates the impact of the balance between saturated fatty acids (SFAs) and unsaturated fatty acids (UFAs), regulated by stearoyl Co-A desaturase (SCD), on ovarian cancer cell survival and tumor progression. Depletion or inhibition of SCD leads to lower levels of UFAs, triggering endoplasmic reticulum (ER) stress response and cell death. However, supplementation with UFAs and reequilibration of SFA/UFA levels rescues stress and apoptosis. This research highlights the importance of targeting lipid balance in the treatment of ovarian cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Hao Huang, Guangyuan Zhao, Horacio Cardenas, Andres Felipe Valdivia, Yinu Wang, Daniela Matei
Summary: In this study, the researchers identified FTO as a tumor suppressor in ovarian cancer that regulates the cellular response to platinum (Pt) through N6-methyladenosine (m6A) RNA demethylation. They also discovered NNMT as a new target of FTO, and inhibition or knockdown of NNMT restored sensitivity to Pt in FTO-overexpressing cells. These findings reveal a novel role of FTO-dependent m6A RNA modifications in regulating the response to Pt through NNMT.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Siqi Chen, Ping Xie, Matthew Cowan, Hao Huang, Horacio Cardenas, Russell Keathley, Edward J. Tanner, Gini F. Fleming, John W. Moroney, Alok Pant, Azza M. Akasha, Ramana Davuluri, Masha Kocherginsky, Bin Zhang, Daniela Matei
Summary: In ovarian cancer patients, priming with the hypomethylating agent guadecitabine before immune checkpoint inhibitors (ICI) treatment can enhance therapeutic efficacy. This treatment regimen resulted in partial responses or stable disease in a subset of patients. Additionally, post-treatment immune responses were activated in these patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Livia Elena Sima, Siqi Chen, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Cristina Ivan, Hao Huang, Bin Zhang, Daniela Matei
Summary: The study showed that host TG2 deficiency delayed tumor growth, increased infiltration of CD8(+) T cells, and decreased myeloid cell numbers in the peritoneal fluid. Loss of TG2 enhanced tumor antigen-specific CD8(+) T cell cytotoxic responses and reduced immune-suppressive signals in the tumor microenvironment, leading to decreased tumor burden.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Yinu Wang, Guangyuan Zhao, Salvatore Condello, Hao Huang, Horacio Cardenas, Edward J. Tanner, JianJun Wei, Yanrong Ji, Junjie Li, Yuying Tan, Ramana V. Davuluri, Marcus E. Peter, Ji-Xin Cheng, Daniela Matei
Summary: The study identifies platinum-tolerant cancer cells with cancer stem cell features characterized by expression of FZD7 and dependency on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival. These cells are highly susceptible to ferroptosis, marking a novel therapeutic vulnerability in platinum-resistant cancer cells.
Article
Biochemistry & Molecular Biology
Horacio Cardenas, Daniel Arango, Courtney Nicholas, Silvia Duarte, Gerard J. Nuovo, Wei He, Oliver H. Voss, M. Elba Gonzalez-Mejia, Denis C. Guttridge, Erich Grotewold, Andrea I. Doseff
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)