Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Adrianne L. Stefanski, Michael D. Renecle, Anita Kramer, Shilpi Sehgal, Purnima Narasimhan, Kristen K. Rumer, Virginia D. Winn
Summary: This study demonstrates that Siglec-6 may act as a signaling molecule in the pregnancy-specific disorder preeclampsia, with phosphorylation by Src family kinases playing a crucial role in recruiting phosphatases like SHP-2 for downstream signaling.
Review
Cell Biology
Bum-Kyu Lee, Jonghwan Kim
Summary: Understanding the molecular mechanisms of early human placenta development is crucial for maternal and fetal health. Recent advancements in human trophoblast models offer new opportunities, but the application of high-throughput omics tools in this field remains limited. Integration of omics approaches with human in vitro model systems has the potential to enhance our understanding of placental development and associated complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Ochiai, Chigure Suzuki, Katsumori Segawa, Yasuo Uchiyama, Shigekazu Nagata
Summary: The study demonstrates the importance of P4-ATPases ATP11A in placental development, with its deficiency leading to poor formation of the labyrinthine layer. ATP11C may compensate for ATP11A in most cell types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Summary: GCM1 is a critical regulator of both EVT and ST development, affecting cell differentiation and invasive capacity, potentially leading to obstetrical complications such as preeclampsia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Summary: GCM1 is a critical regulator of human placenta development, playing a key role in the differentiation and function of EVT and ST. Knockdown of GCM1 hinders TS cell differentiation and impacts their functions in both ST and EVT pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Henrieta Papuchova, Paulina A. Latos
Summary: The placenta is crucial for the development of the embryo and the success of pregnancy. It serves as a site for exchange between the mother and the embryo, has immune functions, and acts as an important endocrine organ. Specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast, are responsible for these diverse functions of the placenta. Transcription factors play a vital role in regulating the emergence, specialization, and identity of these cells, and their coordinated actions determine the specific characteristics of each cell type. This article provides an overview of transcription factors involved in the development and function of human trophoblast and discusses their similarities and differences to their counterparts in mice. The establishment of human in vitro models combined with -omics approaches has greatly advanced our understanding of the human trophoblast field.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Graham J. Burton, Eric Jauniaux
Summary: The development of the placenta precedes that of the embryo and is supported by histotrophic nutrition secreted from endometrial glands, rather than maternal blood. A feed-forward signalling dialogue exists among the trophoblast, decidua, and glands that enables the placenta to stimulate its own development. Pregnancy complications may arise from deficient trophoblast proliferation and impaired decidualization, potentially compromising histotroph secretion. Optimizing endometrial wellbeing prior to conception may prevent common pregnancy complications.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Jingmei Ma, Yawei Liu, Zhirong Guo, Run Sun, Xinrui Yang, Weiran Zheng, Yongdan Ma, Yin Rong, Hongmei Wang, Huixia Yang, Zhenyu Xiao
Summary: This study used single-cell RNA-sequencing analysis to investigate the pathological landscape of invasive placenta accreta spectrum disorders (PAS) placenta and revealed the interaction between invasive trophoblasts and maternal stromal cells during the invasion process. The study also presented the immune microenvironmental landscape of invasive PAS. These findings provide a foundation for future research on PAS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Rebekka Vogtmann, Jacqueline Heupel, Florian Herse, Mahsa Matin, Henning Hagmann, Ivo Bendix, Kristin Kraeker, Ralf Dechend, Elke Winterhager, Rainer Kimmig, Angela Koeninger, Alexandra Gellhaus
Summary: By overexpressing hsFLT1 in mice, the study found that circulating maternal hsFLT1 is sufficient to induce typical maternal preeclampsia-like symptoms, impairing spiral artery remodeling independently from the fetoplacental compartment.
Article
Cell Biology
Robert Morey, Omar Farah, Sampada Kallol, Daniela F. Requena, Morgan Meads, Matteo Moretto-Zita, Francesca Soncin, Louise C. Laurent, Mana M. Parast
Summary: During pregnancy, the EVT invades and remodels maternal blood vessels to ensure blood supply to the placenta, exhibiting polyploidy and senescence in early gestation. Comprehensive profiling of genomic organization and transcriptome shows that both first trimester and term EVT undergo senescence, are primarily tetraploid, and lack high rates of copy number variations. Genes and pathways related to senescence and polyploidy are important for normal EVT differentiation and maturation, with a key role identified for the unfolded protein response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xinlu Liu, Gang Wang, Haiqin Huang, Xin Lv, Yanru Si, Lixia Bai, Guohui Wang, Qinghua Li, Weiwei Yang
Summary: The placenta plays a crucial role in pregnancy by facilitating nutrient and gas exchange between the mother and fetus. Abnormalities in placental development can lead to pregnancy-related disorders and have long-term effects on maternal health. In vitro models, particularly trophoblast stem cell culture and organoids, have been used to study placental development and pregnancy-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Masanaga Muto, Damayanti Chakraborty, Kaela M. Varberg, Ayelen Moreno-Irusta, Khursheed Iqbal, Regan L. Scott, Ross P. McNally, Ruhul H. Choudhury, John D. Aplin, Hiroaki Okae, Takahiro Arima, Shoma Matsumoto, Masatsugu Ema, Alan E. Mast, Elin Grundberg, Michael J. Soares
Summary: TFPI is shown to play a crucial role in processes such as embryonic development and trophoblast cell differentiation. Experimental results in rat and human models demonstrate that TFPI plays a significant regulatory role in the differentiation of trophoblast cells into invasive cells and extravillous trophoblast cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Melissa J. Marchese, Shuman Li, Bin Liu, Jun J. Zhang, Liping Feng
Summary: The study found that BDNF receptors are present in different regions of human placental villi, indicating diverse functions of BDNF signaling in placental development. While exposure to PFOS, PFOA, PFBS, and a PFAS mixture did not significantly affect the BDNF pathway in placental trophoblast cells, exposure to PFNA may affect TrkB phosphorylation. Further research is needed to understand how PFAS impacts other critical signaling pathways during fetal neurodevelopment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Derek C. Sung, Xiaowen Chen, Mei Chen, Jisheng Yang, Susan Schultz, Apoorva Babu, Yitian Xu, Siqi Gao, T. C. Stevenson Keller, Patricia Mericko-Ishizuka, Michelle Lee, Ying Yang, Joshua P. Scallan, Mark L. Kahn
Summary: This study shows that VE-cadherin plays a crucial role in trophoblast migration and endovascular invasion during placental development in mice. Deficiency of VE-cadherin results in failure of spiral artery remodeling, decreased maternal blood flow into the placenta, and fetal growth restriction. These findings highlight a non-endothelial function of VE-cadherin in trophoblasts and suggest that endothelial proteins may have unique roles in these cells.