Article
Hematology
Yoshiyuki Onda, Junya Kanda, Nozomu Hanaoka, Mizuki Watanabe, Yasuyuki Arai, Masakatsu Hishizawa, Tadakazu Kondo, Kouhei Yamashita, Miki Nagao, Tsuguto Fujimoto, Akifumi Takaori-Kondo
Summary: Adenovirus (ADV) or BK virus (BKV)-associated hemorrhagic cystitis (HC) is a common complication after allo-HSCT, with a possible risk of nosocomial transmission. Genetic analysis of the virus and sequencing of the viral genome are important for understanding this issue.
ANNALS OF HEMATOLOGY
(2021)
Article
Immunology
Maryam Mohammadi Najafabadi, Masoud Soleimani, Mohammad Ahmadvand, Mina Soufi Zomorrod, Seied Asadollah Mousavi
Summary: This study demonstrated the feasibility of producing functional BKPyV-specific T cells in healthy donors using BKPyV PepMixes. These cells were able to mount an immune response against BKPyV and exhibited cytotoxic activity.
Article
Immunology
Elizabeth M. Holland, Corina Gonzalez, Elliot Levy, Vladimir A. Valera, Heather Chalfin, Jacquelyn Klicka-Skeels, Bonnie Yates, David E. Kleiner, Colleen Hadigan, Hema Dave, Haneen Shalabi, Dennis D. Hickstein, Helen C. Su, Michael Grimley, Alexandra F. Freeman, Nirali N. Shah
Summary: This case report describes a 16-year-old male with DOCK8 deficiency who underwent haploidentical HSCT and developed severe BKV-associated hemorrhagic cystitis, renal hemorrhage, and VST-associated cytokine release syndrome. The case highlights opportunities for improvement in managing severe BKV-HC post-transplant and underscores rare and potentially life-threatening complications of VST therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Eugenio Galli, Federica Sora, Luca Di Gianfrancesco, Sabrina Giammarco, Elisabetta Metafuni, Maria Assunta Limongiello, Idanna Innocenti, Francesco Autore, Luca Laurenti, Patrizia Chiusolo, Andrea Bacigalupo, Simona Sica
Summary: Hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem-cell transplantation (HSCT), which significantly affects transplant outcomes and patient wellbeing. This study analyzed 237 patients to identify risk factors for HC and their consequences, with a focus on transplant- and gender-related factors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Infectious Diseases
Daniel Ruderfer, Mengfen Wu, Tao Wang, Poyyapakkam R. Srivaths, Robert A. Krance, Swati Naik, Claire E. Bocchini
Summary: Severe BKV-HC in pediatric HSCT recipients is associated with significant renal morbidity, including AKI and CKD, as well as increased risk of mortality. Factors such as age and myeloablative conditioning regimen are predictive of time to development of BKV-HC.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Immunology
Karoline Leuzinger, Amandeep Kaur, Maud Wilhelm, Konstantin Frank, Caroline A. Hillenbrand, Fabian H. Weissbach, Hans H. Hirsch
Summary: In this study, the replication of BK polyomavirus (BKPyV) was found to be associated with failing immune control and BKPyV-associated hemorrhagic cystitis in allogeneic hematopoietic cell transplantation (HCT). Molecular markers of BKPyV replication and disease were identified through quantitative nucleic acid testing (QNAT), DNase-I treatment, next-generation sequencing (NGS), and cell-mediated immunity testing. The fragmentation of BKPyV genome below 250 bp was found to impair the detection of BKPyV diversity and genotype-associated changes involved in immune escape.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Hematology
Sanjeet S. Dadwal, Genovefa A. Papanicolaou, Michael Boeckh
Summary: Preventing viral infections in transplant recipients is crucial. Pre-emptive therapy and prophylaxis with antiviral agents have successfully prevented clinically significant viral infections. Progress has been made in understanding the biology and risk factors of viral infections, as well as the development of new antiviral agents and immunotherapy. Effective prevention strategies exist for herpes simplex virus, varicella-zoster virus, and cytomegalovirus, but limited data are available for other viral infections in transplant recipients.
Article
Oncology
Thomas Pfeiffer, Ifigeneia Tzannou, Mengfen Wu, Carlos Ramos, Ghadir Sasa, Caridad Martinez, Premal Lulla, Robert A. Krance, Lauren Scherer, Daniel Ruderfer, Swati Naik, Claire Bocchini, Iain P. Fraser, Badrish Patel, Dany Ward, Tao Wang, Helen E. Heslop, Ann M. Leen, Bilal Omer
Summary: This study aimed to evaluate the feasibility and safety of posoleucel in allo-HCT recipients infected with viral infections. The results showed that posoleucel had good tolerability and achieved significant efficacy in treating multiple viral infections.
CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Hiroki Hosoi, Shogo Murata, Tetsuro Suzuki, Tian-Cheng Li, Kazuo Hatanaka, Keiko Tanaka-Taya, Toshiki Mushino, Kodai Kuriyama, Shinobu Tamura, Nobuyoshi Hanaoka, Takashi Sonoki
Summary: The study suggests that nosocomial BKV infections may occur after HSCT. Although many cases of BKV-HC are caused by the reactivation of a latent virus, it is necessary to employ appropriate hygiene measures when cases of BKV-HC occur.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Immunology
Eleonore Kaphan, Raphaele Germi, Sebastien Bailly, Claude-Eric Bulabois, Martin Carre, Jean-Yves Cahn, Anne Thiebaut-Bertrand
Summary: Exposure to cyclophosphamide, younger age (<40), and corticosteroid therapy are potential risk factors for developing BKV-HC.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Hematology
Malgorzata Salamonowicz-Bodzioch, Jowita Fraczkiewicz, Krzysztof Czyzewski, Olga Zajac-Spychala, Ewa Gorczynska, Anna Panasiuk, Marek Ussowicz, Krzysztof Kalwak, Zofia Szmit, Grazyna Wrobel, Bernarda Kazanowska, Alicja Chybicka, Bogna Ukielska-Hoffmann, Danuta Wendycz-Domalewska, Mariusz Wysocki, Magdalena Dziedzic, Jacek Wachowiak, Agnieszka Zaucha-Prazmo, Jerzy Kowalczyk, Jolanta Gozdzik, Jan Styczynski
Summary: BK virus is a common cause of hemorrhagic cystitis in children undergoing hematopoietic cell transplantation. Various factors such as age, type of transplantation, conditioning regimen, and presence of acute graft-versus-host disease are associated with the development of BKV-HC in these patients. The study aimed to evaluate the incidence, clinical course, and risk factors for BKV-HC in children undergoing HCT.
ANNALS OF HEMATOLOGY
(2021)
Article
Immunology
Xiang-ting Xie, Yan-fang Zhang, Ying Zhang, Han-qing Zeng, Jian-chuan Deng, Kang Zhou, Lin Chen, Yun Luo, Shi-feng Lou
Summary: BK virus-associated hemorrhagic cystitis is a serious complication after allogeneic hematopoietic stem cell transplantation. Risk factors for BKV-HC include peripheral blood lymphocyte count <1 x 109/L before conditioning and haploidentical transplantation. The occurrence and severity of BKV-HC do not affect overall survival and progression-free survival of patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pediatrics
Gizem Zengin Ersoy, Ceyhun Bozkurt, Basak Adakli Aksoy, Ozlem Basoglu Oner, Selime Aydogdu, Funda Cipe, Murat Sutcu, Ozan Ozkaya, Tunc Fisgin
Summary: This retrospective study investigated the frequency and risk factors of BKV-HC in pediatric patients undergoing HSCT. The study found that age, TBI use, presence of aGVHD, CMV coinfection, and Cy use were significant prognostic factors for BKV-HC. The use of Cy in the post-transplantation period further increased the risk of BKV-HC in pediatric patients.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Adrien Voisot, Francois Triffaux, Isabelle Roland, Cecile Meex, Nancy Detrembleur, Frederic Baron, Evelyne Willems, Waltregny David, Yves Beguin, Sophie Servais
Summary: This study presents a case series of patients with BK polyomavirus-related hemorrhagic cystitis (HC) following allogeneic hematopoietic cell transplantation (alloHCT). The results show that treatment with endovesical cidofovir achieved satisfactory outcomes in most patients, but further large prospective studies are needed to establish the effectiveness of this therapy.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Infectious Diseases
Ant Uzay, Yasemin Gundogdu, Baris Kosan, Tugba Yetis, Hatun Gur, Yildiz Okuturlar, S. Sami Karti
Summary: This study investigated the efficacy of low dose daily consecutive intravesical cidofovir in 25 patients with BK virus associated hemorrhagic cystitis after allo-geneic stem cell transplantation. The overall response rate was 92% and relapse was not observed in 84% of patients during one year of follow-up. The median BK urine viral load significantly decreased after one week of treatment. Only 1 patient experienced post-treatment nephrotoxicity.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)