Article
Clinical Neurology
Ping Wang, Xiaonan Du, Quanli Shen, Wenjin Jiang, Chen Shen, Hongsheng Wang, Shuizhen Zhou, Yi Wang, Xiaowen Qian, Xiaowen Zhai
Summary: The study analyzed the efficacy of unrelated umbilical cord blood transplantation (UCBT) in the treatment of hereditary leukodystrophy. The results showed that UCBT can improve survival rates and stabilize neurological function in patients with hereditary leukodystrophy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Jisela Dimas-Gonzalez, Jorge E. Trejo-Gomora, Carlos Bonilla-Cisneros, Alfredo Lagunas-Martinez
Summary: This study aimed to optimize colony-forming units (CFU) from umbilical cord blood units (UCBU) and detect the human papillomavirus (HPV) genome. The results showed that the DNA concentration extracted from CFU was higher compared to UCB and segments, and all samples tested positive for GAPDH amplification and negative for HPV genes.
GACETA MEDICA DE MEXICO
(2021)
Article
Immunology
Ding-Ping Chen, Tang-Her Jaing, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu
Summary: This study identified specific SNPs in non-HLA genes associated with the effectiveness of unrelated CBT, which can aid in selecting the best donor and predicting the risk of CBT adverse reactions, further suggesting the important role of SNPs in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Summary: This study found that adding an unrelated umbilical cord blood unit to haploidentical hematopoietic stem cell transplantation can improve the prognosis and enhance the graft versus leukemia effect without increasing the incidence of graft versus host disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Xin-Yu Li, Li-Ping Zhan, Dian-Dian Liu, Xia-Wei Han, Han Chen, Zheng-Zhou Wu, Yin Wang, Li-Ping Que, Xiao-Jun Wu, Su Liu, Kai-Mei Wang, Shao-Liang Huang, Jian-Pei Fang, Ke Huang, Hong-Gui Xu
Summary: Using posttransplant cyclophosphamide (PTCY) as a method for controlling peri-engraftment syndrome (PES) and prophylaxis against graft-versus-host disease (GvHD) in single-unit umbilical cord blood transplantation (UCBT) for children with acute leukemia is safe and effective. Higher doses of PTCY may be more suitable for GvHD prophylaxis in UCBT patients.
Article
Hematology
Lauren Bohannon, Helen Tang, Kristin Page, Yi Ren, Sin-Ho Jung, Alexandra Artica, Anne Britt, Prioty Islam, Sharareh Siamakpour-Reihani, Vinay Giri, Meagan Lew, Matthew Kelly, Taewoong Choi, Cristina Gasparetto, Gwynn Long, Richard Lopez, David Rizzieri, Stefanie Sarantopoulos, Nelson Chao, Mitchell Horwitz, Anthony Sung
Summary: Allogeneic hematopoietic stem cell transplantation (HCT) has the potential to cure hematologic malignancies but is associated with significant morbidity and mortality. Umbilical cord blood (UCB) recipients tend to have better overall survival, lower risk of death, lower rates of graft-versus-host disease, and slower time to relapse compared to matched related donor (MRD) and matched unrelated donor (MUD) recipients. Recent advancements in UCB transplantation have made it an attractive donor source for adults, especially in mitigating late effects of HCT.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Review
Medicine, General & Internal
Diana Vanegas, Laura Nino-Quiroga, Mauricio Chaparro, Bernardo Camacho-Rodriguez, Marcela Estupinan, Ana-Maria Perdomo-Arciniegas
Summary: The translated article discusses the main issues associated with using unrelated umbilical cord blood and haploidentical grafts as alternative donors, emphasizing that selecting the best donor depends on various factors.
FRONTIERS IN MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Mailin Gan, Lin Liu, Shunhua Zhang, Zongyi Guo, Ya Tan, Jia Luo, Qiong Yang, Hongmei Pan, Xuewei Li, Jinyong Wang, Linyuan Shen, Li Zhu
Summary: Differential expression of porcine umbilical cord blood miRNA may have differences in immunity and angiogenesis, with great potential in the treatment of human diseases due to their ability for cross-species transmission. miRNA in cord blood may be beneficial for muscle-related diseases and liver- and brain-related diseases, providing insights for potential applications in mother-fetal communication.
Article
Oncology
Alexandre G. Troullioud Lucas, Jaap Jan Boelens, Susan E. Prockop, Kevin J. Curran, Dorine Bresters, Wouter Kollen, Birgitta Versluys, Marc B. Bierings, Anne Archer, Eric Davis, Elizabeth Klein, Nancy A. Kernan, Caroline A. Lindemans, Andromachi Scaradavou
Summary: This study retrospectively evaluated the effectiveness of unrelated cord blood transplantation (CBT) in treating patients with leukemia relapse after transplant. The results showed that using CBT as a salvage therapy option significantly improved the survival rate of pediatric leukemia patients with recurrent disease after the initial hematopoietic cell transplant (HCT), and treatment-related mortality (TRM) has been low in the past decade.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Joanie Hare, Paulina Garcia DeLeon, Krystle Pool, Donna Reioux, Milford Fontenot, Richard E. Champlin, Erin N. Eaton, David Marin, Katayoun Rezvani, Elizabeth J. Shpall, Jeffrey M. Wilson, Chitra Hosing
Summary: The success of umbilical cord blood transplant depends on the dose of total nucleated and CD34+ cells infused, highlighting the importance of collecting high-quality cord blood units with high cell doses. Maternal gestational age and race, and neonatal weight and sex were found to correlate with the total nucleated cell dose, emphasizing the impact of these factors on cell dose. Optimized collection of umbilical cord blood is crucial for its use as a source of stem cells for transplantation.
Article
Cell & Tissue Engineering
Jessica M. Sun, Laura E. Case, Mohamad A. Mikati, Joan M. Jasien, Colleen McLaughlin, Barbara Waters-Pick, Gordon Worley, Jesse Troy, Joanne Kurtzberg
Summary: Studies suggest that appropriately dosed allogeneic sibling HLA-matched umbilical cord blood infusion has the potential to improve motor function in young children with cerebral palsy. This treatment is well tolerated and shows no adverse events related to the infusion.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mohd Razif Mohd Idris, Fazlina Nordin, Zaleha Abdullah Mahdy, S. Fadilah Abd Wahid
Summary: The study showed that GDM affects the differentiation potency of UCB-HSC, leading to significant changes in UCB parameters and HSC differentiation markers. These findings are significant for guiding selection criteria for UCB storage.
FRONTIERS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Patricia Farina-Eckhardt, Cristina Granado, Doris Mueller-Borer, Andreas Schotzau, Dimitrios A. Tsakiris, Irene Hosli, Gwendolin Manegold-Brauer
Summary: The study found that factors associated with higher TNC counts in umbilical cord blood donations may include maternal age, BMI, parity, gestational diabetes, gestational week, birth weight, and mode of delivery.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2022)
Article
Cell Biology
Pei Tian, Andrew Elefanty, Edouard G. Stanley, Jennifer C. Durnall, Lachlan H. Thompson, Ngaire J. Elwood
Summary: Clinical-grade induced pluripotent stem cells (iPSCs) can be efficiently created using small volumes of thawed cord blood from public cord blood banks. This study presents a protocol that involves ex-vivo expansion and reprogramming of erythroid progenitor cells derived from cord blood, resulting in iPSC lines that are tested for pluripotency, genomic integrity, and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Bhagirathbhai Dholaria, Myriam Labopin, Jaime Sanz, Annalisa Ruggeri, Jan Cornelissen, Helene Labussiere-Wallet, Didier Blaise, Edouard Forcade, Patrice Chevallier, Anna Grassi, Ludmila Zubarovskaya, Jurgen Kuball, Patrice Ceballos, Fabio Ciceri, Frederic Baron, Bipin N. Savani, Arnon Nagler, Mohamad Mohty
Summary: This study compared the outcomes of CBT and single-allele-mismatched MMUD allo-HCT with PTCy in acute myeloid leukemia. The results showed that CBT was associated with higher incidence of graft failure and non-relapse mortality compared to MMUD, leading to lower leukemia-free survival, overall survival, and GVHD-free, relapse-free survival. In conclusion, MMUD allo-HCT with PTCy may be a preferred choice over CBT for patients without a fully matched donor.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)