Review
Biochemistry & Molecular Biology
Hidehiko Ikura, Jin Endo, Hiroki Kitakata, Hidenori Moriyama, Motoaki Sano, Keiichi Fukuda
Summary: In AL amyloidosis, unstable monoclonal free light chains (FLCs) secreted by small B-cell clones in the bone marrow form amyloid fibrils that deposit in the interstitial tissue, resulting in organ injury and dysfunction. Promptly lowering FLC levels through chemotherapy is essential for achieving a hematological response. Basic studies have revealed gene mutations associated with AL, characteristics of amyloidogenic LC, and the structural specificity of amyloid fibrils. This review outlines the pathogenesis and treatment strategies for AL amyloidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Tamer Rezk, Rashim Salota, Jaslyn J. Gan, Helen J. Lachmann, Marianna Fontana, Keith Siew, Ana Martinez-Naharro, Christianne Guillotte, Paul Bass, Sajitha Sachchithanantham, Shameem Mahmood, Aviva Petrie, Carol J. Whelan, Jennifer H. Pinney, Mark Dockrell, Darren Foard, Thirusha Lane, Ashutosh D. Wechalekar, Philip N. Hawkins, Stephen B. Walsh, Julian D. Gillmore
Summary: The study examined the relationship between urinary retinol binding protein 4 (uRBP) and renal outcomes in systemic AL amyloidosis patients. It found that elevated uRBP/creatinine ratio (uRBPCR) at diagnosis is a strong independent predictor of end-stage renal disease, especially in patients with eGFR >30 ml/min/1.73 m(2) and those who do not achieve a deep hematological response to chemotherapy within 3 months of diagnosis. This suggests that uRBPCR may be a promising prognostic biomarker for renal function in AL amyloidosis patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Oncology
Giada Bianchi, Yifei Zhang, Raymond L. Comenzo
Summary: AL amyloidosis is an incurable plasma cell disorder characterized by deposition of misfolded immunoglobulin free light chains in target organs, with cardiac involvement as the most adverse prognostic feature. Early clinical suspicion, rapid tissue diagnosis, and effective treatment are crucial in managing the disease.
JACC: CARDIOONCOLOGY
(2021)
Review
Oncology
Chunyan Sun, Xiaohong Wang, Renyi Zhang, Lingjie Xu, Bin Wang, Jian Li
Summary: This systematic review and meta-analysis investigated the efficacy and safety of intravenous daratumumab (DARA IV) for the treatment of amyloid light-chain (AL) amyloidosis. The results showed that DARA IV treatment had a good response rate and survival rate for patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Javier Sicilia-Pasos, Naresh Kewalramani, Juan-Francisco Pena-Cardelles, Angel-Orion Salgado-Peralvo, Cristina Madrigal-Martinez-Pereda, Angel Lopez-Carpintero
Summary: This study investigated the survival of intentionally autotransplanted developing teeth and found a survival rate of over 97% at a 2-year follow-up.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Oncology
Lucie Lafay-Cousin, Christelle Dufour
Summary: Medulloblastoma is the most common malignant tumor in the pediatric population, and treatment strategies vary based on different factors. The best survival rates currently come from maximal surgical resection followed by craniospinal irradiation and chemotherapy. However, there are still challenges and limitations in the use of chemotherapy for metastatic disease, infants, and young children.
Article
Oncology
Yu-Ting Jiang, Kai-Hua Chen, Jie Yang, Zhong-Guo Liang, Ling Li, Song Qu, Xiao-Dong Zhu
Summary: This study revealed that for locoregionally advanced nasopharyngeal carcinoma, high-risk patients could benefit from a higher cumulative cisplatin dose in terms of 3-year progression-free survival and distant metastasis-free survival, while low-risk patients did not show significant survival advantages. A high cisplatin dose increased treatment-related acute toxicities.
Review
Medicine, General & Internal
Mengting Zhang, Chunmei Liu, Huandi Zhou, Wenyan Wang, Lixin Wang, Baojun Shi, Xiaoying Xue
Summary: High-dose chemotherapy combined with autologous stem cell rescue (HDCT + ASCR) has shown significant benefits in prolonging the progression-free survival (PFS) of newly diagnosed medulloblastoma patients, particularly in the standard risk group. However, it is associated with increased gastrointestinal toxicity.
Review
Immunology
Gemma Martinez-Rivas, Sebastien Bender, Christophe Sirac
Summary: Monoclonal immunoglobulin light chain amyloidosis is a rare but severe disease characterized by the deposition of amyloid fibrils in organs. The mechanisms and pathophysiology of this disease are still unclear. The development of reliable animal models for studying AL amyloidosis has proven to be challenging, hampering research efforts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Junyao Yu, Huaping Du, Xueshi Ye, Lifei Zhang, Haowen Xiao
Summary: The study found that there is currently no defined standard treatment for PCNSL except for high-dose methotrexate (HD-MTX). The optimal combination of HD-MTX and consolidation methods were explored through meta-analysis, with results indicating that HD-MTX-based regimens combined with ASCT showed better outcomes. Additionally, WBRT+chemotherapy was also identified as a feasible approach for the treatment of newly diagnosed PCNSL.
SCIENTIFIC REPORTS
(2021)
Review
Multidisciplinary Sciences
Chengyu You, Xianhui Li, Yuelin Du, Hui Wang, Xiaojun Zhang, Tangqiang Wei, Anguo Wang
Summary: The combination of IAC with IVC is a safe and effective treatment for high-risk NMIBC, leading to significantly improved outcomes in terms of tumor recurrence, progression, tumor-specific death, PFS, and RFS, while the efficacy of IAC alone is comparable to IVC alone.
Article
Biochemistry & Molecular Biology
Jeroen van Dorp, Christodoulos Pipinikas, Britt B. M. Suelmann, Niven Mehra, Nick van Dijk, Giovanni Marsico, Maurits L. van Montfoort, Sophie Hackinger, Linde M. Braaf, Tauanne Amarante, Charlaine van Steenis, Kirsten McLay, Antonios Daletzakis, Daan van den Broek, Maaike W. van de Kamp, Kees Hendricksen, Jeantine M. de Feijter, Thierry N. Boellaard, Richard P. Meijer, Toine G. van der Heijden, Nitzan Rosenfeld, Bas W. G. van Rhijn, Greg Jones, Michiel S. van der Heijden
Summary: Cohort 1 of the phase 1B NABUCCO trial showed high pCR rates with preoperative ipilimumab plus nivolumab in stage III UC. In cohort 2, dose adjustment was aimed to optimize responses. Absence of ctDNA in plasma can predict PFS in stage III UC patients treated with high-dose ipilimumab plus nivolumab.
Article
Oncology
Benjamin M. Heyman, Michael Y. Choi, Thomas J. Kipps
Summary: Patients with Richter's Syndrome have a poor prognosis and traditional treatments are not effective. In this study, a novel chemotherapy-free combination of obinutuzumab, high-dose methylprednisolone, and lenalidomide was used to treat Richter's Syndrome patients, showing promising results.
Review
Nutrition & Dietetics
Lei Sun, Jia-Hao Zhao, Wen-Yi Fan, Bo Feng, Wen-Wen Liu, Rui-Qin Chen, Chuang Ban, Ao-Gui Dang, Miao Wang, Kang-Ting Luo, Guo-Yu Zhou, Fang-Fang Yu, Yue Ba
Summary: This meta-analysis explored the therapeutic effects of high-dose vitamin C supplementation for patients with COVID-19, and the results showed that it can alleviate inflammatory response and hinder the aggravation of the disease.
Article
Hematology
Nadine Abdallah, Angela Dispenzieri, Eli Muchtar, Francis K. Buadi, Prashant Kapoor, Martha Q. Lacy, Yi L. Hwa, Amie Fonder, Miriam A. Hobbs, Suzanne R. Hayman, Nelson Leung, David Dingli, John A. Lust, Ronald S. Go, Yi Lin, Wilson Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Robert A. Kyle, S. Vincent Rajkumar, Morie A. Gertz, Shaji K. Kumar
Summary: The study found that the currently used staging systems can be used for restaging at 3 and 6 months after treatment initiation, and migration to a higher stage predicts poor prognosis.
Article
Cell Biology
Brandon T. Larsen, Oana M. Mereuta, Surendra Dasari, Ahmed U. Fayyaz, Jason D. Theis, Julie A. Vrana, Martha Grogan, Ahmet Dogan, Angela Dispenzieri, William D. Edwards, Paul J. Kurtin, Joseph J. Maleszewski
Article
Hematology
Yi L. Hwa, Qian Shi, Shaji K. Kumar, Martha Q. Lacy, Morie A. Gertz, Prashant Kapoor, Francis K. Buadi, Nelson Leung, David Dingli, Ronald S. Go, Suzanne R. Hayman, Wilson I. Gonsalves, Stephen Russell, John A. Lust, Yi Lin, S. Vincent Rajkumar, Angela Dispenzieri
AMERICAN JOURNAL OF HEMATOLOGY
(2017)
Article
Hematology
Eli Muchtar, Dragan Jevremovic, Angela Dispenzieri, David Dingli, Francis K. Buadi, Martha Q. Lacy, Wilson Gonsalves, Suzanne R. Hayman, Prashant Kapoor, Nelson Leung, Stephen Russell, John A. Lust, Yi Lin, Ronald S. Go, Rajshekhar Chakraborty, Steven Zeldenrust, Shaji K. Kumar, Robert A. Kyle, S. Vincent Rajkumar, Morie A. Gertz
Article
Biophysics
R. Chakraborty, E. Muchtar, S. Kumar, F. K. Buadi, D. Dingli, A. Dispenzieri, S. R. Hayman, W. J. Hogan, P. Kapoor, M. Q. Lacy, N. Leung, M. A. Gertz
BONE MARROW TRANSPLANTATION
(2017)
Letter
Hematology
Rajshekhar Chakraborty, Morie A. Gertz, Angela Dispenzieri, Wilson I. Gonsalves, Steven R. Zeldenrust, Stephen J. Russell, Ronald S. Go, Prashant Kapoor, Vincent S. Rajkumar, Suzanne R. Hayman, Yi L. Hwa, Martha Q. Lacy, Robert A. Kyle, Nelson Leung, Shaji K. Kumar
BRITISH JOURNAL OF HAEMATOLOGY
(2017)
Article
Oncology
E. Muchtar, A. Dispenzieri, S. K. Kumar, F. K. Buadi, M. Q. Lacy, S. Zeldenrust, S. R. Hayman, N. Leung, T. V. Kourelis, W. Gonsalves, R. Chakraborty, S. Russell, D. Dingli, J. A. Lust, Y. Lin, P. Kapoor, R. Go, R. A. Kyle, S. V. Rajkumar, M. A. Gertz
Article
Oncology
E. Muchtar, A. Dispenzieri, S. K. Kumar, R. P. Ketterling, D. Dingli, M. Q. Lacy, F. K. Buadi, S. R. Hayman, P. Kapoor, N. Leung, R. Chakraborty, W. Gonsalves, R. Warsame, T. V. Kourelis, S. Russell, J. A. Lust, Y. Lin, R. S. Go, S. Zeldenrust, R. A. Kyle, S. V. Rajkumar, M. A. Gertz
Article
Oncology
W. I. Gonsalves, S. V. Rajkumar, A. Dispenzieri, D. Dingli, M. M. Timm, W. G. Morice, M. Q. Lacy, F. K. Buadi, R. S. Go, N. Leung, P. Kapoor, S. R. Hayman, J. A. Lust, S. J. Russell, S. R. Zeldenrust, L. Hwa, T. V. Kourelis, R. A. Kyle, M. A. Gertz, S. K. Kumar
Article
Oncology
Rajshekhar Chakraborty, Eli Muchtar, Shaji K. Kumar, Francis K. Buadi, David Dingli, Angela Dispenzieri, Suzanne R. Hayman, William J. Hogan, Prashant Kapoor, Martha Q. Lacy, Nelson Leung, Morie A. Gertz
LEUKEMIA & LYMPHOMA
(2017)
Article
Orthopedics
Gavin A. McKenzie, Stephen M. Broski, Benjamin M. Howe, Robert J. Spinner, Kimberly K. Amrami, Angela Dispenzieri, Michael D. Ringler
SKELETAL RADIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arvin Arani, Shivaram P. Arunachalam, Ian C. Y. Chang, Francis Baffour, Phillip J. Rossman, Kevin J. Glaser, Joshua D. Trzasko, Kiaran P. McGee, Armando Manduca, Martha Grogan, Angela Dispenzieri, Richard L. Ehman, Philip A. Araoz
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Letter
Oncology
T. V. Kourelis, A. Dispenzieri
Review
Medicine, General & Internal
David Dingli, Sikander Ailawadhi, P. Leif Bergsagel, Francis K. Buadi, Angela Dispenzieri, Rafael Fonseca, Morie A. Gertz, Wilson I. Gonsalves, Susan R. Hayman, Prashant Kapoor, Taxiarchis Kourelis, Shaji K. Kumar, Robert A. Kyle, Martha Q. Lacy, Nelson Leung, Yi Lin, John A. Lust, Joseph R. Mikhael, Craig B. Reeder, Vivek Roy, Stephen J. Russell, Taimur Sher, A. Keith Stewart, Rahma Warsame, Stephen R. Zeldenrust, S. Vincent Rajkumar, Asher A. Chanan Khan
MAYO CLINIC PROCEEDINGS
(2017)
Letter
Hematology
Jennifer C. Yui, Angela Dispenzieri, Nelson Leung
AMERICAN JOURNAL OF HEMATOLOGY
(2017)
Article
Hematology
Rajshekhar Chakraborty, Eli Muchtar, Shaji K. Kumar, Dragan Jevremovic, Francis K. Buadi, David Dingli, Angela Dispenzieri, Suzanne R. Hayman, William J. Hogan, Prashant Kapoor, Martha Q. Lacy, Nelson Leung, Morie A. Gertz
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
