Article
Medicine, General & Internal
Bo Chen, Wen Liu, Yanbing Chen, Quan She, Min Li, HongYe Zhao, Weihong Zhao, Zhihang Peng, Jianqing Wu
Summary: This study analyzed the correlations between age, nutritional status, comorbidities, and prognosis in pneumonia patients. The level of albumin was negatively associated with infection prognosis. Patients with dementia/Alzheimer's disease and chronic obstructive pulmonary disease/asthma had worse prognosis. Advanced age and comorbidities were identified as risk factors for pneumonia occurrence and poor prognosis.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
James M. Chamberlain, Jaideep Kapur, Robert S. Silbergleit, Jordan J. Elm, Eric S. Rosenthal, Thomas P. Bleck, Shlomo Shinnar, Shahriar Zetabchi, Scott R. Evans
Summary: Most clinical trials evaluate treatment efficacy by considering benefits and harms separately, failing to recognize the finer gradations of patient response and the overall effects on individual patients. The Desirability of Outcome Ranking (DOOR) method offers a patient-centered approach by comparing the desirability of overall patient outcomes in different treatment arms. DOOR considers both the benefits and harms to individual patients in assessing the outcome of a clinical trial.
Article
Nutrition & Dietetics
Guo-Tian Ruan, Hai-Lun Xie, He-Yang Zhang, Qi Zhang, Li Deng, Zi-Wen Wang, Xi Zhang, Yi-Zhong Ge, Chun-Lei Hu, Meng Tang, Meng-Meng Song, Xiao-Wei Zhang, Tong Liu, Xiang-Rui Li, Kang-Ping Zhang, Ming Yang, Yi-Zhen Gong, Yong-Bing Chen, Kai-Ying Yu, Ming-Hua Cong, Lei Pan, Wei-Zhong Tang, Kun-Hua Wang, Han-Ping Shi
Summary: This study aimed to identify the optimal prognostic indicator for older adults with cancer, and found that lymphocyte-C reactive protein ratio (LCR) and C-reactive protein/albumin ratio (CAR) may be more accurate in reflecting patient prognosis.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Simona Loddo, Francesco Salis, Samuele Rundeddu, Luca Serchisu, Maria Monica Peralta, Antonella Mandas
Summary: The study found that in elderly patients with poor nutritional status, the severity of comorbidities, STOPP and START alerts, and BEERS 2019 criteria were significantly worse. Additionally, patients with higher MNA scores had higher estimated 10-year survival rates and lower ADR risk scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Hanlin Mo, Guoying Zhao
Summary: This paper proposes a rotation-invariant coordinate convolution (RIC-C) to address the lack of rotation invariance in traditional convolution operations. RIC-C achieves natural invariance to arbitrary rotations around the input center without additional trainable parameters or data augmentation. Experimental results demonstrate that RIC-C significantly enhances the performance of CNN models across different applications.
PATTERN RECOGNITION
(2024)
Article
Clinical Neurology
Ruiting Zhang, Elisa Ouin, Lina Grosset, Karine Ighilkrim, Jessica Lebenberg, Stephanie Guey, Veronique Francois, Elisabeth Tournier-Lasserve, Eric Jouvent, Hugues Chabriat
Summary: Approximately one in five CADASIL patients can remain neurologically intact after the age of 65, and their clinical and imaging features differ from other age-matched CADASIL patients.
Article
Clinical Neurology
Nils Kuklik, Anika Huesing, Andreas Stang, Marcus Brinkmann, Christoph C. Eschenfelder, Christian Weimar, Hans-Christoph Diener
Summary: This study compares the efficacy of dabigatran with idarucizumab treatment and VKA treatment in patients with intracranial hemorrhage. The results suggest that in-hospital mortality is comparable between idarucizumab and VKA treatment. However, the low precision of estimates should be taken into consideration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Tomoyuki Morisawa, Masakazu Saitoh, Shota Otsuka, Go Takamura, Masayuki Tahara, Yusuke Ochi, Yo Takahashi, Kentaro Iwata, Keisuke Oura, Koji Sakurada, Tetsuya Takahashi
Summary: This study investigated the impact of perioperative changes in physical performance on the prognosis of older patients undergoing cardiac surgery, highlighting the importance of considering both preoperative and postoperative physical performance in predicting patient outcomes.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Clinical Neurology
Attila Racz, Kathryn Menne, Valeri Borger, Kevin G. Hampel, Hartmut Vatter, Christoph Helmstaedter, Christian E. Elger, Rainer Surges
Summary: This study compared complications, seizure control, and neuropsychological outcomes after epilepsy surgery in patients aged 60 or above to younger matched controls. The majority of elderly patients had favorable seizure control, although the proportion was lower compared to the control group. The older population had a higher surgical complication rate, but a lower occurrence of persistent neurological deficits. Neuropsychological and behavioral assessments showed significant impairment both preoperatively and postoperatively in the elderly population.
JOURNAL OF NEUROSURGERY
(2022)
Article
Nutrition & Dietetics
Laura Hoen, Daniel Pfeffer, Rico Zapf, Andrea Raabe, Janosch Hildebrand, Johannes Kraft, Stefan Kalkhof
Summary: Elderly patients, especially those with mild cognitive impairment or dementia, are at increased risk of dehydration. This study utilized bioelectrical impedance vector analysis (BIVA) to identify differences in hydration status based on medication and diseases in geriatric patients. The findings suggest that drug treatment and underlying conditions play a significant role in the hydration status of patients, potentially affecting their prognosis.
Article
Oncology
Muriel Heimann, Niklas Schafer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Guresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss, Matthias Schneider
Summary: In geriatric patients with surgically treated brain metastases, pre-operative frailty is associated with poor survival, with multiple intracranial metastases, infratentorial localization, preoperative CRP >5 mg/l, and frailest patients identified as predictors for reduced overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Catherine Thieblemont, Loic Chartier, Ulrich Duhrsen, Umberto Vitolo, Sally F. Barrington, Jan M. Zaucha, Laetitia Vercellino, Maria Gomes Silva, Ines Patrocinio-Carvalho, Pierre Decazes, Pierre-Julien Viailly, Herve Tilly, Alina Berriolo-Riedinger, Oliver Casasnovas, Andreas Huttmann, Hajira Ilyas, N. George Mikhaeel, Joel Dunn, Anne-Segolene Cottereau, Christine Schmitz, Lale Kostakoglu, Joseph N. Paulson, Tina Nielsen, Michael Meignan
Summary: This study validated a combination model using total metabolic tumor volume and performance status to accurately identify risk categories of patients with aggressive large B-cell lymphoma. The combination model can better predict patients' prognosis before treatment and help determine who will benefit the most from therapy.
Article
Nutrition & Dietetics
Zhen Liu, Di Xu, Wen-xiu Xu, Yin-jiao Fei, Dan-dan Wang, Fei Deng, Jin-hai Tang
Summary: This study investigates the relationships between different dietary patterns or nutritional status and mortality risk in individuals. The results suggest that higher healthy eating index and lower dietary inflammatory index are associated with lower mortality risk in people aged over 60 in the United States, while excessively low nutritional status increases the risk of death.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
XinChao Lin, HongTao Guo, YiGang Lian, Jiajing Kou, GuangLei Wang, YiYun Chen, Juan Wang, Xu Han, Miao Jiang, QiaoHui Yang
Summary: Identifying the high-risk population for osteoporosis is crucial for timely prevention. A study was conducted among elderly urban residents in Beijing to investigate the characteristics and risk factors of osteoporosis. The results showed that the prevalence of osteoporosis in women was higher than in men and increased with aging, while the prevalence of osteopenia was higher in men. A cost-effective method combining grip strength, height loss, and medical history was recommended for identifying high-risk subjects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maximilian Vorstandlechner, Katharina T. T. Obermeier, Christian P. P. Schneider, Jan M. M. Fertmann, Wenko Smolka, Sebastian Michel, Tobias Veit, Michael Irlbeck, Roland Tomasi, Rudolf A. A. Hatz, Teresa Kauke
Summary: Poor oral hygiene can lead to infections and inflammatory diseases, but its impact on post-lung transplantation (LuTX) outcome is not well-studied. This study found that carious dental status, periodontitis, and bone loss do not significantly affect post-TX survival, but literature suggests they can worsen post-LuTX survival by causing systemic/pulmonary infections. Given the lack of standardized guidelines for dental care and LuTX, further research in this field is strongly recommended.
Article
Oncology
Barbara Deschler, Gabriele Ihorst, Michael Huell, Peter Baier
JOURNAL OF GERIATRIC ONCOLOGY
(2019)
Article
Medicine, General & Internal
Niels Reinmuth, Michael Bitzer, Barbara Deschler-Baier, Juergen R. Fischer, Jonas Kuon, Jan Leipe, Justyna Rawluk, Christian Schulz, Claus Peter Heussel, Michael Schultheiss
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2019)
Article
Public, Environmental & Occupational Health
Harvey Checkoway, Peter S. J. Lees, Linda D. Dell, P. Robinan Gentry, Kenneth A. Mundt
Article
Hematology
Li-Wen Huang, Ying Sheng, Charalambos Andreadis, Aaron C. Logan, Gabriel N. Mannis, Catherine C. Smith, Karin M. L. Gaensler, Thomas G. Martin, Lloyd E. Damon, Michael A. Steinman, Chiung-Yu Huang, Rebecca L. Olin
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Review
Oncology
Raffaele Palmieri, Giovangiacinto Paterno, Eleonora De Bellis, Lisa Mercante, Elisa Buzzatti, Fabiana Esposito, Maria Ilaria Del Principe, Luca Maurillo, Francesco Buccisano, Adriano Venditti
Article
Hematology
Monika Engelhardt, Gabriele Ihorst, Jesus Duque-Afonso, Ulrich Wedding, Ernst Spaet-Schwalbe, Valentin Goede, Gerald Kolb, Reinhard Stauder, Ralph Waesch
Article
Otorhinolaryngology
Andrew G. Shuman, Bruce H. Campbell
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Oncology
Naiyer A. Rizvi, Byoung Chul Cho, Niels Reinmuth, Ki Hyeong Lee, Alexander Luft, Myung-Ju Ahn, Michel M. van den Heuvel, Manuel Cobo, David Vicente, Alexey Smolin, Vladimir Moiseyenko, Scott J. Antonia, Sylvestre Le Moulec, Gilles Robinet, Ronald Natale, Jeffrey Schneider, Frances A. Shepherd, Sarayut Lucien Geater, Edward B. Garon, Edward S. Kim, Sarah B. Goldberg, Kazuhiko Nakagawa, Rajiv Raja, Brandon W. Higgs, Anne-Marie Boothman, Luping Zhao, Urban Scheuring, Paul K. Stockman, Vikram K. Chand, Solange Peters
Review
Microbiology
Rym Lalaoui, Emilie Javelle, Sofiane Bakour, Carles Ubeda, Jean-Marc Rolain
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Horst-Dieter Hummel, Peter Kufer, Carsten Gruellich, Ruth Seggewiss-Bernhardt, Barbara Deschler-Baier, Manik Chatterjee, Maria-Elisabeth Goebeler, Kurt Miller, Maria de Santis, Wolfgang Loidl, Christian Dittrich, Andreas Buck, Constantin Lapa, Annette Thurner, Sabine Wittemer-Rump, Gokben Koca, Oliver Boix, Wolf-Dietrich Doecke, Ricarda Finnern, Helena Kusi, Antoinette Ajavon-Hartmann, Sabine Stienen, Cyrus Michael Sayehli, Buelent Polat, Ralf C. Bargou
Summary: The study reported the results of a first-in-human study of pasotuxizumab in patients with advanced castration-resistant prostate cancer. The data showed significant PSA response in some patients, suggesting the potential efficacy of this therapy in treating solid tumors.
Review
Otorhinolaryngology
Mohamad Z. Saltagi, Chelsey A. Wallace, Avinash V. Mantravadi, Michael W. Sim
CASE REPORTS IN OTOLARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Michael M. Lindeborg, Rosh K. V. Sethi, Sidharth V. Puram, Anuraag Parikh, Bharat Yarlagadda, Mark Varvares, Kevin Emerick, Derrick Lin, Marlene L. Durand, Daniel G. Deschler
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2020)
Article
Education, Scientific Disciplines
Rebecca L. Olin
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM
(2019)
Article
Otorhinolaryngology
Anuraag S. Parikh, Ayaz Khawaja, Sidharth Puram, Priya Srikanth, Tjoson Tjoa, Hang Lee, Rosh K. Sethi, Mustafa Bulbul, Mark A. Varvares, James W. Rocco, Kevin S. Emerick, Daniel G. Deschler, Derrick T. Lin
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2019)
Article
Oncology
Sebastian Michels, Carina Heydt, Bianca van Veggel, Barbara Deschler-Baier, Nuria Pardo, Kim Monkhorst, Vanessa Ruesseler, Jan Stratmann, Frank Griesinger, Susanne Steinhauser, Anna Kostenko, Joachim Diebold, Jana Fassunke, Rieke Fischer, Walburga Engel-Riedel, Oliver Gautschi, Eva Geissinger, Stefan Haneder, Michaela A. Ihle, Hans-Georg Kopp, Adrianus J. de Langen, Alex Martinez-Marti, Lucia Nogova, Thorsten Persigehl, Dennis Plenker, Michael Puesken, Ernst Rodermann, Andreas Rosenwald, Andreas H. Scheel, Matthias Scheffler, Werner Spengler, Ruth Seggewiss-Bernhardt, Johannes Braegelmann, Martin Sebastian, Bart Vrugt, Martin Hellmich, Martin L. Sos, Lukas C. Heukamp, Enriqueta Felip, Sabine Merkelbach-Bruse, Egbert F. Smit, Reinhard Buettner, Juergen Wolf
JCO PRECISION ONCOLOGY
(2019)