Review
Clinical Neurology
Fardin Nabizadeh, Kasra Pirahesh, Nazanin Rafiei, Fatemeh Afrashteh, Mona Asghari Ahmadabad, Aram Zabeti, Omid Mirmosayyeb
Summary: This study conducted a comprehensive systematic review and meta-analysis to investigate the efficacy and safety of autologous hematopoietic stem-cell transplantation (AHSCT) in patients with multiple sclerosis (MS). The results showed that AHSCT led to a significant decrease in Expanded Disability Status Scale (EDSS) score and annualized relapse rate. Most patients remained relapse-free after AHSCT and the overall survival rate was high.
NEUROLOGY AND THERAPY
(2022)
Review
Oncology
Xinsheng Liu, Yaxin Zheng, Hongtao Li, Meiyi Wang, M. James You, Chen Tian
Summary: The effect of autologous hematopoietic stem cell transplantation (auto-HSCT) versus conventional chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the survival of patients with advanced follicular lymphoma (FL) is uncertain. This study included 13 studies and found that auto-HSCT improved overall survival (OS), progression-free survival (PFS), and event-free survival (EFS) compared with conventional chemotherapy. In addition, auto-HSCT resulted in longer OS and lower non-relapse mortality (NRM) compared with allo-HSCT.
Review
Oncology
Muhammad Umair Mushtaq, Moazzam Shahzad, Ezza Tariq, Qamar Iqbal, Sibgha Gull Chaudhary, Muhammad U. Zafar, Iqra Anwar, Nausheen Ahmed, Rajat Bansal, Anurag K. Singh, Sunil H. Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk
Summary: A systematic review and meta-analysis evaluated the outcomes of mismatched unrelated donor hematopoietic stem cell transplantation (MMUD-HSCT). The results showed that MMUD-HSCT had favorable treatment outcomes and an acceptable toxicity profile in patients lacking HLA-matched or haploidentical donors, thus expanding the accessibility of HSCT to underrepresented populations.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Muhammad Umair Mushtaq, Moazzam Shahzad, Amna Y. Shah, Sibgha Gull Chaudhary, Muhammad U. Zafar, Iqra Anwar, Karun Neupane, Ayesha Khalid, Nausheen Ahmed, Rajat Bansal, Ramesh Balusu, Anurag K. Singh, Sunil H. Abhyankar, Natalie S. Callander, Peiman Hematti, Joseph P. McGuirk
Summary: NK cells play a vital role in immune reconstitution after allogeneic hematopoietic stem cell transplantation. Higher NK cell reconstitution and graft NK cell content are associated with better overall survival, lower relapse rate, and lower acute GVHD incidence. Pre-emptive NK cell infusions may prevent disease relapse post-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Yongsheng Zheng, Jianian Hu, Chong Sun, Chongbo Zhao, Jie Lin
Summary: This article presents a systematic review and meta-analysis that suggests hematopoietic stem cell transplantation (HSCT) can be an effective treatment for refractory chronic inflammatory demyelinating polyneuropathy (CIDP). The study found a high responsiveness rate and significant reduction in the use of immune modulating or suppressive drugs after HSCT.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Francesco Patti, Clara Grazia Chisari, Simona Toscano, Sebastiano Arena, Chiara Finocchiaro, Vincenzo Cimino, Giuseppe Milone
Summary: Multiple sclerosis (MS) is a chronic disease of the central nervous system that can lead to lifelong disability. Despite various treatment options, some patients still face severe symptoms and long-term disability risk. Recent studies have shown that autologous hematopoietic stem cell transplantation (AHSCT) is a highly effective and relatively safe treatment option for highly active MS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biophysics
N. Aghel, M. Lui, V. Wang, D. Khalaf, H. Mian, C. Hillis, I. Walker, B. Leber, J. H. Lipton, M. Aljama, K. Lepic, T. Berg, A. Garcia-Horton, J. Petropoulos, H. Masoom, D. P. Leong
Summary: Cardiovascular diseases are a significant cause of mortality and morbidity among survivors of hematopoietic stem cell transplantation (HSCT), but there is a lack of detailed description on the incidence of cardiovascular events (CVEs) in this population. This systematic review provides a summary of the evidence on the incidence of CVEs in HSCT recipients. The review includes 57 studies and found that the incidence of CVEs after autologous HSCT was higher compared to allogeneic HSCT, with arrhythmia being a contributing factor. Long-term CVEs were also observed in both types of HSCT survivors. CVEs remain an important but under-reported cause of morbidity and mortality in HSCT recipients.
BONE MARROW TRANSPLANTATION
(2023)
Review
Oncology
Chi-Maw Lin, Lih-Chyun Chang, Wen-Yi Shau, Chi-Ling Chen, Chi-Yuan Yao, Feng-Ming Tien
Summary: Front-line high-dose therapy followed by autologous stem cell transplantation (ASCT) is still a beneficial approach for newly diagnosed multiple myeloma (MM) patients in the era of novel agents. However, the benefit of HDT/ASCT in terms of progression-free survival (PFS) and overall survival (OS) remains inconsistent. We conducted a systematic review and meta-analysis to evaluate the advantages of upfront HDT/ASCT and identified factors influencing survival outcomes.
Review
Immunology
Ying Luo, Sumei Zhang, Hua Shang, Weitong Cui, Qinglu Wang, Bin Zhu
Summary: Hematopoietic stem cell transplant recipients are susceptible to Clostridium difficile infection. A meta-analysis of relevant studies found an overall CDI prevalence of 13.2% in HSCT patients, with higher rates among allogeneic transplantation recipients compared to autologous HSCT recipients. The incidence rates of CDI varied worldwide, with North America having higher rates than Europe but no significant difference with Asia. PCR-diagnosed CDI had a significantly higher prevalence than enzyme immunoassay-diagnosed CDI. CDI was a common complication among HSCT recipients, with recurrence and severe cases observed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Oncology
Narendranath Epperla, Tea Reljic, Sayan Mullick Chowdhury, Andres J. M. Ferreri, Ambuj Kumar, Mehdi Hamadani
Summary: The optimal consolidation strategy for newly diagnosed primary central nervous system lymphoma (PCNSL) remains controversial between autologous hematopoietic cell transplant (auto-HCT) and whole-brain radiotherapy (WBRT). A systematic review and meta-analysis of randomized controlled trials was conducted, revealing no significant differences in survival outcomes between auto-HCT and WBRT consolidation, but a higher degree of neurocognitive decline associated with WBRT. Individualized decision-making based on age, frailty, and co-morbidities is recommended.
HEMATOLOGICAL ONCOLOGY
(2023)
Review
Hematology
Konradin F. Muskens, Caroline A. Lindemans, Rana Dandis, Stefan Nierkens, Mirjam E. Belderbos
Summary: Poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (HCT) is a serious complication with varying incidence and outcomes. This systematic review and meta-analysis examined the impact of different PGF definitions on reported incidence and outcomes.
Review
Cell & Tissue Engineering
Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu, Lihua Wang
Summary: The co-infusion of mesenchymal stem cells (MSCs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has shown improvement in engraftment and reduced risk of chronic graft-versus-host disease (cGVHD). However, the effects varied among different age and disease groups, suggesting potential benefits for certain populations.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pediatrics
Zhuoyu Li, Jia Liu, Bo Jing, Wenlong Shen, Pei Liu, Yaqian Liu, Ziming Han
Summary: While the incidence of acute kidney injury (AKI) in children after hematopoietic stem cell transplantation (HCT) has not been fully addressed, a systematic literature review revealed an estimated incidence of approximately 51%. The incidence of AKI varied depending on the criteria used for evaluation, ranging from 50% to 60%. However, there was no significant correlation between the years of publication and the incidence of AKI. In conclusion, AKI affects approximately half of the pediatric population undergoing HCT, and it is expected to decrease with advancements in medical techniques.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Oncology
Xinjie Xu, Sifei Chen, Zijing Zhao, Xinyi Xiao, Shengkang Huang, Zhaochang Huo, Yuhua Li, Sanfang Tu
Summary: This study systematically evaluated and compared the efficacy and safety of consolidative HSCT after CD19 CAR-T therapy with non-HSCT in the treatment of ALL. The results showed that consolidative HSCT after CD19 CAR-T therapy could prolong OS and LFS and reduce the risk of relapse, with acceptable incidence rates for adverse events. More high-quality randomized controlled trials are needed to further determine the efficacy of HSCT.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Bruna Machado da Silva, Maria Luiza Prosdocimo, Larissa Rodrigues Gasparini, Betania Machado da Silva, Melissa Rodrigues de Araujo, Jose Miguel Amenabar
Summary: This study aimed to identify the most commonly used parameters and their efficacy in photobiomodulation therapy for the management of oral mucositis in patients undergoing hematopoietic stem cell transplantation. The meta-analysis showed that photobiomodulation therapy significantly decreased the severity of oral mucositis, with a higher protection factor when similar parameters were used.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Narendranath Epperla, Tea Reljic, Sayan Mullick Chowdhury, Andres J. M. Ferreri, Ambuj Kumar, Mehdi Hamadani
Summary: The optimal consolidation strategy for newly diagnosed primary central nervous system lymphoma (PCNSL) remains controversial between autologous hematopoietic cell transplant (auto-HCT) and whole-brain radiotherapy (WBRT). A systematic review and meta-analysis of randomized controlled trials was conducted, revealing no significant differences in survival outcomes between auto-HCT and WBRT consolidation, but a higher degree of neurocognitive decline associated with WBRT. Individualized decision-making based on age, frailty, and co-morbidities is recommended.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Allergy
Jennifer W. Leiding, Tiphanie P. Vogel, Valentine G. J. Santarlas, Rahul Mhaskar, Madison R. Smith, Alexandre Carisey, Alexander Vargas-Hernandez, Manuel Silva-Carmona, Maximilian Heeg, Anne Rensing-Ehl, Benedicte Neven, Jerome Hadjadj, Sophie Hambleton, Timothy Ronan Leahy, Kornvalee Meesilpavikai, Charlotte Cunningham-Rundles, Cullen M. Dutmer, Svetlana O. Sharapova, Mervi Taskinen, Ignatius Chua, Rosie Hague, Christian Klemann, Larysa Kostyuchenko, Tomohiro Morio, Akaluck Thatayatikom, Ahmet Ozen, Anna Scherbina, Cindy S. Bauer, Sarah E. Flanagan, Eleonora Gambineri, Lisa Giovannini-Chami, Jennifer Heimall, Kathleen E. Sullivan, Eric Allenspach, Nei Romberg, Sean G. Deane, Benjamin T. Prince, Melissa J. Rose, John Bohnsack, Talal Mousallem, Rohith Jesudas, Maria Marluce Dos Santos Vilela, Michael O'Sullivan, Jana Pachlopnik Schmid, Stepanka Pruhova, Adam Klocperk, Matthew Rees, Helen Su, Sami Bahna, Saf Baris, Lisa M. Bartnikas, Amy Chang Berger, Tracy A. Briggs, Shannon Brothers, Vanessa Bundy, Alice Y. Chan, Shanmuganathan Chandrakasan, Mette Christiansen, Theresa Cole, Matthew C. Cook, Mukesh M. Desai, Ute Fischer, David A. Fulcher, Silvanna Gallo, Amelie Gauthier, Andrew R. Gennery, Jose Goncalo Marques, Frederic Gottrand, Bodo Grimbacher, Eyal Grunebaum, Emma Haapaniemi, Sari Hamalainen, Kaarina Heiskanen, Tarja Heiskanen-Kosma, Hal M. Hoffman, Luis Ignacio Gonzalez-Granado, Anthony L. Guerrerio, Leena Kainulainen, Ashish Kumar, Monica G. Lawrence, Carina Levin, Timi Martelius, Olaf Neth, Peter Olbrich, Alejandro Palma, Niraj C. Patel, Tamara Pozos, Kahn Preece, Saul Oswaldo Lugo Reyes, Mark A. Russell, Yael Schejter, Christine Seroogy, Jan Sinclair, Effie Skevofilax, Daniel Suan, Daniel Suez, Paul Szabolcs, Helena Velasco, Klaus Warnatz, Kelly Walkovich, Austen Worth, Mikko R. J. Seppanen, Troy R. Torgerson, Georgios Sogkas, Stephan Ehl, Stuart G. Tangye, Megan A. Cooper, Joshua D. Milner, Lisa R. Forbes Satter
Summary: This pivotal cohort study defines the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 GOF variants. The study found that patients with this variant present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Early identification and prompt treatment implementation are crucial for the survival of these patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Education, Scientific Disciplines
Andrew Sephien, Tea Reljic, Jeffrey Jordan, Xavier Prida, Ambuj Kumar
Summary: The study found that shorter resident duty hours may be associated with improvement in resident-based outcomes, specifically emotional exhaustion, overall well-being, sleep duration, and sleepiness, without adverse impact on patient hospital length of stay and serious medical errors.
Review
Ophthalmology
John Yu Cheng, Katherine Tsay, Jaemyoung Sung, Steven Isaac Beigelman, Emily Coughlin, Avi S. Robinson, Rahul Mhaskar
Summary: A systematic review and meta-analysis found no significant differences in patient outcomes between resident-led surgeries and attending-led surgeries. However, there were differences in certain critical outcomes of cataract surgery, including posterior capsular tear, lens fragment retainment, and retinal detachment. Resident-led surgeries had slightly longer operative duration and increased risk of unplanned return to the operating room.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Hematology
Aryanna Jordan, Akriti G. Jain, Gautam Krishna Koipallil, Meghana Reddy, Sanjay Chakkoli, Shonali Midha, Vania Phuoc, Jennifer Eatrides, Crystal Erhardt, Ankita K. Patel, Juan Rico, Nathan Visweshar, Rahul Mhaskar, Nainesh Parikh, Damian Laber, Michael Jaglal
Summary: The platelet count threshold of 50 x 10(9)/L does not affect the risk of adverse events in lumbar punctures for intrathecal chemotherapy.
ANNALS OF HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Sephien, Mike Ghobrial, Tea Reljic, Xavier Prida, Nishant Nerella, Ambuj Kumar
Summary: This study provides an overview of systematic reviews and meta-analyses on the efficacy of SGLT2i in the management of heart failure. The results suggest that SGLT2i may be beneficial in patients with heart failure, but further research is needed to compare the efficacy of different types of SGLT2i.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Surgery
Kristen Whalen, Langfeier Liu, Courtney Johns Rejano, Rahul Mhaskar, Nazanin Khakpour, Deniz Dayicioglu
Summary: Reverse abdominoplasty is a simple and safe technique for closing large defects after locally advanced breast cancer excision. It has a short operative time, hospital stay, and turnaround time to initiation of adjuvant therapy.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Obstetrics & Gynecology
Obada Kattih, Valentina Battistoni, Emily Coughlin, Rahul Mhaskar, Lynette Menezes, Kristie Greene
Summary: During the COVID-19 pandemic, surgical societies released guidelines that included cancellation of elective cases. This study aimed to understand patients' perceptions of the severity of their pelvic floor disorders and to determine factors influencing this perception. Factors such as race, health status, and willingness to attend in-person appointments influenced patients' perception of urgency.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Sheon Baby, Tea Reljic, Nuria Villalba, Ambuj Kumar, Sarah Y. Yuan
Summary: The concentration of plasma glycocalyx-associated molecules is higher in patients with sepsis-associated encephalopathy (SAE), indicating their potential use in early identification of cognitive decline in sepsis patients.
Article
Medicine, General & Internal
Andrew Sephien, Rajalakshmi Arunachalam, Rahul Mhaskar, Andrew San Antonio, Jeffrey Jordan
Summary: This study aimed to improve information gathering and confidence of Internal Medicine interns by using an EMR guide. The results showed that the use of an EMR guide significantly increased the completeness of patient information gathering and intern confidence. This study suggests that developing an EMR guide during residency may benefit the transition of interns.
SOUTHERN MEDICAL JOURNAL
(2023)
Article
Surgery
Theo Sher, Abdul-Rahman Diab, Rahul Mhaskar, Salvatore Docimo Jr, Joseph Sujka, Christopher DuCoin
Summary: This study aimed to evaluate the Spanish readability of accredited Bariatric Centers of Excellence (COE) websites and determine accessibility for Spanish-speaking patients. The results showed that only 25% of the websites were translatable to Spanish, with regional differences in Spanish readability. It is suggested to improve the Spanish readability of ASMBS ACS COE websites regardless of geographic differences in Spanish-speaking populations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Cardiac & Cardiovascular Systems
Richard D. Kang, Nariman Nezami, Peter Park, Anthony A. DePalma, Mohammed F. Loya, Rahul Mhaskar, Chad Engel, Bruce Zwiebel, Glenn Hoots, Jamil Shaikh
Summary: This retrospective study evaluated the safety and feasibility of using the Scorpion X access kit for portal vein access in TIPS procedures. The results showed that the use of this kit resulted in successful portal vein cannulation with minimal complications.
Article
Oncology
Dae Hyun Lee, Sanjay Chandrasekhar, Michael D. Jain, Rahul Mhaskar, Kayla Reid, Sae Bom Lee, Salvatore Corallo, Melanie J. Hidalgo-Vargas, Abhishek Kumar, Julio Chavez, Bijal Shah, Aleksandr Lazaryan, Farhad Khimani, Taiga Nishihori, Christina Bachmeier, Rawan Faramand, Michael G. Fradley, Daniel Jeong, Guilherme H. Oliveira, Frederick L. Locke, Marco L. Davila, Mohammed Alomar
Summary: CAR-T immunotherapy can lead to cardiac toxicities and changes in cardiac and inflammatory biomarkers. This study aims to investigate the role of pro-inflammatory cytokines in patients undergoing CAR-T therapy.
Article
Rheumatology
Patricia Teran-Wodzinski, Ambuj Kumar
Summary: In order to improve the lives of individuals with Hypermobile Ehlers-Danlos Syndrome (hEDS) and Generalized Hypermobility Spectrum Disorder (G-HSD), a study was conducted to identify their priorities. An online survey was conducted, with 483 responses analyzed out of 396 participants. The survey revealed the prevalence of pain, fatigue, joint hypermobility, joint instability, and other physical and emotional issues in hEDS and G-HSD individuals. The findings underline the urgent need for better treatment options, diagnostic processes, and healthcare provider education.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Hematology
Narendranath Epperla, Ambuj Kumar, Syed A. Abutalib, Farrukh T. Awan, Yi-Bin Chen, Ajay K. Gopal, Jennifer Holter-Chakrabarty, Natasha Kekre, Catherine J. Lee, Lazaros Lekakis, Yi Lin, Matthew Mei, Sunita Nathan, Loretta Nastoupil, Olalekan Oluwole, Adrienne A. Phillips, Erin Reid, Andrew R. Rezvani, Judith Trotman, Joanna Zurko, Mohamed A. Kharfan-Dabaja, Craig S. Sauter, Miguel-Angel Perales, Frederick L. Locke, Paul A. Carpenter, Mehdi Hamadani
Summary: Autologous hematopoietic cell transplantation has been the standard approach for patients with relapsed/refractory diffuse large B cell lymphoma. However, the introduction of CAR T cell therapy has changed the management of these patients, especially with the approval of CD19-directed CAR-T therapy in the second-line setting for high-risk groups. The American Society of Transplantation and Cellular Therapy has formulated consensus recommendations to address the lack of consensus on the role and sequencing of HCT and cellular therapies in DLBCL.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
